• Journal of the Korea Society for Simulation
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• v.27 no.1
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• pp.15-24
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• 2018

High Level Architecture(HLA) for modeling and simulation is an international technical standard to achieve simulation interoperability and reusability. Building federation through the interworking of federates is being used in various fields and is being used in KR(Key Resolve), UFG(Ulchi-Freedom Guardian) as a representative in domestic military. Currently, United States Department of Defense emphasizes the HLA compliance test, which confirms the compliance of Federate by using HLA. However, due to the limitations of testing tools, an HLA compliance test of DoD is not able to perform some of the functional tests on HLA/RTI services such as federation storage/recovery services and also exclude inspection of exchange data between federates. To solve these problems, this paper proposes an HLA compliance testing system of ROK suitable for domestic situations. This will enable effective HLA compliance testing and improve interoperability between federates.

• Translational and Clinical Pharmacology
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• v.25 no.2
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• pp.63-66
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• 2017

Allopurinol-induced severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome are reportedly associated with the $HLA-B^{\star}58:01$ genotype. Three patients who developed SCARs after allopurinol administration were subjected to HLA-B genotyping and lymphocyte activation test (LAT) to evaluate genetic risk and to detect the causative agent, respectively. All three patients given allopurinol to treat gout were diagnosed with DRESS syndrome. Symptom onset commenced 7-24 days after drug exposure; the patients took allopurinol (100-200 mg/d) for 2-30 days. HLA-B genotyping was performed using a polymerase chain reaction (PCR)-sequence-based typing (SBT) method. All patients had a single $HLA-B^{\star}58:01$ allele: $HLA-B^{\star}13:02/^{\star}58:01$ (a 63-year-old male), $HLA-B^{\star}48:01/^{\star}58:01$ (a 71-year-old female), and $HLA-B^{\star}44:03/^{\star}58:01$ (a 22-year-old male). Only the last patient yielded a positive LAT result, confirming that allopurinol was the causative agent. These findings suggest that patients with $HLA-B^{\star}58:01$ may develop SCARs upon allopurinol administration. Therefore, HLA-B genotyping could be helpful in preventing serious problems attributable to allopurinol treatment, although PCR-SBT HLA-B genotyping is time consuming. A simple genotyping test is required in practice. LAT may help to identify a causative agent.

• Journal of the military operations research society of Korea
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• v.30 no.1
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• pp.81-91
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• 2004

Since HLA (High Level Architecture) was selected as a standardized distributed simulation architecture by US DoD in order to guarantee interoperability among all types of simulations, weapons system and C4I systems, to improve reusability of developed models in mid 1990s, a large number of federates have been developed and certified in accordance with HLA specifications. This paper illustrates case studies on HLA compliance test which are helpful for developers and managers. Based on experiences obtained from international HLA compliance test of CJ21_NG being developed for ground warfare simulation during ROKA's BCTP and UFL exercises, compliance procedures of US Defense and Modelling Simulation Office (DMSO) are introduced, and detail information at each phase of compliance test is provided.

• Journal of the Korea Society for Simulation
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• v.26 no.1
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• pp.1-11
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• 2017

During the past several years the ROK military has made an effort to build LVC synthetic battlefield that reflects the real world environment. In spite of its efforts, little has been accomplished. The disappointing achievement is mainly due to the lack of operational requirements and concepts, and policies or systematic approaches on the architecture and technology. Furthermore, there is insufficient understanding on the basic concepts and principles, and conflicting interests between organizations. In this study, I propose to construct an LVC based on the HLA that focuses on the system view and technical standard view, rather than the operational view. The proposed approach employs the information centric integration, focuses on an architecture convergence efforts based on the HLA/RTI, emphasizes the HLA compliance test and federation test, adapts to DSEEP, DMAO, and FEAT, and finally invents and implements an LVC Compliance Test System.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.749-752
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• 2003

The HLA is defined by three components: (1) Rules, (2) the HLA Interface Specification, and (3) the Object Model Template(OMT). The RTI(Run-Time Infrastructure) software implements the interface specification. It provides services in a manner that is comparable to the way a distributed operating system provides services to applications. A way to test whether is suitable for a standard, and all service was implemented is tested through two phases of processes to verify the RTI which proposed in DMSO. In this paper, we discuss Level One Test Procedures and a method. Confirms whether RTI was implemented in Interface Specification according to Level One Test Procedures appropriately through a test. Develops Test Suite for every each step to test whether a correct command and the expected results are occur.

• Journal of the Korea Society for Simulation
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• v.12 no.4
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• pp.41-50
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• 2003

HLA (High Level Architecture) is the object, time, and interface standard that proposed for distribution simulation in the US Department of Defense. The HLA is defined by three components: Rules, the HLA Interface Specification, and the Object Model Template (OMT). The RTI (Run-Time Infrastructure) software implements the interface specification. It provides services to simulation applications. To test whether a RTI software is suitable for the standard and all service was implemented is performed through two phases of processes proposed by DMSO. In this paper, we implement Level One Test Procedures of DMSO and apply to NetCust's RTI software. The experimental results are discussed.

• Korean Journal of Biological Psychiatry
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• v.1 no.1
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• pp.79-87
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• 1994

For the purpose of evaluating the human leukocyte antigen(HLA) disease-association with bipolar disorder, HLA class I and class II allelic frequencies were assessed in 37 bipolar patients and were compared to the data from normal population. HLA class 1 typing was performed with microlymphocytotoxicity method while class II(DRB1) genotyping with reverse dot blot hybridization and sandwich method. Statistical analysis consisted of relative risk, Haldane's modified relative risk, Fisher's exact test and Bonferoni's corrected P. The results were as follows : 1) Bipolar patients showed increased allelic frequency of HLA A3 which has statistical significance. 2) Allelic frequencies of HLA B7, B14 and B54 were higher, while those of B51 and B55 were lower in bipolar patients, but they were not statistically significant. 3) Both of increased frequencies of DR2 in bipolar patients and DR15 in normal controls had statistical significance. The results of the present study suggested that some of HLA allelic types might be associated with bipolar disorder. To clarify the genetic influence of HLA to bipolar disorder, we should do consecutive study of bipolar disorder with new information about HLA system including alleles.

• Neonatal Medicine
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• v.16 no.2
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• pp.248-254
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• 2009

Neonatal alloimmune thrombocytopenia (NAIT) is induced by maternal antibodies to fetal platelet alloantigens. Because the main cause of NAIT is incompatibility to platelet specific antibodies, NAIT due to HLA antibodies are relatively rare. We managed a case of NAIT induced by maternal anti-HLA-B35 antibodies. The patient was a second born male. He had no petechiae or purpura at birth. He was admitted to the hospital due to fever for 5 days and a platelet count of $106\times10^9/L$. The fever subsided after admission but on the 2nd day of admission, petechiae developed on the chest wall and the platelet count decreased to $25\times10^9/L$. Other laboratory findings included C-reactive protein, prothrombin time, and partial thromboplastin time were normal. His mother's platelet count was normal and she had no history of bleeding. Anti-HLA-B35, B52, B56, C3, and C14 were identified in the mother's serum by a panel reactive antibody test and HLA-B35 antigen was identified in the father's and patient's sera. These finding suggested that maternal Anti-HLA-B35 antibody was a response to neonatal HLA-B35 antigen inherited from the father. The patient received concentrated platelet and intravenous immunoglobulin. The platelet count rose to $248\times10^9/L$ and was maintained thereafter.

• Childhood Kidney Diseases
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• v.12 no.2
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• pp.133-142
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• 2008

For solid organ transplant, ABO blood type of donor and recipient should be compatible in principle. Recent improvement of immunosuppressant made HLA typing not so important while no-mismatch transplant still shows the longest graft survival. PRA(panel reactive antibody) test is to screen and identify recipients with HLA sensitization. When solid organ transplant is scheduled, cross-match test of donor cell and recipient serum should be performed and positive result of cross-match prohibits transplantation. Donor specific antibody(DSA) test can predict the severity of recipient immune reaction against donor organ. Today's mainstay of allograft immunosuppressant regimen is triple therapy of steroid, calcineurin inhibitor(cyclosporine, tacrolimus), azathioprine or mycophenolate mofetil(MMF). Antibody induction using Thymoglobulin or anti-IL-2 receptor antibody(basiliximab or daclizumab) is frequently practiced as well.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.7007-7010
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• 2013

Background: In the literature, data concerning the relationship between breast cancer and HLA class II gene polymorphisms are limited, so the aim of this study was to determine if HLA-DQB1 and HLA-DRB1 MHC class-II alleles may confer susceptibility or resistance to the disease among Jordanian females. Materials and Methods: This case control study enrolled 56 Royal Hospital breast cancer patients and 60 age matched healthy controls, all of whom provided blood samples (2011-2013). A questionnaire was filled after signing a consent form and DNA was extracted, nucleic acids being amplified for assessment of HLA-DQB1 and HLA-DRB1 alleles by muliplex INNO-LiPA and allele typing carried out by reverse hybridization. Comparison of HLA-DQB1 and HLA-DRB1 allele distributions was carried out with paired t-test and chi-square statistics. Risk factors were assessed by odd ratios with 95% confidence intervals. Results: A significant negative correlation was observed between $HLADQB1^*$ 02 alleles and breast cancers (p=0.013). No significant associations were observed among $HLADQB1^*$ 03, 04, 05 and 06 or among $HLA-DRB1^*$ 01, 03, 04, 07, 08, 10, 11, 13, 14 and 15. Conclusions: $HLADQB1^*$ 02 alleles may provide positive protection against breast tumor risk among Jordanians, but not $HLADQB1^*$ 03, 04, 05 and 06 or $HLA-DRB1^*$ 01, 03, 04, 07, 08, 10, 11, 13, 14 and 15 alleles.