• 대한의용생체공학회:의공학회지
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• 제43권1호
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• pp.27-34
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• 2022

Drunk driving defines a driver as unable to drive a vehicle safely due to drinking. To crack down on drunk driving, alcohol concentration evaluates through breathing and crack down on drinking using S-shaped courses. A method for assessing drunk driving without using BAC or BrAC is measurement via biosignal. Depending on the individual specificity of drinking, alcohol evaluation studies through various biosignals need to be conducted. In this study, we measure biosignals that are related to alcohol concentration, predict BrAC through SVM, and verify the effectiveness of the S-shaped course. Participants were 8 men who have a driving license. Subjects conducted a d2 test and a scenario evaluation of driving an S-shaped course when they attained BrAC's certain criteria. We utilized SVR to predict BrAC via biosignals. Statistical analysis used a one-way Anova test. Depending on the amount of drinking, there was a tendency to increase pupil size, HR, normLF, skin conductivity, body temperature, SE, and speed, while normHF tended to decrease. There was no apparent change in the respiratory rate and TN-E. The result of the D2 test tended to increase from 0.03% and decrease from 0.08%. Measured biosignals have enabled BrAC predictions using SVR models to obtain high Figs in primary and secondary cross-validations. In this study, we were able to predict BrAC through changes in biosignals and SVMs depending on alcohol concentration and verified the effectiveness of the S-shaped course drinking control method.

• Child Health Nursing Research
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• 제16권3호
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• pp.184-194
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• 2010

Purpose: The purpose of this research was to develop an interpersonal caring program "Muldan Dongsan" for vulnerable adolescents in mental health clinics and to identify the effect of this program. Methods: The interpersonal caring program was composed of group interpersonal caring (one time per week for two weeks, for a total of 8 hr) and individual interpersonal caring (1-2 times per day for 2 weeks). For this research, a non-synchronized quasi-experimental model including nonequivalent experimental and control groups was used. The experimental group was made up of 17 students and the control group, of 22 students. The data were collected from May 11 to July 25, 2009 and the collected data were analyzed using the SPSS/WIN 17.0 program. Results: The interpersonal caring program "Muldan Dongsan' was effective for mental health, including self-esteem, hope, and quality of life for vulnerable adolescents. Conclusion: The positive findings on the effectiveness of the interpersonal caring program "Muldan Dongsan" and the participants' high satisfaction with this program indicate that it can be utilized actively as a specific nursing intervention program for adolescents at school and in the community.

• 한국환경농학회지
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• 제3권1호
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• pp.1-9
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• 1984

Alachlor의 토양중 분해산물인 2,6-diethyl-N-(methoxymethyl) acetanilide(분해산물 1)와 2-hydroxy-2',6'-diethyl-N-(methoxymethrl) acetanilide (분해산물 2)를 합성하였다. 분해산물 1은 실온에서 아연분말 존재하에 alachlor를 3N-염산과 반응시켜서 얻었고 분해산물 2는 alachlor를 중탄산소다의 포화용액과 $90^{\circ}C$에서 78시간 반응시켜 합성하였다. 분해산물 2는 $5{\times}10^{-4}M$와 $1{\times}10^{-3}M$의 농도에서 특히 어린벼에 alachlor와 거의 같은 독성을 보인 반면 분해산물 1은 그 약효를 상실하였다. 따라서 alachlor 구조중의 염소원자를 수산기로 치환해도 alachlor의 식물독성은 별 영향을 받지 않으나 수소원자로 치환할 경우는 영향을 받는 것으로 보인다.

• Food Science and Biotechnology
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• 제18권3호
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• pp.706-711
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• 2009

Lysozyme was treated with digestive enzymes and the production of interleukin 8 (IL-8) was measured in Caco-2 cell with the peptides from lysozyme upon stimulating with lipopolysaccharide (LPS) to investigate the overall anti-inflammatory activity of lysozyme when it is in digestive tracts. Lysozyme reduced IL-8 production, and the peptides from pepsin hydrolysis of lysozyme had the similar effect. The products of trypsin digestion of lysozyme had no effect on the reduction of IL-8 production while those of pepsin-trypsin hydrolysis did. The effectiveness of lowering IL-8 production was not different by time of the peptide addition. When Caco-2 cells were pre-incubated with peptides for 24 hr, the reduction effects were observed from the peptides from pepsin hydrolysis, indicating that some of the peptides are still remaining in the cells. Therefore, it can be concluded that the IL-8 reduction effect of lysozyme against LPS still remained even after the pepsin and trypsin hydrolysis.

• Advances in concrete construction
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• 제15권6호
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• pp.431-444
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• 2023

This study investigated the use of latex-modified sand concrete reinforced with sisal fibers (LMSC) as a repair material. Notably, no prior research has explored the application of LMSC for this purpose. This paper examines the interface bond strength and the type of failure between LMSC as a repair material and the normal concrete (NC) substrate utilising four different surfaces: without surface preparation as a reference (SR), hand hammer (HA), sandblasted (SB), and grooved (GR). The bond strength was measured by bi-surface shear, splitting tensile, and pull-off strength tests at 7, 28, and 90 days. Scanning electron microscopy analysis was also performed to study the microstructure of the interface between the normal concrete substrate and the latex-modified sand concrete reinforced with sisal fibers. The results of this study indicate that LMSC has bonding strength with NC, especially for HR and SB surfaces with high roughness. Therefore, substrate NC surface roughness is essential in increasing the bonding strength and adhesion. Eventually, The LMSC has the potential to repair and rehabilitate concrete structures.

• Journal of information and communication convergence engineering
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• 제22권1호
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• pp.44-55
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• 2024

High-utility itemset mining (HUIM) is a dominant technology that enables enterprises to make real-time decisions, including supply chain management, customer segmentation, and business analytics. However, classical support value-driven Apriori solutions are confined and unable to meet real-time enterprise demands, especially for large amounts of input data. This study introduces a groundbreaking model for top-N high utility itemset mining in real-time enterprise applications. Unlike traditional Apriori-based solutions, the proposed convolutional sequential embedding metrics-driven cosine-similarity-based multilayer perception learning model leverages global and contextual features, including semantic attributes, for enhanced top-N recommendations over sequential transactions. The MATLAB-based simulations of the model on diverse datasets, demonstrated an impressive precision (0.5632), mean absolute error (MAE) (0.7610), hit rate (HR)@K (0.5720), and normalized discounted cumulative gain (NDCG)@K (0.4268). The average MAE across different datasets and latent dimensions was 0.608. Additionally, the model achieved remarkable cumulative accuracy and precision of 97.94% and 97.04% in performance, respectively, surpassing existing state-of-the-art models. This affirms the robustness and effectiveness of the proposed model in real-time enterprise scenarios.

• 산경연구논집
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• 제10권3호
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• pp.73-83
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• 2019

Purpose - This study is to clarify the structural relationship between the direct supervisor and organizational commitment and organizational citizenship behavior through mediation of the Leader-member exchange (LMX) in the hospital organization, and to confirm the mediating effect of the LMX. Through this study, we will provide basic data on the aspects of HR to enhance organizational immersion and organizational civic behavior in hospital organizations, and present suggestions on academic contribution and effective organizational operation measures. Research design, data, and methodology - This study is to investigate the relationship between authentic leadership and OC and OCB of the organization member, which is proposed to secure more active and high competitiveness in the recent changing medical environment, with multi-regression and B&K(1986) method. For this purpose, 653 employees of senior hospitals in Seoul and Kyeong-In area were surveyed using structured questionnaires. Each questionnaire was composed of 7-point scale, and each hypothesis was testified by multiple leaner regression and by BK method for testifying mediator effect. Result - As a result of the analysis, it was found that the male and non-medical staff had higher recognition level than the medical staff in the LMX, organizational commitment and organizational citizenship behavior. In the senior management or more than 5 years' experience group, organizational commitment and organizational citizenship behavior were recognized higher than the group of subordinate managers. Second, authentic leadership has a positive influence on LMX, organizational commitment and organizational citizenship behavior, and LMX has a significant positive impact on organizational commitment and organizational citizenship behavior. In addition, as a result of analyzing LMX mediating effect in the relationship of authentic leadership and organizational effectiveness by BK method, LMX had partial mediating effects between authentic leadership and organizational citizenship behavior, and between authentic leadership and organizational commitment. Conclusion - Results of the study confirmed that all the members of the hospital organization that were lacking served as positive factors for the relationships of authentic leadership and LMX, and authentic leadership and organizational effectiveness. It is expected that the hospital organization will be able to suggest such as the organizational approach to expect high organizational effectiveness centering on authentic leadership ability as psychological capital.

• 한국의학물리학회지:의학물리
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• 제18권2호
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• pp.87-92
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• 2007

최대출력 30 MW, 하나로(HANARO) 다목적 연구용 원자로의 접선 중성자공에 붕소중성자포획치료(Boron Neutron Capture Therapy, BNCT)를 위한 열중성자 조사장치가 개발되었다. BNCT 조사장치에서는 서로 다른 물리적 특성과 생물학적 효과비를 가진 여러 성분의 방사선이 방출되기 때문에 정확한 투여선량을 결정하기 위해서는 각 성분의 정량적 분석이 필수적이다. 따라서 본 연구에서는 방사화 분석, 열형광선량계 및 이온전리함 등 여러 유형의 검출기를 사용하여 BNCT 조사장치에서 방출되는 열중성자 및 감마선 혼합장의 선량 성분을 분리, 측정하였다. 선량측정은 물 속에 함유된 불순물과 중성자의 이차반응을 최소화하기 위해 증류수를 채운 물팬텀을 이용하였다. 그리고 측정 결과는 MCNP4B 전산계산의 결과와 상호 비교하였다. 측정 결과 열중성자속은 물팬텀 10 mm와 20 mm 깊이에서 각각 $1.02E9n/cm^2{\cdot}s$과 $6.07E8n/cm^2{\cdot}s$이었고, 고속중성자선량율은 10 mm 깊이에서 0.11 Gy/hr로 미세하였다. 감마선량률은 물팬텀 20 mm 깊이에서 5.10 Gy/hr로 나타났다. 측정된 중성자와 감마선량값은 MCNP의 결과와 5% 이내로 잘 일치하였고, 열중성자속은 14%의 비교오차를 나타내었다. 이러한 결과들은 중성자 검출의 난이도를 고려할 때 충분히 신뢰할 수 있는 수준이라 판단되며, BNCT 임상 연구를 위한 선량평가 자료로 활용할 수 있을 것으로 사료된다.

• IMMUNE NETWORK
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• 제1권1호
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• pp.45-52
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• 2001

Background: Many types of cancer become resistant to current chemotherapeutic and radiotherapeutic intervention. To overcome this situation application of gene therapy by the introduction of suicide genes followed by their prodrugs may be promising. A viral enzyme, Herpes simplex thymidine kinase (HSV-tk), which converts ganciclovir from an inactive prodrug to a cytotoxic agent by phosphorylation, are being actively investigated for use in gene therapy for cancer. The purpose of this study was to determine whether combining prodrug-activating gene therapy and irradiation might result in enhanced antitumor effects. Methods: The HSV-tk gene was cloned into the retroviral vector, pLXSN and established the clones producing retroviruses carrying the HSV-tk gene. The carcinoma cell line, HCT116 and Huh-7 were transduced with high-titer recombinant retroviruses. These cell lines were treated with ganciclovir before or after irradiation for the defining combinational effect of suicide gene therapy and radiotherapy. Results: The titers of cloned PA3 17 amphotropic retroviruses ranged from 4 to 6 X $10^6CFU/ml4$. After selectional periods, the expression of HSV-tk was confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR). The growth of cells expressing HSV-tk was inhibited as increase of GCV dose after 48 hr and the growth inhibitory effect of GCV was much higher after 72 hr. When the cells transduced with HSV-tk gene were exposed to radiation, the growth inhibitory effect of GCV was significantly increased, as compared with non-transduced parental cells. Conclusions: The results suggest that the addition of HSV-tk gene therapy to standard radiation therapy may improve the effectiveness of treatment for solid tumors.

• 재활복지공학회논문지
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• 제10권4호
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• pp.243-249
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• 2016

본 논문에서는 건강한 성인 26명(남자 14명, 여자 12명)을 대상으로 기계승마의 적용을 통한 심폐기능의 변화 및 그에 따른 운동 강도를 정량적으로 측정하여, 기계식 승마 치료의 임상 적용가능성과 유효성을 추정하였다. 기계승마 장비인 JOBA(R)(Panasonic Electric Works, Osaka, Japan)을 이용하였고, 운동의 강도는 level 2 (0.73 Hz)에서 4 (0.9 Hz), 6 (1.03 Hz), 8 (1.2 Hz), 9 (1.3 Hz)까지 증가시키고, 각각의 level에서 3분간 유지하였다. 운동 중 참여자의 심폐 반응은 호흡가스분석 시스템(TruOne 2400, Parvo Medics, USA)과 운동부하검사 시스템(Q Stress, Cardiac Science, USA)을 이용하여 심박수, 혈압, 최대산소소모량(VO2max)을 측정하였다. 또한 기계승마를 통해 유발되는 유산소 운동 강도를 평가하기 위해 대사당량(MET)을 측정하고, 예비심박수율(%HRR), 최대심박수율(%peak HR)과 칼로리소모량을 계산하였다. 그 결과는 SPSS 18.0 프로그램을 이용해 분석하였으며, 건강한 성인에서 간단한 사전 교육 후 15분간의 JOBA(R)를 이용한 기계식 승마 치료시 증등도의 운동 강도에 도달할 수 있는 것으로 평가되었다.