• 농촌계획
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• 제9권2호
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• pp.49-55
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• 2003

The purpose of this study is to analyze the impact of land-use and population change in rural area by new expressway. Chungbu expressway constructed in 1987, going through the south area of Kyunggi province from Seoul, was selected as a case expressway, and also 2 cities and 18 subdivisions of county in its surrounding area, as a case study area. To analyze the change characteristics before and after the construction, land-use maps of 1986 and 1996 were collected, including the census data for the years in cities and counties yearbooks. Remote sensing technology was applied to classify the land-use maps with six types of land use. Geographic information system was also used for spatial analysis, such as the land-use and accessibility changes. A 5 km buffer zone from interchange of the expressway showed about two times increase of urbanized built-up area than a 5 km buffer zone from the expressway. Accessibility from Seoul and cities was improved in most areas, which is accessing to Seoul through existing Youngdong expressway. Ten rural areas showed increased population with accessibility of average 52 minutes to Seoul and 19 minutes to cities, while eight areas showed decreased population with average 73 minutes to Seoul and 35 minutes to cities. This shows that the threshold value, which is time distance to Seoul and cities for population increase or decrease, one and half hours, respectively. Urbanized area was increased in most areas, even in population decrease areas, so this indicates that there are thinning rural areas, increasing urbanized area while decreasing population.

• Biomolecules & Therapeutics
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• 제17권2호
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• pp.205-210
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• 2009

The present study investigated the effects of hydrocortisone on the pharmacokinetics of loratadine in rats after intravenous and oral administration. A single dose of loratadine was administered either orally (4 mg/kg) or intravenously (1 mg/kg) with or without oral hydrocortisone (0.3 or 1.0 mg/kg). Compared to the control group (without hydrocortisone), after oral administration of loratadine, the area under the plasma concentration-time curve (AUC) was significantly increased by 30.2-81.7% in the presence of hydrocortisone (p<0.05). The peak plasma concentration ($C_{max}$) was significantly increased by 68.4% in the presence of 1.0 mg/kg hydrocortisone after oral administration of loratadine (p<0.05). Hydrocortisone (1.0 mg/kg) significantly increased the terminal plasma half-life ($t_{1/2}$) of loratadine by 20.8% (p<0.05). Consequently, the relative bioavailability of loratadine was increased by 1.30- to 1.82-fold. In contrast, oral hydrocortisone had no effects on any pharmacokinetic parameters of loratadine given intravenously. This suggests that hydrocortisone may improve the oral bioavailability of loratadine by reducing first-pass metabolism of loratadine, most likely mediated by P-gp and/or CYP3A4 in the intestine and/or liver. In conclusion, hydrocortisone significantly enhanced the bioavailability of orally administered loratadine in rats, which may have been due to inhibition of both CYP 3A4-mediated metabolism and P-gp in the intestine and/or liver by the presence of hydrocortisone.

• Archives of Pharmacal Research
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• 제22권2호
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• pp.165-172
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• 1999

In the present work , the transport mechanism of a capsaicin derivative, DA-5018, through blood-brain barrier (BBB) has been investigated to evaluate the feasibility of potential drug development. The result of pharmacokinetic parameters obtained from the intravenous injection of plasma volume marker,$[3^H]RSA$ and $[{14}^C]DA-5018$, indicated that both AUC, area under the plasma concentration curve and VD, volume of distribution in brain of $[3^H]RSA$ agreed with those reported ($1620{\pm}10 $percentage injected dose minute per milliliter (%IDmin/ml) and $12.0{\pm}0.1{\mu}l/g$, respectively). Elimination half-life and AUC of $[{14}^C]DA-5018$is corrected by the PHLC analysis, 19.6$\pm$1.2 min and 7.69$\pm$0.85% IDmin/ml, respectively. The metabolic rate of $[{14}^C]DA-5018$was very rapid. The blood-brain barrier permeability surface area (PS) product of $[{14}^C]DA-5018$ was calculated to be 0.24$\pm$0.05 $\mu$l/min/g. The result of internal carotid artery perfusion and capillary depletion suggested that [14C]DA-5018 pass through BBB with the time increasingly. Investigation of transport mechanism of $[{14}^C]DA-5018$ using agonist and antagonist suggested that vanilloid (capsaicin) receptor did not exist in the BBB, and nutrient carrier system in the BBB has no effect on the transport of DA-5018. In conclusion, despite the fact that penetration of DA-5018 through BBB is significant, the intact drug found in the brain tissue is small because of a rapid metabolism. Therefore, for the central analgesic effect of DA-5018, the method to increase the metabolic stability in plasma and the brain permeability should be considered.

• 한국노년학
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• 제37권1호
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• pp.151-171
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• 2017

본 연구는 사회변동의 한 실태로 나타나는 다양한 가족형태 중 꾸준히 증가하고 있는 40세 이상 60세 미만의 직업이 있는 중년 여성가구주를 대상으로 그들의 현재 삶을 생생히 들여다보고 노후를 위한 준비 현황을 파악함으로써 여성가구주에 대한 삶을 이해하는 데 목적이 있다. 따라서 여성가구주가 된 배경 및 여성가구주로서 삶에 적응하기까지의 삶의 궤적과 향후 노후준비를 해가는 경험에 대한 본질과 의미를 탐색하고자 Colaizzi의 현상학적 질적 분석방법으로 진행하였다. 자료 수집은 2014년 9월~12월까지 총 4개월에 걸쳐 진행하였으며, 1회당 1시간~1시간 30분의 개방형 질문을 통한 인터뷰를 총 2회에 걸쳐 실시하였으며 자세한 답변에 대한 불충분한 부분은 전화나 메일을 통해 추가하였다. 본 연구의 본질주제는 <외발로 선 낯선 세상>, <서서히 밀려오는 노후불안>, <힘이 되어주는 울타리>, <한걸음 다가선 자립적 노후준비>, <채우고 싶은 반쪽>, <노후 삶에 대한 소망> 등 6개였다. 이러한 결과를 토대로 중년 여성가구주에게 노후를 자연스럽게 받아들이고 긍정적으로 인식할 수 있도록 다양한 정보 제공과 노후대비 교육 및 노후 적응프로그램 등 국가적인 지원이 필요함을 제언하였다. 마지막으로는 연구의 제한점과 의의, 그리고 후속연구를 위한 제언을 논의하였다.

• 한국임상수의학회지
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• 제36권3호
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• pp.159-165
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• 2019

Pimobendan is an inodilator used to treat canine heart failure, and pentoxifylline is reported to be beneficial for microcirculation and heart disease. The purpose of this study was to evaluate the pharmacokinetic and pharmacodynamic profiles of a novel pimobendan-pentoxifylline liquid mixture after oral administration to dogs. Eight healthy Beagle dogs were included in the study. The dogs were divided into the control group (orally administered water; n = 4) and experimental group (orally administered pimobendan-pentoxifylline liquid mixture [pimobendan 0.25 mg/kg, pentoxifylline 15 mg/kg]; n = 4). Plasma samples were obtained and echocardiographic indices were measured for 24 hours after administration. The concentrations of pimobendan and pentoxifylline were quantified by using a liquid chromatography-mass spectrometer (LC-MS). The elimination half-life ($T_{1/2}$) was $32.96{\pm}9.80mins$ for pimobendan and $29.49{\pm}6.67mins$ for pentoxifylline. The time to reach maximum concentration ($T_{max}$) were $52.50{\pm}31.22mins$ for pimobendan and $41.25{\pm}18.87mins$ for pentoxifylline. The maximum blood concentration ($C_{max}$) was $96.92{\pm}75.64ng/mL$ for pimobendan and $7074.07{\pm}3261.1ng/mL$ for pentoxifylline. Of the echocardiographic indices, fractional shortening (FS) and left ventricular internal diameter at end systole (LVIDs) were significantly altered at 1-3 hours after the administration of pimobendan-pentoxifylline liquid mixture. The pimobendan-pentoxifylline liquid mixture was well tolerated by the dogs, with no adverse effects observed during the study.

• Journal of Radiation Protection and Research
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• 제46권4호
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• pp.184-193
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• 2021

Background: The radionuclides released by the Fukushima Daiichi Nuclear Power Plant (FDNPP) accident 9 years ago are still being monitored by various research teams and the Japanese government. Comparison of different surveys' results could help evaluate the exposure doses and the mechanism of radiocesium behavior in the urban environment in the area. In this study, we clarified the relationship between land use and temporal changes in the ambient dose rates (air dose rates) using big data. Materials and Methods: We set a series of 1 × 1 km² meshes within the 80 km zone of the FDNPP to compare the different survey results. We then prepared an analysis dataset from all survey meshes to analyze the temporal change in the air dose rate. The selected meshes included data from all survey types (airborne, fixed point, backpack, and carborne) obtained through the all-time survey campaigns. Results and Discussion: The characteristics of each survey's results were then evaluated using this dataset, as they depended on the measurement object. The dataset analysis revealed that, for example, the results of the carborne survey were smaller than those of the other surveys because the field of view of the carborne survey was limited to paved roads. The location factor of different land uses was also evaluated considering the characteristics of the four survey methods. Nine years after the FDNPP accident, the location factor ranged from 0.26 to 0.49, while the half-life of the air dose rate ranged from 1.2 to 1.6. Conclusion: We found that the decreasing trend in the air dose rate of the FDNPP accident was similar to the results obtained after the Chernobyl accident. These parameters will be useful for the prediction of the future exposure dose at the post-accident.

• 방사선산업학회지
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• 제18권1호
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• pp.89-93
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• 2024

Accidents at nuclear facilities and nuclear power plants led to leaks of large amounts of radioactive substances. Of the various radioactive nuclides released, ¹³⁷Cs are radioactive substances generated during the fission of uranium. Therefore, due to the high fission yield (6.09%), strong gamma rays, and a relatively long half-life (30 years), a rapid and efficient removal method and a study of adsorbents are needed. Accordingly, an adsorbent was prepared using Prussian blue (PB), a material that selectively adsorbs radioactive cesium. As a result of evaluating the adsorption performance with the prepared adsorbent, it was confirmed that 82% of the removal efficiency was obtained, and most of the cesium was rapidly adsorbed within 10 to 15 minutes. The purpose of this study was to adsorb cesium using the Prussian blue alginate bead and to compare the change in detection efficiency according to the amount of adsorbent added for quantitative evaluation. However, in this case, it is difficult to determine the detection efficiency using a standard source with the same conditions as the measurement sample, so the efficiency change of the HPGe detector according to the different heights of Prussian blue was calculated through MCNP simulation using certified standard materials (1 L, Marinelli beaker) for radioactivity measurement. It is expected to derive a relational equation that can calculate detection efficiency through an efficiency curve according to the volume of Prussian blue, quantitatively evaluate the activity at the same time as the adsorption of radioactive nuclides in actual contaminated water and use it in the field of nuclear facility operation and dismantling in the future.

• Journal of Veterinary Science
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• 제25권4호
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• pp.58.1-58.8
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• 2024

Importance: Over the past decade, catfish farming has increased in Southeast Asia. However, there has been no existing for pharmacokinetic data in the hybrid catfish (Clarias macrocephalus x C. gariepinus). Objective: This study was designed to evaluate the pharmacokinetic characteristics of oxytetracycline (OTC) in the hybrid catfish, following single intravascular (IV) or oral (PO) administration at a single dosage of 50 mg/kg body weight (BW). Methods: In total, 140 catfish (each about 100-120 g BW) were divided into two groups (n = 70). Blood samples (0.6-0.8 mL) were collected from ventral caudal vein at pre-assigned times up to 144 h (sparse samples design). OTC plasma concentrations were analyzed using high-performance liquid chromatography-photodiode array detector. Results: The pharmacokinetic parameter of OTC was evaluated using a non-compartment model. OTC plasma concentrations were detectable for up to 144 and 120 h after IV and PO, respectively. The elimination half-life value of OTC was long with slow clearance after IV administration in hybrid catfish. The average maximum concentration value of OTC was 2.72 ㎍/mL with a time at the maximum concentration of 8 h. The absolute PO bioavailability was low (2.47%). Conclusions and Relevance: These results showed that PO administration of OTC at a dosage of 50 mg/kg BW was unlikely to be effective for clinical use in catfish. The pharmacodynamic properties and clinical efficacy of OTC after multiple medicated feed are warranted.

• 한국콘텐츠학회논문지
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• 제19권6호
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• pp.620-631
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• 2019

현대 사회에서는 남녀를 불문하고 외모관리가 중요한 사회적인 영향력과 경쟁력으로 대두되면서 외모관리의 중요성이 점점 더 부각되고 있다. 외모관리행동은 전통적으로 여성을 중심으로 받아들여지고, 거의 모든 소비시장의 주체가 여성이라는 인식이 최근까지 확산되어져 왔으나 1990년대 이후 성역할에 대한 고정관념의 변화와 여성들의 사회 진출로 인해 독립적인 성향이 강해지면서 남녀의 지위와 역할에도 상당한 영향을 미쳤다. 이에 따라 남성들은 여성적 영역에 있어서 과거보다 긍정적인 시각과 포용적인 태도를 보이기 시작했으며, 남성들도 자신의 외모를 가꾸고 자신을 잘 표현하기 위해서 외모관리행동에 많은 시간과 돈을 투자하는 경향이 증가하고 있다. 여성의 전유물로만 여겨졌던 화장품 모델에서도 남자가 등장하는가 하면 그루밍족, 노무족, 로엘족 등 연령대에 상관없이 외모에 관심을 갖는 남성 인구가 증가하고 더 나아가 직장인 남성들에게 외모는 승진이나 연봉 등 직업적 성취를 위한 경쟁력 요소라는 인식이 점차 확산되고 있다. 사회생활의 주체인 남성들은 호감 가는 외모와 긍정적인 이미지를 형성하기 위하여 후광효과를 발휘하게 된다. 자아존중감과 외모관리행동에 관한 연구는 두 가지 면에서 중요한 시사점을 가지고 있다. 첫째, 외모관리를 통하여 남성의 매력성을 증가시키며 그로 인한 스스로의 자아존중감 향상과 사회적 경쟁력을 확보할 수 있어 이는 업무 성취도에 있어서도 긍정적인 영향을 미친다. 둘째, 남성 고유의 자아존중감이 높을수록 심리적으로 안정되어 사회적인 승인에 대한 의존도가 적으며 의복의 심미성을 중요시하게 되어 외모 관리행동력이 높아진다. 본 연구의 분석 결과에 따라 자기 자신에 대한 외모평가와 신체만족도가 자아존중감과 높은 상관관계가 있음을 연구결과 확인하였으며 대인관계형성에도 유의한 영향을 준다고 규명하였다.

• 한국학교ㆍ지역보건교육학회지
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• 제3권
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• pp.35-58
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• 2002

This research attempted to investigate the real state of adolescent smoking and drinking, and to study how stress influences on smoking and drinking of high school students. This data was collected from 837 first and second grade students in a vocational high school in Go-yang city, Gyeonggi province. Data analysis consisted of frequency, percentage, Chi-square, T-test, step-wise regression analysis, using SPSSWIN. The results of analysis were as follows: First, 51.7% of the students have never smoked, while 48.3% have experienced smoking. Most students started smoking in the second year of the middle school, though 17.6% of the smokers already started in the elementary school. The strongest motive of initial smoking was curiosity, next the inducement of friends, and 10.9% of them smoked to get rid of stress. Their favorite place for smoking was in the order of the entertainment centers, schools, and private academies. They personally purchased cigarettes mostly at the store. Most of them smoked less than 5 cigarettes a day, but 3.7% smoked more than a pack of cigarettes a day, usually with friends rather than alone. Second, the ratio of drinking was relatively high 78.1%, and their initial drinking experience was most frequent at the third year of the middle school. The initial motive of drinking was mostly curiosity and the inducement of friends, but 10.7% of them started drinking to reduce stress and anxiety. The places for buying alcohol and drinking were bars or restaurants. The ratio of habitual drinking was 45.1%, and the ratio of irregular drinking was 53.3%. 1.8% of the drinking students enjoyed drinking everyday. The amount of drinking varied from half a bottle to two bottles of Soju, and the drinking problem was serious to see that 11% of them drank more than two bottles at a time. Because 84.4% drank in groups with friends, a thorough and systematic supervision and education of the peer group drinking is essential. Third, as for the relationship between personal matters and smoking, it was found that there was a positive relation between smoking and sex, but there was no correlation between smoking and school years. Adolescent smoking was also related with scholastic achievement, the number of friends, and the existence of parents. Fourth, as for the relationship between personal matters and drinking, it was found that there was no correlation between drinking and sex, but there was a positive relation between drinking and school years. Fifth, the average index of stress was students themselves(2.58), school life(2.53), family life(2.19), friends(2.00), and the total index of stress was 2.33. Sixth, there appeared a marginal negative correlation between stress and 'drinking and smoking' in Pearson coefficient of correlation r to see the influence of stress on smoking and drinking. The difference of the average index of stress according to smoking and drinking bears meaningful difference for all students, smokers and non-smokers, drinkers and abstainers in students themselves, school life, family life, friends, and total stress. Smoking has an effect on family life most, school life next, and drinking has an effect on school life most, family life next, with the explanation power of 11% and 9% respectively, in a regression analysis to analyze the factors influencing on smoking and drinking among the factors of stress.