• Genomics & Informatics
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• 제6권1호
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• pp.54-58
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• 2008

Genotyping Tool for Viral SEQuences (GTVseq) provides scientists with the genotype information on the viral genome sequences including HIV-1, HIV-2, HBV, HCV, HTLV-1, HTLV-2, poliovirus, enterovirus, flavivirus, Hantavirus, and rotavirus. GTVseq produces alternative and additive genotype information for the query viral sequences based on two different, but related, scoring methods. The genotype information produced is reported in a graphical manner for the reference genotype matches and each graphical output is linked to the detailed sequence alignments between the query and the matched reference sequences. GTVseq also reports the potential 'repeats' and/or 'recombination' sequence region in a separated window. GTVseq does not replace completely other well-known genotyping tools such as NCBI's virus sequence genotyping tool (http://www.ncbi. nlm.nih.gov/projects/genotyping/formpage.cgi), but provides additional information useful in the confirmation or for further investigation of the genotype(s) for the newly isolated viral sequences.

• Genomics & Informatics
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• 제6권2호
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• pp.57-63
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• 2008

The Korean HapMap Project has been carried out for the last 5 years since it started in June, 2003. The project generated data for a sum of 1,764,000 Korean SNPs and formally registered the data to the dbSNP of NCBI (The dbSNP website. 2008). We have developed a series of software programs for association studies as well as for the comparison and analysis of Korean HapMap data with four other populations (CEPH, Yoruba, Han Chinese, and Japanese populations). The KHapmap Browser was developed and integrated to provide haplotype retrieval and comparative study tools of human ethnicities for comprehensive disease association studies (http://www.khapmap.org). On that basis, GBrowse was adopted in the KHapmap Browser for inherent Korean genetic data, and a provision of extended services was pledged with the distributed sequence annotation system (DAS). The dynamic linking service of the KHapmap Browser to other tools in our intranetwork environment provides many enhanced functions over GBrowse without DAS. KHapmap Browser is expected to be an invaluable tool for the study of Korean and international Hapmap data.

• 셀메드
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• 제2권2호
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• pp.18.1-18.16
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• 2012

An oncology-specific database called OncoRx (http://bit.ly/cancerRx) was previously set up in cyberspace to aid clinicians in identifying interactions of anticancer drugs (ACDs) and chemotherapy regimens with traditional Chinese medicines (TCMs) and complementary and alternative medicines (CAMs). Since then, users have requested the drug-CAM interactions (DCIs) of 5 specific CAMs (cranberry, melatonin, co-enzyme Q10, huachansu, reishi mushroom) to be updated in the database. Pharmacokinetic properties (metabolism, enzyme induction/inhibition, elimination), TCM properties and DCIs of each CAM were collated with 117 ACDs using 9 hardcopy compendia and online databases as resources. Additionally, individual ACDs and CAMs were used as keywords for PubMed searches in combination with the terms 'anticancer drugs', 'drug interactions', 'herb-drug/drug-herb interactions', 'pharmacokinetic interactions' and 'pharmacodynamic interactions'. DCI parameters consisted of interaction effects, evidence summaries, proposed management plans and alternative non-interacting CAMs, together with relevant citations and update dates of the DCIs. OncoRx is also used as a case to introduce the "Four Pharmaco-cybernetic Maxims" of quality, quantity, relationship and manner to developers of digital healthcare tools. Its role in Hayne's "5S" hierarchy of research evidence is also presented. OncoRx is meant to complement existing DCI resources for clinicians and alternative medicine practitioners as an additional drug information resource that provides evidence-based DCI information for ACD-CAM interactions.

• 대한의용생체공학회:의공학회지
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• 제37권2호
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• pp.84-89
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• 2016

In this study, we proposed ameliorated method for region of interest (ROI) study to improve its accuracy using partial volume effect (PVE). PVE which arose in volumetric images when more than one tissue type occur in a voxel, could be used to reduce an amount of gray matter and cerebrospinal fluid within ROI of diffusion tensor image (DTI). In order to define ROIs, individual b0 image was spatially aligned to the JHU DTI-based atlas using linear and non-linear registration (http://cmrm.med.jhmi.edu/). Fractional anisotropy (FA) and mean diffusivity (MD) maps were estimated by fitting diffusion tensor model to each image voxel, and their mean values were computed within each ROI with PVE threshold. Participants of this study consisted of 20 healthy controls, 27 Alzheimer's disease and 27 normal-pressure hydrocephalus patients. The result showed that the mean FA and MD of each ROI were increased and decreased respectively, but standard deviation was significantly decreased when PVE was applied. In conclusion, the proposed method suggested that PVE was indispensable to improve an accuracy of DTI ROI study.

• 동의신경정신과학회지
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• 제19권2호
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• pp.141-149
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• 2008

Objective : This study was designed to analyze the herbal medicine case-control studies of tic disorder in traditional chinese medicine. Method : For this study, we searched the studies on tic disorder, which had been published 2007, through web-site CNKI(中國知識基魔設施工程) http://www.cnki.net). There were 15 herbal medicine case-control studies and we focused on those studies. Results: 1. DSM-IV(7 studies), CCMD(5 studies) and ICD-10(3 studies) were frequently used in the diagnosis of tic disorder. 2. Paeonia radix alba, Uncariae ramulus et uncus and Glycyrrhizae radix were frequently used in treatment. Moreover Scorpio, Gastrodiae rhizoma, Pinelliae rhizoma and so on were used. 3. Treatment results were assessed by improvement of symptom, YGTSS and so on. 4. Herbal medicine treatment was more effective than western medicine treatment in most studies, and side effects of herbal medicine were far less than those of western medicine. Conclusion : There have been reported many herbal medicine treatment studies of tic disorder in traditional chinese medicine. We believe that these studies can be applied to the clinical practices in Korean medicine.

• Journal of Biosystems Engineering
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• 제29권3호
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• pp.243-250
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• 2004

본 연구에서는 국내 미곡도정공장의 도정기계 작동상태와 가공된 발 품질의 원격감시를 위해서 인터넷기반 감시시스템을 개발하고자 하였다. 인터넷 감시시스템은 Laboratory Virtual Instrument Engineering Workbench(Lab VIEW)를 이용하여 개발되었으며 Hypertext Transfer Protocol(HTTP)을 제공할 수 있는 중앙서버, 현장제어용 Programmable logic controller (PLC) 및 각종 센서 등으로 구성되었다. 비상상태를 대비하기 위하여 도정기계를 원격으로 제어(ON/OFF)할 수 있도록 제어알고리즘을 설계하였다. 개발된 인터넷기반 감시시스템은 미곡 도정공장에 설치한 모든 도정기계의 작동상태, 백미 탱크내의 백미 무게와 백미의 온도 및 평형상대습도를 실시간으로 감시할 수 있었으며, 원격으로 측정한 백미탱크내의 평형온도 및 평형상대습도를 이용하여 백미의 함수율도 예측할 수 있었다. 거리 및 인터넷속도에 의해 발생된 시간지연의 측정과 원격으로 수집된 자료의 검증을 통해 인터넷 감시시스템의 성능을 평가하였다. 인터넷상의 시간지연(서울-광주간)은 약 1.2$\pm$0.2s 이었다.

• 대한임베디드공학회논문지
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• 제15권2호
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• pp.79-85
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• 2020

IIoT stands for Industrial Internet of Things used in manufacturing, healthcare, and transportation in networked smart factories. Recently, IIoT's environment requires an automated control system through intelligent cognition to improve efficiency. In particular, IIoT can be applied to automatic calibration of production equipment for improved management in industrial environments. Such automation systems require a wireless network for transmitting industrial data. Self-calibration systems in laser transmission paths using wireless networks can save resources and improve production quality by real-time monitoring and remote control of laser transmission path. In this paper, we propose a wireless networked system for self-calibration of laser equipment that requires a laser transmission path, and we show the results of the prototype evaluation. The self-calibration system of laser equipment measures the coordinates of the laser points with sensors and sends them to the host using the proposed application protocol. We propose a wireless network service for the wired motor controller to align the laser coordinates. Using this wireless network, the host controls the motor by sending a control command of the motor controller in an HTTP message based on the received coordinate values. Finally, we build a prototype system of the proposed design to verify the detection performance and analyze the network performance.

• Child Health Nursing Research
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• 제18권3호
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• pp.101-108
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• 2012

Purpose: This study was designed to analyze recent trends in research about caregivers of hospitalized children in Korea and to suggest future research directions in this area. Methods: Eighty one studies selected from http://www.kan.or.kr, www.childnursing.or.kr, www.riss4u.net, and www.ndsl.kr published from 1995 to 2011 were used. The analysis framework of concepts was derived from client domain (Kim, 2000) and knowledge type (Kim et al., 2004). Results: In terms of research design, nonexperimental studies (82.7%) were the most frequent, followed by experimental studies (14.8%) and qualitative studies (2.5%). Mothers were the most frequent caregivers, and hospitalization was the most frequent health problem of the children. In terms of categories of the concepts, 35 (39.3%) studies included essentialistic concepts like coping and adaptation, 15 (16.9%) studies included problematic concepts like anxiety and uncertainty, and 39 (43.8%) studies included health-care experiential concepts like educational needs and nursing needs. In term of knowledge types, there were 35 (39.3%) studies of the explanatory knowledge type, 44 (49.5%) descriptive ones, and 10 (11.2%) prescriptive ones. Conclusion: The results indicate that further research is necessary on problematic concepts and prescriptive knowledge types for child health nursing practice which will lead to expanding nursing knowledge.

• Molecules and Cells
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• 제21권2호
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• pp.269-275
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• 2006

A recent report of the Korean Intellectual Property Office(KIPO) showed that the number of biological sequence-based patents is rapidly increasing in Korea. We present biological features of Korean patented sequences though bioinformatic analysis. The analysis is divided into two steps. The first is an annotation step in which the patented sequences were annotated with the Reference Sequence (RefSeq) database. The second is an association step in which the patented sequences were linked to genes, diseases, pathway, and biological functions. We used Entrez Gene, Online Mendelian Inheritance in Man (OMIM), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Ontology (GO) databases. Through the association analysis, we found that nearly 2.6% of human genes were associated with Korean patenting, compared to 20% of human genes in the U.S. patent. The association between the biological functions and the patented sequences indicated that genes whose products act as hormones on defense responses in the extra-cellular environments were the most highly targeted for patenting. The analysis data are available at http://www.patome.net

• Genomics & Informatics
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• 제8권2호
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• pp.90-93
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• 2010

A-kinase-anchoring proteins (AKAPs) are scaffold proteins which compartmentalize protein kinase A (PKA, cAMP-dependent protein kinase) and other enzymes to specific subcellular sites. The spatiotemporal control of these enzymes by AKAPs is important for cellular function like cell growth and development etc. Hence, it is important to understand the basic function of AKAPs and their functional domains. However, diverse names, function, cellular localizations and many members of AKAPs increase difficulties when researchers search appropriate AKAPs for their experimental purpose. Nevertheless, there was no previous AKAPs-related database regardless of their important cellular functions and difficulty of finding appropriate AKAPs. So, we developed AKAPs database (AKAPDB), which contains their sequence information, functions and other information derived from prediction programs and other databases. Therefore, we propose that AKAPDB can be an important tool to researchers in the related fields. AKAPDB is available via the internet at http://plaza3.snu.ac.kr/akapdb/.