• The Korean Journal of Applied Statistics
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• v.15 no.1
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• pp.85-105
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• 2002

To explore the relationships among frequencies for sets of alleles, within or between loci, is one of the first analyses in population genetic study. The general question is whether the frequency of a set of alleles is the same as the product of each of the separate allele frequencies. For two alleles of a single locus, Hardy-Weinberg equilibrium is tested and for an allele from each of two loci, linkage disequilibrium is tested. However, it is more useful if we can quantify and graphically represent this information. In this study, we suggest graphical methods to find associations between alleles. We also analyze the STR data of Korean population as an illustration.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• v.2
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• pp.101-106
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• 2006

The geoidal undulations are needed for determining the orthometric heights from the Global Positioning System GPS-derived ellipsoidal heights. There are several methods for geoidal undulation determination. The paper presents a method employing a simple architecture Two Layer Multiquadric-Biharmonic Artificial Neural Network (TLMB-ANN) to approximate an area of 4200 square kilometres quasigeoid surface with GPS-levelling data. Hardy’s Multiquadric-Biharmonic functions is used as the hidden layer neurons’ activation function and Levenberg-Marquardt algorithm is used to train the artificial neural network. In numerical examples five surfaces were compared: the gravimetric geometry hybrid quasigeoid, Support Vector Machine (SVM) model, Hybrid Fuzzy Neural Network (HFNN) model, Traditional Three Layer Artificial Neural Network (ANN) with tanh activation function and TLMB-ANN surface approximation. The effectiveness of TLMB-ANN surface approximation depends on the number of control points. If the number of well-distributed control points is sufficiently large, the results are similar with those obtained by gravity and geometry hybrid method. Importantly, TLMB-ANN surface approximation model possesses good extrapolation performance with high precision.

• Bulletin of the Korean Mathematical Society
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• v.36 no.2
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• pp.225-231
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• 1999

Let Mf(x) be the Hardy-Littlewood maximal function on $\mathbb{R}^n$. Let $\Phi$ and $\Psi$ be functions satisfying $\Phi$(t) = ${\int^t}_0$a(s)ds and $\Psi(t)$ = ${\int^t}_0$b(s)ds, where a(s) and b(s) are positive continuous such that ${\int^\infty}_0\frac{a(s)}{s}ds$ = $\infty$ and b(s) is quasi-increasing. We show that if there exists a constant $c_1$ so that ${\int^s}_0\frac{a(t)}{t}dt\;c_1b(c_1s)$ for all $s\geq0$, then there exists a constant $c_1$ such that(0.1) $\int_{\mathbb{R^{n}}$ $\Phi(Mf(x))dx\;\leq\;c_2$ $\int_\mathbb{R^{n}}$$\Psi(c_2\midf(x)\mid)dx$ for all $f\epsilonL^1(R^n_$. Conversely, if there exists a constant $c_2$ satisfying the condition (0.1), then there exists a constant $c_1$ so that ${\int^s}_\delta\frac{a(t)}{t}dt=;\leq\;c_1b(c_1s$ for all $\delta$ > 0 and $s\geq\delta$.

• Korean Journal of Mathematics
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• v.31 no.1
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• pp.17-23
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• 2023

For a locus with two alleles (I^A and I^B), the frequencies of the alleles are represented by $$p=f(I^A)={\frac{2N_{AA}+N_{AB}}{2N}},\;q=f(I^B)={\frac{2N_{BB}+N_{AB}}{2N}}$$ where N_AA, N_AB and N_BB are the numbers of I^AI^A, I^AI^B and I^BI^B respectively and N is the total number of populations. The frequencies of the genotypes expected are calculated by using p², 2pq and q². Choi defined the density and operator for the value of the frequency of one gene and found the adapted partial differential equation as a follow-up for the frequency of alleles and applied this adapted partial differential equation to several diploid model [1]. In this paper, we find adapted equations for the model for selection against recessive homozygotes and in case that the alley frequency changes after one generation of selection when there is no dominance. Also we consider the triploid model with three alleles I^A, I^B and i and determine whether six genotypes observed are in Hardy-Weinburg for equilibrium.

• Nutrition Research and Practice
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• v.18 no.1
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• pp.88-97
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• 2024

BACKGROUND/OBJECTIVES: Mitigating insulin resistance and hyperglycemia is associated with a decreased risk of diabetic complications. The effect of Daraesoon (shoot of hardy kiwi, Actinidia arguta) on hyperglycemia was investigated using a type 2 diabetes animal model. MATERIALS/METHODS: Seven-week-old db/db mice were fed either an AIN-93G diet or a diet containing 0.4% of a 70% ethanol extract of Daraesoon, whereas db/+ mice were fed the AIN-93G diet for 7 weeks. RESULTS: Consumption of Daraesoon significantly reduced serum glucose and blood glycated hemoglobin levels, along with homeostasis model assessment for insulin resistance in db/db mice. Conversely, Daraesoon elevated the serum adiponectin levels compared to the db/db control group. Furthermore, Daraesoon significantly decreased both serum and hepatic triglyceride levels, as well as serum total cholesterol levels. Additionally, consumption of Daraesoon resulted in decreased hepatic tumor necrosis factor-α and monocyte chemoattractant protein-1 expression. CONCLUSIONS: These results suggest that hypoglycemic effect of Daraesoon is mediated through the improvement of insulin resistance and the downregulation of pro-inflammatory cytokine expression in db/db mice.

• Proceedings of the Korean Society of Near Infrared Spectroscopy Conference
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• 2001.06a
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• pp.1253-1253
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• 2001

The ability to accurately assess wine quality is important during the wine making process, particularly when allocating batches of wines to styles determined by consumer requirements. Grape payments are often determined by the quality category of the wine that is produced from them. Wine quality, in terms of sensory characteristics, is normally a subjective measure, performed by experienced winemakers, wine competition judges or winetasting panellists. By nature, such assessments can be biased by individual preferences and may be subject to day-to-day variation. Taste and aroma compounds are often present in concentrations below the detection limit of near infrared (NIR) spectroscopy but the more abundant organic compounds offer potential for objective quality grading by this technique. Samples were drawn from one of Australia's major wine shows and from BRL Hardy's post-vintage wine quality allocation tastings. The samples were scanned in transmission mode with a FOSS NIR Systems 6500, over the wavelength range 400-2500 ㎚. Data analysis was performed with the Vision chemometrics package. With samples from the allocation tastings, the best correlations between NIR spectra and tasting data were obtained with dry red wines. These calibrations used loadings in the wavelengths related to anthocyanins, ethanol and possibly tannins. Anthocyanins are a group of compounds responsible for colour in red wines - restricting the wavelengths to those relating to anthocyanins produced calibrations of similar accuracy to those using the full wavelength range. This was particularly marked with Merlot, a variety that tends to have relatively lower anthocyanin levels than Cabernet Sauvignon and Shiraz. For dry white wines, calibrations appeared to be more dependent on ethanol characteristics of the spectrum, implying that quality correlated with fruit maturity. The correlations between NIR spectra and sensory data obtained using the wine show samples were less significant in general. This may be related to the fact that within most classes in the show, the samples may span vintages, glowing areas and winemaking styles, even though they may be made from only one grape variety. For dry red wines, the best calibrations were obtained with a class of Pinot Noir - a variety that tends to be produced in limited areas in Australia and would represent the least matrix variation. Good correlations were obtained with a tawny port class - these wines are sweet, fortified wines, that are aged for long periods in wooden barrels. During the ageing process Maillard browning compounds are formed and the water is lost through the barrels in preference to ethanol, producing “concentrated” darkly coloured wines with high alcohol content. These calibrations indicated heaviest loadings in the water regions of the spectrum, suggesting that “concentration” of the wines was important, whilst the visible and alcohol regions of the spectrum also featured as important factors. NIR calibrations based on sensory scores will always be difficult to obtain due to variation between individual winetasters. Nevertheless, these results warrant further investigation and may provide valuable Insight into the main parameters affecting wine quality.

• Korean Journal of Biological Psychiatry
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• v.7 no.2
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• pp.152-158
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• 2000

Background : No association between schizophrenia and dopamine D4 receptor polymorphisms have been reported. Despite these results, it is premature to exclude the association. It has been suggested that the susceptibility to develop schizophrenia could result from variation at a number loci which may interact or coact with each other. Therefore, we investigated a possible association of combinations of exon III 48bp polymorphism[D4E3] and exon I 12bp polymorphism of the DRD4 gene [D4E1] with schizophrenia. Methods : 207 unrelated Korean schizophrenic patients and 191 healthy controls were recruited. DRD4 genotype was established using the polymerase chain reaction. Statistical analysis consisted of ${\chi}^2$ tests for Hardy-Weinberg proportions and genotypic and allelic frequencies in the patients and control groups. Results : There were no statistically significant differences in the each polymorphisms between schizophrenics and controls. And all genotype frequencies were within Hardy-Weinberg expectations. When the combinations of the polymorphism in schizophrenia and controls were compared, however, there were significant differences at $A1A2^*2/4$ in the distributions of the combinations of D4E1 and D4E3(p<0.01). Conclusions : These findings suggest that the certain combination of D4E1 and D4E3($A1A2^*2/4$) has the protective role to a susceptibility for schizophrenia.

• Korean Journal of Food Science and Technology
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• v.47 no.4
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• pp.539-543
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• 2015

A hardy kiwifruit is a good source of phenolics and antioxidants. This study was aimed at investigating the effects of hot air drying at three different temperatures (35, 50, and $70^{\circ}C$) for 24 h on the total phenolic and flavonoid contents and the antioxidant capacity of hardy kiwifruits of Actinidia arguta ${\times}$ A. deliciosa cv. Mansoo. Dried kiwifruit extracts were produced using 80% (v/v) aqueous ethanol under homogenization. Hot air drying lowered the total phenolic and flavonoid contents and decreased the antioxidant capacity in the dried kiwifruits compared with their fresh counterparts. The results also revealed high positive linear correlations of antioxidant capacity with total phenolic and flavonoid contents, indicating that phenolics are the major contributors to antioxidant capacity. Our results suggested that an optimal drying process must be determined for industrial application in order to obtain dried kiwifruits with increased antioxidant capacity for consumers.

• Animal cells and systems
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• v.3 no.3
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• pp.237-241
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• 1999

Philophylla heringi, sp. nov., and P. nigroscutellata(Hering) are described, illustrated, and distinguished from related species. These two species, both of which were collected from Kambaiti, Myanmar, closely resemble each other in external appearance, but show many differences in the female postabdominal structures. In addition, previous identification of P. nigroscutellata and P. bisecta Hardy and Adachi are elucidated based on a comparison of the holotypes of both species.

• Kyungpook Mathematical Journal
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• v.45 no.2
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• pp.255-272
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• 2005

This paper is concerned with studying the weighted $L^P$ boundedness of a class of maximal operators related to homogeneous singular integrals with rough kernels. We obtain appropriate weighted $L^P$ bounds for such maximal operators. Our results are extensions and improvements of the main theorems in [2] and [5].