Browse > Article
http://dx.doi.org/10.5934/KJHE.2012.21.3.587

An assessment of hair loss ameliorating effect of medicinal plant extracts, amino acid and vitamin complex in human subject  

Oh, Hyun-Ji (LG Household & healthcare R&D center)
Park, Hyung-Kook (LG Household & healthcare R&D center)
Ly, Sun-Yung (Dept. of Food Science and Human Nutrition, Chungnam National University)
Publication Information
Korean Journal of Human Ecology / v.21, no.3, 2012 , pp. 587-596 More about this Journal
Abstract
Alopecia is usually presented as patchy, no scarring hair loss. It seems to be a hormonal imbalance or an immune mediated disease, whereas genetic predisposition, environmental and psychological factors may be involved in its etiology. Many treatments of alopecia disease have been widely applied, but their side effects are also well known. The purpose of this study is to demonstrate efficacy and safety of a food supplement containing medicinal plant extracts, amino acid and vitamin complex on the prevention of hair loss in human. A total of 20 subjects aged between 29-50 years with subjective hair loss complaint were recruited for this study. Each subject took 1 g/day supplement for 3 months. 5-Scale self-assessment test, hair loss count and measurement of hair thickness were conducted to evaluate the effect of supplement on the improvement of hair loss. Subjective hair loss was decreased and hair damage and thickness were improved in self-assessment test. After 3 months of supplementation, hair loss counts were decreased (P<0.05) while hair thickness was increased(P<0.001) significantly. There was no side effect observed during the study. These results suggest that the supplement consist of medicinal plant extracts, amino acid and vitamin complex might be useful for the improvement of hair loss with no significant side effects.
Keywords
alopecia; medicinal plant extracts complex; hair loss count;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
연도 인용수 순위
1 Kim, D. K. (2002). The textbook of pharmacognosy. Seoul: Dong-myong.
2 Korea Food and Drug Administration. (2010). Clinical test guidelines for the hair growth medication. Seoul: Korea Food and Drug Administration.
3 Korea Food and Drug Administration. (2009). Guidlines for the efficacy test of hair growth agents. Seoul: Korea Food and Drug Administration.
4 Korea Food and Drug Administration. (2010). Guidebook for appropriate usage of drugs on pregnant women. Seoul: Korea Food and Drug Administration.
5 National Health Insurance Corporation. (2009). National survey of medical expenditure of patients with medical health insurance in 2009. Seoul: National Health Insurance Corporation.
6 Marshall, R. C., Orwin, D. F., & Gillespie, J, M. (1991). Structure and biochemistry of mammalian hard keratin. Electron Microscopy Reviews, 4(1),47-83.   DOI   ScienceOn
7 Park, H. J., Zhang, N., & Park, D. K. (2011). Topical application of Polygonummultiflorum extractinduceshairgrowthofrestinghairfolliclesthrou ghupregulatingShhandb-catenin expression in C57BL/6 mice. Journal of Ethnopharmacology, 135(2),369-375.   DOI   ScienceOn
8 Park, W. S., Lee, C. H., Lee, B. G., & Chang, I, S. (2002). The extract of Thujaeoccidentalis semen5a-reductase and androchronogenetic alopecia of B6CBAF1 /j hybrid mouse. Journal of Dermatological Science,31(2),91-98.
9 Petri. H., Pierchalla. P., & Tronnier. H. (1990). Efficacy of a pharmacotherapy in diffuse effluvium capillorum and structural alterations of hair. Schweiz. Rundschau Med 79(47), 1457-1462.
10 Rocha, J., Ventura, F., Vieira, A. P., Pinheiro, A. R., Femandes, S., & Brtito, C. (2011). Alopecia areata: a retrospective study of the paediatric dermatology department(2000-2008). Acta Medica Portuguesa, 24(2),207-214.
11 Stough, D. (2007). Dutaseride improves male pattern hair loss in a randomized study in identical twins. Journal of Cosmetic Dermatology, 6(1),9-13.   DOI   ScienceOn
12 Tak, M. J., Jung, I. K., Kim, D. K., Jung, H. S., & Lee, C. H. (2007). Influence of extracts of Biotae Orientalison the efficiency of hair grow thin hair removed C57BL/ 6Nmice. Korean Journal of Oriental Physiology &Pathology, 21(1),136-144.
13 Lee, K. H., & Lee, H. J. (2000). An analysis of psychiatric characteristics of the alopecia - A comparative study between alopecia areata and alopecia totalis. Journal of Korean Neuropsychiatric Association. 39(3),539-555.
14 Traish, A. M., Hassani, J., Guay, A. T., Zitzmann, M., & Hansen, M. L. (2011). Adverse side effects of 5$\alpha$-reductase inhibitors therapy: Persistent diminished libido and erectile dysfunction and depression in a subset of patients. Journal of sexual medicine, 8(3),872-884.   DOI   ScienceOn
15 Yoo, J. H., Eun, H. C., Kim, K. J., & Moon, S. E. (1995). The prevalence and types of androgenetic alopecia in Korean. Korean Dermatological Association, 33(1),67-75.
16 Kim, M. Y., & An, B. J. (2004). A study of hair loss prevention and hair growth promotion by Korean traditional formula. Korean Journal of Herbology, 19(2),9-20.
17 Lee, M. S. (2005). An investigation into actual management of hair loss and hair losing customers' satisfaction with it in a scalp clinic -centering on eight scalp clinics in Seoul. Unpublished master thesis. Hansung University, Korea
18 Lucky, A. W., Piacquadio, D. J., Ditre, C. M., Dunlap, F., Kantor, I., & Pandya, A. G. (2007). A randomized, placebo-controlled trial of 5% and 2% topical minoxidil solutions in the treatment of female pattern hair loss. Journal of America Academy Dermatology, 50(4),541-553.
19 Ludwig, G. (1977). Classification of the types of androgenetic alopecia (common baldness) occurring in the female sex. British Journal of Dermatology, 97(3),247-254.   DOI   ScienceOn
20 Naser, B., Bodinet, C., Tegtmeier, M., & Lindequist, U. (2005). Thujaoccidentalis(Arborvitae): A review of its pharmaceutical,pharmacological and clinical properties. Evidence Based Complementary and Alternative Medicine, 2(1),69-78.   DOI
21 Ashrafuzzaman, Md., Yamamoto, T., Shibata, N., Hirayama, T. T., & Kobayashi, M. (2010). Potential involvement of the stem cell factor receptor c-kit in alopecia areata and androgenetic alopecia: Histopathological, immunohistochemical, and semicquantitative investigation. The Japan Society of Histochemistry and Cytochemicstry, 43(1),9-17.
22 Naser, B., Lund, E., Heinneicke-von, Zepelin, H. H., Kohler, G., Lehmacher, W., & Scaglione, F. (2002). A randomized double-blind placebo-controlled clinical dose-reponse trial of an extract of Baptisia/Echincea and Thuja in the treatment of patients with common cold. Phytomedicine, 12(10),715-722.
23 Norwood, OT. (1975). Male pattern baldness: classification and incidence. South Medicine Journal, 68(11),1359-1365.   DOI
24 Manns, M. P., & Strassburg, C. P. (2011). Therapeutic strategies for autoimmune hepatitis. Digestive Diseases, 29(4),411-415.   DOI   ScienceOn
25 Bostelmann, H. C., Bodeker, R. H., Dames, W., Henneicke-von, Zeplin. H. H., Siegers, C. P., & Stammwitz, U. (2002). Immunomodulation durch pflanzliche Wirkstoffe. Fortschritteder Medizin, 120(4),119-123.
26 D'Agostini, F., Fiallo, P., Pennisi, T. M., & Flora, S. D. (2007). Chemoprevention of smoke-induced alopecia in mice by oral administration of L-cystine and vitamin $B_6$. Journal of Dermatological Science, 46(3),189-198.   DOI   ScienceOn
27 D'Amico, A. V. & Roehrborn, C. G. (2007). Effect of 1 mg/day finasteride on concentrations of serum prostate-specific antigen in men with androgenic alopecia: a randomized controlled trial. The lancetoncology, 8(1),21-25.   DOI   ScienceOn
28 Fujimoto, W., Inaoki, M., Fukui, T., Inoue, Y., & Kuhara, T. (2005). Biotin deficiency in an infant fed with amino acid formula. Journal of Dermatology, 32(4),256-261.   DOI
29 Jiang, Z. X., Long, M., Tu, Z., Yang, G., & He, G. (2009). 2,3,5,4' tetrahydroxystilbene-2-O-beta-glucoside(THSG) induced melanogenesis in B16 cells by MAP kinase activation and tyrosinase upregulation. Life Science, 85(9-10),345-350.   DOI   ScienceOn
30 Hertel, H., Gollnick, H., Matthies, C., Baumann, I., & Orfanos, C. E. (1989). Low dosage retinol and L-cystine combination improve alopecia of the diffuse type following long-term oral administration, Hautarzt, 40(8),490-495.
31 Kang, H. J., Kang, S. H., Lee, S. S., Cho, S, H., & Park, S. W. (2004). A clinical study of androgenetic alopecia. Korean Journal of Dermatology, 42(11),1431-1439.   과학기술학회마을
32 Alkhalifah, A., Alsantali, A., Wang, E., McElwee, K. J., & Shapiro, J. (2010). Alopecia areata update Part II. Treatment. Journal of American Academy of Dermatology 62(2),191-202.   DOI   ScienceOn