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Effects of DaeSiHo-Tang extract on Hypertension and Arterial Contraction  

Yeo Un-Hong (Department of Physiology, College of Oriental Medicine, Semyung University)
Jo Hak-Jun (Department of Korean Medical Classics, College of Oriental Medicine, Semyung University)
Kim Ho-Hyun (Department of Physiology, College of Oriental Medicine, Semyung University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.19, no.6, 2005 , pp. 1573-1579 More about this Journal
Abstract
This study was undertaken to define the effect of DaeSiHo-Tang extract on the hypertension in spontaneous hypertensive rat and norepinephrine-induced arterial contraction in rabbit. Systolic blood pressure and blood velocity were significantly attenuated by administration of DaeSiHo-Tang extract. but blood flow and renin-angiotensin-aldosterone system unaffected by DaeSiHo-Tang extract. The relaxation effect of DaeSiHo-Tang extract was dependent on the presence of endothelium, showing that DaeSiHo-Tang extract-induced relaxation was not observed in the strips without endothelium. The endothelium-dependent relaxation induced by DaeSiHo-Tang extract was decreased by the pretreatment of $N{\omega}$-nitro-L-arginine or methylene blue, but it was not observed in the strips pretreated with indomethacin or tetraethylammonium chloride. When $Ca^{2+}$ was applied, the strips which were contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But pre-treatment of DaeSiHo-Tang extract inhibited contractile response to $Ca^{2+}$. These results indicate that antihypertensive effect of DaeSiHo-Tang extract is due to descend arterial resistance by the arterial relaxation through the formation of nitric oxide in the vascular endothelial cells.
Keywords
DaeSiHo-Tang; Hypertension; Nitric Oxide; Endothelium; Arterial Relaxation;
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1 何紹奇, 現代中醫內科學, 北京, 中國醫藥科技出版社, pp 263-268, 1991.
2 上海中醫學院, 中醫內科學, 香港, 中華商務聯合印刷有限公司, pp 453-454, 1975.
3 汪訒庵, 醫方集解, 圖書出版 成輔社, 서울, pp 95-96, 1983.
4 陳潮祖, 中醫治法與方劑, 人民衛生出版社, 北京, pp 701-704, 1995.
5 해리슨 번역 편찬위원회, HARRISON’S 내과학( I ), 도서출판 정담, 서울, pp 1202-1220, 1997.
6 金世吉, 風의 病理的 意味糾明과 中風의 原因및 治療에 대한 東西醫學的 比較 大韓韓醫學會誌, 16(1):96-117, 1995.
7 加藤正秀, 柴胡劑の摘出平滑筋に對する作用, 日本藥學雜誌, 102(4):371-380, 1982.
8 Ingrid Fleming, Cytochrome P540 2C is an EDHF Synthase in Coronary Arteries, Trends Cardiovase. Med., 10:166-170, 2000.
9 Victoria, L., Lamb, Annette, J., Schwartz, William, R., Rohn, Lana Kaiser, Cyclooxygenase inhibitors depress norepinephrine constriction of rat abdominal, but not thoracic aorta, European J. of Pharmacol., 256:221-226, 1994.
10 Levi, R. Therapies for perioperative hypertension: Pharmacodynamic considerations, Acta Anaesthesiol. Scand. Suppl., 37(99):16-19, 1993.
11 Roger, A. Johns, Endothelium-derived relaxing factor : Basic review and clinical implications, J. Cardiothorac. Vasc. Anesth., 5(1):69-79, 1991.
12 Gross, F., Robertson, J.I.S., Arterial Hypertension, G.K. Hall & Co., 5:1-6, 1980.
13 이영준, 지규용, 엄현섭, 대시호탕합오령산이 고혈압백서 및 Cholesterol 식이 백서에 미치는 영향, 대한동의병리학회지, 14(2):47-69, 2000.
14 Ignarro, L.J., Harbison, R.G., Wood, K.S., Kadowitz, P.J. Activation of purified soluble guanylate cyclase by endothelium-derived relaxing factor from intrapulmonary artery and vein: Stimulation by acetylcholine, bradyklinin and arachidonic acid, The J. of Pharmacol. and Experimental therapeutics, 237(3):893-900, 1986.
15 Jon, D., Blumenfeld John, H., Largh. Renin system analysis: A rational method for the diagnosis and treatment of the individual patient with hypertension, Am. J. of Hypertension, 11:894-896, 1998.
16 江蘇新醫學院, 中藥大辭典(上), 大城出版社, 大邱, pp 102-108, 706-709, 1508-1511, 1832-1837, 2018-2021, 1984.
17 Fabiato, A., Fabiato, F., Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned cells from adult human, dog, cat, rabbit, rat, and frog hearts and from fetal and new-born rat ventricles, Annuals New York Academy of Sciences, pp 491-521, 1978.
18 Deth, R., Breemen, C. van, Relative contributions of $Ca^{++}$ influx and cellular $Ca^{++}$ release during drug induced activation of the rabbit aorta, Pflugers Arch., 348(1):13-22, 1974.
19 Matthew, R., Weir Victor, J., Dzau. The renin-angiotensinaldosterone system : A specific Target for hypertension management, Am. J. of Hypertension, 12:205S-213S, 1999.
20 박치상, 박창국, 한승동, 박순달, 대시호탕가미방이 고혈압 및 고지혈증에 미치는 영향, 대한한방내과학회지, 19(2):159-184, 1999.
21 許 浚, 東醫寶鑑, 서울, 大成出版社, P 106, 1984.
22 Jose, A., Santiago, Etoi, A., Garrison, Philip, J. Kadowitz, Comparative of N${\omega}$-nitro-L-arginine and N${\omega}$-nitro-L-arginine methyl ester on vasodilator responses to acetylcholine, bradykinin, and substance P, European J. of Pharmacol., 254:207-212, 1994.
23 江蘇新醫學院, 中藥大辭典(上), 大城出版社, 大邱, pp 102-108, 706-709, 1508-1511, 1832-1837, 2018-2021, 1984.
24 李尙仁. 本草學, 圖書出版 修書院, 서울, pp 103-105, 198-200, 295-298, 354-356, 505-507, 1981.
25 盛增秀, 王琦, 臟象槪說, 上海, 上海科學技術出版社, pp 24-27, 36-40, 104-105, 123-133, 1980.
26 Kunio Ishii, Bing Chang, James, F., Kerwin, Jr., Zei-Jing Huang, Ferid murad, N${\omega}$-nitro-L-arginine : a . potent inhibitor of endothelium-derived relaxing factor formation, European J. of Pharmacol., 176:219-223, 1990.
27 王洛生, 中藥藥理與應用, 人民衛生出版社, 北京, pp 67-78, 886-898, 956-965, 1983.
28 何紹奇, 現代中醫內科學, 北京, 中國醫藥科技出版社, pp 263-268, 1991.
29 黃度淵, 對譯 證脈方藥合編, 南山堂, 서울, pp 128-129, 1985.
30 E., Demirel, J., Rusko, R., E., Laskey, D.J. Adams, C., Van Breemen. TEAinhibits ACh-induced EDRF release : endothelial $Ca^{2+}$-dependent $K^{+}$-channels contribute to vascular tone, Am. J. Physiol., 267(heart Circ. Physiol. 36:H1135-H1141, 1994.
31 Bernd Mayer, Friedrivh Brunner, Kurt Schmidt, Inhibition of nitric oxide synthesis by methylene blue, Biochemical Pharmacology, 45(2):367-374, 1993.
32 金完熙 外, 東醫生理學, 서울, 慶熙大學校出版局, pp 99-100, 322-323, 1993.
33 Markus Hecker, Endothelium derived hyperpolarizing factor-Fact or Fiction?, News Physiol. Sci., 15:1-5, 2000.
34 Louis, J., Ignarro, Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein, Circ. Res., 65(1):1-21, 1989.
35 稻木一元, 高血壓症, 治療, 77(6):1779-1784, 1995.
36 Donald, W., Cheung, Guifa Chen, Calcium activation of hyperpolarization response to acetylcholine in coronary endothelial cells, Journal of Cardiovascular Pharmacol., 20(12):5120-S123, 1992.
37 Gloria Segarra, Pascual Medina, Francisco Revert, Salvador Masia, Jose M. Vila, Luis Such, Martin Aldasoro, Modulation of adrenergic contraction of dog pulmonary arteries by nitric oxide and prostacyclin, General Pharmacol., 32:583-589, 1999.
38 趙光勝, 高血壓, 上海, 上海科學技術文獻出版社, pp 123-125, 1991.
39 성호경, 김기환. 생리학, 도서출판 의학문화사, 서울, pp 176, 202-207, 1996.
40 金完熙, 高血壓治療의 辦證에 關한 硏究, 大韓韓醫學會誌, 3(2):3-13, 1982.
41 Paul, M., Vanhoutte, Gabor, M., Rubanyi, Virginia, M., Miller, Donald, S., Houston, Modulation of vascular smooth muscle contraction by the endothelium, Ann. Rew. Physiol., 48:307-320, 1986.