• Korean Journal of Veterinary Research
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• v.39 no.2
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• pp.267-275
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• 1999

Bovine somatotropin is known to improve the growth rate and lactation in cattle. In this study, we examined the concentration-time profiles of a sustained-release formulation of bovine somatotropin (BST) and insulin-like growth factor-1 (IGF-1) in plasma and milk in cows. In addition, the possible effect of co-administrated vitamin ADE complex on the pharmacokinetic parameters of BST and IGF-1 was evaluated. 1. Plasma BST and IGF-1 levels reached the peak at 12~24 and 48 hours after the administration of BST, and plasma half-lives ranged 100 to 137 and 201 to 310 hours, respectively. To 8th day after administration, BST and IGF-1 levels in milk were not significantly different from the control levels. 2. Plasma BST levels showed cyclic pattern with high concentrations in early stage after each injection and following gradual declining during repeated administrations at 2 week intervals, while plasma IGF-1 levels in treated animals did not show such a cyclic pattern, but remained higher than the control levels. 3. Milk BST and IGF-1 levels during repeated treatments were not significantly different from the control levels. 4. Co-administration of vitamin ADE complex yielded slightly increased AUC of plasma BST for high dose group, but such effect was not evident in the IGF-1 levels. Co-administration of ADE complex tended to increase plasma BST levels and decrease the elimination half-life of IGF-1. 5. These results suggest that the BST formulation tested is one of the ideal sustained-release formulation for long term use in dairy industry. As for the co-administration of vitamin ADE complex, the benefit of co-administration with BST is needed to be further evaluated.

• Journal of Families and Better Life
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• v.21 no.2
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• pp.175-185
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• 2003

The purpose of this study was to investigate whether there is any difference between the dual residence couples and the single residence couples in terms of the situation of child care, development of their child and mother's parenting guilty or parenting stress. Also, this study aimed to explore the variables which influence parenting guilty and parenting stress of dual residence mothers. The 178 mothers of three to eight tear-old participated the survey. Half of them were dual residence mothers and another half were those of single residence. These two groups were matched in terms of the occupation of the mother and the age of the child. Major finding were as follows. 1) Compared with single residence couples, dual residence couples used multiple methods of child care. And they depended maternal families more than paternal ones as a care-giver. They also payed much more for the child care than single residence couples. 2) Children of the dual residence couples did not differ with those of the single residence couples in terms of cognitive and social development. 3) Dual residence mothers had more parenting guilty than those of single residence while these two groups did not differ in terms of parenting stress. 4) While dual residence mother's parenting guilty was significantly related with the amount of information provided by the paternal families, their parenting stress was significantly related with the frequencies of communicating with the husband, the mother's age, the flexibility of time in the mother's work place, the mother's orientation to the career, and the supports of the husband. In conclusion, dual residence families in Korea were not so negative as expected. Furthermore, this study suggests that the parenting difficulties of the dual residence mothers could be decreased by the change of social and economic situations and the psycho-social support of the husband.

• Archives of Pharmacal Research
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• v.27 no.7
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• pp.806-810
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• 2004

Metformin is a biguanide antihyperglycemic agent often used for the treatment of non-insulin dependent diabetics (NIDDM). In this study, the pharmacokinetics and pharmacodynamics of metformin were investigated in Korean healthy volunteers during a fasting state for over 10 h. In order to evaluate the amount of glucose-lowering effect of metformin, the plasma concentrations of glucose were measured for a period of 10 h followed by the administration of metformin (oral 500 mg) or placebo. In addition, the concentration of metformin in blood samples was determined by HPLC assay for the drug. All volunteers were consumed with 12 g of white sugar 10 minutes after drug intake to maintain initial plasma glucose concentration. The time courses of the plasma concentration of metformin and the glucose-lowering effect were analyzed by nonlinear regression analysis. The estimated $C_{max}$, $T_{max}$, $CL_{t}$/F (apparent clearance), V/F(apparent volume of distribution), and half-life of metformin were 1.42$\{pm}$0.07 $\mu\textrm{g}$/mL, 2.59$\{pm}$0.18h, 66.12$\{pm}$4.6 L/h, 26.63 L, and 1.54 h respectively. Since a significant counterclock-wise hysteresis was found for the metformin concentration in the plasma-effect relationship, indirect response model was used to evaluate pharmacodynamic parameters for metformin. The mean concentration at half-maximum inhibition $IC_{50}$, $k_{in}$, $k_{out}$ were 2.26 $\mu\textrm{g}$/mL, 83.26 $H^{-1}$, and 0.68 $H^{-1}$, respectively. Therefore, the pharmacokinetic-pharmacodynamic model may be useful in the description for the relationship between plasma concentration of metformin and its glucose-lowering effect.

• Journal of the East Asian Society of Dietary Life
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• v.13 no.3
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• pp.155-166
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• 2003

This study was conducted to investigate the dietary behavior and health-related lifestyles of university students in Incheon arear Self administered questionnaires were collected ken 179 food and nutrition major and non-major students. Statistical data analysis was completed using a SPSS v.10.0 program. The results are summarized as follows: The average weight, height, BMI and PIBW of the major and non-major male and female students were 69.89kg, 172.89cm, 23.4 and 106.49 ; 67.27kg, 173.98cm, 22.2 and 101.35 ; 50.61kg, 161.20cm, 19.53 and 92.25 ; 53.77kg, 161.53cm, 20.56 and 97.18, respectively. The breakfast skipping ratio of the subjects were very high, which was mainly due to the reason“lack of time”More than 75% of male students and 61% of female students responded to have lunch at university canteens or restaurants around campus regularly. About 56% of male students and 68% of female students responded to have dinner irregularly, which mainly caused by the reasons“irregularity of lecture”and “appointment with friends”. The ratio of snacks intake of the subjects were high; Ramyun was the snack item taken the most by the male students and fruits and cookies by the female ones. More than 50% male students and 2% of female students were smokers. A half of students dunk alcohol once or twice a week. The dietary behaviors and health-related lifestyles between major and non-major male students tended to be very similar. The major female students showed more health-oriented dietary behaviors in comparison with the non-major ones. Therefore, they should have a major-oriented and practically organized nutritional education program to correct their dietary behaviors and health-related lifestyles fur health.

• The Research Journal of the Costume Culture
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• v.7 no.6
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• pp.98-115
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• 1999

As sports infiltrates each field of modern society and becomes familiar, sports wear was changed functionally and was introduced and enveloped into everyday dress. Modern sports wear has been the settled in everyday life deeply and become the clothes of life which are worn regardless of place, time and age. The aim of this paper was to clarify what kind of fashion of sports style would be given to the modern people. In this study, sports wear which has become everyday dress classified from a gender point of view. It was divided into masculine image, feminine image, and neutral image. Sports wear of masculine image generated a silhouette which emphasized the shoulder with the aspiration for youth and health. Wide shoulder was considered as the symbol of masculine beauty and the expression of healthy beauty. It was reflected well in body conscious look. And owing to the development of up-to-data materials, innovation of design, and the study of human body technology, the functional character was settled in the sports wear which showed masculine image. Sports wear of feminine image was represented fashion of body exposure, body feet with body conscious look, and romantic mode. This image was expressed fashion as comforts, pleasant, active design, materials, color, and romantic feminine beauty. Sports wear of neutral image was expressed into unisex clothes. This cloths have no difference in gender, age, and class. It was used as casual sports wear. In the 1960s, young generation participated in such street sports as street basketball and skate. They usually sore the sports wears of neutral image such as cycling, skating, and ski. In the materials of sports, the development of up-to-data material like lycra made the sayings lifelike, “up-to-data material is the second skin” It show that glamorous feminine image and strong masculine image coexisted. The contemporary concept of sportswear is no longer limited to those clothes for sports found in such places like tennis court or swimming pool. Now, the sports wear become more like casual activity wear all classes of people can enjoy in their life regardless of where they are, when they wear, and even how old they are.

• Journal of Korean Academy of Nursing Administration
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• v.18 no.4
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• pp.357-373
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• 2012

Purpose: The purpose of this study was to define the experience of nursing education in the Jinju area of Gyeongsang-Namdo from the 1940s to 1960s. Methods: An oral history study was done using personal interviews with 8 nurses who graduated in nursing in Gyeong Nam area during the period under study. Results: In this study, the individual's educational background before entering the nursing school, school life, and life as a nurse after graduating from nursing school were defined. Conclusion: For most of the respondents, their educational background before entering nursing school was middle school. They studied very hard in poor surroundings. After graduation from a nursing school, they worked in hospitals, public health centers, midwifery centers, and schools. Half of the respondents had experience as a midwife. Their income as a midwife was relatively high at that time. They all had positive identities and lived a life devoted to the individual, society, and the nation.

• Journal of the Korean Home Economics Association
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• v.29 no.3
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• pp.227-246
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• 1991

The study examined work and family life of married women employed in a manufacturing industry. Data were gathered from the use of face-to-face interview method from a sample of 230 married working women. The major findings of this study can be summarized as follows: (1) Most of the respondents found the work repetitive and unappealing, with the double burden of a paid work and housework. Thus, it is necessary for the government to implement social policies for married working women, such as establishment of various child care centers, part-time jobs, and dissemination of egalitarian sex-role attitudes. (2) More than half of the respondents were born in rural areas and immigrated to the urban sectors, forming a nuclear family structure. Most of these women were married with love, but some of them could not have a marriage ceremony because of the economic reasons. Thus, it may be necessary to increase the service centers to offer a free marital ceremony. (3) About 30% of the respondents answered they left their preschool aged children unattended, after dismissing from a kindergarden on a private institution. It was shown that working women, even though they were in charge of child-rearing, did not have an effective mechanism to control or protect their children while they were away from home. Most of them frequently used material compensations from their children in order to make up their absence at home. (4) It was found that the strategy for working women to decrease a dual-role conflict is to make a hierachy on the work they to do and to do only basic housework for everyday life and to do the rest of work on a off-day.

• Journal of Life Science
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• v.10 no.2
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• pp.150-156
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• 2000

This experiment was performed to evaluate the effect of TSH (thyroid-stimulating) on the ERp29 (endoplasmic reticulum resident 29 kDa protein) gene expression in the rat thyrocytes of FRTL-5 cells. Although ERp29 mRNA was constantly expressed, its expression began to increase remarkably from 10-9 M TSH. and its maximum expression was at 5×10-9 M TSH (about 3.5 fold). On the other hand, the effect of TSH on the abundance of ERp29 mRNA started within 6 h, and peaked at 8 h (about 2.5 fold). Actinomycin D (transcription inhibitor) strongly blocked this effect while cycloheximide (translation inhibitor) did not. The half-life of ERp29 mRNA was about 4.5 h in the presence or absence of TSH that was not affected by the stability of ERp29 mRNA. The effect of TSH on the ERp29 gene expression was specific, while other growth factors (transfferin, insulin, and hydrocortisone) did not alter its expression. Our data indicate for the first time that the expression of ERp29 is regulated transcriptionally by TSH in the thyrocytes.

• Korean Journal of Environmental Agriculture
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• v.39 no.4
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• pp.305-311
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• 2020

BACKGROUND: The healthy food trend has encouraged the consumption of natural products, including berries. This trend is expected to increase the strawberry consumption. There has been a concern about the exposure of pesticides approved for use on strawberry. In this study, the dissipation patterns of systemic and non-systemic pesticides were evaluated in strawberry under plastic-covered greenhouse conditions. METHODS AND RESULTS: Cyflumetofen and dimethomorph were applied on strawberry in the critical GAP (Good Agricultural Practices). Strawberries were harvested at 0, 1, 2, 3, 5, 7 and 10 days after final application of the pesticides. The analyses of the residual pesticides were performed by HPLC-DAD with C18 column. The limits of quantitation (LOQ) of cyflumetofen and dimethomorph were 0.04 and 0.02 mg/kg, respectively. The recovery of cyflumetofen and dimethomorph were 88.1 ~ 103.3% and 79.0 ~ 110.2% for the spiked two levels (LOQ and 10LOQ), respectively. The biological half-lives of cyflumetofen and dimethomorph werer 7.5 and 8.9 days, respectively. The dissipation rates in strawberry were calculated by the statistics method at a 95% confidence level. The distribution showed that pesticides with low log Pow were indicated by the decreased dissipation rate and pesticides with similar log Pow and low solubility also showed the decreased dissipation rate. CONCLUSION: The residues of cyflumetofen and dimethomorph in strawberry at time 0 after the final application were below the established MRL in Korea. The dissipation behavior of systemic and non-systemic pesticides in strawberry is affected by their log Pow and water solubility values.

• Journal of the Korean Wood Science and Technology
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• v.49 no.2
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• pp.122-133
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• 2021

The radon gas from nature mainly considers a cause of radon problems, and it is closely affect human life cycle. Korean yellow residual soil, Hwangtoh, widely used as a building material, is considered to be one of major sources of indoor radon. However, there have, as yet, been no studies about radon from Hwangtoh in mass market brands. Here, we investigated the indoor radon concentrations and exhalation rates in four Hwangtohs from different brand names and regional features. The Closed Chamber Method (CCM) conducted by a Continuous Radon Monitor (CRM) has been used for the rates of radon exhalation. Based on equations of previous references, the indoor radon concentrations were deducted. As a result, the radon surface exhalation rates resulted in the 1.4208 to 3.0293 Bq·㎡·h-1 range. Significant differences were found among Hwangtohs according to production regions. Materials with higher radon concentration required a longer time to reach a quasi-steady state in a given environment, in other words, the number of half-life cycles increased from a set starting point. The experimentally identified Hwangtohs demonstrated its safety for construction purposes. There exists, so far, a possibility to exert influence radon emanation due to unidentified factors. Therefore, it is necessary to corroborate with more research by increasing the number of Hwangtohs, considering the other references reported high radon exhalation rates. In addition, it is highly recommended that the radon exhalation rates should be measured for all building materials for preventing human health before the material usage.