• Animal cells and systems
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• 제4권3호
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• pp.239-243
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• 2000

Most space-related life science programs are expensive and time-consuming, requiring international cooperation and resources with trans-disciplinary expertise. A comprehensive future program in "life sciences in space" needs, therefore, well-defined research goals and strategies as well as a sound ground-based program. The first half of this review will describe four key aspects such as the environment in space, previous accomplishments in space (primarily focusing on amphibian embryogenesis), available resources, and recent advances in bioinformatics and biotechnology, whose clear understanding is imperative for defining future directions. The second half of this review will focus on a broad range of interdisciplinary research opportunities currently supported by the National Aeronautics and Space Administration (NASA), National Institute of Health (NIH), and National Science Foundation (NSF). By listing numerous research topics such as alterations in a diffusion-limited metabolic process, bone loss and skeletal) muscle weakness of astronauts, behavioral and cognitive ability in space, life in extreme environment, etc., we will attempt to suggest future opportunities.

• 한국생활과학회지
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• 제23권1호
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• pp.149-161
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• 2014

The purpose of this study was to investigate the nutrition teachers' operation and demand of dietary life education in Jeonbuk Province. The study was carried out using a self administered questionnaire and the subjects were 190 nutrition teachers. The questions were general characteristics of the subjects, operating status as frequency, place, the main use time, and training demand on dietary life education by elementary school and middle & high school, teaching career, and training hours. The results are as follows. Most of the subjects were female(98.9%), more than half were 40's(52.1%) in their age, school work career was 13.2 years. Frequency of the dietary life education operation was once per month(56.8%), 2~3 times per month(27.9%), and place of education were dinning room (49.7%), classroom(25.9%). Almost of the subjects(90.4%) recognized the facilities for education was lack, 89.3% of them did the education materials was lack, also. The desirable frequency of dietary life education was once per month(48.9%), and once per week(35.3%.) The half of the subjects recognized the objects of the dietary life education was not only students but also their parents and teachers. The proper education time was dietary life education tim (34.2%), discretion activity time(31.1%). Most of the subjects(95.7%) had willing to get training, the proper training program was 30 hours, and they prefer summer vacation(61.0%) than winter vacation(30.5%) and semester(8.6%). Proper experimental practice ratio of environment : health : thanks were 30% : 43% : 27%. It is concluded that the demand of nutrition teachers is necessary for their education program in elementary and middle & high school.

• 공업화학
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• 제31권5호
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• pp.475-480
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• 2020

Lactic acid와 키토산을 Cu(II) 이온과 반응시켜 합성한 착물을 사용하여 유기인 유사 독성물질인 DFP (Diisopropyl fluorophosphate) 분해반응에 적용하였다. Cu(II)-lactic acid 착물의 경우 homogeneous 상태에서 분해반응 반감기가 37. 1 min으로 분해성능이 우수하였다. 1 kDa 저분자량 수용성 키토산으로 합성한 Cu(II)-LMWS chitosan 착물은 결정화 후에는 용해도가 낮아 heterogeneous 한 상태에서 분해반응이 진행되었으며 그 반감기는 32.9 h이었다. 이 결과는 기존에 연구된 18 kDa 키토산 Cu(II)착물의 분해반응속도보다 약 16배 정도 증가된 것이다. Cu(II)-LMWS chitosan 착물을 결정화하지 않고 homogeneous한 상태로 진행한 분해반응에서는 반감기가 8.75 h로 용해도에 따라 약 4배의 차이를 확인할 수 있었다.

• 분석과학
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• 제13권1호
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• pp.34-40
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• 2000

기체크로마토그래피로 살균제 iminoctadine triacetate의 잔류분석을 위한 최적 측정 조건을 구하고, 토양에서 반감기와 잔류농도를 조사하였다. 토양시료 중의 iminoctadine triacetate를 2.0 M NaOH/methanol과 chloroform으로 추출하고, hexafluoropentanedione과 반응시켜 pyrimidine 유도체를 얻었다. Pyrimidine 유도체를 trifluoroacetic anhydride로 아세틸화시키고, Sep-Pak 컬럼에서 수분과 불순물을 제거한 후 전자포획형 검출기가 장착된 기체크로마토그래피(GC/ECD)로 분석하였다. 0.1 ppm과 1.0 ppm 표준물을 첨가하였을 때, 83.8~93.2% 의 회수율을 얻었며, 검출한계는 0.005 ppm이었다. Iminoctadine triacetate 의 반감기가 미사질 양토 경우에는 실내에서 30일, 야외에서 19.5일이었으며, 미사질 식토의 경우에는 실내에서 27일, 야외에서 17.5일이었다.

• Biomolecules & Therapeutics
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• 제6권4호
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• pp.400-405
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• 1998

The pharmacokinetics of CJ-50001 (recombinant human granulocyte-colony stimulating factor, developed by R&D center of Cheil Jedang Corp.) were investigated in rats and dogs. The serum concentrations of CJ-50001 were measured by a sandwich enzyme immunoassay. After single intravenous (iv) administration of Cf-50001 to rats at a dose of 5 $\mu$g/kg, the mean terminal half-life and area under the concentration-time curve (AUC) were 0.96 h and 124.497g . h/ml, respectively. After single subcutaneous (sc) administration at the same dose, maximum serum concentration was observed at about 2 hours after administration, and the mean terminal half-life, AUC and the bioavailability were 1.11 h,63.58$\mu$g . h/ml and 51.07%, respectively. In repeated dosing studies, CJ-50001 was administered iv and sc to rats at a daily dose of 5$\mu$g/kg for 7 days. The pharmacokinetic parameters, such as mean AUC and terminal half-life, were no significantly different from those of single administration. Following single iv and sc administration of CJ-50001 to dogs at a dose of 5 $\mu$g/kg, mean AUCs were much higher than those of rats, due to the decreased clearence (CL). After sc administration to dogs, maximum serum concentration was observed at 2~4 hours after administration and the bioavailability was 54.60%.

• International Journal of Internet, Broadcasting and Communication
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• 제15권2호
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• pp.181-186
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• 2023

With the development of VR technology, the visual immersion of VR games has been greatly enhanced nowadays. There has been an issue that has been troubling players in previous VR games, which is motion sickness. Therefore, VR games have been limited in terms of game mechanics, game duration, and game scale, greatly reducing the immersive experience of visual immersion. However, <Half-Life: Alyx> is different from previous VR games in that players can actually perform spatial displacement in the game scene, rather than being fixed in one place for 360-degree observation and interaction. At the same time, compared to traditional games, VR games no longer need to rely on screens, and the complete visual immersion enhances the fun and playability of the game. This research focuses on the VR game <Half-Life: Alyx> to explore its immersive factors in terms of visual perception. Through in-depth analysis of elements such as color, texture mapping, lighting, etc. in VR games, it was found that the game creates a strong sense of visual immersion in these aspects. Through analysis, it is helpful to gain a deeper understanding of the factors that contribute to visual immersion in VR games, which has certain reference value for game developers and related professionals.

• Archives of Pharmacal Research
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• 제26권6호
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• pp.499-503
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• 2003

Because physiological changes that potentially alter pharmacokinetics occurs in diabetes mellitus patients, pharamacokinetics of drugs used in the treatment of hypertension was studied using acebutolol as a model anti-hypertensive drug. Thus, the pharmacokinetics of acebutolol was investigated after oral administration of acebutolol (15 mg/kg) to control rabbits and rabbits with acute or chronic diabetes mellitus induced by alloxan. Kidney and liver functions were documented for acute and chronic diabetes mellitus groups based on plasma chemistry data. After oral administration of acebutolol to acute and chronic groups, the plasma concentrations appeared higher; As a result, area under the plasma concentration-time curve from time zero to time infinity10575 and 8668 $\mu g\cdot$ h/mL for acute and chronic group, respectively. In comparison, the area was apparently smaller in the control group (i.e., 7132 $\mu g\cdot$ h/mL). The half-life in acute groups was significantly prolonged 8.45 h compared with the half-life in the control group (i.e., 6.30 h). Alteration in acebutolol pharmacokinetics was more pronounced in the acute group as evidenced by the significantly higher values the area under the plasma concentration time curve, absorption rate constant and maximum plasma concentration compared with chronic or control group. Therefore, these observations indicate that acebutolol pharmacokinetics may be affected in patients with diabetes mellitus, especially in the early stage of the disease.

• Nuclear Engineering and Technology
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• 제54권12호
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• pp.4644-4651
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• 2022

Due to its short half-life, thoron gas has been assumed to have negligible health hazards on humans compared to radon. But, one of the decay products with a long half-life can make it to be transported to a long distance and to cause a severe internal dose through respiration. Since most commercial radon detectors can not discriminate thoron signals from radon signals, it is very common to overestimate radon doses which in turn result in biased estimation of lung cancer risk in epidemiological studies. Though some methods had been suggested to measure thoron and radon separately, they could not be used for real-time measurement because of CR-39 or LR-115. In this study, an effective method was suggested to measure radon and thoron separately from the free air. It was observed that the activity of thoron decreases exponentially due to delay time caused by a long pipe between two chambers. Therefore from two ion chambers apart in time, it was demonstrated that thoron and radon could be measured separately and simultaneously. We also developed a collimated alpha source and with this source and an SBD, we could convert the ion chamber reading to count rate in cps.

• 분석과학
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• 제13권6호
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• pp.722-730
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• 2000

감자와 토양 중에서 pyrethroid계 살충제인 cyfluthrin의 반감기와 잔류농도를 기체 크로마토그래피로 조사하였다. 감자시료는 n-hexane으로 분리, 농축하여 Sep-Pdk 실리카겔 컬럼 상에서 aretonitrile과 acetone 혼합액으로 정제하였으며, 전자포획검출기가 장착된 기체 크로마토그래피(GC-ECD)로 분석하였다. 0.01과 $0.1{\mu}g$의 표준물 첨가 실험결과 회수율은 85-87%이였고, 검출한계는 0.005ng 이였다. 토양시료는 acetone과 dichlorormthane으로 추출하여 농축하였으며, n-hexane으로 재용해하여 Sep-Pak 컬럼으로 정제한 후 GC-ECD로 분석하였다. 0.01과 $0.1{\mu}g$ 표준물 첨가 실험 결과 85-91%의 회수율을 얻었으며, 검출한계는 0.005 ng이였다. Cyfluthrin의 반감기는 미사질식토의 경우 실내에서 25일, 야외에서는 0.6일이었으며, 미사질양토의 경우에는 실내에서 38일, 야외에서는 0.5일이었다.

• 한국도서관정보학회지
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• 제39권4호
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• pp.377-395
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• 2008

본 연구의 목적은 Burton & Kebler의 문헌이용률 감소법칙을 적용하여 과학기술분야 학술잡지의 이용가능기간 즉 시간이 경과함에 따른 이용확률을 밝혀냄으로써 과학기술분야 잡지의 가치를 측정하고, 도서관이 이용자가 필요로 하는 정보를 제공하기 위해서는 어떤 잡지의 무슨 연도, 무슨 권호까지 소장해야 하는가를 결정하는데 도움이 되고자 하는 것이다. 국내 연구자들이 1991-2005년(15년간) 동안에 SCI 학술지에 발표한 과학기술분야 논문 126,425편 중에서 인용문헌 2,351,419건을 대상으로 과학기술 4개 주제(수학 4개, 물리학 12개, 화학 12개, 공학 14개)분야로 나누어 분석하였다. 분석 결과, 인용나이는 수학이 20-29년, 물리학, 화학, 공학이 각각 8-11년이었다. 평균 반감기는 수학이 11.22년, 물리학이 7.5년, 화학이 8.4년, 공학이 8.88년이었다.