• 재활복지공학회논문지
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• 제11권4호
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• pp.377-383
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• 2017

본 연구에서는 휠체어 컬링 샷정확도 향상을 위한 압박형 훈련장비를 제안하였다. 제안된 장비는 가이드폭 조절을 퉁해 샷의 좌 우정확도 향상을 위한 심리적 압박을 제공하고, 레이저디스턴스 모듈 세트를 통해 샷의 강도 정확도 향상을 제공함으로써 종합적인 샷의 정확도 향상을 꾀할 수 있으며, 샷 진행영상 피드백을 통해 현장에서의 즉각적인 경기력 분석을 지원할 수 있도록 개발되었다. 휠체어 컬링 대표팀 코칭스태프, 협회관계자, 아이스메이커 등과의 파일럿 시험을 수행하고 의견을 청취한 결과, 종합적인 샷 정확도 훈련, 심리적 압박, 경기력 분석에서의 개발장비의 유용성을 확인할 수 있었다.

• Journal of Microbiology and Biotechnology
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• 제5권3호
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• pp.154-157
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• 1995

MRK-22, an inhibitor of aminopeptidase M was isolated from the culture broth of Streptomyces sp. SL20209. The structure of MRK-22 was defined to be 3-amino-2-hydroxy-5-methylhexanoyl-valyl-valine, des-$Asp^4$-amastatin, by spectroscopic analysis and this was also confirmed by solid phase synthesis of the inhibitor. The molecular formula and weight of MRK-22 were $C_17H_33N_3O_5$ and MW 359($M^+$), respectively, and its $IC_50$ value against hog kidney AP-M was 0.79 $\mu$ g/ml.

• Journal of Microbiology and Biotechnology
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• 제5권1호
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• pp.36-40
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• 1995

Valistatin, a new inhibitor of aminopeptidase M(AP-M) was discovered in the culture broth of Streptomyces sp. SL20209 isolated from a soil sample. The inhibitor was purified by extraction with n-butanol and the various column chromatographies, and then isolated as whitish powder. The $^1 H-and ^1 H, ^1 H-COSY$ NMR studies, amino acid analysis, and fragmentation patterns by FAB-MS suggested the presence of one 3-amino-2-hydroxy-4-phenylbutanoic acid and two valine residues in the inhibitor. Thus, the structure of valistatin was determined as 3-amino-2-hydroxy-4-phenylbutanoyl-valyl-valine. Valistatin has the molecular formular $C_20H_31N_3 O_5$ (MW 394), and its $IC_50$ value against hog kidney AP-M was determined to be 3.12 $mu g/ml$.