• Journal of Environmental Science International
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• v.7 no.4
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• pp.425-432
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• 1998

The purpose of the present study is to estimate the release of dissolved Inorganic nitrogen and photophorous from sediments of Deukryang Bay. One method used In this study is to calculate nutrients released from a concentration gradient between sediment porewaters and the overlying water based on periments. The calculated and measured ammonium released from the sediments were 8.93mg-atN/$m^2$ hr and 60.4mg/atN/$m^2$ hr, respectively In July. 8.57mg-atN/$m^2$. hr and 32.9mg/atN/$m^2$ hr, respectively in October. The ammonium was released more highly in truly than in October, and the measured ammonium flux was higher than the calculated one. The calculated nitrate plus nitrite released from the sediments were 0.31mg/atN/$m^2$. hr in July and 0.84mg/atN/$m^2$. hr in October. The measured nitrate plus nitrite released from the sediments was 282mg/atN/$m^2$. hr in October. The calcuated was lower than the measured because the content of the nutrients in the sediments was always much more than in the overlying waters, and it has shown a differently seasonal pattern compared to the ammonium flux. The calculated phosphorous released from the sediments were 0.97mP/atN/$m^2$ hr and measured negative fluxed -6.50mP/atN/$m^3$ hr In truly, and alculated 0.18mg/atP/$m^2$. hr and measured 24.6mg/atP/$m^2$. hr, respectively in October.

• Korean journal of food and cookery science
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• v.24 no.3
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• pp.304-311
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• 2008

This study examined Jeung-pyun(JP) Retrogradation in samples containing 3% whole protein, 7S protein, or 11S protein(w/w) that were stored at $4^{\circ}C$ for 6, 12, 24 and 72 hr. Rheometery and differential scanning calorimetry(DSC) were used in the analysis. The pH of the dough decreased during the fermentation process, but it increased after steaming. The JP prepared with soybean protein isolate(SPI) had higher pH than the control group. During storage the textural characteristics of the JP showed effects according to the additions of SPI. After 6 hr of storage, the JP samples containing soybean flour, whole protein, 7S protein, and 11S protein had lower hardness valuse. From 4 hr to 12 hr, higher springiness values were found in the samples containing whole protein, 7S protein and 11S protein. At 0 hr, the control group had the highest cohesiveness value, but after 24 hr it presented the lowest value. For gumminess, after 6 hr of storage, the control group offered the lowest value. Whereas after 12 hr of storage the whole protein group showed the highest value, and at 24 hr, the whole protein, 7S protein, and 11S protein groups had higher values. According to the DSC results, the 11S protein group had lower enthalpy values(${\bigtriangleup}H$) suggesting that adding 11S protein to JP might improve starch retrogradation. After 72 hr of storage, the control group had the highest onset temperature($T_{o}$) and peak temperature($T_{p}$) whereas the 7S and 11S protein JP samples had higher conclusion temperatures($T_{c}$). Therefore, based on the different analysis result between the control and treatment groups, the addition of SPI to Jp had effects on retrogradation.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.16
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• pp.6799-6804
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• 2014

Background: Chemotherapy is the mainstay of treatment for the majority of patients with advanced non-small cell lung cancer (NSCLC) without driver mutations and many receive therapies beyond first-line. Second-line chemotherapy has been disappointing both in terms of response rate and survival and we know relatively little about the prognostic factors. Materials and Methods: One thousand and eight patients with advanced NSCLC who received second-line chemotherapy after progression were reviewed in Shanghai Pulmonary Hospital, China, from September 2005 to July 2010. We analyzed the effects of potential prognostic factors on the outcomes of second-line chemotherapy (overall response rate, ORR; progression free survival, PFS; overall survival, OS). Results: The response and progression free survival of first-line chemotherapy affects the ORR, PFS and OS of second-line chemotherapy (ORR: CR/PR 15.4%, SD 10.1%, PD2.3%, p<0.001; PFS: CR/PR 3.80 months, SD 2.77 months, PD 2.03 months, p<0.001; OS: CR/PR 11.60 months, SD 10.33 months, PD 6.57 months, p=0.578, p<0.001, p<0.001, respectively). On multivariate analysis, better response to first-line therapy (CR/PR: HR=0.751, p=0.002; SD: HR=0.781, p=0.021) and progression within 3-6 months (HR=0.626, p<0.001), together with adenocarcinoma (HR=0.815, p=0.017), without liver metastasis (HR=0.541, p=0.001), never-smoker (HR=0.772, p=0.001), and ECOG PS 0-1 (HR=0.745, p=0.021) were predictors for good OS following second-line chemotherapy. Conclusions: Patients who responded to first-line chemotherapy had a better outcome after second-line therapy for advanced NSCLC, and the efficacy of first-line chemotherapy, period of progression, histology, liver metastasis, smoking status and ECOG PS were independent prognostic factors for OS.

• Journal of Gynecologic Oncology
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• v.29 no.6
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• pp.91.1-91.12
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• 2018

Objective: To examine the association between tumor grade and survival for women with squamous cervical cancer. Methods: This retrospective observational study utilized the Surveillance, Epidemiology, and End Result program data between 1983 and 2013 to examine women with squamous cervical cancer with known tumor differentiation grade. Multivariable analyses were performed to assess independent associations between tumor differentiation grade and survival. Results: A total of 31,536 women were identified including 15,175 (48.1%) with grade 3 tumors, 14,084 (44.7%) with grade 2 neoplasms and 2,277 (7.2%) with grade 1 tumors. Higher tumor grade was significantly associated with older age, higher stage disease, larger tumor size, and lymph node metastasis (all, p<0.001). In a multivariable analysis, grade 2 tumors (adjusted-hazard ratio [HR]=1.21; p<0.001) and grade 3 tumors (adjusted-HR=1.45; p<0.001) were independently associated with decreased cause-specific survival (CSS) compared to grade 1 tumors. Among the 7,429 women with stage II-III disease who received radiotherapy without surgical treatment, grade 3 tumors were independently associated with decreased CSS compared to grade 2 tumors (adjusted-HR=1.16; p<0.001). Among 4,045 women with node-negative stage I disease and tumor size ${\leq}4cm$ who underwent surgical treatment without radiotherapy, grade 2 tumors (adjusted-HR=2.54; p=0.028) and grade 3 tumors (adjusted-HR=4.48; p<0.001) were independently associated with decreased CSS compared to grade 1 tumors. Conclusion: Our study suggests that tumor differentiation grade may be a prognostic factor in women with squamous cervical cancer, particularly in early-stage disease. Higher tumor grade was associated with poorer survival.

• Journal of fish pathology
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• v.33 no.2
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• pp.153-161
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• 2020

Cytochrome P450(CYP) gene is involved in the biotransformation of drugs and environmental pollutants. In this study, we analyzed the nucleotide sequence of the Anguilla japonica CYP1(AjCYP1) family gene and examined the relative expression of AjCYP1A, AjCYP1B and AjCYP1C1 in response to the exposure to environmental pollutants. After exposure to B[a]P 20mg/kg bw, the expression of AjCYP1 family gene increased over time. Among four tissues examined (liver, spleen, gill and kidney), AjCYP1 family gene was expressed significantly in the kidney. Compared with the control group, AjCYP1A was expressed about 5-fold at 48 hr, AjCYP1B about 6-fold at 24 hr, and AjCYP1C1 about 4-fold at 24 hr. However, after exposure to B[a]P 200mg/kg bw, AjCYP1A did not change in all tissues. On the other hand, AjCYP1B was expressed at about 4-fold at 24 hr in the spleen and 4-fold at 48 hr in the gill. Finally AjCYP1C1 was expressed 3.7-fold and 4.3-fold in the spleen and kidneys at 48 hr, respectively. Taken together, our results suggest that the expression of AjCYP1 gene in eel tissues might be used as a useful tool to assess the exposure to environmental pollutants in aquaculture system.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.2
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• pp.970-976
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• 2013

An evaluation of the organic matter removal efficiency showed high removal efficiencies of 91.1~96.3% and 91.4~97.5% for TCODcr and TBOD5, respectively, for 9hr or longer of HRT. However, the removal efficiencies decreased to 86.9~90.5% and 88.0~90.9%, respectively for 6hr of HRT. $NH_3$-N showed a high removal efficiency of 95% or higher for 9hr or longer of HRT. The total nitrogen removal efficiency was 67.6~76.7% for 9~12hr of HRT, and it decreased to 50% for 6hr of HRT, which seems to be due to the insufficient carbon source required for denitrification. The T-P removal efficiency was 32% on average. To comply with the legal standards, a chemical phosphorus removal process is needed after the reactor.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.3
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• pp.98-102
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• 2009

Almost all injection molds have multi-cavity runner system for mass production, which are designed with geometrically balanced runner system in order to accomplish filling balance between cavity to cavity during processing. However, even though geometrically balanced runner is used, filling imbalance has been observed. Filling imbalance could be decreased by modifying processing conditions such as injections rate, mold temperature, injection pressure, melt temperature that are related to shear, viscosity. In this study, a series of experiment was conducted to investigate filling imbalance variation when modifying runner layout and polymer and to determine which processing condition influences as the primary cause of filling imbalance in geometrically balanced runner system. The filling imbalance was decreased up to result range of $3{\leq}DFI{\leq}8(%)$ by using a new runner system for balanced filling.

• Microbiology and Biotechnology Letters
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• v.27 no.3
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• pp.246-251
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• 1999

To extend the storage period and to inhibit contamination of Kimchi by Escherichia coli, conditions of Kimchi brining and effects of the fermentation starter, halophilic Lactobacillus HL-48 were investigated. Optimum brining condition for Kimchi was accomplished in 15% NaCl and at pH2.5-3.0 adjusted by lactic acid. Starter-treated Kimchi showed pH 4.2 after 18hr fermentation, while the pH of starter-untreated Kimchi resulted in 3.3. After 36hr fermentation, the number of E. coli in starter-treated Kimchi was found clearly to decrease and not detected macroscopically, but contamination of E. coli (5.3$\times$103CFU/ml) was observed in starter-untreated sample. Organic acids in Kimchi contained organic acids such as oxalic acid, citric acid, malic acid and lactic acid. among ther, lactic acid content was remarkably high in the early fermentation stages. However, from 24hr fermentation, lactic acid content of starter-untreated Kimchi was higher than that of starter-treated Kimchi.

• Microbiology and Biotechnology Letters
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• v.27 no.3
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• pp.260-265
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• 1999

The structural $\beta$-galactosidase gene (lacZ) from Lactococcus lactis ssp. lactis 7962 was cloned into plamid vector pKF18, which was designated as pKF-gal. Expression of the lacZ from L. lactis 7962 was found to be higher when cells were grown at 3$0^{\circ}C$ than 37$^{\circ}C$. Maximum $\beta$-galactosidase activity was obtained when E. coli/pKF-gal was cultivated for 6hr at 3$0^{\circ}C$ and for 3hr at 37$^{\circ}C$, and L. lactis 7962 was grown for 8hr at 3$0^{\circ}C$. Enzyme induction was achieved by the addition of lactose, galactose, or lactose+IPTG to growing culture. The addition of glucose had no effect on enzyme induction.

• The Korean Journal of Zoology
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• v.23 no.2
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• pp.69-76
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• 1980

Mice were dosed with $HgCl_2$ (5, 10 and 20 mg per kilogram body weight) and $CdCl_2$ (10, 15 and 20 mg per kilogram body weight) by the abdominal injection. Acid phosphatase activites of the liver at 24, 48 and 72 hours following the injection were measured by the Mundry colorimetric method using disodium p-nitrophenyl phosphate as the substrate, and the following results were obtained. The enzyme activities measured were 3.47 mg Pi/ml/0.5 hr at 24 hr and 5.00mg/ml/0.5 hr at 72hr respectively following the injection of 5 mg/kg body weight of $HgCl_2$ and 6.79 mg Pi/ml0.5 hr at 24 hr and 3.47 mg Pi/ml/0.5 hr respectively following the injection of 20 mg/kg body weight of the mercury compound, as compared with the activity of 8.3 mg Pi/ml/0.5 hr for the control. With the cadmium treatment, about 50% of the animals injected with 10mg/kg body weight, and none of the animals injected with 15 and 20mg/kg body weight, survived. Of the surviving animals, the sublethal concentration of cadmium was shown to activate the enzyme: the activities at 24, 48 and 72hr following the injection were around 11.2 mg Pi/ml/0.5 hr as compared with 8.63 mg Pi/ml/0.5 hr for the control.