• Journal of the Korean Data and Information Science Society
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• 제19권4호
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• pp.1233-1246
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• 2008

This study examines characteristics of people who are experiencing severe hair loss problems. We focus on how these characteristics are related to their psychological problems, hair loss treatments, wig-wearing practices, and life styles. We gathered survey data from people who visited wig shops for their hair loss problems. The study shows that men and women have different characteristics in every aspect we consider.

• Biomolecules & Therapeutics
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• 제31권5호
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• pp.550-558
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• 2023

Hair loss is a common condition that can have a negative impact on an individual's quality of life. The severe side effects and the low efficacy of current hair loss medications create unmet needs in the field of hair loss treatment. Hyaluronan and Proteoglycan Link Protein 1 (HAPLN1), one of the components of the extracellular matrix, has been shown to play a role in maintaining its integrity. HAPLN1 was examined for its ability to impact hair growth with less side effects than existing hair loss treatments. HAPLN1 was predominantly expressed in the anagen phase in three stages of the hair growth cycle in mice and promotes the proliferation of human hair matrix cells. Also, recombinant human HAPLN1 (rhHAPLN1) was shown to selectively increase the levels of transforming growth factor-β receptor II in human hair matrix cells. Furthermore, we observed concomitant activation of the ERK1/2 signaling pathway following treatment with rhHAPLN1. Our results indicate that rhHAPLN1 elicits its cell proliferation effect via the TGF-β2-induced ERK1/2 pathway. The prompt entering of the hair follicles into the anagen phase was observed in the rhHAPLN1-treated group, compared to the vehicle-treated group. Insights into the mechanism underlying such hair growth effects of HAPLN1 will provide a novel potential strategy for treating hair loss with much lower side effects than the current treatments.

• 대한약침학회지
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• 제25권1호
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• pp.63-67
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• 2022

Black soybean (BS) is widely thought to prevent or alleviate hair loss, which has been demonstrated by in vitro experiments. However, few clinical studies have directly assessed the effect of BS on hair growth. To assess the safety and efficacy of BS, we administered BS extract to 10 adult patients for 3 months without any other hair products and treatments. The number and diameter of hair lost from washing were examined every 4 weeks. In addition, the participants' satisfaction with their hair condition was also measured using the VAS (1 to 10) before and after treatment. The mean number of lost hair was 140.7 (SD 59.4) at baseline and 38.8 (SD 54.4) after 12 weeks, and the diameter of lost hair was 72.4 ㎛ (SD 11.9) at baseline and 80.4 ㎛ (SD 8.8) after 12 weeks, which indicated a statistically significant improvement (p = 0.002, p = 0.022, paired t-test). The satisfaction score was significantly increased from 6.10 (SD 1.2) to 8.2 (SD 1.1) after 12 weeks. These results suggest that BS extract may promote hair growth and prevent hair loss.

• 한국생활과학회지
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• 제21권3호
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• pp.587-596
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• 2012

Alopecia is usually presented as patchy, no scarring hair loss. It seems to be a hormonal imbalance or an immune mediated disease, whereas genetic predisposition, environmental and psychological factors may be involved in its etiology. Many treatments of alopecia disease have been widely applied, but their side effects are also well known. The purpose of this study is to demonstrate efficacy and safety of a food supplement containing medicinal plant extracts, amino acid and vitamin complex on the prevention of hair loss in human. A total of 20 subjects aged between 29-50 years with subjective hair loss complaint were recruited for this study. Each subject took 1 g/day supplement for 3 months. 5-Scale self-assessment test, hair loss count and measurement of hair thickness were conducted to evaluate the effect of supplement on the improvement of hair loss. Subjective hair loss was decreased and hair damage and thickness were improved in self-assessment test. After 3 months of supplementation, hair loss counts were decreased (P<0.05) while hair thickness was increased(P<0.001) significantly. There was no side effect observed during the study. These results suggest that the supplement consist of medicinal plant extracts, amino acid and vitamin complex might be useful for the improvement of hair loss with no significant side effects.

• 한국융합학회논문지
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• 제3권3호
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• pp.21-27
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• 2012

본 연구에서는 20대와 30대를 대상으로 성별, 직업별, 모발의 굵기 등 다양한 탈모의 원인들을 통한 자가인식의 정도를 파악하고 이에 따른 두피관리 행위의 실태를 알아보고자 하였다. 본 연구의 자료는 부산 경남지역에 거주하는 20대와 30대 262명을 대상으로 설문조사를 하였으며, 수집된 자료는 SPSS version 12.0을 이용하였다. 연구문제와 관련하여 빈도, 백분율, ${\chi}^2$검정 등을 적용하였다. 이상의 연구 분석 결과로 탈모에 관한 자가인식이 두피관리의 행위요인으로 귀결시킴으로써 연구대상자의 행위정도를 가름할 수 있었다. 이는 20대와 30대에서도 탈모에 관한 자가인식이 높을 수록 두피관리행위 또한 잘 실천하고 있다는 사실을 반영하는 것으로 탈모에 관한 자가인식은 두피관리와 밀접한 관계임을 알 수 있었다.

• 한방안이비인후피부과학회지
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• 제29권3호
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• pp.259-273
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• 2016

Objectives: Objectives of this research is to test hair growth effect of the hair scalpdetox five step program.Methods : Data for this research is gathered from participants who are suffering from hair loss and have completed scalpdetox five step program at a esthetic by receiving treatments twenty times constantly with once or twice a week during three months from March 2015 to April 2016. The hair scalpdetox program consists of five steps : the first step is shampooing, the second is scalp massage with aroma oils, the third is vertical meridian scrapping massage, the fourth is applying scalp and hair pack made with natural herbs, and the last is scalp massage with an indirect high frequency massaging device.Results: Subjective evaluations from the participants show that overall hair scalp conditions are meaningfully improved. Participants evaluated that tested approach helps hair growth by increasing the number of hair (p<.01) and helps to make their hair thicker (p<.01). Visual observations with magnification by 60 times and 200 times show improvement in hair scalp condition and clean opening of pores. Photographs of hair loss parts of each participant also show improvement in hair growth.Conclusions: From the evaluation of the participants for the test program and from visual observations, we conclude that suggested hair scalpdetox five step program has effect on improving scalp, hair condition, and hair growth.

• 한국식품과학회지
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• 제44권2호
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• pp.257-262
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• 2012

본 연구에서는 경구용과 경피용 육모 조성물의 병용 사용에 따른 육모 상승효과를 평가하기 위하여 C57BL/6 model을 이용하여 검은콩을 포함한 경구용 생약 복합 조성물과 탈모 방지 의약외품의 주요 효능 조성물로 구성된 경피용 육모 조성물의 복합사용에 따른 육모 상승 효과를 평가하였다. 그 결과 경구용 생약복합물을 섭취하거나 경피용 외용제외 도포하였을 때 성장기 모낭을 유도하여 모발의 성장을 촉진시키는 효과가 유사하게 나타나는 것을 확인하였고, 이 두 가지 방법을 병용하였을 때 그 효과가 더욱 상승하는 것을 관찰 할 수 있었다. 이러한 상승 효과는 외용제에서 나타나지 않은 경구제의 혈액 지표 개선 효과가 두 방법을 복합 사용할 경우 더해지기 때문인 것으로 추정된다. 경구제와 외용제의 병용에 따른 상승 효과를 확신하고 그 작용기전을 규명하기 위해서는 $5{\alpha}$-reductase를 비롯하여 탈모의 원인이 되는 다른 지표들의 변화를 평가하고, 이러한 효과가 인체를 대상으로 하였을 때도 나타나는지 확인하는 연구가 후속되어야 할 것이다. 또한 본 연구에서 사용된 조성물의 특이적인 효과가 아님을 확인하기 위하여 다양한 물질을 이용한 평가가 검증 연구가 필요할 것이다. 그러나 본 연구는 그간 막연하게 사용하였던 경구제와 외용제의 복합적인 사용이 기전적으로 구분되어 상승 효과를 가지는 것을 실험적으로 확인하였다는 것에 의의가 있으며 본 연구 결과를 바탕으로 탈모 치료법의 적절한 병용을 통하여 보다 나은 탈모 치료 효과를 기대할 수 있을 것이다.

• Archives of Plastic Surgery
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• 제43권6호
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• pp.498-505
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• 2016

Background Algae have traditionally been used for promotion of hair growth. Use of hair regrowth drugs, such as minoxidil, is limited due to side effects. The aim of this study was to examine a mixture of Saccharina japonica and Undaria pinnatifida (L-U mixture) on hair growth and to compare the promoting effect of hair growth by a 3% minoxidil and a L-U mixture. Methods To evaluate the hair growth-promoting activity, saline, 50% ethanol, 3% minoxidil, and the L-U mixture were applied 2 times a day for a total of 14 days on the dorsal skin of C57BL/6 mice after depilation. Analysis was determined by using a high-resolution hair analysis system, real-time polymerase chain reaction, and H&E staining. Results On day 14, the hair growth effect of the L-U mixture was the same as that of the 3% minoxidil treatment. The L-U mixture significantly (P<0.05) stimulated hair growth-promoting genes, as vascular endothelial growth factor (VEGF) and insulin-like growth factor -1. Increase of VEGF was observed in the L-U mixture group compared with minoxidil and the negative control. In contrast, the L-U mixture suppressed the expression of transforming growth factor-${\beta}1$, which is the hair loss-related gene. In histological examination in the L-U mixture and minoxidil groups, the induction of an anagen stage of hair follicles was faster than that of control groups. Conclusions This study provides evidence that the L-U mixture can promote hair growth in mice, similar to the effect from minoxidil, and suggests that there is potential application for hair loss treatments.

• Journal of Ginseng Research
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• 제33권3호
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• pp.223-228
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• 2009

총 32 명의 남성형 및 여성형 탈모 환자를 대상으로 24주 동안 이중 맹검 위약 비교 임상 시험을 시행한 결과 고려 홍삼 분말을 복용한 치료군이 대조군에 비해 통계적으로 유의하게 모발의 밀도와 굵기가 증가하는 것을 객관적으로 확인할 수 있었으며 환자 만족도 평가에서도 역시 치료군이 대조군 보다 높은 만족도를 보였다. 따라서 고려 홍삼의 복용이 임상적으로 탈모증 개선에 큰 도움이 될 것으로 사료된다.

• 대한약침학회지
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• 제24권2호
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• pp.68-75
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• 2021

Objectives: The hair follicle is composed of more than 20 kinds of cells, and mesoderm derived dermal papilla cells and keratinocytes cooperatively contribute hair growth via Wnt/β-catenin signaling pathway. We are to investigate β-catenin expression and regulatory mechanism by CBD in alopecia hair tissues and dermal papilla cells. Methods: We performed structural and anatomical analyses on alopecia patients derived hair tissues using microscopes. Pharmacological effect of CBD was evaluated by β-catenin expression using RT-PCR and immunostaining experiment. Results: Morphological deformation and loss of cell numbers in hair shaft were observed in alopecia hair tissues. IHC experiment showed that loss of β-catenin expression was shown in inner shaft of the alopecia hair tissues, indicating that β-catenin expression is a key regulatory function during alopecia progression. Consistently, β-catenin expression was decreased in testosterone or PMA treated dermal papilla cells, suggesting that those treatments are referred as a model on molecular mechanism of alopecia using dermal papilla cells. RT-PCR and immunostaining experiments showed that β-catenin expression was decreased in RNA level, as well as decreased β-catenin protein might be resulted from ubiquitination. However, CBD treatment has no changes in gene expression including β-catenin, but the decreased β-catenin expression by testosterone or PMA was restored by CBD pretreatment, suggesting that potential regulatory effect on alopecia induction of testosterone and PMA. Conclusion: CBD might have a modulating function on alopecia caused by hormonal or excess of signaling pathway, and be a promising application for on alopecia treatment.