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A Study of TNF-${\alpha}$(G308A) Genetic Polymorphism and Risk Factors Associated with Rheumatoid Arthritis by Sasang Constitution (사상체질에 따른 류마티스 관절염의 위해요인 및 TNF-${\alpha}$(G308A) 유전자 다형성간의 연관성 연구)

  • Kim, Su-Young;Chun, Hyung-Jon;Lee, Doo-Ik;Lee, Yun-Ho;Choi, Do-Young;You, Yong-Gu;Lee, Jae-Dong
    • Journal of Acupuncture Research
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    • v.24 no.1
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    • pp.137-159
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    • 2007
  • Objectives: The purpose of this study is to examine the risk factors and the genetic polymorphism of TNF-alpha associated with rheumatoid arthritis by Sasang constitution Methods : This study was planned to detect the susceptibility of the patients diagnosed by rheumatoid arthritis to Sasang Constitution and to examine the risk factor such as life style and environmental stress (smoking, environmental tobacco smoke, alcohol intake and so on). The genetic polymorphism of TNF-alpha (G308A) were analyzed by PCR-RFLP in rheumatoid arthritis patients and controls. Rheumatoid arthritis patients and matched controls are assessed with QSCCII question for Sasang Typology. Then the genetic polymorphism of patients by Sasang constitution are compared to those of control, which are statistically analyzed and adjusted by age, sex, smoking status, alcohol intake, BMI, and econocmic status. Results: Differential effect of passive smoking on the association between Sasang constitution and rheumatoid arthritis risk was found. This study showed that the genetic polymorphism (TNF-${\alpha}$(G308A)) of rheumatoid arthritis patients and controls associated with the susceptibility to rheumatoid arthritis by sasang constitution was analyzed. Differential effects of TNF-${\alpha}$(G308) genetic polymorphism on the association between rheumatoid arthritis risk and Sasang constitution were found. Conclusion : It is suggested that the genetic polymorphism correlated with susceptibility to rheumatoid arthritis by specific sasang constitution used as its susceptibility marker and further as basic data to prevent the risk factors for rheumatoid arthritis. But larger studies will be needed to confirm these preliminary findings.

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Landscape Design Proposal for Seoul Yeouido Riverside Park (여의도 한강공원 조성계획)

  • Kim, Do-Kyong;Choi, Won-Man;Hong, Hyoung-Soon
    • Journal of the Korean Institute of Landscape Architecture
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    • v.36 no.2
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    • pp.14-23
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    • 2008
  • Ran Gang is a huge, attractive river which meanders through Seoul, the capital of South Korea. However, during the modernization of Seoul, the river gradually lost its natural beauty and healthy condition. Han Gang Renaissance is a project to upgrade the look of the Seoul waterfront, by overcoming this disaster and reorganizing the surroundings of Han Gang. This research articulates the design strategies and description of the prizewinning work of the International Design Competition for Yeouido Riverside Park that was linked to the Han Gang Renaissance Project. There are three key points that basically speak to the identity of the new waterfront, Yeouido Riverside Park. First, the current day Yeouido was recreated as an artificial island through the rapid expansion of the city and the initiation of the shore protection works. However, because it is the only island still remaining that shows the history of Han Gang, the park was designed to be the place which preserves the lyric of sand island and the emotional memory of riverside. Secondly, among the six districts of the Han Gang Renaissance Project, the two districts that are facing each other, Yongsan and Yeouido, are the central areas promoting international finance and business. Despite Yongsan's complete urban image, the exquisite harmony of pastoral scenes and skyscrapers of the Yeouido waterfront is presented to develop an active mutual relation with Yongsan. Lastly, this design scheme re-establishes the relationship between this competition's site, Yeouido Riverside Park, and a neighboring site, Yeouido Park.

Comparative Analysis on Security Needs Satisfaction and Life Satisfaction of Electronic Security System Users by City Size (도시크기에 따른 기계경비시스템 이용자의 안전욕구충족과 생활만족 비교분석)

  • Yoo, Young-Chang;Lee, Jong-Hwan;Kim, Chan-Sun
    • The Journal of the Korea Contents Association
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    • v.10 no.2
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    • pp.330-341
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    • 2010
  • The purpose of this study is to have comparative analysis on the differences between metropolis and provincial city's electronic security system users' security needs satisfaction and life satisfaction. This study sampled total 400 users with using purposeful sampling after selecting specific metropolis and provincial cities as population. It was conducted on 4 realms-bank, jewelry store, convenience store and communication industry- with two times. First one was on June, 2008, it was conducted in Seoul, 5 areas divided based on Hangang, which are Gang-dong, Gang-seo, Gang-nam, Gang-buk, and civic center. We sampled 40 electronic security system users of each area which are 200 in sum. Second one was on January, 2009, with users in Cheonan and Asan, 200 was sampled in the same way with metropolis; 100 users of each city. The reliability of the questionnaire showed Cronbach's ${\alpha}$ value over .812. The results are as follows. First, there showed difference on physical security needs satisfaction of electronic security system users with the size of city. In other word, users in metropolis have higher environmental, psychological, and informational security needs satisfaction than users in provincial city. Second, there is also difference in life satisfaction. Namely, users in metropolis have higher security needs satisfaction than users in provincial city. Third, security needs satisfaction of electronic security system users by city size effects life satisfaction. That is, in case of users in metropolis, the more physical, environmental, and informational security needs satisfaction it shows, the more life satisfaction it showed.

Morphometric Characteristic between Diploid and Spontaneous Triploid Carp in Korea

  • Lim, Sang Gu;Han, Hyeng Keun;Goo, In Bon;Gil, Hyun Woo;Lee, Tae Ho;Park, In-Seok
    • Development and Reproduction
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    • v.21 no.1
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    • pp.55-62
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    • 2017
  • We used flowcytometry to ploidy verification after that investigate difference between diploid and spontaneous triploid through the truss dimension and classical dimension at crucian carp, Carassius auratus, crucian carp C. cuvieri and common carp, Cyprinus carpio collected from Hangang river, Hantangang river, Imjingang river, Geumgang river, Yeongsangang river and Nakdonggang river, Korea. There were significant differences among the three species for the truss dimensions anterior origin of dorsal fin $(2){\times}$ anterior origin of anal fin (5), $2{\times}$ anterior origin of pelvic fin (6), $2{\times}$ origin of pectoral fin (7), posterior origin of dorsal fin $(3){\times}5$, $3{\times}6$, and $3{\times}7$ (P<0.05). There were no significant differences among the three species in the truss dimensions dorsal fin length ($2{\times}9$) and eye diameter (ED)(P>0.05). On the other hand, there were no significant differences in the several classical dimensions of each species (P>0.05). Three classical dimensions, most anterior extension of the head $(1){\times}2$, $1{\times}6$ and $2{\times}$ most posterior scale in lateral line (4) did not differ between the C. auratus diploid and spontaneous triploid (P>0.05). Two classical dimensions, $1{\times}6$ and longest length between most anterior extension of the head and gill cover ($1{\times}8$) did not differ between the C. cuvieri diploid and spontaneous triploid (P>0.05). One classical dimensions, $1{\times}2$ did not differ between the common carp diploid and spontaneous triploid (P>0.05). There were significant differences in the each diploid and triploid species (P<0.05). These results suggest that the classification of each species and classification between diploid and spontaneous triploid morphometrical parameters used in this study are useful indices of morphometrical status in the each species from major river of Korea.

Characteristics of Ferralsols Soils and Rice Growth in Buchanan Region, Liberia (LIBERIA BUCHANAN 지역 FERRASOLS 토양의 이화학적 특성과 수도생육)

  • Jo, Guk Hyun;Kim, Kwang Sik;Kim, Yong Woong
    • Korean Journal of Soil Science and Fertilizer
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    • v.30 no.2
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    • pp.168-177
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    • 1997
  • This study was carried out to find the physico-chemical properties of soils and the rice growth at the pilot project rice farm of Buchanan city, Liberia. The results were as follows. Soils were classified as Plinthic Ferralsols. Real tropical soils had an oxic B horizon of 30cm thick with diffused horizon boundaries. The surface soils have Ochric A horizon with low organic matter. Plinthite was distributed throughout the whole soil profile unevenly. Exposed to sun light, Plinthite was dried out, hardened, and developed irreversibly into ironstone. There were 286 termite hills in 20ha in the project area. The pH value of the termite hills was higher than that of the ordinary soil two units. Soils of the termite hills had higher contents of carbon, nitrogen, available phosphate and exchangeable bases, especially calcium(2,000mg/kg). Available Fe contents was 230~330mg/kg in the surface soil, and 2,200mg/kg in the subsoil. This caused bronzing of rice in a few days after transplanting. The tolerance of Fe toxicity was lower in Korean cultivars than in Liberian cultivars. The tolerant cultivar was Hangang among Korean cultivars and Nizersail and Suakoko 8 among Liberian cultivars. Area weighted average percolation rate was 8.3mm/day and infiltration rate was 2~2.5mm/hr.

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Electrophoretic Patterns of Hemolymph Proteins of Varieties with Long and Short Life Span in the Silkworm Bombyx mori L. (${\cdot}$단명 누에 품종의 체액단백질의 전기영동상)

  • Kang, Pil-Don;Yoon, Hyung-Joo;Ryu, Kang-Sun;Sohn, Bong-Hee;Sohn, Hung-Dae
    • Journal of Sericultural and Entomological Science
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    • v.41 no.1
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    • pp.1-8
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    • 1999
  • Hemolymph protein patterns of silkworms in terms of short and long life span were analyzed by native- and SDS-polyacrylamide gel electrophoresis (PAGE) with the developmental stages. From the native-PAGE patterns of silkworm major hemolymph proteins there were varietal differences on the first day of the pupal stage and were classified into there groups MHP-a, b and c SA 10, JAM109 and J037 were grouped into MHP-Ⅰ, Hangang, Chungmun and Daizo(sdi) into MHP-Ⅱ and NTZN, Sulak, Qoichuk and PR varieties into MHP-Ⅲ group. It was found that the MHP in each group revealed similar patterns and changes with development of pupal stage. In the first day of adult, MHP-c was clearly detected in both female and male of the Daizo(sdi), but not in the J037, indicating that there was significantly varietal differences in electrophoretical protein pattern. In addition, the results of protein pattern of hemolymph by SDS-PAGE showed also varietal differences in the concentration of hemolymph protein.

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Analysis of Hydraulic Effects of Singok Submerged Weir in the Lower Han River (한강하류부 신곡수중보의 수리학적 영향분석)

  • Kim, Sang-Ho;Kim, Won;Lee, Eul-Rae;Choi, Kyu-Hyun
    • Journal of Korea Water Resources Association
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    • v.38 no.5 s.154
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    • pp.401-413
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    • 2005
  • This study analyzed the hydraulic effects of Singok submerged weir in the lower Han River. 1-D hydraulic flood routing model was used and calibration and verification were performed using 8 flood or nonflood events. Flow characteristics were analyzed using various outflows of Paldang Dam and tidal data of the Yellow Sea. Water level increase effects by establishment of Singok submerged weir were as following, when maximum flood tidal was 2.4m, highest water level increased about 0.65m, and lowest water level increased about 1.25m in the downstream of Jamsil submerged weir. In Hangang Bridge, due to the Singok submerged weir, when maximum flood tidal was 2.4m, tidal range was 0.07m and decrement of tidal range was about $90\%$. And when maximum flood tidal was 5.5m, tidal range was 1.6m and decrement of tidal range was about $35\%$. When the outflow of Paldang Dam was over 20,000cms, tidal range was below about 0.06m, and tidal effect did not appear hardly.

Organic Analysis of Charred Residues on the Pottery in the Proto-Three Kingdom from Joong-do Site, Chuncheon (춘천 중도 유적에서 출토된 원삼국시대 토기 탄착물에 대한 화학적 분석)

  • Kang, Soyeong;Jee, Sanghyun;Kim, Yun Ji;Chang, Hong Sun
    • Journal of Conservation Science
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    • v.29 no.4
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    • pp.437-444
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    • 2013
  • We studied for the chemical characterizations of the charred residues obtained from the ancient potteries in the Proto-Three Kingdom period from archaeological sites in Joong-do, Chuncheon. Organic components of the charred residues were extracted and analysed using mass spectrometry and infrared spectroscopy. Lipid profiles from these samples were not identified in gas chromatography-mass spectrometry. Bulk stable isotope analyses of charred residues was used to infer an average values of the foods prepared. The average carbon isotope values (${\delta}^{13}C$) of the residues are $-14.7{\pm}2.8$‰ (ranging from -8.7‰ to -18.4‰, n=9), and nitrogen isotope values (${\delta}^{15}N$) are $6.2{\pm}1.1$‰ (ranging from -4.4‰ to -7.6‰, n=9). This is the first approach to analyse charred residues using stable isotopic method in Korea. Charred food residues on the interior surface of archaeological pottery can provide valuable information about pottery use and dietary habits of its population.

A Clinical Analysis of the Thyroid Cancer (갑상선암의 임상적 고찰)

  • Park Ki-Min;Kang Hyung-Kil;Kim Lee-Su;Lee Bong-Hwa
    • Korean Journal of Head & Neck Oncology
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    • v.13 no.2
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    • pp.213-220
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    • 1997
  • Background: Thyroid cancer is a relatively rare neoplasm and its incidence varies geographically and ethnically around the world. Thyroid cancer is the most common endocrine malignancy, but it has a wide spectrum of biologic behavior, histologic appearance, and management. Purpose: The purpose of the study was to analyse and evaluate all aspects of the clinical consideration in thyroid cancer. Method: Between 1986 and 1995, a retrospective analysis of 77 thyrod cancer patients admitted at the Department of Surgery, Hangang Sacred Heart Hospital, Hallym University was made to assess clinical entities. Result: By the pathological classification, the papillary carcinoma was the most common type(83.1%). Male to female ratio was 1 : 5.4 and most prevalent age group was noted from fourth decade to fifth decade(46.8%). The most common duration of illness between the appearance of the symptoms and the treatment was below 6 months(44.2%), and the most common symptom was the palpable mass at the anterior portion of the neck(96.1%). Most cases of the thyroid cancer were appeared as cold nodule in the $^{99m}$Tc-thyroid scan(95.7%). In the site of tumor location, the right and left lobe was distributed similarly. In the extent of tumor, incidence of intrathyroidal location was 41.6%, and that of the metastasis to the cervical lymph nodes was 44.2% and that of the direct capsular invasion was 27.3%, and incidence of both involved case was 13%. Surgical procedures were total thyroidectomy alone in 27 cases(35.1%) or with modified neck dissection in 6 cases(7.8%), or with radical neck dissection in 2 cases (2.6%), near total thyroidectomy alone in 22 cases(28.6%), ipsilateral lobectomy with isthmectomy alone in 12 cases(15.6%) or with modified neck dissection in 1 case(1.3%), and biopsy only in 7 cases(9.1%). The most common postoperative complications were transient hypoparathyroidism(5.2%) and transient unilateral recurrent laryngeal nerve paralysis(5.2%). Conclusion: The major problem of management of thyroid cancer include a wide spectrum of clinical behaviour of this tumor entity, the lack of reliable prognostic factors and lack of an objective assessment of the various treatment modalities. But because of showing the favorable prognosis for most thyroid cancer, appropriate and aggressive management should be recommended.

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THE EFFECTS OF PHYSICAL ABUSE TO THE EMOTIONS AND BEHAVIORS IN CHILDREN (신체적 학대가 아동의 정서 및 행동에 미치는 영향)

  • Kwon, Ja-Young;Ahn, Dong-Hyun;Lee, Jung-Sook
    • Journal of the Korean Academy of Child and Adolescent Psychiatry
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    • v.3 no.1
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    • pp.73-83
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    • 1992
  • The purpose of this study was to undrstand the emotional and behavioral sequela in the abused child caused by phygical abuse. To achieve the purpose. the emotional and behavioral differences between not or less abused children group and severely abused children group were compared in this study. The subjects in this study were 61 male children who were selected among children under custody at 4 child-welfare institutions in Seoul. A violence scale in CTS(Conflict Tactics Scale) developed by Straus(1979) was modified and used as a research tool to measure the children's physical abuse. The Korean text of Child Behavior Checklist(CBCL) was also used to measure the emotional and behavioral problems of abused children. The results of this study were as follows : 1) The total scores of behavioral problems in physically abused children were significantly higher than those in control group. 2) The comparison of behavioral problems has shown significant differences between two groups in social withrawal. somatic symptom, emotional disturbance, obsessive-depressive behavior, hyperactivity and psychotic-sexual factors. However. there were no differences in aggressive and delinquent factors. The above results presents us the profile of children's emotional and behavioral problems caused by physical abuse, and can be used as a framework for the treatment protection and preservation of abused children in the course of social work practice.

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