• Journal of the Korean Association of Geographic Information Studies
• /
• v.14 no.4
• /
• pp.63-76
• /
• 2011

This study purposes to develop a model to analyze soil loss in estimating prior disaster influence. The model of analyzing soil loss develops the soil loss analysis system on the basis of Internet by introducing cloud computing system, and also develops a standalone type in connection with HyGIS. The soil loss analysis system is developed to draw a distribution chart without requiring a S/W license as well as without preparing basic data such as DEM, soil map and land cover map. Besides, it can help users to draw a soil loss distribution chart by applying various factors like direct rain factors. The tools of Soil Loss Anaysis Model in connection with HyGiS are developed as add-on type of GMMap2009 in GEOMania, and also are developed to draw Soil Loss Hazard Map suggested by OECD. As a result of using both models, they are developed very conveniently to analyze soil loss. Hereafter, these models will be able to be improved continuously through researches to analyze sediment a watershed outlet and to calculate R value using data of many rain stations.

• Korean Journal of Microbiology
• /
• v.50 no.2
• /
• pp.164-168
• /
• 2014

The ecosystem of the Arctic region has been increasingly affected by global warming. Archaeal ammonia monooxygenase alpha subunit coding gene (amoA) which is a key enzyme for nitrification was used to investigate the effect of runoff water of ice melt on microbial community of nitrogen cycle. The archaeal amoA genes at coastal area of Svalbard, Arctic region were PCR-amplified and sequenced after clone library construction. Analysis of archaeal amoA gene clone libraries suggested that the station 188 which is in the vicinity to the area of runoff water harbor lower ammonia-oxidizing archaeal diversity than the station 176 and 184. The average amino acid sequence identity within all archaeal amoA gene clones was 94% (with 91% nucleotide sequence identity). While all the clones of the station 188 were affiliated with Nitrosoarchaeaum clade containing strains isolated from low-salinity and terrestrial environments, about 45% of total clones of the station 176 and 184 were related to marine Nitosopumilus clade. Interestingly, other typical archaeal amoA gene clones of thaumarchaeal I.1b clade frequently retrieved from terrestrial environments was identified at station 188. Microbial community of nitrogen cycle in marine sediment might be affected by input of sediments caused by runoff glacier melt waters.

• Tuberculosis and Respiratory Diseases
• /
• v.80 no.2
• /
• pp.187-193
• /
• 2017

Background: Third-generation tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR-TKIs) have proved efficacious in treating non-small cell lung cancer (NSCLC) patients with acquired resistance resulting from the T790M mutation. However, since almost 50% patients with the acquired resistance do not harbor the T790M mutation, retreatment with first- or second-generation EGFR-TKIs may be a more viable therapeutic option. Here, we identified positive response predictors to retreatment, in patients who switched to a different EGFR-TKI, following initial treatment failure. Methods: This study retrospectively reviewed the medical records of 42 NSCLC patients with EGFR mutations, whose cancers had progressed following initial treatment with gefitinib or erlotinib, and who had switched to a different first-generation EGFR-TKI during subsequent retreatment. To identify high response rate predictors in the changed EGFR-TKI retreatment, we analyzed the relationship between clinical and demographic parameters, and positive clinical outcomes, following retreatment with EGFR-TKI. Results: Overall, 30 (71.4%) patients received gefitinib and 12 (28.6%) patients received erlotinib as their first EGFR-TKI treatment. Following retreatment with a different EGFR-TKI, the overall response and disease control rates were 21.4% and 64.3%, respectively. There was no significant association between their overall responses. The median progression-free survival (PFS) after retreatment was 2.0 months. However, PFS was significantly longer in patients whose time to progression was ${\geq}10months$ following initial EGFR-TKI treatment, who had a mutation of exon 19, or whose treatment interval was <90 days. Conclusion: In patients with acquired resistance to initial EGFR-TKI therapy, switched EGFR-TKI retreatment may be a salvage therapy for individuals possessing positive retreatment response predictors.

• Journal of the Society of Disaster Information
• /
• v.16 no.2
• /
• pp.276-290
• /
• 2020

Purpose: The construction history of domestic port facilities has been more than 100 years, and until recently, modern facilities have been continuously built and expanded. However, it is not easy to keep the required performance conditions at the time of initial construction due to changes in the marine environment and increase in volume. In particular, in the case of harbor structures that have a long service life, safety performance and function management are becoming very important due to the increase in the size of ships, the increasing frequency of use, and the increase in the scale of natural disasters. Method: Therefore, this study investigates the state change by structural type of port facilities and analyzes the rehabilitation activities and the history that contribute to the performance improvement and life extension activities. Result: Through this, we distinguished between performance improvement cost (CAPEX) and repair maintenance activity (OPEX) that can be used to establish port facility maintenance strategy, and suggested cost model that can be used to establish maintenance strategy. Conclusion: These studies are expected to contribute greatly to mid- to long-term investment decisions.

• Journal of the Korean Geosynthetics Society
• /
• v.14 no.4
• /
• pp.87-96
• /
• 2015

Geosynthetics are widely used in different ways such as reinforcement of structures in road, railway, harbor and dam engineering, drainage, separation and erosion prevention. They are especially applied to reinforced retaining wall and slope or ground reinforcement. Recently, geosynthetics reinforced pile supported (GRPS) embankment was developed to improve stability and construability of embankments in railway engineering. Extension strains are usually measured by strain gauges adhered to geosynthetics to evaluate the stability of geosynthetics. However, the measurements are influenced by manufacturing method and stiffness of geosynthetics and also adherence of strain gauge. In this study, wide-width tensile strength tests were performed on three types of geosynthetics including geogrid, woven geotextile and non-woven geotextile. During the test, strains of geosynthetics were measured by both video extensometer and strain gauges adhered to the geosynthetics and the measured results were compared. Results show that the measured results by strain gauges have high reliability in case of large stiffness geosythetics like geogrid and woven geotextile, whereas they have very low reliability for small stiffness geosythetics like non-woven geotextile.

• Journal of Korean Society of Environmental Engineers
• /
• v.27 no.1
• /
• pp.43-51
• /
• 2005

This paper presents a waste load allocation study for the Incheon coastal environment, where a computer model, called AQUASEA, was applied. A finite element mesh was constructed and refined to cover the complicated geometry of Incheon coastal sea. The tidal height at 13 places of Incheon coastal boundary and flow of the Han River were given as an input condition to the tidal simulation. All pollution sources that discharge into Incheon coast were given as input data to the water quality simulation. The modeled parameters include tidal flow and COD(Chemical Oxygen Demand). The model was calibrated and verified with the field measurements. The model results showed reasonable agreements with field measurements in both tidal flow and water quality. Systems analysis showed that the pollution load from the Han River caused recognizable impacts on the water quality of Incheon coast from Yeomhwa waterway to northern area of Younghungdo. The loads from Incheon City affected water quality from the area below Youngjongdo to the area above Jawalldo. The discharge from the Sihwa Lake caused discernible impacts on the coastal zone from the dike outlet to the Incheon harbor, and pollution loads from Kyungkido affected the sea near the Oido. An effective water quality management plan was developed from the waste load allocation analysis of the validated model, that the maximum waste loads can be discharged without violating the water quality standard given in the Incheon coastal environment.

• Microbiology and Biotechnology Letters
• /
• v.17 no.4
• /
• pp.283-288
• /
• 1989

To reduce the size of 5.0kb HindIII fragment containing $\beta$-xylosidase gene, the 5.0kb insert of pAX278 which was previously cloned was reduced by various deletions and thus 1.4kb EcoRI-Xbal fragment was subcloned into pUC19, and the recombinant plasmid was named pAK208. The $\beta$-xylosidase acnivity of E. coli harboring pAK208 was higher about 1.3times than that of pAX278. For the improvement of $\beta$-xylosidase activity, we cloned and expressed the $\beta$-xylosidase gene in E. coli using vector pKK223-3 containing a potent tac-promoter, and enzyme activity of the transformant harboring pKHR212 was increased about 3.3 and 1.8 times than that of E. coli(pAX278) and Bacillus sp. K-17, respectively. To obtain better expression of $\beta$-xylosidase gene, the whole 5.0kb HineIII fragment was recloned into pC194, and the Bacillus sp. K-17 transformant harbor-ing the recombinant plasmid pCX174 showed higher activity than that of the E. coli (pAX278) and Bacillus sp. K-17, respectively. The characteristics of enzyme purified from transformants were consistent with those front alkalophilic Bacillus sp, K-17.

• Journal of Korean Society of Coastal and Ocean Engineers
• /
• v.25 no.1
• /
• pp.34-39
• /
• 2013

In this study, the quantitative analysis and pattern analysis of the error bounds with respect to recording period were carried out using the wave climate data from coastal areas. Arbitrary recording periods were randomly sampled from one month to six years using the bootstrap method. Based on the analysis, for recording periods less than one year, it was found that the error bounds decreased rapidly as the recording period increased. Meanwhile, the error bounds were found to decrease more slowly for recording periods longer than one year. Assuming the absolute estimate error to be around 10% (${\pm}0.1m$) for an one meter significant wave height condition, the minimum recording period for reaching the estimate error for Sokcho and Geoje-Hongdo stations satisfied this condition with over two years of data, while Anmado station was found to satisfy this condition when using observational data of over three years. The confidence intervals of the significant wave height clearly show an increasing pattern when the percentile value of the wave height increases. Whereas, the confidence intervals of the mean wave period are nearly constant, at around 0.5 seconds except for the tail regions, i.e., 2.5- and 97.5-percentile values. The error bounds for 97.5-percentile values of the wave height necessary for harbor tranquility analysis were found to be 0.75 m, 0.5 m, and 1.2 m in Sokcho, Geoje-Hongdo, and Anmado, respectively.

• International Journal of Industrial Entomology and Biomaterials
• /
• v.39 no.2
• /
• pp.45-53
• /
• 2019

The popularity of keeping stag beetles (Dorcus titanus castanicolor Motschulsky 1861, Coleoptera: Lucanidae) as pets has increased. Consistent with the rise in the number of insect farms using these beetles, the number of contaminated or diseased D. titanus castanicolor has also increased. This investigation was conducted to analyze the cause of D. titanus castanicolor disease. The contaminated larvae of D. titanus castanicolor showed Allomyrina nudivirus infection symptoms similar to those of Allomyrina nudivirus infection. However, the disease carried by of D. titanus castanicolor is not derived from the virus infecting Allomyrina, as determined by PCR. Our study revealed that the major gut microbes of infectious D. titanus castanicolor belonged to the phylum Proteobacteria, and specifically, Pseudomonas knackmussi (Symptom 1 - 39.62% to Symptom 2 - 41.50% to Symptom 3 - 76.76% as the disease progressed severely) and Citrobacter koseri (Symptom 1 - 1.48% to Symptom 2 - 6.04% to Symptom 3 - 6.16% as the disease progressed severely) were detected. Additionally, a high proportion of larvae from the uninfected group were found to harbor bacteria belonging to the phylum Firmicutes (72%). However, as the disease progressed severely in these beetles, the proportion of Firmicutes decreased (Symptom 1 - 72.03% to Symptom 2 - 44.7% to Symptom 3 - 26.3%). These findings imply that colonization by Firmicutes was inversely proportional to Proteobacteria colonization in the gut. This was found to be true for both the normal and disease conditions of D. titanus castanicolor. In this study, we examined the distribution of intestinal microbial communities in normal and contaminated larvae. We observed a correlation between these contaminated microbes and the overall health of the beetle, and our findings suggest that there may be a link between disease progression and the gut microbiome.

• Journal of Wetlands Research
• /
• v.13 no.3
• /
• pp.523-534
• /
• 2011

In this study, the particle size distribution and pollutants content of sediments collected from different sites in the coastal area of Chungnam province were analyzed. The sediment samples were collected from different parking lots near beaches, harbors, museum and bridges. The particle size distribution analysis showed that the particle is generally $106-500{\mu}m$ and the effective size $D_{10}$ ranges from 40 to $60{\mu}m$ while the $D_{50}$ and $D_{60}$ ranges from 200 to $810{\mu}m$ and 235 to $1005{\mu}m$, respectively. For particle size $D_{10}$, there was no significant difference in all sites. However, for $D_{50}$ and $D_{60}$, the range is large. Sediment analysis implicates that as the particle size decreases, the pollutant content increases. This is because smaller particles have higher specific surface area resulting to have more adsorption capacity. Particles from tires, emission gas from vehicles and dust particles belongs to smaller particles. For particle sizes less than $63{\mu}m$, the analysis showed that as the particles become coarser, the concentration of VS, $COD_{cr}$, TN, and TP is at least 2 to 14 times higher. Cu and Pb were detected in all sites and shows a higher concentration with smaller particle size. Cu concentration are almost the same for all sites but in the case of Pb, the sediments from Sinjindo has higher concentration of up to 2 to 3 times as compared to those collected from the other sites. In the Beach site as well as in the Seocheon Ocean Museum, Cd was contained only in fine particles. However, in Daechon Harbor and Sinjindo Bridge sites, Cd was detected in all the sediment particle size.