The Framingham risk score (FRS) has been used to assess the risk of a cardiovascular event and to identify patients for risk factor modifications. Therefore, the purpose of this study was to evaluate the relationship of the FRS with dietary intake and inflammatory biomarkers. We conducted a cross-sectional study of 180 men ($49.2{\pm}10.2$ years) with MS. Serum levels of high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), and adiponectin were examined. Participants were asked to complete the food frequency questionnaire (FFQ) using the previous 1 year as a reference point. The absolute cardiovascular disease (CVD) risk percentage over 10 years was calculated to estimate the FRS, which was classified as low risk (< 10%), intermediate risk (10-20%), and high risk (> 20%). Mean intake of polyunsaturated fatty acids was lower in subjects who had > 20% FRS than in subjects who had < 10% FRS ($3.7{\pm}1.9$ g/day vs. $4.7{\pm}1.9$ g/day; P < 0.05). Significant differences in the Index of Nutritional Quality of protein, phosphorus, iron, vitamin A, vitamin $B_1$, niacin, vitamin $B_6$, and vitamin C were observed between the > 20% FRS group and the < 10% FRS group (P < 0.05). IL-6 concentrations were significantly lower in subjects with a < 10% FRS than in subjects who were 10-20% FRS or > 20% FRS ($0.91{\pm}0.26$ vs. $1.48{\pm}033$ vs. $2.72{\pm}0.57$ pg/mL, respectively; P < 0.05). IL-6 and dietary intake of polyunsaturated fatty acids together explained 6.6% of the variation in FRS levels in a stepwise multiple regression model. Our results provide some evidence that dietary intake in the higher CVD risk group was inferior to that in the lower risk group and that dietary fat intake and IL-6 were associated with FRS and MS in Korean men.
Proceedings of the Korean Radioactive Waste Society Conference
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2003.11a
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pp.676-680
/
2003
Dissolution of magnetite powders by 0.05 M citric acid was investigated at $50^{\circ}C$. All the tests were performed in the pH range between 2.0 to 5.0, which was adjusted using nitric acid or sodium hydroxide. Concentration of each of the dissociated chemical species of citric acid under various solution pHs was calculated using the ionization constants. Variation of zeta potential of magnetite with pH changes was also investigated. The dissolution reaction was explained by comparing the concentration of the dissociated chemical species of citric acid with the zeta potential. Longer than 3 h of induction time was required to dissolve the magnetite. The dissolution behaviour of magnetite was well described by the equation. The physical meaning of each parameter was explained successfully from the model equation.
Extract of Taraxacum platycarpum (AF-343) has been reported to have several biological properties such as skin hydration and anti-inflammatory effects. Although clinical evidences of skin hydration and antiinflammatory effect were proven in clinical trial, precise mechanism of skin hydration was not fully understood yet. In this study, we have focused skin hydration mechanism related filaggrin, collagen, and matrix metalloproteinase (MMP) in vitro and animal study. Herein, skin hydration mechanism of AF-343 is due to recovery of filaggrin in mice model and increased production of collagen with suppression of matrix MMP in vitro fibroblast cell line.
Oh, Se Young;Lim, Myung Ho;Jaung, Ji Suk;Lyu, Mi Kyung;Lim, Kyoung-Ok;Kim, Seon Kyung;Jang, Soyeong;Cha, Seung-Min;Choi, Jong Hyuk
Anxiety and mood
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v.14
no.2
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pp.112-119
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2018
Objective : This study aims to identify personality characteristics in female homicide offenders by using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) test. Methods : This study retrospectively analyzed the mental appraisals and MMPI-2 scores of 54 women charged with homicide and 67 women charged with non-violent crimes, who were referred to National Forensic Hospital in Gongju city for psychiatric evaluation between January 2012 and March 2016. Results : Women charged with homicide scored significantly higher on Hs (p=0.018), D (p<0.001), Hy (p=0.002) and Pt (p=0.004) than the women charged with non-violent crimes. The women charged with homicide may have developed the following characteristics: hypochondriasis, depression, hysteria and psychasthenia. In multiple regression analyses, a final regression model including age of crime onset and depression was significant, explaining 16.5% of the variance in homicides committed by females. Conclusion : These findings suggest that personality characteristics in the female homicide offenders might be different compared to the non-violent crime offenders.
Lee, Gena;Jeong, Yun Seong;Kim, Do Won;Kwak, Min Jun;Koh, Jiwon;Joo, Eun Wook;Lee, Ju-Seog;Kah, Susie;Sim, Yeong-Eun;Yim, Sun Young
Experimental and Molecular Medicine
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v.50
no.11
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pp.7.1-7.12
/
2018
Recent findings from The Cancer Genome Atlas project have provided a comprehensive map of genomic alterations that occur in hepatocellular carcinoma (HCC), including unexpected mutations in apolipoprotein B (APOB). We aimed to determine the clinical significance of this non-oncogenetic mutation in HCC. An Apob gene signature was derived from genes that differed between control mice and mice treated with siRNA specific for Apob (1.5-fold difference; P < 0.005). Human gene expression data were collected from four independent HCC cohorts (n = 941). A prediction model was constructed using Bayesian compound covariate prediction, and the robustness of the APOB gene signature was validated in HCC cohorts. The correlation of the APOB signature with previously validated gene signatures was performed, and network analysis was conducted using ingenuity pathway analysis. APOB inactivation was associated with poor prognosis when the APOB gene signature was applied in all human HCC cohorts. Poor prognosis with APOB inactivation was consistently observed through cross-validation with previously reported gene signatures (NCIP A, HS, high-recurrence SNUR, and high RS subtypes). Knowledge-based gene network analysis using genes that differed between low-APOB and high-APOB groups in all four cohorts revealed that low-APOB activity was associated with upregulation of oncogenic and metastatic regulators, such as HGF, MTIF, ERBB2, FOXM1, and CD44, and inhibition of tumor suppressors, such as TP53 and PTEN. In conclusion, APOB inactivation is associated with poor outcome in patients with HCC, and APOB may play a role in regulating multiple genes involved in HCC development.
KSII Transactions on Internet and Information Systems (TIIS)
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v.15
no.10
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pp.3834-3857
/
2021
The design of cluster-based routing protocols is necessary for Wireless Sensor Networks (WSN). But, due to the lack of features, the traditional methods face issues, especially on unbalanced energy consumption of routing protocol. This work focuses on enhancing the security and energy efficiency of the system by proposing Energy Efficient Based Secure Routing Protocol (EESRP) which integrates trust management, optimization algorithm and key management. Initially, the locations of the deployed nodes are calculated along with their trust values. Here, packet transfer is maintained securely by compiling a Digital Signature Algorithm (DSA) and Elliptic Curve Cryptography (ECC) approach. Finally, trust, key, location and energy parameters are incorporated in Particle Swarm Optimization (PSO) and meta-heuristic based Harmony Search (HS) method to find the secure shortest path. Our results show that the energy consumption of the proposed approach is 1.06mJ during the transmission mode, and 8.69 mJ during the receive mode which is lower than the existing approaches. The average throughput and the average PDR for the attacks are also high with 72 and 62.5 respectively. The significance of the research is its ability to improve the performance metrics of existing work by combining the advantages of different approaches. After simulating the model, the results have been validated with conventional methods with respect to the number of live nodes, energy efficiency, network lifetime, packet loss rate, scalability, and energy consumption of routing protocol.
Hybrid simulation (HS) has attracted community attention in recent years as an efficient and effective experimental technique for structural performance evaluation in size-limited laboratories. Traditional hybrid simulations usually take deterministic properties for their numerical substructures therefore could not account for inherent uncertainties within the engineering structures to provide probabilistic performance assessment. Reliable structural performance evaluation, therefore, calls for stochastic hybrid simulation (SHS) to explicitly account for substructure uncertainties. The experimental design of SHS is explored in this study to account for uncertainties within analytical substructures. Both computational simulation and laboratory experiments are conducted to evaluate the pseudo-random Sobol sequence for the experimental design of SHS. Meta-modeling through polynomial chaos expansion (PCE) is established from a computational simulation of a nonlinear single-degree-of-freedom (SDOF) structure to evaluate the influence of nonlinear behavior and ground motions uncertainties. A series of hybrid simulations are further conducted in the laboratory to validate the findings from computational analysis. It is shown that the Sobol sequence provides a good starting point for the experimental design of stochastic hybrid simulation. However, nonlinear structural behavior involving stiffness and strength degradation could significantly increase the number of hybrid simulations to acquire accurate statistical estimation for the structural response of interests. Compared with the statistical moments calculated directly from hybrid simulations in the laboratory, the meta-model through PCE gives more accurate estimation, therefore, providing a more effective way for uncertainty quantification.
In this study, a series of three-dimensional numerical parametric study was conducted to investigate deformation mechanisms of an existing box culvert due to an adjacent multi-propped basement excavation in clays. Field measurements from an excavation case history are first used to calibrate a baseline Hardening Soil Small Strain (HS-small) model, which is subsequently adopted for parametric study. Results indicate that the basement-box culvert interaction along the basement centerline can be considered as a plane strain condition when the length of excavation (L) reaches 14 He (i.e., final excavation depth). If a plane strain condition (i.e., L/He=12.0) is assumed for analyzing the basement-box culvert interaction of a short excavation (i.e., L/He=2.0), the maximum settlement and horizontal movement of the box culvert are overestimated significantly by up to 15.7 and 5.1 times, respectively. It is also found that the deformation of box culvert can be greatly affected by the basement excavation if the distance between the box culvert and retaining wall is less than 1.5 He. The induced deformation in the box culvert can be dramatically reduced by improving the ground inside the excavation or implementing other precautionary measures. For example, by adding jet grouting columns within the basement and installing an isolation wall behind the retaining structures, the maximum settlements of box culvert are shown to reduce by 37.2% and 13.4%, respectively.
S. Sivakumar;R. Prakash;S. Srividhya;A.S. Vijay Vikram
Structural Engineering and Mechanics
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v.87
no.3
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pp.221-229
/
2023
Urbanization and industrialization have significantly increased the amount of solid waste produced in recent decades, posing considerable disposal problems and environmental burdens. The practice of waste utilization in concrete has gained popularity among construction practitioners and researchers for the efficient use of resources and the transition to the circular economy in construction. This study employed Lytag aggregate, an environmentally friendly pulverized fuel ash-based lightweight aggregate, as a substitute for natural coarse aggregate. At the same time, fly ash, an industrial by-product, was used as a partial substitute for cement. Concrete mix M20 was experimented with using fly ash and Lytag lightweight aggregate. The percentages of fly ash that make up the replacements were 5%, 10%, 15%, 20%, and 25%. The Compressive Strength (CS), Split Tensile Strength (STS), and deflection were discovered at these percentages after 56 days of testing. The concrete cube, cylinder, and beam specimens were examined in the explorations, as mentioned earlier. The results indicate that a 10% substitution of cement with fly ash and a replacement of coarse aggregate with Lytag lightweight aggregate produced concrete that performed well in terms of mechanical properties and deflection. The cementitious composites have varying characteristics as the environment changes. Therefore, understanding their mechanical properties are crucial for safety reasons. CS, STS, and deflection are the essential property of concrete. Machine learning (ML) approaches have been necessary to predict the CS of concrete. The Artificial Fish Swarm Optimization (AFSO), Particle Swarm Optimization (PSO), and Harmony Search (HS) algorithms were investigated for the prediction of outcomes. This work deftly explains the tremendous AFSO technique, which achieves the precise ideal values of the weights in the model to crown the mathematical modeling technique. This has been proved by the minimum, maximum, and sample median, and the first and third quartiles were used as the basis for a boxplot through the standardized method of showing the dataset. It graphically displays the quantitative value distribution of a field. The correlation matrix and confidence interval were represented graphically using the corrupt method.
Objectives Advanced researches on the relationship between obesity and heart rate variability (HRV), heretofore, focused on characteristics of HRV depending on the state of obesity. However, the previous researches have not quantified predictive power of HRV toward the obesity-related variables, which is rather more meaningful for clinicians who regularly treat obese patients. Hence, we designed a research to investigate whether HRV could predict serum levels of obesity-related metabolites. Methods Ninety obese premenopausal women meeting the inclusion criteria were recruited. The HRV test, blood sampling, and measurement of physical traits were conducted. Multiple regression analysis of the measurement data was carried out, putting obesity-related metabolites (insulin, glucose, triglyceride, hs-CRP, HDL, LDL, total cholesterol) as outcome variables and the others as predictors. To select appropriate predictive variables, the Akaike's Information Criterion (AIC) was applied. Normality and homoskedasticity of residuals for each model were tested to identify if there were any violations of the regression analysis's basic assumption. Logarithm transformation was used for the values of the concentration of metabolites and the HRV. Results The regression model including Total Power (TP) value and BMI had significant predictive power for serum insulin concentration (F(2, 88)=835.7, p<0.001, $R^2=0.95$). The regression coefficient of ln (TP) was -0.1002. However, it was not sure if the HRV could predict concentrations of other metabolites. Conclusions The results suggest that the Total Power (TP) value of the HRV can predict the level of serum insulin. If the BMI could be assumed as being constant, when the TP value is multiplied by n, the predicted change of insulin could be drawn by multiplying $n^{-0.1002}$. The uncertainty of this model can be assumed as approximately 5%.
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