• 대한한방부인과학회지
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• 제26권4호
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• pp.94-106
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• 2013

Objectives: The purpose of this study is to find the effect of Far Infrared Radiation (FIR) about improvement of chief complaints and health state. Methods: For this study we evaluated thermographic images, heart rate variability (HRV), visual analogue scale (VAS) score of 34 patients with various diseases. Tests were done two times, before and after treatments and we compared the test results. We used the temperature difference between CV12 and CV4, both sides of PC8, LR3 for recognizing improvement of blood circulation. We analyzed the change of complexity, stability of autonomic nervous system (ANS) by HRV test. The patients were asked to fill out questionnaire about the severity of symptoms by VAS score. Analyses were undertaken using SPSS ver.12.0.1 and p-value of < 0.05 was considered significant. Results: Statistical analysis shows that Far Infrared Radiation (FIR) had significant efficiency in increasing surface temperature and reducing VAS pain scores. In heart rate variability (HRV) test, LF/HF ratio showed tends to improve. Conclusions: The application of an FIR to whole body appears to alleviate various complaints of patients.

• 한국건강관리협회지
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• 제4권1호
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• pp.28-38
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• 2006

Background : Phentermine classified by "sympathomimmetic amie", is a stimulant of sympatheic tone But there has been no concrete study which presents the influence of phentermine on autonomic nervous system. Analysis of Heart rate variability is reliable, non-invasive and very useful for evaluating function of autonomic nervous system. We tried to elucidate the influence of phentermine on autonomic nervovs system by heart rate variability. MethodsAmong the 70 candidates who participated in the double-blind case control study whichwas designed in purpose of approving whether- Adipekⓓ is effective for treatment of obesity, 45persons were folled up. From April, 2005 to May 2005, HRV of the candidates who takes phentermine or placebo for 1month, was recorded using BFM-5000ⓓ(medi-core) for 5 minutes in resting state. HRV measures were assessed by time-domain and by frequency- domain analysis. Time domain parameters contain SDNN(Standard Deviation of NN intervals) and RMSSD(Root-Mean-Square of Successive Differences), etc and frequency domain Parameters contain Total Power(TP), Low frequency(LF'0.04-0.15Hz) power. High Frequency(HF:0.15-0.4Hz) power and LF/HF ratio etc. Results: Intakes of phentermine reduce HRV significant1y. SDNN & RMSSD, the main tine domain parameters of HRV, were decreased significantly(P=0.007. 0.016). PSI(Physical Stress Index of Pressure Index) was increase significantly(P=0.002)The main frequency domain parameters(TP, LF & VLF), also decreased significantly. (P=0.024,0.033, 0.015)Conclusion: The result showed that intakes of phentermine reduce heart rate variability and influence on most parameters of HRV. So phentermine not only accelerates sympathetic tone, but also inhibit the balance and function of autonomic nervous system.

• 척추신경추나의학회지
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• 제4권2호
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• pp.61-74
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• 2009

Objectives : The purpose of this study was to investigate the effect of chuna treatment(manipulation) on lumbar sprain caused by traffic accident in early stage, by analysis of the Heart Rate Variability(HRV) and Visual Analogue Scale(VAS). Methods : This study carried out on 20 patients who have received hospital treatment in Daejeon Univ. cheonan Oriental Hospital. Non-chuna group got acupuncture-therapy, herbal medication, physical therapy and Chuna group got all the therapies and chuna treatment. We measured HRV and VAS on 2nd, 4th day. Results : After being treated by our methods, Chuna group showed the inclination to balance between the sympathetic and parasympathetic nerve. In chuna group as compared with non-chuna group, an autonomic nerve activity and stress resistance showed the inclination to increase(p<0.05). And chuna treatment reduced the rate of stress increase. Conclusions : The results suggest that chuna treatment help traffic accident patients in early stage to reduce pain. Refer to autonomic nerve system, chuna treatment seem to do positive effect but Further long term study in a large scale is needed.

• Journal of Acupuncture Research
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• 제27권5호
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• pp.51-58
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• 2010

Objectives : The purpose of this study is to assess the effect of laser acupuncture at $HT_7$ for reducing mental stress using power spectrum analysis of the heart rate variability. Methods : 36 healthy volunteers(control group: 18, treatment group: 18) participated in this study. After instrumentation and 5-minute rest period, 5-minute metal stress by operation was provided. HRV was recorded before and after the mental stress(1st, 2nd HRV). After 2nd HRV recording, the control group rested for 15 minutes without any treatments. Participants in the treatment group received laser acupuncture to $HT_7$ unilaterally and rested for 15minutes. Points were irradiated for 60seconds, and the intensity was 1.8J(output 20%). And then 3rd HRV was recorded. Results : In simple rest group, LF norm showed a significant change after mental stress. In laser acupuncture group, LF norm, HF norm, LF, HF and LF/HF ratio showed a significant change after mental stress. But there were no significant difference between two groups(ANCOVA test, p>0.05). In laser acupuncture group, LF norm, HF norm, HF and LF/HF ratio showed a significant change after laser acupuncture treatment. And there were significant differences between two groups(p<0.05). Conclusions : This study suggests that laser acupuncture at $HT_7$ can regulate and prevent the alternation of autonomic nervous system due to mental stress.

• Journal of Animal Science and Technology
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• 제44권6호
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• pp.809-816
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• 2002

키틴의 탈아세틸화로 얻어지는 화합물인 키토산과 키토올리고당은 다양한 생리활성 기능을 나타내므로 생물의학적인 응용에 많은 관심이 집중되고 있다. 본 연구는 키토올리고당과 수용성 키토산의 열처리 후 올리고당 함량의 변화와 어린이 바이러스성 설사를 유발하는 HRV(human rotavirus)의 MA-104 세포감염에 억제작용을 나타내는지 확인하기 위하여 수행하였다. 그 결과 열처리 후 비색법으로 측정한 올리고당의 함량은 수용성키토산의 경우 62.67 %에서 60.45%로 약 2%정도, 키토올리고당은 59.48%에서 54.31%로 약 5%정도 감소하였다. 키토산 유래물질의 항로타바이러스성 탐색은 AEC staining으로 측정하였으며, 수용성키토산은 농도 0.125% 이상에서 HRV S2의 세포감염에 있어 90% 이상의 감염 억제효과가 있었으며, HRV Wa의 경우 89% 이상의 억제효과가 있었다. 키토올리고당은 HRV의 세포감염에 억제효과가 없었다. 열처리한 시료의 경우, 수용성 키토산과 키토올리고당 모두 열처리가 HRV의 감염 억제에 영향을 미치지 못하는 것으로 나타났다. 따라서 중합도가 높은 수용성키토산은 열처리를 거치는 식품에 첨가하여도 그 기능이 크게 감소하지 않으므로 향후 식품첨가물로서 이용가능성이 클 것으로 사료된다.

• 대한물리의학회지
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• 제14권4호
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• pp.133-142
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• 2019

PURPOSE: This study examined the effectiveness of an active lifestyle on the HRV and fitness of the older female adults. METHODS: Eighty female older adults (72.68±3.78 years) were sampled from a senior wellness institute. Accelerometers were distributed to each participant to have the device attached to them for one week, and the physical activity data (Energy expenditure in Kcal) of each participant were analyzed. Participants were divided into 3 groups (<1,000 Kcal vs 1,000 to 1,500 Kcal vs ≥1,500 Kcal) based on the amount of weekly physical activity. Before and after data analysis, the HRV was measured at resting state and the Senior Fitness Test was performed. RESULTS: One way ANOVA showed a significant difference in the HRV between the three groups. Group A (≥ 1,500 Kcal) was superior in HF and HF/HF + LF whereas Group C (<1,000 Kcal) showed high level of LF, LF/HF, and LF/HF+LF. The same statistics revealed significant differences in fitness. Most of the fitness variables were superior in Group A and B compared to Group C. Significant correlations were observed between physical activity and both HRV and in fitness. CONCLUSION: Theses results suggest that an active lifestyle may be an effective intervention for the prevention of both cardiometabolic disorder and improvement of the fitness level in older female adults.

• 동의신경정신과학회지
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• 제21권2호
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• pp.75-85
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• 2010

Objectives : This study was designed to evaluate the correlation between patterns of dyspepsia(acute dyspepsia, functional dyspepsia, dyspepsia with the organic disease) and autonomic nerve system dysfunction using HRV analysis. Methods : The patient group consisted of 88 patients diagnosed as a dyspepsia (Acute dyspepsia group-35 patients, Functional dyspepsia group-28 patients, Dyspepsia with the organic disease group-28 patients) who visited in the Oriental Medical Hospital of Dong-eui University from 2005.3.OO to 2008.8.OO. And the control group consisted of 33 patients diagnosed as a normal state of stomach during the same period. We checked HRV of the 4 groups over 5 minutes and compared the HRV index between groups. Results : 1. HF, LF, VLF and TP were significantly lower in the acute dyspepsia, functional dyspepsia and organic dyspepsia patient group than in the control group. 2. HF, LF, VLF and TP were higher in the acute dyspepsia patient group than in the organic dyspepsia patient group, but the differences were not statistically significant. 3. HF, LF, VLF and TP were higher in the acute dyspepsia patient group than in the functional dyspepsia patient group, but the differences were not statistically significant. 4. HF, LF, VLF and TP were lower in the functional dyspepsia patient group than in the organic dyspepsia patient group, but the differences were not statistically significant. Conclusions : Compared to the control group, all of the dyspepsia patient groups showed the tendency that the overall activity of the autonomic nervous system and the activity of sympathetic nerves decreased. Although there was no significant difference in the suppression of the autonomic nervous system, chronic dyspepsia patient group was lower than acute dyspepsia patient group, functional dyspepsia patient group was lower than the organic dyspepsia patient group in HRV.

• Journal of Acupuncture Research
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• 제25권6호
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• pp.35-46
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• 2008

Objectives : Chronic pain affects and is affected by physical and psychosocial factors. It also has a complicated and indefinite mechanism. This research is for clarifying relations with chronic pain, stress, and autonomic nerve system by comparing HRV and Stress Reaction Index(SRI) of chronic pain patients with those of acute pain patients. Methods : The subjects were 32 patients who visited Kangnam Kyunghee Hospital for nuchal pain or low back pain treatment from March 2008 to September 2008. Among them, 16 patients who suffered over 6 months are classified chronic pain group and 16 patients who suffered under 6 months as acute pain group. All subjects had their HRV(SA-2000E: Medicore Co..Ltd. Korea) and SRI measured at first visit. We studied the difference of HRV between two groups.(Statistics by Student t-test, p<0.05) Results : R-MSSD, TP, VLF, LF, HF and LF/HF ratio of the chronic pain group were significantly lower than those of the acute pain group. Compared with those of the acute pain group, total SRI of the chronic pain group were low but it's not significant except frustration. Conclusion : The results of HRV of the chronic pain group patients show that chronic pain is related to psychosocial factor and autonomic disturbance.

• 한국학교보건학회지
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• 제30권3호
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• pp.266-273
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• 2017

Purpose: This study was performed to compare the mental health of school age children residing in urban and rural areas and to analyze the correlations between the subjective mental health indicators such as depression and attention deficit-hyperactivity behavior and heart rate variability (HRV) indicators. Methods: For this study, a convenience sample of one hundred and three children was recruited. Depression and attention deficit-hyperactivity behavior were measured using self-reported questionnaires and HRV indicators were measured using an electronic instrument. Results: Among the HRV parameters of the rural children, their normalized LF and the LF / HF were significantly lower than those of the urban children. The RMSSD and the normalized HF were statistically significantly higher. The level of depression showed a significant positive correlation with the normalized LF and LF/HF, but showed a negative correlation with the normalized HF. Also, the level of attention deficit-hyperactivity behavior was significantly correlated with the normalized LF, LF/HF, and the normalized HF. Conclusion: Based on the findings, we expect that HRV indicators can be applied to predict the level of depression and attention deficit-hyperactivity behavior in elementary school children.

• 대한한방내과학회지
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• 제29권2호
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• pp.359-374
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• 2008

Objective : Hyperhidrosis is a condition characterized by excessive sweating. Some studies suggest that hyperhidrosis is associated with autonomic nervous system dysfunction. Hyperhidrosis is often accompanied by hypersensitivity, tension, irritability, heat flashes, fatigue, etc. This study was designed to evaluate the correlation between Oriental Medicine diagnosis and the autonomic nervous system function in patients with hyperhidrosis using Heart Rate Variability (HRV) analysis. Methods : 23 palmar and plantar hyperhidrosis patients and 10 systemic hyperhidrosis patients were recruited and evaluated by Oriental Medicine diagnostic questionnaire and HRV analysis. The Oriental Medicine diagnostic questionnaire used a three-dimensional diagnosis that classified patients into Cold or Heat Syndrome, Yin or Yang Syndrome, and Deficiency or Excess Syndrome. Measured indices of HRV used the frequency domain analysis(i.e. TP, VLF, LF, HF and LF/HF ratio). Also, measure indices of HRV adjusted for aging effects were evaluated. Results : Cold/Heat Syndrome was not associated with hyperhidrosis prevalence nor the HRV analysis in hyperhidrosis patients. The Yang Syndrome group(78.8%) was more strongly correlated than the Yin Syndrome group(21.2%), and character of Yang was correlated with the adjusted TP and adjusted LF. The LF/HF ratio in the Excess Syndrome group was significantly higher than the LF/HF ratio in the Deficiency Syndrome group. Conclusion : Hyperhidrosis was not associated with the Cold/Heat Syndrome, but was found to be closely associated with the Yang Syndrome. The LF/HF ratio was significantly higher in the Excess Syndrome group than in the Deficiency Syndrome group in hyperhidrosis patients.