• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2004년도 하계학술대회
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• pp.282-290
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• 2004

80년대 초반에 등장한 퍼스널 컴퓨터에서부터 90년대에 급격히 확산된 클라이언트/서버 환경에 이르기까지 분산 컴퓨팅은 관리가 어렵다고 증명되었다. IBM의 Tivoli나 HP의 OpenView 등을 포함한 거대한 엔터프라이즈 관리 시스템 산업이 이러한 표면상의 극복하기 힘든 법칙처럼 여겨지는 것이 그 증거라고 하겠다. 이 후 무선의 개념이 등장했다. NOP World Technology가 Cisco사를 위해 2001년에 시행한 조사에 의하면 최종 사용자는 무선랜을 사용함으로써 생산성이 최고 22% 향상되었고 조사대상의 63%가 일상적인 직무에서 정확도가 향상되었다. 이 모든 것은 투자대비수익(ROI) 계산상 사용자 당 $550 해당한다. 현재 이동성과 IT 관리 기능의 딜레마를 동시에 고려하며 저렴한 몇몇 솔루션들이 소개되고 있다. 본 논문에서는 분산 컴퓨팅의 다음 진화 단계인 무선 네트워킹과 관련된 문제를 해결할 수 있는 혁신적이고 전체적인 접근법을 소개한다. 본 논문에서는 무선 컴퓨팅과 보안의 본질 및 무선랜이라는 새로운 컴퓨팅 패러다임으로 인하여 파생되는 운영과 관리의 어려움을 소개한다. 이러한 환경이 정의되면 본 논문은 이해하기 쉬운 5x5 레이어 매트릭스를 바탕으로 각 레이어의 독특한 본질을 고려한 혁신적인 무선랜 관리 방법에 대해 설명한다. 마지막으로 무선 네트워킹, 컨버젼스, 궁극적으로 분산 컴퓨팅만이 가지는 문제점을 해결할 수 있는 Red-M의 백 오피스 애플리케이션에 기반한 솔루션을 소개한다. 본 논문의 목표는 Red-M의 성공에 관한 두 가지 중요한 과정을 설명하고자 함이다. 이는 안전한 무선 네트워크 제어에서 비롯되는 무선 환경이 약속하는 장점들을 고루 제공하는 것과 나쁜 의도의 사용자를 차단할 뿐 아니라 올바른 사용자와 또한 나머지 일반 사용자를 총체적으로 관리할 수 있는, 안정적이고 확장 가능하며 직관적인 시스템을 제공하는 것이다.가 생성된다. $M_{C}$에 CaC $l_2$를 첨가한 경우 $M_{C}$는 완전히 $M_{Cl}$ 로 전이를 하였다. $M_{Cl}$ 에 CaC $l_2$를 첨가하였을 경우에는 아무런 수화물의 변화는 발생하지 않았다. 따라서 CaS $O_4$.2$H_2O$를 CaC $O_3$및 CaC $l_2$와 반응시켰을 때의 AFm상의 안정성 순서는 $M_{S}$ < $M_{C}$< $M_{Cl}$ 로 된다.phy. Finally, Regional Development and Regional Environmental Problems were highly correlated with accommodators.젼 공정을 거쳐 제조된다는 점을 고려할 때 이용가능한 에너지 함량계산에 직접 활용될 수는 없을 것이다.총단백질 및 AST에서 시간경과에 따른 삼투압 조절 능력에 문제가 있는 것으로 보여진다.c}C$에서 5시간 가열조리 후 잔존율은 각각 84.7% 및 73.3%였고, 질소가스 통기하에서는 잔존율이 88.9% 및 81.8%로 더욱 안정하였다.8% 및 12.44%, 201일 이상의 경우 13.17% 및 11.30%로 201일 이상의 유기의 경우에만 대조구와 삭제 구간에 유의적인(p<0.05) 차이를 나타내었다.는 담수(淡水)에서 10%o의 해수(海水)로 이주된지 14일(日) 이후에 신장(腎臟)에서 수축된 것으로 나타났다. 30%o의 해수(海水)에 적응(適應)된 틸라피아의 평균 신사구체(腎絲球體)의 면적은 담수(淡水)에 적응된 개체의 면적보다 유의성있게 나타났다. 해수(海水)에 적응(適應)된 틸라피아의 신단위(腎

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.70-81
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• 2000

DA-5018 is a synthetic capsaicin derivative under development as a non-narcotic a analgesic ag$\varepsilon$nt. DA-50 18 showed a potent analgesic activity against acute and chronic pain m model(Tablel, 2.), but it had a narrow margin of safety. DA-5018 did not bind to opioid(${\kappa}, {\delta}, {\mu}$), NKl, CGRP receptors in vitro and its analgesic effect was not antagonized by naloxone, a and it did not develop analgesic tolerance. In addition DA-5018 had no inhibitory effects against c cyclooxygenase and 5-lipooxygenase activities. DA-5018 significantly increased the relcase of substance P from the slices of the rat spinal cord. These results suggest that DA-50 18 is not a narcotic nor aspirin-like analgesic and the release of substance P is one of analgesic mechanism of action of DA-5018. We found that DA-5018 was almost ten times more potent and was at l least IOO-times less irritable compared to capsaicin. Accordingly development of topical formula was adopted. Topical formula was desiged and screened by flux test of DA-5018 using hairless mouse skin and several formulas were selected. With these topical formulas we a assessed the analgesic efficacy and carried out the toxicity, skin irritation and pharmacokinetic studies. In streptozotocin-induced hyperalgesic rat and 50 % galactose-fed hyperalgesic rat as diabetic pain models, DA-5018 cream increased the pain thresh이ds up to 77.0% and 24.4% respectively, while Zostrix-HP(capsaicin cream) incr$\varepsilon$as cd by 65.9% and 21.0%. DA-5018 c cream showed a good analgesic effect as welI in FCA-induced arthritic rat. DA-5018 cream did not show any toxicological signs in acute and chronic toxicity test and had little skin irritation in car swclIing and scratching t$\varepsilon$st. Pharmacokinetics of DA-50 18 were studied after topical application of ${14}^C$-Iabelled or unlabelIed DA-5018 cream. Plasma and skin concentrations c except applied skin wcre below the dctection limit and after 7-day cummulative application, plasma concentrations were also below detection limit DA-50 18 may have an advantag$\varepsilon$ ov$\varepsilon$r c capsaicin and is now being developed as a topical agent for the treatment of pains. DA-50 18 cream was approved for Korean IND and is now under a Phase II clinical study for arthritic pain a after finising Phase I study. DA-50 18 was also liscensed out to Stiefel Company in America in

• 한국산학기술학회논문지
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• 제21권1호
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• pp.223-231
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• 2020

본 연구는 간호학생을 대상으로 HPS를 활용한 뇌경색환자 간호과정 시뮬레이션 시나리오를 개발하고 적용하여 전통적 강의방식과 그 효과를 비교·평가해 보고자 함이다. 본 연구는 2018년 11월 27일부터 12월 26일까지 간호대학의 4학년 학생을 대상으로 하였으며, 실험군 38명, 대조군 39명으로 최종 77명을 대상으로 하였다. 본 연구는 분석단계와 연구 설계단계를 거쳐 개발단계에서 시나리오를 개발하여 적용하는 과정을 거쳤다. 실험군과 대조군의 중재 전, 후의 자신감, 이론적 지식, 임상수행기술은 t-test를 통해 분석하였다. 본 연구결과 뇌경색 환자에 대한 간호과정을 기반으로 한 시뮬레이션 시나리오가 개발 되었으며, 이는 3가지 간호진단을 유추할 수 있도록 설계되었다. 연구결과 두 그룹 모두 임상수행기술을 제외한 사전사후 점수가 통계적으로 유의하였으며, 실험군과 대조군간 사후점수 및 사전, 사후의 차이검증에서 실험군이 유의하게 높게 나타났다. 본 연구는 표준화된 뇌경색환자 간호과정 시뮬레이션 시나리오를 개발하였다는 점에서 의의가 있다. 또한 개발된 시나리오가 실습 뿐 아니라 이론적 학습까지 통합할 수 있는 교수학습방법으로의 가능성을 보여주고 있다.

• 한국식품과학회지
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• 제30권5호
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• pp.1006-1011
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• 1998

신고, 만삼길, 추황배의 휘발성 향기성분을 LLEP 방법으로 추출하였고 GC의 RI와 GC/MS 분석에 의하여 동정하였다. 신고, 만삼길, 추황배에서 52종, 47종, 22종의 화합물이 분리동정되었고, 신고의 향기성분으로 alcohol류 20종, ester류 16종, hydrocarbon류 7종, acid류 6종, aldehyde류 2종, ketone류 1종이 확인되었다. 이 중에서 ethyl acetate, ethyl butanoate, hexanal, 1-hexanol, ethyl-3-hydroxy butanoate, ethyl-3-hydroxy nonanoate가 신고의 주요 향기성분으로 여겨졌다. 만삼길에서 분리동정 된 향기성분으로 alcohol류 23종, acid류 8종, ester류 5종, hydrocarbon류 5종, aldehyde류 4종, ketone류 2종이 동정되었다. 이 중에서 ethyl acetate, hexanal, ethyl-2-hydroxy propanoate, methyl eugenol, 2-pentanol, cis-3-hexenol, propyl acetate가 만삼길의 향기에 기여하는 것으로 여겨졌다. 추황배에서 분리동정 된 향기성분으로 ester류 6종, alcohol류 6종, acid류 6종, aldehyde류 3종, hydrocarbon류가 1종이 동정되었다. 이 중에서 ethyl acetate, propyl acetate, hexanal, 1-dodecanol, ethyl butanaote가 추황배의 주요 향기성분으로 간주되었다. 신고, 만삼길, 추황배에서 추출된 휘발성 향기성분의 함량은 각각 6.972, 2.776, 2.653 mg/kg을 차지하였다.

• 한국잡초학회지
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• 제16권1호
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• pp.42-53
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• 1996

400여 벼 품종(品種)과 다수의 잡초종들로 부터 oxyfluorfen에 대하여 내성(耐性) 및 감수성(感受性)으로 선발된 벼 7품종(品種)과 피를 공시하여 이들의 oxyfluorfen에 대한 유묘(幼苗), callus, 단세포(單細包) 및 원형질체(原形質體)의 반응 결과를 체계적으로 비교함으로써 내성(耐性) 및 감수성(感受性)요인의 소재와 분포현상을 파악하고저 하였다. 1. Oxyfluorfen 에 대한 기(旣) 선발 벼품종(品種) 및 피의 $I_{50}$ 검정결과는 기(旣) 선발기준과 유사하게 확인되었다. 즉 내성(耐性) 벼품종(品種)의 $I_{50}$은 $10^{-4}M$ 전후(前後)였고, 감수성(感受性) 벼품종(品種)과 피는 $10^{-6}M$ 전후(前後)로 유의적 차이를 보였다. 2. 내성(耐性) 및 감수성(感受性) 식물들에서 유기(誘起)한 callus에 oxyfluorfen 처리 후 callus 생장량은 내성(耐性) 벼품종(品種)들에서 감수성(感受性) 벼품종(品種)들과 피보다 많았으나 유묘검정(幼苗檢定) 경우보다 차이는 적어지는 경향이었다. 3. Oxyflurofen 처리후 현탁배양(懸濁培養)의 세포(細包) 생장율(生長率)은 내성(耐性) 벼품종(品種)들이 감수성(感受性) 벼품종(品種)인 HP1033, Weldpally와 피보다 높았다. 4. Oxyfluorfen 처리 1, 2시간 후 원형질체(原形質體)의 viability는 내성(耐性) 벼품종(品種)들이 감수성(感受性) 벼품종(品種) Weldpally와 피에서만 높았을 뿐, 그 밖의 품종(品種)들에서는 차이가 없었다. 그러나 원형질체(原形質體)의 intactness는 내성(耐性) 벼품종(品種)들이 감수성(感受性) 벼품종(品種)들과 피보다 높았다.

• 한국작물학회지
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• 제62권4호
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• pp.373-381
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• 2017

The main objective of this study was to increase the germination percentage of kenaf seeds with less number of times under non-saline and saline conditions. Therefore, the first goal was to assess the response of kenaf seeds to NaCl. The second goal was to evaluate the effects of $KNO_3$ on kenaf seed germination. The germination percentage exhibited a decreasing tendency in germination rate. Plant dry weight was approximately 0.2 g in all treatments at 5 days after germination. As time passed, the electrical conductivity (EC) value of hydro-priming (HP) consistently increased by 8.7 mS/cm at 24 hours of immersion. However, seeds primed with $KNO_3$ showed no difference in EC values even as times passed. Regarding the priming effect, priming in 100 mM $KNO_3$ concentration for 12 hours increased germination up to 85% in $H_20$ solution and in 0 mM $KNO_3$ concentration upto 73.8% under 0.3% NaCl solution, compared to that of Control. Germination synchronization, shoot length, and leaf unfolding of primed seeds were greater than those of the Control. In addition, main root and hair roots appeared more rapidly in the treated seeds and were more abundant compared to that of the Control. The T50 (times to reach 50% of the final germination percentage) of the Control in both $H_20$ and 0.3% NaCl solutions was 18 and 22 hours, respectively. However, when treated $KNO_3$ priming (0 to 100 mM) in $H_20$ and 0.3% NaCl solution, 9 hours was sufficient to reach T50. Primed (hydro-priming and $KNO_3$) seeds had a lower MDG (mean days untill germination; 0.6-0.62) compared to that of the Control (1.13-1.31) in $H_20$ and 0.3% NaCl solutions. Regarding dry weight of plants after priming, an increasing tendency after the priming treatment in the H20 solution was observed. Furthermore, no significant difference in plant dry weight under 0.3% NaCl stress was observed between the Control and primed seeds. Taken together, the results suggest that 50-100 mM $KNO_3$ priming for 24 hours optimize seed germination rate in less number of times of exposure with great vigor. Therefore, it is recommended for kenaf seed invigoration before planting.

• 보건행정학회지
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• 제29권2호
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• pp.206-219
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• 2019

This paper aims to demonstrate current health expenditure (CHE) and National Health Accounts of the years 2018 constructed according to the SHA2011, which is a manual for System of Health Accounts (SHA) that was published jointly by the Organization for Economic Cooperation and Development (OECD), Eurostat, and World Health Organization in 2011. Comparison is made with international trends by collecting and analyzing health accounts of OECD member countries. Particularly, scale and trends of the total CHE financing as well as public-private mix are parsed in depth. In the case of private financing, estimation of total expenditures for (revenues by) provider groups (HP) is made from both survey on the benefit coverage rate of National Health Insurance (by National Health Insurance Service) and Economic Census and Service Industry Census (by National Statistical Office); and other pieces of information from Korean Health Panel Study, etc. are supplementarily used to allocate those totals into functional classifications. CHE was 144.4 trillion won in 2018, which accounts for 8.1% of Korea's gross domestic product (GDP). It was a big increase of 12.8 trillion won, or 9.7%, from the previous year. GDP share of Korean CHE has already been close to the average of OECD member countries. Government and compulsory schemes' share (or public share), 59.8% of the CHE in 2018, is much lower than the OECD average of 73.6%. 'Transfers from government domestic revenue' share of total revenue of health financing was 16.9% in Korea, lower than the other social insurance countries. When it comes to 'compulsory contributory health financing schemes,' 'transfers from government domestic revenue' share of 13.5% was again much lower compared to Japan (43.0%) and Belgium (30.1%) with social insurance scheme.

• Hip & pelvis
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• 제35권3호
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• pp.183-192
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• 2023

Purpose: This study aims to determine which intertrochanteric (IT) hip fracture and patient characteristics predict the necessity for adjunct reduction aides prior to prep and drape aiming for a more efficient surgery. Materials and Methods: Institutional fracture registries from two academic medical centers from 2017-2022 were analyzed. Data on patient demographics, comorbidities, fracture patterns identified on radiographs including displacement of the lesser trochanter (LT), thin lateral wall (LW), reverse obliquity (RO), subtrochanteric extension (STE), and number of fracture parts were collected, and the need for additional aides following traction on fracture table were collected. Fractures were classified using the AO/OTA classification. Regression analyses identified significant risk factors for needing extra reduction aides. Results: Of the 166 patients included, the average age was 80.84±12.7 years and BMI was 24.37±5.3 kg/m². Univariate regression revealed increased irreducibility risk associated with RO (odds ratio [OR] 27.917, P≤0.001), LW (OR 24.882, P<0.001), and STE (OR 5.255, P=0.005). Multivariate analysis significantly correlated RO (OR 120.74, P<0.001) and thin LW (OR 131.14, P<0.001) with increased risk. However, STE (P=0.36) and LT displacement (P=0.77) weren't significant. Fracture types 2.2, 3.2, and 3.3 displayed elevated risk (P<0.001), while no other factors increased risk. Conclusion: Elderly patients with IT fractures with RO and/or thin LW are at higher risk of irreducibility, necessitating adjunct reduction aides. Other parameters showed no significant association, suggesting most fracture patterns can be achieved with traction manipulation alone.

• 대한한의학회지
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• 제19권2호
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• pp.450-467
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• 1998

To research the characteristics of ion currents induced by inhibitory and excitatory herbs of oriental medicine, we used nystatin-perforated patch clamp technique under voltage clamp condition in periaqueductal gray neuron dissociated from Sprauge-Dawley rat, 10-15 days old. The results are as follows. 1. Ion current induced by $10mg/m{\ell}$ of Bupleuri Radix was inhibited $59.50{\pm}4.29%$ by $10^{-4}M$ bicuculline(p>0.01) but inhibition of $10.75{\pm}4.77%$ by $10^{-4}M$ tubocurarine and $4.75{\pm}4.23%$ by $10^{-4}M$ verapamil had no statistical significance(p>0.05). So ion current induced by Bupleuri Radix revealed only GABA induced $Cl^-$ current, not acetylcholine and $Ca^{2+}$ current. 2. Ion current induced by $20mg/m{\ell}$ of Coptidis Rhizoma was inhibited $47.20{\pm}7.88%$ by $10^{-4}M$ bicuculline(p<0.01) but $3.20{\pm}2.33%$ inhibition by $10^{-4}M$ tubocurarine and $1.00{\pm}1.00%$ inhibition by $10^{-4}M$ verapamil had no significance(p>0.05). So ion current induced by Coptidis Rhizoma revealed only GABA induced $Cl^-$ current, not acetylcholine and $Ca^{2+}$ current. 3. Ion current induced by $20mg/m{\ell}$ of Ecliptae Herba was inhibited $55.00{\pm}4.92%$ by $10^{-4}M$ bicuculline (p<0.01), and also inhibited $15.00{\pm}4.26%$ by $10^{-4}M$ tubocurarine(p<0.05), but inhibition of $6.00{\pm}3.03%$ by $10^{-4}M$ verapamil had no significance(p>0.05). So ion current induced by Ecliptae Herba showed GABA activated $Cl^-$ current and acetylcholine activated cation current, not $Ca^{2+}$ current 4. Ion current induced by $5mg/m{\ell}$ of Liriopis Tuber was inhibited $15.20{\pm}4.57%$ by $10^{-4}M$ bicuculline<0.05) and also inhibited $14.00{\pm}3.00%$ by $10^{-4}M$ tubocurarine(p<0.05), but inhibition of $5.20{\pm}4.80%$ by $10^{-4}M$ verapamil had no significance(p>0.05). So ion current induced by Liriopis Tuber showed GABA. activated $Cl^-$ current and acetylcholine activated cation current, not $Ca^{2+}$ current. 5. Ion current induced by $5mg/m{\ell}$ of Aconiti Tuber was inhibited $97.00{\pm}1.34%$ by $10^{-4}M$ bicuculline(p<0.01), $80.00{\pm}9.83%$ by $10^{-4}M$ tubocurarine(p<0.01), and $24.00{\pm}6.18%$ by $10^{-4}M$ verapamil(p<0.05). So ion current induced by Aconiti Tuber revealed GABA activated $Cl^-$ current and acetylcholine activated cation current and $Ca^{2+}$ current. 6. Ion current induced by $10mg/m{\ell}$ of Zingiberis Rhizoma was inhibited $33.00{\pm}7.43%$ by $10^{-4}$ bicuculline(p<0.05), $10.20{\pm}1.83%$ by $10-^{-4}M$ tubocurarine(p<0.01), and $14.00{\pm}2.16%$ by $10^{-4}M$ verapamil(p<0.01) So ion current induced by Zingiberis Rhizoma revealed GABA activated $Cl^-$ current and acetylcholine activated cation outtent and $Ca^{2+}$ current. 7. Ion current induced by $10mg/m{\ell}$ of Boshniakiae Herba was inhibited $65.00{\pm}13.75%$ by $10^{-4}M$ bicuculline(p<0.05), $38.00{\pm}9.24%$ by $10^{-4}M$ tubocurarine(p<0.05), and $33.25{\pm}7.42%$ by $10^{-4}M$ verapamiHp<0.05). So ion current induced by Bpshniakiae Herba revealed GABA activated $Cl^-$ current and acetylcholine activated cation current and $Ca^{2+}$ current. These results suggest that a point of difference between inhibitory and excitatory herbs is existence of$Ca^{2+}$ current.

• 한국토양비료학회지
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• 제50권5호
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• pp.434-451
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• 2017

For this study, groundwater samples for 3 years from 2011 through 2013 were collected at 106 groundwater monitoring site in Korea. These groundwater samples were analyzed for 13 pesticides such as cabofuran, pentachlorobenzene, hexachlorobenzene, simazine, atrazine, lindane (gamma-HCH), alachlor, heptachlor, chlordane (total), endosulfan (1, 2), dieldrin, endrin, 4,4-DDT. The objectives of this study were to determine the detection frequency and their concentrations of 13 pesticides and evaluate the health risk level considering ingestion, inhalation, and skin contact using concentrations of 13 pesticides in groundwater samples. An analysis was used for the simultaneous determination for 13 pesticides using GC-MS. GC-MS was performed on HP-5ms, using helium ($1ml\;min^{-1}$) as carrier gas. The average recoveries of the pesticides were from 92.8% to 120.8%. The limits of detection (LODs) were between $0.004{\mu}g\;L^{-1}$ and $0.118{\mu}g\;L^{-1}$ and the limits of quantification (LOQs) were between $0.012{\mu}g\;L^{-1}$ and $0.354{\mu}g\;L^{-1}$. 106 groundwater wells were selected. 54 wells were from well to monitor background groundwater quality and 52 wells were from well to monitor groundwater quality in industrial or contamination source area. Eight pesticides including pentachlorobenzene, lindane (Gamma-HCH), heptachlor, chlordane (total), Endosulfan (1, 2), dieldrin, endrin, and 4,4-DDT were not detected in groundwater samples. The detection frequency for hexachlorobenzene, alachlor, carbofuran and simazine was 23.4%, 11.4%, 7.3%, and 1.0%, respectively. Atrazine was detected once in 2011. The average concentrations were $0.00423{\mu}g\;L^{-1}$ for carbofuran, $0.000243{\mu}g\;L^{-1}$ for alachlor, $0.00015{\mu}g\;L^{-1}$ for simazine, and $0.00001{\mu}g\;L^{-1}$ for hexachlorobenzene. The detection frequency of hexachlorobenzene was high, but the average concentration was low. In the contaminated groundwater, the detection frequency for hexachlorobenzene, alachlor, carbofuran, simazine and atrazine was 26.1%, 21.3%, 7.1%, 1.9% and 0.3%, respectively. In the uncontaminated groundwater, detection frequency for hexachlorobenzene, carbofuran and alachlor were 20.2%, 7.5%, and 1.9% respectively. Simazine and atrazine were not detected at uncontaminated groundwater wells. According to the purpose of groundwater use, atrazine was detected for agricultural groundwater use. Hexachlorobenzene showed high detection frequency at agricultural groundwater use area where the animal feeding area and golf course area were located. Alachlor showed more than 50% detection frequency at cropping area, pollution concern river area, and golf course area. Atrazine was detected in agricultural water use area. By land use, the maximum detection frequency of alachlor was found near an orchard. For human risk assessment, the cancer risk for the 5 pesticides was between $10^{-7}$ and $10^{-10}$, while the non-cancer risk (HQ value) was between $10^{-4}$ and $10^{-6}$. For conclusion, these monitoring study needs to continue because of the possibility of groundwater contamination based on various purpose of groundwater use.