• The Korean Journal of Physiology and Pharmacology
• /
• 제13권3호
• /
• pp.181-187
• /
• 2009

Intestinal ischemia/reperfusion (I/R) is one of common causes of acute lung injury (ALI). Early and accurate diagnosis of patients who are like to develop serious acute respiratory distress syndrome (ARDS) would give a therapeutic advantage. Ferritin and heme oxygenase-1 (HO-1) are increased by oxidative stress and are potential candidates as a predictive biomarker of ARDS. However, the mechanisms responsible for the increases of ferritin and HO-1, and their relationship to ALI, are unclear. In order to elucidate the interactions between ferritin and HO-1, we studied the changes in ferritin and HO-1 levels in serum and bronchoalveolar lavage (BAL) fluid after intestinal I/R injury in rats. Leukocyte number and protein contents in BAL fluid were elevated following I/R, and the increases were attenuated by mepacrine pretreatment. Both serum ferritin and HO-1 concentrations were progressively elevated throughout the 3 h observation period. Mepacrine pretreatment attenuated the increase of serum and BAL fluid ferritin concentrations, but did not suppress the increase of serum HO-1. Moreover, BAL fluid HO-1 levels did not change after I/R or after mepacrine pretreated I/R compared with sham rats. Unlike ferritin, HO-1 levels are not exactly matched with the ALI. Therefore, there might be a different mechanism between the changes of ferritin and HO-1 in intestinal I/R-induced ALI model.

• ETRI Journal
• /
• 제37권6호
• /
• pp.1065-1076
• /
• 2015

Network densification is regarded as the dominant driver for wireless evolution into the era of 5G. However, in this context, interference-limited dense small cell deployments are facing technical challenges in mobility management. The recently announced results from an LTE field test conducted in a dense urban area show a handover failure (HOF) rate of over 21%. A major cause of HOFs is the transmission failure of handover command (HO CMD) messages. In this paper, we propose two enhancements to HO performance in LTE networks - radio link failure-proactive HO, which helps with the reliable transmission of HO CMD messages while the user equipment is under a poor radio link condition, and Early Handover Preparation with Ping-Pong Avoidance (EHOPPPA) HO, which assures reliable transmission of HO CMD under a good radio link condition. We analyze the HO performance of EHOPPPA HO theoretically, and perform simulations to compare the performance of the proposed schemes with that of standard LTE HO. We show that they can decrease the HOF rate to nearly zero through an analysis, and based on the simulation results, by over 70%, without increasing the ping-pong probability.

• International Journal of Internet, Broadcasting and Communication
• /
• 제7권1호
• /
• pp.6-9
• /
• 2015

The use of Intelligent Transportation System (ITS) is promising to bring better solutions for managing and handling the city traffic. This system combines many fields in advanced technology such as Global Positioning System (GPS), Geographic Information System (GIS) and so on. The basement of applications in ITS is the effective collections and data integration tools. The purpose of our research is to propose solutions which involve the use of GPS time series data collected from GPS devices in order to improve the quality of output traffic data. In this study, GPS data is collected from devices attached to vehicles travelling on routes in Ho Chi Minh City (HCMC). Then, GPS data is stored in database system to serve in many transportation applications. The proposed method combines the data usage level and data coverage to improve the quality of traffic data.

• 혜화의학회지
• /
• 제9권1호
• /
• pp.201-214
• /
• 2000

Precise and detailed clinical research and evaluation based on objective standards are imperative factors in securing reliability of a clinical test. Built on this principle, this clinical test has been conducted during the period between March 1999 and March 2000 dealing with 31 outpatients treated with ShiHo-GuizhiTang or ShiHo-GuizhiTang modify and ShiHo-GuizhiTang mixed prescriptions at the Sung-bo ORIENTAL MEDICAL CLINIC. A variety of information relating to those patients has been collected and analyzed under such criteria as precise diagnoses and their clinical effectiveness. The analysis was duly based on "The theory of cold syndrome". Then, the 31 patients' individual clinical information was compared one another by breaking down the results into sub-categories including gender, age, disease, main symptom, blood pressure, pulse beats, syndrome of abdomen, treatment period, modify and mixed prescription, and evaluation. The result of this clinical test can be summarized as follows: First, ShiHo-GuizhiTang appears to be more frequently prescribed in the case of female patients than in the case of male patients despite the fact that it does not necessarily need to be applied only to female. In addition, the numbers of prescriptions of ShiHo-GuizhiTang in the two age groups consisting of elementary school children and economically active adults respectively were the highest among other age groups. Second, ShiHo-GuizhiTang proved to be most effective in treatment for respiratory ailments and arthritis. Third, ShiHo-GuizhiTang brought down blood pressure of hypertension patients and at the same time benefited patients with normal or lower-than-normal blood pressure who were vulnerable to diseases due to low disease-resistance. Fourth, ShiHo-GuizhiTang was effective in the case of frequent pulse(rapid pulse) and thereby indicating the fact it carries Taiyang superficies syndrome. 지맥 arises from suppressed immune responses owing to adrenocortical hormones. ShiHo-GuizhiTang controls and revitalizes those suppressed immune systems which stem from slow pulse and, as a consequence of that process, helps them return to normal condition of pulse. Fifth, from the standpoint of syndrome of abdomen, feeling of obstruction in the epigastrium serves as an important standard in the process of diagnosing diseases and evaluating effectiveness of treatments. Sixth, according to the results of the clinical test with the 31 patients, a total of 81 percent of test subjects benefited from the treatment. The figure is the sum of 52 percent of I-class (both main symptom and accompanying symptoms had been eliminated) and 29 percent of II-class (part of main symptom and accompanying symptoms had been eliminated) respectively. All told it is safe to say that ShiHo-GuizhiTang can elect to be a viable clinical treatment. In conclusion, it is estimated that this clinical study has drawn up guidelines for objective diagnostic standards and evaluation on specific treatments' effectiveness. This will lead to more general application of ShiHo-GuizhiTang. On top of that, this study could also provide an opportunity to stress the significance of ShiHo-GuizhiTang and ShiHo-GuizhiTang modify and ShiHo-GuizhiTang mixed prescriptions as an alternative treatment for collagen disease which comes from environmental degradation and pollution.

• 수산해양기술연구
• /
• 제49권4호
• /
• pp.385-394
• /
• 2013

This study has conducted a comparative analysis on the fishing efficiency of LED fishing lamps by squid jigging vessels, the Yeongrak-ho (16 tons) and Somang-ho (9.77 tons), which operated during September and October 2010 and during October 2011, comparing with MH (Metal Halide) fishing lamp-equipped fishing vessels. This study has also examined vessel's fuel consumption level. The light powers of LED fishing lamps of the Yeongrak-ho and Somang-ho were 25.8kW and 32kW, respectively. Those of the MH fishing vessels, that is, the MH fishing lamp-equipped fishing vessels, were 105kW and 81kW, respectively. The average squid catch in number of an LED vessel, Yeongrak-ho, was 39.2% of the MH fishing lamp-equipped fishing vessels; however, that of the Somang-ho improved to 78.7% of the MH fishing lamp-equipped vessels. Average catch in number by Yeongrak-ho crew was 2.6 times more than catch in number by automatic jigging machines. Average catch in number by MH fishing vessel crew was 1.8 times more than that by automatic jigging machines. An LED vessel, Yeongrak-ho's fishing rate was 17.5%~152.2% of the MH fishing vessels, that is, 61.1% on average, in comparison of combined catch in number per automatic jigging machine and per crewmember. Somang-ho's fishing rate was 6.7%~127.6% of the MH fishing vessels, that is, 73.1% on average. The average fuel consumption level of the Somang-ho, throughout its departure from to arrival at the port, was 475.7l, and that during fishing hours was 109.6l, or 23.0% of the total fuel consumption level. Somang-ho's fuel consumption level per fishing hour was 9.7l on average.

• 동의생리병리학회지
• /
• 제19권6호
• /
• pp.1573-1579
• /
• 2005

This study was undertaken to define the effect of DaeSiHo-Tang extract on the hypertension in spontaneous hypertensive rat and norepinephrine-induced arterial contraction in rabbit. Systolic blood pressure and blood velocity were significantly attenuated by administration of DaeSiHo-Tang extract. but blood flow and renin-angiotensin-aldosterone system unaffected by DaeSiHo-Tang extract. The relaxation effect of DaeSiHo-Tang extract was dependent on the presence of endothelium, showing that DaeSiHo-Tang extract-induced relaxation was not observed in the strips without endothelium. The endothelium-dependent relaxation induced by DaeSiHo-Tang extract was decreased by the pretreatment of $N{\omega}$-nitro-L-arginine or methylene blue, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. When $Ca^{2+}$ was applied, the strips which were contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But pre-treatment of DaeSiHo-Tang extract inhibited contractile response to $Ca^{2+}$. These results indicate that antihypertensive effect of DaeSiHo-Tang extract is due to descend arterial resistance by the arterial relaxation through the formation of nitric oxide in the vascular endothelial cells.

• 한국대기환경학회지
• /
• 제22권6호
• /
• pp.779-790
• /
• 2006

This study examines relative contributions of volatile organic compounds (VOCs) to the formation of hydroxyl (OH) and peroxy radicals such as $HO_2$ and $RO_2$ during the intensive sampling period (Jun. $1{\sim}30$, 2004) in the air of Seoul metropolitan area. As to the contribution of VOCs to $HO_x$ levels, the impact of individual VOC concentration change on $HO_2$ concentration change was more than an order of magnitude higher than that on OH concentration change during the study period. The contribution of change in isoprene concentration to $HO_2$ concentration change was 38 times higher than OH and that in the concentration of alkene compounds to $HO_2$ concentration change was 31 times higher than OH. Moreover, the concentration changes of isoprene and aromatic compounds (AROM) played significant roles in $HO_x$ concentration changes. On the other hands, aldehydes (ALD2) and alkanes (ALKA) showed anti-correlation (negative) in $HO_x$ concentration changes with low contribution ($-4{\times}10^{-3}$ pptv/ppbv (OH) and $-58{\times}10^{-3}$ ($HO_2$) for ALD2; $-1{\times}10^{-3}$ (OH) and $-15{\times}10^{-3}$ ($HO_2$) for ALKA). Unlike other VOCs, $C_2H_6$ and $C_3H_8$ showed positive or negative contribution to peroxy radicals, depending on ambient air conditions. The contribution of VOC concentration changes to changes in $CH_3O_2$ and $RO_2$ concentration showed similar pattern to $HO_x$ contribution.

• Bulletin of the Korean Chemical Society
• /
• 제30권4호
• /
• pp.897-901
• /
• 2009

Heme oxygenase-1 (HO-1) is an anti-inflammatory and anti-apoptotic protein and has been applied to various gene therapy researches. However, constitutive expression of HO-1 may induce deleterious side effects. In this research, hypoxia inducible HO-1 expression plasmid, pEpo-SV-HO-1, was constructed with the erythropoietin (epo) enhancer and simian virus 40 (SV40) promoter to avoid these unwanted side effects. Dexamethasone conjugated polyethylenimine (PEI-Dexa) was used as a gene carrier. It was previously reported that dexamethasone protected cardiomyocytes from apoptosis under hypoxia. In this research, PEI-Dexa reduced the caspase-3 level in hypoxic H9C2 cardiomyocytes as a derivative of dexamethasone, suggesting that PEI-Dexa is an anti-apoptotic reagent as well as a gene carrier. pEpo-SV-HO-1 was transfected to H9C2 cardiomyocytes using PEI-Dexa and the cells were incubated under normoxia or hypoxia. HO-1 expression was induced in the pEpo-SV-HO-1 transfected cells under hypoxia. In addition, cell viability under hypoxia was higher in the pEpo-SV-HO-1 transfected cells than the pEpo-SV-Luc transfected cells. Also, caspase-3 level was reduced in the pEpo-SV-HO-1 transfected cells under hypoxia. In addition to the anti-apoptotic effect of PEI-Dexa, hypoxia inducible HO-1 expression by pEpo-SVHO- 1 may be helpful to protect cardiomyocytes under hypoxia. Therefore, pEpo-SV-HO-1/PEI-Dexa complex may be useful for ischemic heart disease gene therapy.

• 생약학회지
• /
• 제31권1호
• /
• pp.63-71
• /
• 2000

'Si Ho'(柴胡) is one of the chinese crude drugs used mainly to cure inflammation, fever, cough, hepatitis, jaundice, etc. Though the botanical origin of the crude drug has been considered to be Bupleurum species of Umbelliferae, there has been no pharmacognostical study. To clarify the botanical origin of 'Si Ho', the morphological and anatomical characteristics of the roots of Bupleurum species growing in Korea, such as Bupleurum euphorbioides Nakai, Bupleurum falcatum L., Bupleurum leveillei Bois., Bupleurum longiradiatum Turcz. and Bupleurum scorzoneraefolium Wild. were studied. As a result, it is authentified that 'Si Ho' was proved to be the root of Bupleurum falcatum and B. scorzoneraefolium and 'Jug Si Ho' was the root of B. longiradiatum.

• 셀메드
• /
• 제3권1호
• /
• pp.1.1-1.7
• /
• 2013

The present review investigates the role of the cytoprotective enzyme heme oxygenase-1 (HO-1) in human diseases and explores strategies for its clinical use. In recent years, there has been a growing evidence, for the beneficial effects of some phytoconstituents via induction of HO-1 expression, contained in commonly used spices, fruits, and herbs, in preventing various pathologic conditions, including cancer, diabetes, and cardiovascular diseases. HO-1 catalyzes the rate-limiting step in heme catabolism to generate ferrous iron, carbon monoxide, and biliverdin. HO-1 is reported to play crucial roles in cellular protection, such as anti-inflammatory, anti-proliferative and anti-apoptotic effects. These evidences indicate that HO-1 may functions as a potential therapeutic target in various human diseases. The article highlights the current status of the development of the HO-1 modulation pathway using dietary phytoconstituents.