• Journal of Applied Biological Chemistry
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• 제65권4호
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• pp.307-312
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• 2022

A hair essence containing α-tocopheryl acetate, retinyl palmitate, and phytantriol (TRP-hair essence) was prepared. TRP-hair essence was excellent in thermal stability to the extent that it did not harden at all even at 210 ℃. TRP-hair essence potently protected the hair from heat stress, significantly reducing the protein leakage in heat-treated hair (p <0.001). Treatment of TRP-hair essence to dyed human hair significantly protected hair against heat stress (p <0.05) as well as improved hair cuticle and color persistence (p <0.05). In addition, as a result of directly treating human hair with TRP-hair essence, the cuticle and tensile strength of human hair were significantly improved (p <0.05). These results suggest that TRP-hair essence can be effective for hair protection and hair quality improvement.

• 패션비즈니스
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• 제17권3호
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• pp.48-57
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• 2013

This study was performed to quantitatively and qualitatively estimate the effect of keratin essence on hair protection against physicochemical damage. Damaged hairs were obtained from an early thirty woman who dyed her hair two times and did digital permanent treatment of her hair two times. The damaged hairs were divided into four experimental groups, which are the control hair (CH) group without additional beauty treatment, the damaged hair (DH) group by additional dyeing treatment, basic essence-treated hair (BEH) group, and keratin essence-treated hair (KEH) groups according to the research goal. The protection effect of keratin essence against the physicochemical damage was quantitatively compared by difference of chrominance measured using a color difference meter and qualitatively compared by difference of outer morphological structure images pictured using scanning electron microscopy (SEM). The brightness and yellowish blue color of KEH were relatively lower but the reddish blue color was relatively higher than other groups of test hairs. Cuticle structure of the previously DH was irregularly deformed and more strongly deformed or partially broken by additional dyeing treatment. On the other hand, the gaps between cuticle scales of the DH were reformed by treatment with basic essence and reformed and filled by treatment with keratin essence in comparison with the DH group. Conclusively, the keratin essence was effective to protect hair structure against the structural damage induced by the dyeing-treatment, by which the coloring efficiency is thought to be improved.

• 한국패션뷰티학회지
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• 제3권1호
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• pp.72-77
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• 2005

The present study was to investigate the effects of different types of conditioner on the morphological changes of hair cuticles after coloring treatment. The virgin hair, aged 22 years served as a subject. Coloring treatment was done with a commercial hair dye agent for 35 minutes as routine procedures at $25^{\circ}C$, 50% R.H. environmental condition. The two different types of conditioner, Essence and LPP were applied to the colored hair 10 times with 2 days interval for 20 days. The hair cuticles were observed by a scanning electron micro scopy before and after coloring and conditioner treatment. The main results were as follows. Coloring treatment damaged the hair cuticles, and both of Essence and LPP had a direct conditioning effect. Also, the damaged hair cuticles were recovered by the repeated application of hair conditioner. Moreover, LPP was more effective in hair curing compared to Essence. These results show that a hair conditioner can be helpful to keep healthy hair and to shorten an interval of coloring.

• 대한한의학회지
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• 제25권1호
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• pp.152-160
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• 2004

Backgrounds : Androgenetic alopecia is a relatively common disorder, but its precise mechanism is not elucidated. There are two commercial drugs approved by FDA. One(finasteride) has an inhibition activity of 5$\alpha$-reductase(type 2) and the other(minoxidil) has a vasodilation activity. Objectives : A verified herbal remedy for baldness is needed for medicinal treatment or preventing alopecia, which could be demonstrated by alopecia-related in vitro & in vivo tests Methods : On the basis of oriental pharmacognosy, we classified many herbal medicines into four groups (malnutrition, aging, alopecia and gray hair) according to its effect. The mitosis induction of hairy dermal papillae cell and the metabolic inhibition for type 2 $5{\alpha}-reductase$ were tested with five herbal extracts. Also, five herbal extracts were added to the normal essence formulation (HHRHG0202-80) in ranges of 0.1~0.3%, which was applied two-mouse models to validate each hair growing activity in vivo. Results : Stimulation of follicular papillae cell proliferation was observed in treatment of three herbal extracts (Glycyrrhizae radix:159.7%, Corni fructus : 144.7%, and Coicis semen : 136.6%) at a dose of $10\mu\textrm{g}/ml$. Three herbal extracts (Biotae semen. Glycyrrhizae radix and Coicis semen) showed inhibitory activity for $5{\alpha}-reductase$(type 2) at 93.18%, 73.36% and 47.6%, respectively at the same dose. We observed the enhancement of hair growth activity in C57b1/6 mouse and the inhibition of alopecia in AGA mouse after topical administration of the hair essence. Conclusions : Hair essence product, which contains five medicinal plants, would be used for the remedy for male pattern baldness (MPB) and the other alopecia diseases.

• 대한화장품학회지
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• 제45권4호
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• pp.353-361
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• 2019

본 연구에서는 Fervidobacterium islandicum AW-1를 이용하여 케라틴 펩타이드를 생산하고, 두피 및 모발에 관련된 인자를 확인하여, 화장품 원료로서 케라틴 펩타이드의 가능성을 알아보았다. 모유두 세포주에 케라틴 펩타이드를 농도에 따라 세포 독성 및 증식을 살펴본 결과, 세포 독성은 나타나지 않았고, 세포증식에도 효과가 없었다. 케라틴 펩타이드를 함유한 헤어 샴푸, 헤어 에센스를 제조하여 인체 첩포 시험을 거쳐 무자극을 확인하였다. 30 명의 건강한 성인 피험자를 대상으로 4 주 동안 샴푸 및 에센스를 2 그룹으로 나누어 사용한 결과, 육안평가에서 윤기, 탈모, 두피 트러블, 푸석거림에서 통계적으로 유의한 긍정적 결과를 나타내었다. 두피 수분량은 샴푸와 에센스 사용 전 대비 2, 4 주 후에 통계적으로 유의한 증가를 나타내었다. 두피에 대한 경피수분손실양은 에센스를 사용한 그룹에서 사용 전 대비 4주 후에 통계적으로 유의한 감소를 나타내었다. 두피 피지량 역시, 에센스를 사용한 그룹에서 사용 전 대비 4 주 후에 통계적으로 유의한 감소를 나타내었다. 정상 모발, 손상 모발을 이용한 헤어 샴푸와 에센스의 사용 전후의 빗질에 의한 마찰력을 측정한 결과, 사용 전 대비 모두 통계적으로 유의한 변화를 나타내었다. 정상 모발의 경우, 사용 전보다 빗질의 마찰력이 증가하였고, 손상 모발의 경우 사용 전보다 빗질의 마찰력이 감소하였다. 이를 통해 케라틴 펩타이드는 모발 및 두피 관련한 제품에 사용할 수 있는 원료로 확인하였다.

• 동의생리병리학회지
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• 제16권6호
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• pp.1110-1116
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• 2002

The skin(皮膚) separates epidermis(皮) and dermis(膚) in Oriental medicine. epidermis and hair come from ectoderm as dermis comes from mesoderm in embryology. Epidermis and hair belong to the Metal(金) and dermis belongs to the Earth(土) in Oriental medicine. The lung is related to the skin and hair. The skin surface is nourished by the essence from the lung, and the. lung has the function of sending wei-qi(衛氣.: defensive Energy) to the skin surface to guarantee body resistance. The skin takes nourishment from blood(血) and express by qi(氣). The supply of nutrients to the lung and skin relies on the function of the spleen, pancreas and subcutis. Flaming of the heart fire may scorch the essence of the lung-metal, inducing dermatosis.

• 한국융합학회논문지
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• 제13권5호
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• pp.35-43
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• 2022

인체 유래 Leuconostoc mesenteroides 배양액을 함유한 에센스로 탈모 증상 완화에 대한 유효성을 검증하고 기능성 화장품 소재로써의 가능성 여부를 규명고자 41명의 피험자를 시험군과 대조군으로 분류하여 2021. 4. 15 ~ 2021. 11. 4 까지 총 24주간 이중맹검, 대조시료, 단일기관, 무작위 배정 인체적용시험을 시행하였다. 포토트리코그램을 통한 모발 수(N/cm²)는 시험군에서 8주, 16주, 24주 후 모두 유의미한 차이가 (p<0.001) 있었고 연구자의 육안 평가는 시험 24주 후부터 수치 상 호전된 것으로 나타났다. 피험자 주관 평가는 8주, 16주, 24주 후 시험군과 대조군 간 모발 수 변화량이 유의미한(p<0.017) 차이를 보여 L. mesenteroides 배양액 1%를 함유한 에센스는 탈모 증상 완화에 유효한 것으로 확인되었다. 이러한 결과로 인체 유래 유산균 L. mesenteroides는 향후 탈모 예방을 위한 다양한 제형의 기능성 화장품 소재로 활용 가능할 것으로 기대된다.

• 셀메드
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• 제3권3호
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• pp.23.1-23.3
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• 2013

According to the traditional Korean medicine (TKM), kidney has been recognized as the roof of innate endowment because it plays an important role in the birth, growth, sexual reproduction, and aging. Kidney essence insufficiency syndrome (KEIS) is caused when kidney is impaired. KEIS is characterized by retarded development, decreased reproduction, tinnitus, loosening of teeth, and loss of hair and forgetfulness. In traditional Chinese medicine, KEIS mouse model was established by use of threatinjuring the kidney combined with over-fatigue. However, the TKM theory-based KEIS experiment model has not been described correctly. In the present study, we suggest a new KEIS experiment model including following cases; 1) weakness of father essence and mother blood, 2) life nurturing during pregnancy, 3) full-term gestation period.

• 생약학회지
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• 제42권3호
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• pp.260-264
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• 2011

The bacterial growth and pH of Cornus officinalis fermented with Lactobacillus rhamnosus during fermentation were evaluated. As the results, the number of the fermentation after fermentation always remained higher than 6 log CFU/mL and the pH of those ranged from 4 to 6. To evaluate the effect of Cornus officinalis fermented with Lactobacillus rhamnosus on hair growth promotion in C57BL/6 mice, Six weeks old male mice were divided into four groups including normal group (saline), negative control group (essence base), positive control group (minoxidil) and experimental group (Cornus officinalis and animal milk fermented with Lactobacillus rhamnosus mixed in negative control). And they were applied topically with test materials for 8 days. Hair regrowth effect in experimental group using gross and histological examination was higher than that in positive control group. Body weight and food intake of four groups didn't show significant difference. These results indicated that the Cornus officinalis fermented with Lactobacillus rhamnosus can be used practically for hair growth or prevention of hair loss.

• 한방안이비인후피부과학회지
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• 제29권4호
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• pp.1-13
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• 2016

Objectives : The purpose of this study is to compare hair and alopecia of Korean Medicine with those of western medicine. Methods : We studied relationships between hair and essense(精), qi(氣), blood(血), five vicera(五臟) and meridians(經絡) through literature review about hair and alopecia. We compared Korean medicine with western medicine on physiology of hair and treatment of alopecia based on the study. Results & Conclusion : 1. Congenital essense(先天之精) is related with genetic factor and acquired essence(後天之精) is connected with nutritional factor. Defending function of Defense qi(衛氣) is related with immune reaction and qi stagnation(氣鬱) is associated with stress reaction. Atrophy of vascular tissues observed in alopecia scalp means deep relationship between blood(血) and alopecia, further deficiency of blood can cause telogen effluvium. 2. Kidney qi(腎氣) is related with inhibiting combination of Androgen receptor and Dihydrotestosterone(DHT) or activating hair growth factior. Pi(脾) is connected with alopecia seborrheica caused by damp-heat(濕熱) and alopecia areata caused by excessive prudence(思慮過度). Heart(心) is associated with atrophy in vascular tissue of scalp and liver(肝) is connected with metabolism. 3. Armpit hair and pubic hair as secondary sex characteristics are realated with Yangming Meridian(陽明經) and beard and hair at crown part where Type II $5{\alpha}$-reductase is activated much are associated with Taiyang Meridian(太陽經). 4. Juglandis Semen pharmacopuncture and Ganoderma lucidum pharmacopucture have better effects on inhibit $5{\alpha}$-reductase than Finasteride. Minoxidil and PRP are similar with promoting blood flow and removing stasis(活血祛瘀). Seven-star needling(七星針) is similar with microneedling. 5. Alopecia can be caused by due to lack of circulation Views we need solution to improve circulation coincide in opinion with Korean Medicine and Western medicine.