• Journal of Radiation Protection and Research
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• 제28권4호
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• pp.271-279
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• 2003

영광 및 울진 원전 반경 5 km 내 12 곳의 논토양 블록을 재배상자에 채취하여 벼의 이식 전과 출수 시작 $1{\sim}2$ 일 전에 $^{90}Sr$을 담수의 표면에 처리하였다. 이식 전 처리에 있어서는 전이계수를 $2{\sim}4$ 년 간 조사하였다. 이식전 처리시 당년도 $^{90}Sr$의 전이계수$(m^2\;kg^{-1}-dry\;plant)$는 지역 간에 이렇다할 차이없이 토양에 따라 2 배 정도의 변이를 보였고 평균은 쌀알의 경우 $2.6{\times}10^{-4}$, 볏짚의 경우 $1.3{\times}10^{-2}$였다. 출수 전 처리시 전이계수는 이식전 처리에 비해 대체로 2 배정도 높았다. 토양의 pH와 치환성 Ca 함량이 높을수록 $^{90}Sr$ 전이계수가 감소하는 경향이었다. 우리나라 논에 대하여 침적 당년도 $^{90}Sr$ 전이계수의 대표치가 제안되었다. 처리 1차 년도에 대한 2차 년도 전이계수의 감소 정도는 대체로 모래함량이 높은 울진 토양에서 영광 토양보다 높았다. 영광 토양 전체로 볼 때 년차에 따른 전이계수의 감소는 반감기가 2.2년 정도의 지수함수로 묘사될 수 있었다.

• Journal of Radiation Protection and Research
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• 제25권4호
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• pp.233-239
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• 2000

원자력 시설의 정상 운영중 오염 음식물 섭취에 의한 피폭선량 평가모델 (미국 원자력규제위원회의 규제지침 1.109 모델)의 입력변수에 대한 민감도 분석을 3가지 음식물 (쌀, 엽채류, 우유)과 2가지 핵종 $(^{137}Cs,\;^{131}I)$에 대해 수행하였다. 입력변수 값의 표본추출은 Monte Ca린o 방법에 근거한 Latin hypercube sampling 기법을 사용하였다. 모델 예측결과에 대한 입력변수의 영향력 또는 중요도를 나타내는 민감도지수는 partial rank correlation coefficient 의해 정량적으로 나타냈다. 평가결과, 고려된 음식물과 핵종에 대해 농작물의 수율에 대한 차단계수의 비와 음식물의 소비율은 중요한 입력 변수로 나타났다. 그외 우유의 경우 사료에서 우유로의 전달계수와 젖소의 사료 섭취율도 한 중요한 입력변수로 나타났다. $^{137}Cs$ 침적의 경우에는 기후에 의한 핵종의 제거 반감기가, $^{131}I$ 침적의 경우에는 생산에서 소비까지의 지연시간이 상대적으로 중요한 입력변수였다.

• Journal of Radiation Protection and Research
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• 제45권3호
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• pp.101-107
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• 2020

Background: An important lesson learned from the Fukushima accident is that the transition to the mid- and long-term phases from the emergency-response phase requires less than a year, which is not very long. It is necessary to know how much radioactive material has been deposited in an urban area to establish mid- and long-term countermeasures after a radioactive accident. Therefore, an urban deposition model that can indicate the site-specific characteristics must be developed. Materials and Methods: In this study, the generalized urban deposition velocity and the subsequent variation in radionuclide contamination were estimated based on the characteristics of the Korean urban environment. Furthermore, the application of the obtained generalized deposition velocity in a hypothetical scenario was investigated. Results and Discussion: The generalized deposition velocities of ¹³⁷Cs, ¹⁰⁶Ru, and ¹³¹I for each residence type were obtained using three-dimensional (3D) modeling. For all residence types, the deposition velocities of ¹³¹I are greater than those of ¹⁰⁶Ru and ¹³⁷Cs. In addition, we calculated the generalized deposition velocities for each residential types. Iodine was the most deposited nuclide during initial deposition. However, the concentration of iodine in urban environment drastically decreases owing to its relatively shorter half-life than ¹⁰⁶Ru and ¹³⁷Cs. Furthermore, the amount of radioactive material deposited in nonresidential areas, especially in parks and schools, is more than that deposited in residential areas. Conclusion: In this study, the generalized urban deposition velocities and the subsequent deposition changes were estimated for the Korean urban environment. The 3D modeling was performed for each type of urban residential area, and the average deposition velocity was obtained and applied to a hypothetical accident. Based on the estimated deposition velocities, the decision-making systems can be improved for responding to radioactive contamination in urban areas. Furthermore, this study can be useful to predict the radiological dose in case of large-scale urban contamination and can support decision-making for long-term measurement after nuclear accident.

• 한국게임학회 논문지
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• 제8권3호
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• pp.43-50
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• 2008

UI(User Interface)디자인은 하드웨어의 발달과 다양하게 만들어지는 콘텐츠들로 인해 자체의 의미와 형태를 발전시켜왔다. 특히 입력장치와 그래픽기술의 발달로 인해 이용자와 콘텐츠와의 풍부해진 교감을 통해 이용자는 신체와 정신의 확장으로써 UI를 받아들이게 되었다. 본 연구에서는 디지털스토리텔링의 입장에서 UI를 재해석하여, 콘텐츠와 이용자 간의 역할을 관찰하고, 특히 그래픽 기반 게임에서 나타는 스토리 요소들의 구분과 이유 분석을 통한 스토리텔링UI의 이론적기반성립과 활용을 위한 요소탐구를 실시하였다. 이를 위해 그래픽 요소 및 입력장치의 활용의 입장과 논문 내에서 밝힌 분절형 스토리텔링의 적용체로써 게임이 적합함에 입각하여 요소연구대상으로 디아블로, 하프라이프, 홈월드를 선정, 분석하였다. 본 분석을 통해 게임의 UI와 콘텐츠의 결합형태에서 인터페이스가 부분적으로, 또는 특화된 형태로의 콘텐츠정보를 지님으로 디지털스토리텔링의 스토리분절과 선택의 역할을 하고 있음을 밝혔다. 또한 개발자가 내재시킨 스토리와 이용자가 인터페이스를 통해 재구성하는 스토리가 공존하는 공간으로써 작동하며 이는 인터페이스에 스토리요소의 대입과 활용이 가능함을 유추하였다. 스토리텔링UI는 각각의 분절된 스토리를 사용한 능동적 즐거움의 복합체로써 끊임없는 흥미를 발생시킬 수 있는 좋은 수단이 될 것이다. 게임UI를 통한 스토리 중심의 UI제작은 콘텐츠의 내면적 맥락을 살리는 동시에 인터페이스의 감성형 인터페이스의 구체적인 구성 방법에 대한 대안이 될 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권1호
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• pp.125-129
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• 2016

Background: Patients with differentiated thyroid cancers (DTC) who receive radioactive iodine-131 (RAI) are released from isolation when their dose rate is below the regulatory requirements. The purpose of this study was establish predicting factors for early release from the isolation facility after RAI administration in patients with DTC. Materials and Methods: This was a prospective study which included 96 (58 females and 38 males) patients with DTC who had received RAI from April 2013 till August 2015. The study was duly approved by the ethical committee of the institute. Patients who had complete information of primary tumor size (PTS), serum TSH, stimulated thyroglobulin level [sTg] with antibodies (IU/ml) at the time of RAI treatment were included. All had a normal serum creatinine level. To attain lower effective half-life good hydration and administration of soft laxative were ensured. Dose rate was measured (immediately, 24 h and 36 h) at 1 meter distance from anterior mid trunk and a dose rate <$50{\mu}Sv/h$ was considered as the releasing criterion. At 24 h 50 patients were released while the remaining 46 patients were released at 36 h. A post-ablative whole body scan (PA-WBIS) was performed 5-8 days after RAI ablation in all patients. Results: Patients released after 24 h were significantly younger, had smaller lesions with higher proportion of papillary cancer, lower sTg, lower sTg/TSH ratio and had received a lower dose of RAI as comapred to those who were discharged after 36 h. Serum TSH and gender were not found to have any significant correlation between two cohorts. ROC and multivariate analysis have shown age ${\leq}37years$, PTS ${\leq}3.8cm$, $RAI{\leq}150mCi$, $sTg{\leq}145ng/ml$ and $sTg/TSH{\leq}1.085$ as strong indepedent predictors for early release. Conclusions: We conclude that younger age (${\leq}37years$), smaller tumor size (${\leq}3.8cm$), lower RAI dose (${\leq}150mCi$), lower sTg (${\leq}145ng/ml$) and a lower sTg/TSH ratio (${\leq}1.085$) are significant independent predictors for release at 24 h after RAI treatment in DTC patients. Effective utilization of these factors could help the treating physicians to use limited number of internment facilities with higher throughput, lower cost and lower psychological stress to patients.

• Neonatal Medicine
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• 제18권1호
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• pp.153-157
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• 2011

공기심장막증은 신생아의 공기누출의 종류 중 가장 드문 형태이지만 신생아 심장 압전의 가장 흔한 원인이 되며 대부분 신생아 호흡곤란 증후군으로 기계 환기 치료를 받는 미숙아에서 발생하고 사망률은 70-80%에 이른다. 공기심장막증은 심혈관계 허탈을 초래하고 환아를 사망에 이르게 할 수 있으며 생존하더라도 뇌출혈 등의 뇌 손상이 발생하여 발달지연 등의 신경학적 후유증을 남길 수 있으므로 신속한 발견과 중재 시술이 중요하다. 저자들은 공기심장막증 이후 심장막천자 만으로 증상이 호전되었던 경우와 심장막관 삽입술이 필요했던 경우를 각각 1예씩 경험하여 이를 보고하는 바이다.

• Asian-Australasian Journal of Animal Sciences
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• 제29권1호
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• pp.43-50
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• 2016

Quantitative trait locus (QTL) is a particular region of the genome containing one or more genes associated with economically important quantitative traits. This study was conducted to identify QTL regions for body weight and growth traits in purebred Korean native chicken (KNC). F1 samples (n = 595) were genotyped using 127 microsatellite markers and 8 single nucleotide polymorphisms that covered 2,616.1 centi Morgan (cM) of map length for 26 autosomal linkage groups. Body weight traits were measured every 2 weeks from hatch to 20 weeks of age. Weight of half carcass was also collected together with growth rate. A multipoint variance component linkage approach was used to identify QTLs for the body weight traits. Two significant QTLs for growth were identified on chicken chromosome 3 (GGA3) for growth 16 to18 weeks (logarithm of the odds [LOD] = 3.24, Nominal p value = 0.0001) and GGA4 for growth 6 to 8 weeks (LOD = 2.88, Nominal p value = 0.0003). Additionally, one significant QTL and three suggestive QTLs were detected for body weight traits in KNC; significant QTL for body weight at 4 weeks (LOD = 2.52, nominal p value = 0.0007) and suggestive QTL for 8 weeks (LOD = 1.96, Nominal p value = 0.0027) were detected on GGA4; QTLs were also detected for two different body weight traits: body weight at 16 weeks on GGA3 and body weight at 18 weeks on GGA19. Additionally, two suggestive QTLs for carcass weight were detected at 0 and 70 cM on GGA19. In conclusion, the current study identified several significant and suggestive QTLs that affect growth related traits in a unique resource pedigree in purebred KNC. This information will contribute to improving the body weight traits in native chicken breeds, especially for the Asian native chicken breeds.

• Asian-Australasian Journal of Animal Sciences
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• 제29권4호
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• pp.555-563
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• 2016

Purple rice is a strain of glutaneous rice rich in anthocyanins and ${\gamma}$-oryzanol. Both types of compounds are involved in antioxidant and lipid metabolism of mammals. Three experimental diet types were used which consisted approximately by half either of purple rice, white rice or corn. Diets were fed to $3{\times}10$ pigs growing from about 30 to 100 kg. Meat samples were investigated either as raw or cured loin chops or as smoked bacon produced from the belly. Various physicochemical traits were assessed and data were evaluated by analysis of variance. Traits describing water-holding capacity (drip, thaw, and cooking losses) and tenderness (sensory grading, shear force) of the meat were mostly not significantly affected by the diet type. However, purple rice feeding of pigs resulted in lower fat and cholesterol contents of loin and smoked bacon compared to white rice, but not compared to corn feeding except of the fat content of the loin. The shelf life of the raw loin chops was improved by purple rice as well. In detail, the occurrence of thiobarbituric acid reactive substances after 9 days of chilled storage was three to four times higher in the white rice and corn diets than with purple rice. The n-6:n-3 ratio in the raw loin chops was 9:1 with purple rice and clearly higher with 12:1 with the other diets, meat lipids. Level and kind of effect of purple rice found in raw meat was not always recovered in the cured loin chops and the smoked bacon. Still the impression of flavor and color, as well as overall acceptability were best in the smoked bacon from the purple-rice fed pigs, whereas this effect did not occur in the cured loin chops. These findings suggest that purple rice has a certain, useful, bioactivity in pigs concerning meat quality, but some of these effects are of low practical relevance. Further studies have to show ways how transiency and low recovery in meat products of some of the effects can be counteracted.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3267-3272
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• 2015

Purpose: To retrospective assess the potential predictors for relapse and create an effective clinical mode for surveillance after orchidectomy in clinical stage I non-seminomatous germ cell testicular tumors (CSI-NSGCTs). Materials and Methods: We analyzed data for CSI-NSGCTs patients with non-lymphatic vascular invasion, %ECa < 50% (percentage of embryonal carcinoma < 50%), and negative or declining tumor markers to their half-life following orchidectomy (defined as low-risk patients); these patients were recruited from four Chinese centers between January 1999 and October 2013. Patients were divided into active surveillance group and retroperitoneal lymph node dissection (RPLND) group according to different therapeutic methods after radical orchidectomy was performed. The disease-free survival rates (DFSR) and overall survival rates (OSR) of the two groups were compared by Kaplan-Meier analysis. Results: A total of 121 patients with CSI-NSGCT were collected from four centers, and 81 low-risk patients, including 54 with active surveillance and 27 with RPLND, were enrolled at last. The median follow-up duration was 66.2 (range 6-164) months in the RPLND group and 65.9 (range 8-179) months in the surveillance group. OSR was 100% in active surveillance and RPLND groups, and DFSR was 89.8% and 87.0%, respectively. No significant difference was observed between these two groups ($X_2=0.108$, P=0.743). No significant difference was observed between the patients with a low percentage of embryonal carcinoma (<50%) and those without embryonal carcinoma (87.0% and 91.9%, $X_2=0.154$, P=0.645). No treatment-related complications were observed in the active surveillance group whereas minor and major complications were observed in 13.0% and 26.1% of the RPLND group, respectively. Conclusions: Active surveillance resulted in similar DFSR and OSR compared with RPLND in our trial. Patients with low-risk CSI-NSGCTs could benefit from risk-adapted surveillance after these patients were subjected to radical orchidectomy.

• 대한한의학회지
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• 제24권2호
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• pp.166-178
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• 2003

Objectives : Nitric oxide (NO) plays an important role in normal and pathophysiological cells as a messenger molecule, neurotransmitter, microbiological agent, or dilator of blood vessels and arteriosclerosis, respectively. This study was undertaken to understand the mechanism of NO production and effect of Hyeolbuchukeo-tang (Xiefuzhuyu-tang) on NO production in cultured vascular smooth muscle cell (VSMC). Methods and Results : VSMC was isolated from aorta and cultured. Cultured primary cells were identified as VSMC with anti--smooth muscle actin antibody. A large amount of NO was produced in cultured VSMC treated with $IFN-{\gamma}$ plus TNF in a time- and dose-dependent manner. $TNF-{\alpha}$ was a more efficient stimulator than $IFN-{\gamma}$ in NO production of cultured VSMC. iNOS protein wasdetected within 3 hrs and it increased up to 12 hrs in a time-dependent manner. However, accumulated NO in cytokine-treated VSMC was not detected within 3 hrs. NO production in cytokine-treated VSMC showed the dose- and time-dependent manner, and increased up to 48 hrs. The activated VSMC produced a large amount of NO (about 60 uM). Hyeolbuchukeo-tang (Xiefuzhuyu-tang) alone did not induceNO production, but it potentiated the effect of $TNF-{\alpha}$ on NO production and increased NO production by about 20%. Hyeolbuchukeo-tang (Xiefuzhuyu-tang) did not affect the transcriptional activity of iNOS gene, but increased the accumulation of iNOS. These results indicate that Hyeolbuchukeo-tang (Xiefuzhuyu-tang) could modulate the translational level of iNOS. PKC did not modulate NO production, but calcium ionophore A23187 decreased NO production. However, Hyeolbuchukeo-tang (Xiefuzhuyu-tang) elevated the decreased NO production in A23187-treated VSMC by modulating the stability of iNOS transcripts. Half-life of the synthesized transcripts appeared to have about 6 hrs. PDTC, an $NF-{\kappa}B$ inhibitor, blocked the accumulation of iNOS mRNA, indicating that $NF-{\kappa}B$ served as an important modulator in the transcriptional regulation of iNOS. As Hyeolbuchukeo-tang (Xiefuzhuyu-tang) potentiated the effect of the $TNF-{\alpha}$ on NO production but had no additional effect on PDTC-modulated NO production, it is suggested that Hyeolbuchukeo-tang (Xiefuzhuyu-tang) enhances the $TNF-{\alpha}-mediated$ NO production of VSMC by modulating the iNOS activity and the stability of iNOS transcripts in activated VSMC having the elevated intracellular calcium ion. Conclusions : This study suggests that Hyeolbuchukeo-tang (Xiefuzhuyu-tang) has a potential capacity for preventing and treating diseases of the circulation system, including arteriosclerosis.