• Journal of Nutrition and Health
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• v.41 no.3
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• pp.242-253
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• 2008

It is a common clinical practice to recommend taking iron supplements for pregnant women during gestation. Although it is required to ensure adequate iron stores during pregnancy, there has been some debate over the interference effects of excessive iron load, because it is possible to compete in the transport in the intestine and placenta and in binding to serum proteins of other trace minerals. In this study, maternal and neonatal serum concentrations of Fe, Zn, Cu, Se, Cr, Mn, and Co were assessed along with maternal Fe intakes. A total of 124 pregnant women and their term neonates participated voluntarily in this research. The women were divided into one of the three groups {high Fe intake (HFI), median Fe intake (MFI), and low Fe intake (LFI)} by their total Fe intakes and one of the two groups (Anemic and Normal) by their Fe nutritional status. All the data were compared among the three groups and between the two groups also. Total Fe intakes of HFI, MFI, and LFI groups were 140.8 ${\pm}$ 76.1, 68.0 ${\pm}$ 11.2, and 30.2 ${\pm}$ 8.6 mg/day, respectively. Those of Anemic and Normal groups were 90.1 ${\pm}$ 74.8 and 86.6 ${\pm}$ 46.8 mg/day, respectively. Maternal Hb concentration and Hct were not significantly different among HFI, MFI, and LFI groups but those were significantly different between Anemic and Normal groups. However, neonatal Hb concentration was not significantly different among HFI, MFI, and LFI groups and between Anemic and Normal groups either. Maternal serum Fe concentrations of the three groups, HFI, MFI, and LFI, were similar but that of Anemic group was significantly lower compared to Normal group. However, there was no significant difference in neonatal serum Fe concentrations among the three groups and between the two groups either. Serum concentrations of the other trace minerals in both mothers and neonates were not significantly different among HFI, MFI, and LFI groups and between Anemic and Normal groups. In addition, in the maternal serum, Fe concentration was positively correlated to Zn and Se concentration, respectively. As for the neonatal serum, Fe concentration showed a positive correlation to Zn, Cu, Mn, Se, and Co concentration, respectively. No trace mineral concentration was found to correlate negatively to Fe concentration in both maternal and neonatal serum, The results in this study indicate that Fe intakes of pregnant women, even if it is considerably above the level of estimated average requirement (EAR), may not affect serum Fe concentration in both mothers and neonates. In addition it might not influence adversely on the availability of other trace minerals including Zn and Cu in both mothers and neonates.

• Journal of Environmental Impact Assessment
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• v.29 no.3
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• pp.182-197
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• 2020

This study investigated the home range and characteristics of activities to contribute to the improvement of management techniques and the successful promotion of management policies of invasive nutria, which is a representative invasive species of South Korea. Six individuals were captivated for the study. Remote radio tracking on three of them was carried out followed by the analysis of the results. The average home range of the follow-up individuals were confirmed to be 0.043 ㎢ at MCP 95%, 0.085 ㎢ at K 95%. It was 0.018 ㎢ at K 50%, which is the core space. In 95% MCP, males exhibited the home range with 0.058 ㎢, showed wider home range 0.046 ㎢ than females who showed 0.012 ㎢, and showed a wider home range 0.015 ㎢ more at night than during the day. As a result of comparing the results of this study with the case studies of overseas studies, it is determined that the magnitude of the derived home range is the result of a stable habitat in which the procurement of food resources is smooth and human interference is limited. The daily moved distance of males was larger than that of females, with a maximum moved distance of 1,278 m per day. Activity at the study site is high from around sunset to around 6 A.M., 10 P.M., 7 P.M., 1 A.M., and 5 A.M., and high around sunrise and low during the daytime such as 2 P.M., which reflected the propensity of nocturnal animals to act. The results of this study on the home range and activity in nutria can be used as useful data forimproving the management of invasive alien species for the installation and operation of traps, the spatial setting of controlled areas, and the calculation of the amount ofresources together with a basic understanding of nutria's behaviors in South Korea.

• Korean Journal of Food Science and Technology
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• v.42 no.4
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• pp.390-397
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• 2010

Residual solvents in foods are defined as organic volatile chemicals used or produced in manufacturing of extracts or additives, or functional foods. The solvents are not completely eliminated by practical manufacturing techniques and they also may become contaminated by solvents from packing, transportation or storage in warehouses. Because residual solvents have no nutritional value but may be hazardous to human health, there is a need to remove them from the final products or reduce their amounts to below acceptable levels. The purpose of this study was to develop and evaluate an analytical method for the screening of residual solvents in health functional foods. Furthermore, the aim of this study was to constitute a reasonable management system based on the current state of the market and case studies of foreign countries. Eleven volatile solvents such as MeOH, EtOH, trichloroethylene and hexane were separated depending on their column properties, temp. and time using Gas Chromatography (GC). After determining the GC conditions, a sample preparation method using HSS (Head Space Sampling) was developed. From the results, a method for analyzing residual solvents in health functional foods was developed considering matrix effect and interference from the sample obtained from the solution of solvents-free health functional foods spiked with 11 standards solutions. Validation test using the developed GC/HSS/MS (Mass Spectrometry) method was followed by tests for precision, accuracy, recovery, linearity and adequate sensitivity. Finally, examination of 104 samples grouped in suits was performed by the developed HSS/GC/MS for screening the solvents. The 11 solvents were isolated from health functional foods based on vapor pressure difference, and followed by separation within 15 minutes in a single run. The limt of detection (LOD), limit of quantification (LOQ), recovery and coefficient of variation (C.V.) of these compounds determined by the HSS/GC/MS were found to be 0.1 pg/mL, 0.1-125 pg/g, 51.0-104.6%, and less than 15%, respectively. Using the developed HSS/GC/MS method, residual solvent from 16 out of 104 health functional products were detected as a EtOH. This method therefore seems t o be a valuable extension ofanalytical method for the identification of residual solvents in health functional food.

• Weed & Turfgrass Science
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• v.4 no.3
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• pp.188-198
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• 2015

This study was conducted in order to investigate the distribution pattern of weeds and ecological characteristics on the dry field in the Eastern region of Korea. The weed species data were obtained from 12 regions in Gangwon-do and Gyeongsang-do. 150 taxa were recorded from three main distinguished habitats; inside of dry field (IDF), embankment around the end of dry field (EDF), levee slope of dry field (LS). The weed species of three different habitats were IDF 83 taxa, EDF 133 taxa and LS 105 taxa. The species showing higher rNCD value was Portulaca oleracea in IDF, Digitaria sanguinalis in EDF and Humulus japonicus in LS. Compositae was dominant family followed by Gramineae, Polygonaceae and Leguminosae. Life form was distinguished as Th-R5-D4-e and three different habitats showed the same results. Disturbance index was analysed as IDF 83.1%, EDF 68.4%, and LS 62.9%. Naturalized rate was analysed as IDF 28.9%, EDF 22.6%, and LS 20.0%. These results indicate that the weeding management, land use intensity, and human interference effect on the distribution index and naturalized rate of weed.

• Journal of Life Science
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• v.15 no.3 s.70
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• pp.406-414
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• 2005

The genetic instability of cancer cells may be related to inappropriately activated DNA repair pathways. In present study, the modulated expression of DNA-dependent protein kinase (DNA-PK), a major DNA repair protein, in human cancer metastatic cells was tested. The expressions of Ku70/80, regulatory subunit of DNA-PK, and the Ku DNA-binding activity in various highly metastatic cell lines were higher than those in each parental cell line. Also, the expression of DNA-PKcs, catalytic subunit of DNA-PK, and the kinase activity of the whole DNA-PK complex in highly metastatic cells were significantly increased as compared to those of parental cells, suggesting that the enhanced DNA repair capacity of metastatic cells could be associated with aberrant use of DNA repair, which may mediate tumor progression and metastatic potential. Increased EGFR (epidermal growth factor receptor) signaling has been associated with tumor invasion and metastasis, and the linkage between EGFR-mediated signaling and DNA-PK has been suggested. This study showed that PKI166, the new EGFR tyrosine kinase inhibitor, modulated the expressions of Ku70/80 and DNA-PKcs and also revealed the chemosensitization effect of PKI166 against metastatic cells may be in part due to inhibition of Ku70/80. These results suggest that interference in EGFR signaling by EGFR inhibitor resulted in the impairment of DNA repair activity, and thus DNA-PK could be possible molecular targets for therapy against metastatic cancer cells.

• Journal of Digital Convergence
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• v.9 no.6
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• pp.91-102
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• 2011

Smart work is deeply embedded in our contemporary lives. This is called Smart Life. The expansion of communication, caused by smart life is utilized for the political purposes of politicians, political candidates, and political policies. Chiefly, smart life includes improvement in awareness, personal relations, and policy advocacy. Socially, smart life leads the proliferation of issues and civil movement. In particular, smart life has a significant effect on culture. In the case of K-POP, it is disseminated going beyond space time. It enhances economic value added by joining and sharing at the same time. Smart life has numerous advantages such as improving the quality of life, but it might cause inconvenience depending on users because there are differences in acceptance according to generations. Due to the heavy weight on the device, there are some side-effects such as lacking in human thinking, disclosure in private life, lacking in basic securities, increase in information addicts who are anxious when they do not get on the Internet or SNS, and interference with work. However, this inconvenience can change into convenience when users are accustomed to it. Like this, smart life influences politics, economy, society, and culture a lot. Working environment of smart life is a new paradigm, which can generate high performance through working in an exciting and bright atmosphere with easy economy and putting value on results.

• Korean Journal of Environment and Ecology
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• v.23 no.1
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• pp.66-77
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• 2009

This study aims at classifying and interpreting on the forest vegetation located in the whole area of Mt. Boryeonsan in Noeunmyeon, Chungju city, Chungcheongbuk Province, Korea using the methodology of the ZM school of phytosociology. The forest vegetation was classified into one Larix leptolepis afforestation, five secondary communities including Qurecus acutissima community, Pinus densiflora community, Quercus aliena community, Quercus serrata community, Quercus variabilis community and one association, Ainsliaeo-Quercetum mongolicae Song et al. 1999(Rhododendro schlippenbachii-Quercion mongolicae, Aceri pseudosieboldiani-Quercetalia mongolicae, Quercetea mongolicae). The research expatiated on the relationship between species composition of the forest communities and the environmental conditions, such as human interference, altitude, slope, topography and chemical properties of soil, and also analyzed the life form by each community. As a result, the Ainsliaeo-Quercetum mongolicae was judged as the most stable community among the forest communities identified here. On the other hand, a division of cluster analysis based on the dominance of the component species, appeared similar to the community units classified phytosociologically. Thus, it is inferred that the survey area will be dominated by the potential natural vegetation, Ainsliaeo-Quercetum mongolicae finally, if progressive succession is advanced continuously.

• Proceedings of the Korea Crystallographic Association Conference
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• 2003.05a
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• pp.18-18
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• 2003

Thioredoxin (Trx) is a small redox protein that is ubiquitously distributed from achaes to human. In diverse organisms, the protein is involved in various physiological roles by acting as electron donor and regulators of transcription and apoptosis as well as antioxidants. Sequences of Trx within various species are 27～69% identical to that of E. coli and all Trx proteins have the same overall fold, which consists of central five β strands surrounded by four α helices. The N-terminal cysteine in WCGPC motif of Trx is redox sensitive and the motif is highly conserved. Compared with general cysteine, the N-terminal cysteine has low pKa value. The result leads to increased reduction activity of protein. Recently, novel thio.edoxin-related protein (TRP14) was found from rat brain. TRP14 acts as disulfide reductase like Trx1, and its redox potential and pKa are similar to those of Trx1. However, TRP14 takes up electrons from cytosolic thioredoxin reductase (TrxR1), not from the mitochondrial thioredoxin reductase (TrxR2). Biological roles of TES14 were reported to be involved in regulating TNF-α induced signaling pathways in different manner with Trx1. In depletion experiments, depletion of TRP14 increased TNF-α induced phosphorylation and degradation of IκBα more than the depletion Trx1 did. It also facilitated activation of JNK and p38 MAP kinase induced by TNF-α. Unlike Trx1, TRP14 shows neither interaction nor interference with ASK1. Here, we determined three-dimensional crystal structure of TRP14 by MAD method at 1.8Å. The structure reveals that the conserved cis-Pro (Pro90) and active site-W-C-X-X-C motif, which may be involved in substrate recognition similar to Trx1 , are located at the beginning position of strand β4 and helix α2, respectively. The TRP14 structure also shows that surface of TRP14 in the vicinity of the active site, which is surrounded by an extended flexible loop and an additional short a helix, is different from that of Trx1. In addition, the structure exhibits that TRP14 interact with a distinct target proteins compared with Trx1 and the binding may depend mainly on hydrophobic and charge interactions. Consequently, the structure supports biological data that the TRP14 is involved in regulating TNF-α induced signaling pathways in different manner with Trx1.

• Journal of Korean Society of Forest Science
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• v.88 no.3
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• pp.342-351
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• 1999

The forest vegetation developing on Mt. Inwang, an isolated forestland in Seoul, Korea was analyzed phytosociologically and its spatial distribution mapped out. Using the vegetation map, The characteristics of landscape structures in terms of the number and size of patches are discussed. Forest vegetation of the study area was classified into ten communities, ten groups, and eighty subgroups. Landscape element types were classified into secondary forests, relict communities, introduced plantations, and other elements including urbanized area. Pinus densiflora community, natural forest and Robinia pseudo-acacia community, plantation, formed matrix and some secondary forest elements, relict communities and the ether plantations of small size tended to distribute as small patches in such matrix. The number of patches per unit area in secondary forest elements was more than that in plantation elements. The result in patch size was vice versa. The vascular plant species richness of the landscape element types in Mt. Inwang was found to he positively related to their size. As the results of landscape ecological analyses, it was estimated that differentiation of patches recognized in community level would be related to human interference a and those in subordinate levels to natural process such as progression of succession.

• Journal of Korean Society of Forest Science
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• v.89 no.2
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• pp.145-160
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• 2000

This study is focused to the national park of Korean typical Sea Hally$\check{o}$ Haesang, and its visual resources and practiced inspect course by the way of suppositions and tests, to show the visual resource management objectively, and that of qualitative basic data. Accordingly by measuring the physical amount spatial structure with the visual amount originated from the Mesh Analyzing Method and the Visual Preference from the Scenic Beauty Estimation(S.B.E.) method and analyzed the valuation of the visual resource by Iverson method. Spatial image structure measured by Semantic Differential(S.D.) Scale was shown through the factor analysis algorithm for the analyzing psychological amount and examined the flowing out of decisive factor and the objective importance related to the mutual factors by appling the measurement of the visual quality. As a national Park, the visual factors that have natural landscape harmonized with forest, sky, surface of the water, curious stones and rocks, and temples should be escalated their values affirmatively so as to be the scenery of pointed direction and enjoyable, and it is of more needed for visual resource and its' controlling technique to make artificial structures more intentional planning and systemical setting. When we are viewing the improvement for the national park along with the visual resource management, reasonable level of development is needed, because when men interference surpass plantations and leasts will be damaged and the quality of natural landscape can be lowered, so it is needed to set up a management end, tangibly or clearly; and it is permitted limit coming and going ablably by accounting the suitable number for availing. But the controling end should be set in every level, positive management, very actively within the permissive varcability. It is the main business for the national park to prevent the damage from human for their gay life or to prevent the damage of a land carpet, and to restorate for the visual resource management.