• Journal of Preventive Medicine and Public Health
• /
• 제26권1호
• /
• pp.110-125
• /
• 1993

본 연구는 범죄자의 경우 필수 금속원소와 독성금속의 함량에 기초하여 정상적 인구집단으로부터 구별될 수 있다는 가설을 검정하기 위해 시도되었다. 금속 원소함량 및 중금속함량의 차이를 알아보기 위해 두발을 채취하였으며, 아울러 이들 금속과 인성과의 관련성을 알아보기 위해 MMPI 검사를 시행하였다. 두발채취는 범죄자의 경우 유죄판결을 받은 직후 실시 하였으며, 후두부의 5cm 이내의 두발을 2g을 취하여 두발중 금속함량을 원자흡광분광광도계로써 측정 하였다. 두발 중 금속원소들의 함량을 비교해 오면 아연과 마그네슘이 비폭력범죄자에 있어 유의하게 낮았으며, 납과 카드뮴 비폭력범죄자군이 대조군에 비해 유의하게 높았다. 연령군별 함량차이를 보면 나트륨, 아연, 철, 마그네슘, 납에서 차이를 보이고 있으나 연령에 따른 어떠한 추세는 보이지 않았다. 연령군별로 층화하여 두 집단과의 차이를 보면 나트륨은 20대에서 비폭력범죄자군이 유의하게 높았으며 아연은 20대 30대 40대에서 마그네슘은 20대와 30대에 있어서 비폭력범죄자가 유의하게 낮았다. 반면 납과 카드뮴은 20대 30대 40대에서 비폭력범죄자군이 유의하게 높았다. MMPI의 각 척도별 T 점수중 우울증 척도(D)는 대조군이 유의하게 높았고, 반사회성 척도(Pd), 편집증 척도(Pa), 경조증 척도(Ma)의 척도에서는 비폭력군이 유의하게 높았다. 금속 금속함량과 MMPI의 각 척도별 T 점수와의 상관성을 보면 범죄자 군에서는 구리와 Ma 척도를 제외한 Hs D Hy Pd Mf Pa Pt Sc Si 척도의 점수와 통계적으로 유의한 음의 상관관계를 보이고 있으며 (P<0.05, p<0.01), 아연함량과 Hy Mf Pa Pt 척도의 점수가 음의 상관관계를 보이고 있다. 반면 대조군에서는 나트륨과 Ma 척도가 음의 상관관계를 철과 Sc척도, Pt척도는 양의 상관 관계를 보이고 있다. 본 연구의 결과로 볼때 비폭력범죄자와 정상 대조군 사이에서 일부 금속원소의 함량 차이가 있는 것으로 보여지며, 금속원소 함량과 MMPI 척도와도 상관관계가 있는 것으로 나타났다. 향후 폭력범과 비폭력범, 폭력범과 일반인과의 차이를 비교하여 볼 필요성을 느낀다.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제25권1호
• /
• pp.28-36
• /
• 2014

Objectives : The goal of this study was to examine the association between zinc and lead level and symptoms of attention-deficit hyperactivity disorder (ADHD) among Korean children. Methods : A total of 89 clinic-referred children participated in the study (ADHD group=45, control group=44). The participants were 5-15 years old, and were mainly from urban areas of Seoul, Korea. ADHD was diagnosed using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version. We excluded children with a comorbid psychiatric disorder, medical illness requiring medication, or a prior history of taking ADHD medication. In order to evaluate the severity of ADHD symptoms, parents' Korean ADHD Rating Scale (K-ARS) was used. The ADHD diagnostic system (ADS) was used for evaluation of the severity of inattention and impulsivity. All participants completed the intelligence test and hair mineral analysis. Multiple regression analysis was used to examine the effect of hair zinc and lead levels on the K-ARS and ADS. We measured the predictive ability of the zinc and lead levels using logistic regression analysis. Results : The lead level explained the score for omission errors, commission errors, and response time SD in visual ADS in the ADHD group (adjusted $R^2$=.243, p<.01, adjusted $R^2$=.362, p<.01, and adjusted $R^2$=.275, p<.01), the score for omission errors of auditory ADS in ADHD group (adjusted $R^2$=.407, p<.01) and the entire group (adjusted $R^2$=.292, p<.01). Zinc was significantly explanatory for the K-ARS scores for the entire group (adjusted $R^2$=.248, p<.001) and the ADHD group (adjusted $R^2$=.247, p<.05). Conclusion : These findings suggest a possible role of zinc and lead in ADHD. Lead concentration in hair samples affected the ADS scores, and this was more prominent in children with ADHD. Children with ADHD had a lower zinc concentration in their hair, and the zinc concentration in hair showed negative correlation with the K-ARS score.

• 한국멀티미디어학회논문지
• /
• 제6권1호
• /
• pp.148-160
• /
• 2003

현재 세계 48개국의 의료기관에서 임상을 위해 널리 사용 중인 모발분석(TMA)은 중요 미네랄 비율을 분석하여 체내에 과잉, 결핍 및 불균형 상태를 평가하고 인체에 미치는 영향을 예측하여 건강유지 방향을 제시하는 임상 영양학 및 독성학 검사방법을 말한다. 그러나 국내 모발분석방법에는 몇 가지 문제점이 있다. 즉, 모발분석결과를 처리하고 해석할 수 있는 한국형 의료정보 데이터베이스가 없으므로 미국에 의뢰하고 있는데, 외화낭비는 물론 보내오는 모발분석 검사결과지가 영문이고 철저한 보안 위주파일이므로 국내의료 기관에서의 활용도가 매우 낮다. 또한 모발분석 결과가 서구식 데이터베이스로부터 분석된 것이므로 검사결과의 신뢰성 문제도 발생한다. 따라서 본 논문에서는 이러한 문제점을 해결하기 위해 국내 최초로 TMA 기반 한국형 의료정보시스템을 구축하였다. 이 시스템은 복잡한 모발분석 자료의 분류를 다단계 통계분석 방법에 의한 결정트리 분류기를 통해 수행하고, 다중 퍼지 규칙방식의 데이터베이스를 구축하여 지능형 퍼지추론 방법에 의해 모발분석 자료를 분석한다. 본 시스템의 성능을 실제 작업 환경에서 측정한 결과, 시스템을 사용하는 경우가 사용하지 않았을 경우보다 업무능률과 사용자 만족도가 각각 86%, 92% 증가하였다.

• 대한한방소아과학회지
• /
• 제21권2호
• /
• pp.51-67
• /
• 2007

Objectives The study was designed to find out the relationships between short stature and low weight among children and teenagers. Methods This research was performed in 21 children and teenagers from August 2006 to June 2007. We measured height, weight, body mass index, obesity rare, bone age, and HTMA. Moreover, we analyzed correlation with height, weight, mineral concentrations and ratios obtained from HTMA. Results There were significant correlations between HTMA and short stature and low weight. 1. Most subjects(76%) had slow metabolic types. 2. Ca, Mg, Zn, Ca/P, and Cr had significant differences between high bone age group and high chronological age group. 3. Fe/Cu had significant differences between a group that recent height is more smaller than inherited height and a group that recent height is more taller than inherited height. 4. Ca, Mg, Ca/P had significant differences between a low weight group and a normal weight group classified by obesity rate. Conclusions Children and teenagers with short stature and low weight have specific mineral characters.

• 대한수의학회지
• /
• 제33권3호
• /
• pp.493-505
• /
• 1993

Present experiments were undertaken in order to clarify the clinico-pathological characteristics of lead poisoning in goats. Twenty goats were divided into three experimental groups(A, B and C) and a control(D). The three experimental groups received diets contaminated artificially with 10(A group), 200(B group) and $1,000(C group){\mu}g/g$ of lead for 70 days, respectively. The control group received normal diets. Hair samples collected one or two weeks interval were examed for the lead content. On day 70. all the animals were necropsied and various organs were examined pathoanatomically. In addition, various organs were analyzed for lead, zine, copper, iron and calcium content by atomic absorption spectrophotometry. From these experiments following results were obtained ; The lead content of hair was significantly increased from the $42^{nd}$, $21^{st}$ or $14^{th}$ day in all the three groups, which showed significant correlation with lead content of liver and spleen. The lead content of various organs including kidney, liver, spleen, ileum, bone and abomasum were significantly increased in accordance with the lead contamination. The increase was most prominent in abomasal wall. The zinc and copper content of liver, brain, ileum, skin, kidney, lung or muscle were increased in B and C groups whereas the iron and calcium content showed no significant change. Pathoanatomically, degeneration or necrosis of proximal convoluted tubules of kidney, peripheral necrosis of liver, fundic gland necrosis of abomasum and cerebral edema were observed in B and C groups.

• Journal of Preventive Medicine and Public Health
• /
• 제27권1호
• /
• pp.25-43
• /
• 1994

어떤 금속성분의 과다 또는 과소가 폭력성향에 영향을 미치는 지를 분석하고자 1992년 5월부터 1992년 10월까지 대구교도소에 수감된 사람중 형이 확정된 남자 재소자로서 폭력범죄자(살인, 강도, 강간, 상해, 폭력 행위 등과 같은 폭력범죄로 구형 받은 사람 또는 이와 같은 폭력범죄의 전과가 있는 사람) 111 명과 비폭력 범죄자(사기, 절도, 도로교통법 위반, 간통 등과 같은 범죄로 구형받은 사람이면서 폭력범죄의 전과가 없는 사람) 89명, 총 200명을 대상으로 두발중 독성 중금속인 카드뮴 및 납과 필수금속인 아연, 구리, 철, 마그네슘 및 나트륨 함량을 원자흡광분광광도계 (IL, 551)로 분석하였다. 두발중 카드뮴과 납 함량은 폭력범죄자군에서 각각 $0.56{\pm}0.14ppm,\;11.53{\pm}3.32ppm$으로 비폭력범죄자군의 $0.42{\pm}0.20ppm,\;9.63{\pm}4.31ppm$보다 유의하게 높은 함량을 나타냈으나(각각, p<0.01), 구리 함량은 폭력군이 $9.07{\pm}3.85ppm$으로 비폭력군의 $10.53{\pm}5.82ppm$ 보다 유의하게 낮았다 (p<0.05). 다중지수형 회귀분석 결과 폭력성향과 관련되는 요인으로 카드뮴 함량(odds ratio=98.09)이 높을 수록, 미혼인 경우(odds ratio=0.39), 전과(odds ratio=1.57)가 많을 수록, 거주지역(odds ratio=0.44)이 농촌인 경우에 더 폭력적인 성향을 보이는 것으로 나타났다.

• International Journal of Contents
• /
• 제7권2호
• /
• pp.26-31
• /
• 2011

People with obesity or over-weight need nutritional intervention to reduce their weight, because weight loss reduces the incidence rate of chronic diseases such as hypertension, type II diabetes, cardiovascular diseases and cancer in obese people. This study was to develop a system for individualized weight control program available both for wired and wireless internet users. This system is especially useful to users carrying wireless internet mobile device. If they input their physical information (height, weight and waist circumference) and mineral levels measured by hair tissue mineral analysis, the system provides evaluation of their health status and metabolic related functions such as endocrine and carbohydrate tolerance. Based on these evaluations, food menus are then offered to them to manage their health status and to improve their metabolic related physiological functions in a personalized way. The system also provides more information for recommended foods, such as nutritional information, food ingredients, recipes, and videos related to cooking. Bibimbap was selected as an example dish for customized contents for mobile web. Bibimbap is one of the most well-known Korean traditional dishes prepared with various kinds of ingredients including several different kinds of vegetables, meat, and egg so that it is a low calorie dish as well as a well-balanced diet. Therefore, this system developed in this study allows the mobile users to access web site through wired wireless internet everywhere and provides a customized content to the users to manage their weight and finally to achieve a desirable weight.

• 대한한방소아과학회지
• /
• 제22권1호
• /
• pp.25-34
• /
• 2008

Objectives The purpose of this study is to investigate whether Korean oriental pediatrics hospitals are using their feedback surveys to improve their medical conditions. Methods We selected 24 oriental medicine university hospitals and sent surveys to investigate. 15 of those surveys were analyzed. Results The results were classified as follows; Only 9 of university hospital said that they are currently using their feedback surveys to improve their services. Question for asking the purpose of doing their feedback surveys, 58.3% of hospital responded to get some information for diagnosis, 25% of them said to see the progress of treatment of specific disease, and 16.7% answered for using their data to the further studies. The question about the reason why hospital were need to make these feedback surveys, 46.2% of them answered to apply better service, 38.4% of them said to post medical journal. The question for asking what do oriental medical hospitals check from feedback surveys, 40% of them said they check Ryodoraku, 33.3% was pulse diagnostic apparatus, EAV(Electro-puncture According to Voll) was 26.7%. The classification according to purpose of test resulted as follows; information for diagnosis was 48.1%, the progress of a disease was 37.3%. In addition oriental medical test there were blood test, radiological test, brain waves test, Hair Tissue Mineral Analysis(HTMA), ultrasonic test, body composition analysis. Conclusions Further clinical research is necessary for improvement of using the feedback survey effectively.

• 한국임상수의학회지
• /
• 제39권5호
• /
• pp.235-239
• /
• 2022

A 10-year-old neutered male Siberian Husky presented with paraparesis and severe lethargy. On physical examination, the patient was unable to weight-bear and walk and exhibited significant muscle mass loss in both hindlimbs and generalized truncal alopecia with a dull coat of hair. On neurological examination, cranial lumbar vertebral pain, hind limb cross-extensor reflex, delayed hindlimb postural reaction, upper motor neuron bladder dysfunction, and total absence of cutaneous trunci reflex were identified. Computed tomography revealed diffuse idiopathic skeletal hyperostosis and spondylosis deformans of the cervical and thoracolumbar vertebrae. In addition, a generalized decrease in bone mineral density of the vertebrae was identified. Magnetic resonance imaging showed hyperplasia of the epidural fat compressing the spinal cord in the thoracolumbar region and concurrent mild multiple intervertebral disc herniations. No specific findings were observed in cerebrospinal fluid analysis. Blood analysis of thyroid function revealed decreased total T4 and free T4 levels, and increased TSH levels. The patient was tentatively diagnosed with spinal epidural lipomatosis (SEL) secondary to hypothyroidism. The patient was treated with levothyroxine, firocoxib, and gabapentin. Clinical signs gradually improved, and the patient showed normal ambulation 40 days after treatment initiation. SEL is extremely rare in dogs. To the best of our knowledge, this is the first case report of SEL secondary to hypothyroidism that was treated conservatively. Secondary SEL can be sufficiently managed by treating the underlying cause, if possible.

• 농촌의학ㆍ지역보건
• /
• 제22권2호
• /
• pp.215-223
• /
• 1997

두발의 중금속 성분분석을 통하여 필수 원소이외에 흔히 문제시 될 수 있는 유해중금속과 당뇨병과의 관련성을 파악하기 위하여 1993년 3월부터 6월까지 경북대학교병원 내과에 내원한 69명(남자 32명, 여자 37명)의 인슐린 비익존형 당뇨병(NIDDM)환자와 그 대조군으로 74명(남자 47명, 여자 27명)의 정상인을 대상으로 필수원소인 아연, 구리, 망간과 유해중금속으로 연, 카드뮴, 알루미늄으로 함량분석을 원자흡광광도계(IL.551)로 분석하였다. 필수원소인 아연과 구리의 경우 대조군이 각각 $152.51{\pm}46.15$ ppm, $12.48{\pm}6.56$ ppm으로 NIDDM군의 $132.99{\pm}9.61$ ppm, $8.58{\pm}5.07$ ppm에 비해 유의하게 높게 나타났다. 망간의 경우는 당뇨군이 $0.44{\pm}0.27$ ppm으로 대조군의 $0.34{\pm}0.18$ ppm에 비해 오히려 높게 나타났다. 유해중금속인 연의 경우 대조군의 $8.10{\pm}2.45$ ppm에 비해 NIDDM군이 $10.04{\pm}4.60$ ppm으로 유의성 있게 높게 나타났고, 카드뮴과 알루미늄의 경우도 대조군의 $0.41{\pm}0.23$ ppm, $7.61{\pm}4.16$ ppm에 비해 각각 $0.57{\pm}0.12$ ppm, $11.31{\pm}3.98$ ppm으로 NIDDM군이 모두 높게 나타났다. 당화혈색소치 및 당뇨병의 유병기간과 분석대상 원소의 함량과는 유의한 상관 관계가 나타나지 않았다. 혈중요소질소 및 크레아티닌과 분석대상 원소의 함량과는 유의한 상관관계가 나타나지 않았다. 대조군과 NIDDM군에 대해 실시한 다중 로지스틱 회귀분석에서 유의한 변수는 카드뮴, 아연, 구리 등으로 나타났다. 아연과 구리는 함량이 낮을 경우 당뇨병의 발생과 연관성이 있는 것으로, 카드뮴은 그 함량이 높을 경우 당뇨병의 발생과 연관성이 있는 것으로 나타났다.