• Clinical and Experimental Pediatrics
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• v.48 no.6
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• pp.624-633
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• 2005

Purpose : This study analyzed the expression of HLA-DR and DQ genotypes and anti-thyroid autoantibodies[anti-thyroid peroxidase(TPO) and anti-thyroglobulin(TG) antibodies] in Korean patients with type 1 diabetes(T1DM) to investigate the susceptible HLA alleles to T1DM in Korea and the prevalence of thyroid autoantibodies and their significance for the development of thyroid disorders. Methods : A total of 59 Korean patients with type 1 diabetes[26 males, median age 13.7 years(range 5.7-29.9 years), diabetes duration 7.6 years(-1.7-22.5 years)] were enrolled in this study, and 200 healthy Koreans without a family history of diabetes were selected as a normal control for the comparison of HLA genotypes. Seventeen patients with anti-TPO or anti-TG were followed [median duration 3.96 years(1 day-10.7 years)] with measurement of anti-TPO, anti-TG, $T_3$, $T_4$ or free $T_4$, TSH levels and physical examinations. HLA-DR and DQ genotyping were done by PCR-SSO, PCR-SSCP, PCR-RFLP and PCR-SSP methods. Results : HLA analysis showed higher frequencies of HLA-DRB1*0301, *090102 and DQB1*0201, *030302 alleles, DRB1*0301/*090102, *090102/*090102 and DQB1 *0201/*030302, *030302/*030302, *0201/ *0302 genotypes in T1DM patients compared to controls(Pc<0.05). Fifteen(25.4 percent) had anti-TPO antibody, 12(20.3 percent) had anti-TG, 17(28.8 percent) had either autoantibody and 10(16.9 percent) had both autoantibodies. No clinical or subclinical hypothyroidism developed during follow-up after the first detection of anti-thyroid autoantibody. There was no significant correlation between thyroid autoimmunity and gender, onset age of T1DM, and diabetes duration, respectively(P>0.05). Conclusion : We thought this unique HLA-DR, DQ allele distribution might be an important factor for the low incidence of T1DM in Korea. And a high prevalence of thyroid autoantibodies in these populations suggests examinations of thyroid antibodies should be performed regularly. Optimal age for the initial screening and the frequency of re-screening for associated thyroid autoimmune diseases in T1DM remains to be determined through prospective follow-up.

• Tuberculosis and Respiratory Diseases
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• v.54 no.4
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• pp.367-377
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• 2003

Background : It is well known that only 10% of those infected with Mycobacterium tuberculosis actually develop clinical disease, indicating the existence of host genetic factors regulating disease expression. In this study, we investigated HLA-DRB1 and -DQB1 gene polymorphisms in Korean patients with pulmonary tuberculosis (PTB). Methods : HLA-DRB1 and -DQB1 gene polymorphisms were investigated in 67 PTB patients without previous treatment history, 38 drug-sensitive (DS) and 29 multidrug-resistant (MDR) cases, and 200 healthy controls. HLA-DRB1 typing was done using reverse SSO (sequence specific oligonucleotide) and PCR-SSCP (single strand conformational polymorphism) methods and DQB1 typing was done using PCR-RFLP (restriction fragment length polymorphism), PCR-SSCP and PCR-SSP (sequence specific primer) methods. Results : Among the PTB patients, MDR-TB cases showed frequencies of DRB1*0701 and *08032 increased by about two-fold compared to those of normal controls, and likewise for their associated DQB1 alleles, DQB1*0202 and *0601 (15.5% vs. 34.5%, p=0.01). The frequency of HLA-DQB1*0609 was significantly increased in PTB patients (4.0% vs. 14.9%, p=0.004), showing similar increases in both DS and MDR cases. There was also an association of HLA alleles with the clinical severity of the disease according to the extent of lung lesion. Significantly increased frequencies of DRB1*08032 (4.2% vs. 32.6%, p=0.007) and DQB1*0601 (12.5% vs. 34.9%, p=0.047) were observed in more advanced (moderately & far advanced/DS and far advanced/MDR), compared with less advanced (minimal/DS and moderately advanced/MDR) lung lesions. Although DRB1*0701, DQB1*0202 and DQB1*0609 showed significant increases in different subsets of the disease, these HLA alleles did not show consistent association with disease severity. Conclusion : HLA-DRB1*08032 and DQB1*0601 alleles were associated with genetic susceptibility to MDR-TB in Korean patients, and also with disease severity and progression of PTB.

• Transactions of the Korean Society of Automotive Engineers
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• v.4 no.6
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• pp.97-108
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• 1996

A modeling technique is proposed for dynamic simulations of OHC valve trains with HLA(hydraulic lash adiuster). HLA is expressed by an air-oil mixture model considering HLA leak-down and aeraton effects. A compact nonlinear equation is derived which describe the short term dynamic behavior of the HLA. Valve spring is analyzed by a distributed parameter model including nonlinear characteristics in the spring surge phenomena. Global behavior of the remaining valve train is expressed by a lumped mass model. The experiental results prove that the simulation model developed here is accurate and useful for the dynamic simulations of OHC valve trains with HLA.

• Proceedings of the Korea Society for Simulation Conference
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• 2002.11a
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• pp.53-57
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• 2002

최근들어 분산 시뮬레이션을 위해 미국 국방성에서 제안한 HLA(High Level Architecture)를 산업계에 적용하기 위하여 미들웨어 개발이 활발하다. 주요 응용분야는 게임 및 다자간 회의 시스템, 실시간 제어 시스템 등이다. 본 논문에서는 (주)넷커스터마이즈가 HLA Spec. 1.3 표준안에 기반하여 순수 Java 언어를 사용하여 개발한 미들웨어인 Java/RTI를 소개한다. Java/RTI는 Java 언어만을 사용함으로써 운영체제에 제한을 받지 않고 RTI의 이식이 가능하게 하여 이식성을 크게 향상시켰다 또한, HLA 규격이 요구하는 모든 기능을 자체 개발함으로써 향후 RTI의 성능 및 서비스 확장을 위한 기반을 마련하였으며 실시간 제어 및 VOIP 응용 소프트웨어 개발을 통해 개발 편의성 및 성능이 검증되었다. RTI의 실행 환경을 모니터링 할 수 있는 소프트웨어까지 개발함으로써 소프트웨어의 운용 및 관리 효율성을 높였다. 본 논문에서 소개한 Java/RTI는 군사용 분산 시뮬레이션은 물론 게임, 실시간 제어 소프트웨어 등 다양한 분야에 응용될 수 있으며 현재 팩키지 소프트웨어로 상품화가 추진중에 있다. 또한, 개발된 Java/RTI를 확장하여 실시간 환경에서 QoS(Quality of Service)를 제공하는 성능 측정자 및 자원 관리자를 개발 중에 있다.

• Proceedings of the Korea Society for Simulation Conference
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• 2002.11a
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• pp.85-89
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• 2002

Development of distributed simulation environment must be required in order to simulate the distributed models regionally and inter-operate with running simulations individually, Simulation based on DEVS formalism is difficult to simulate the distributed models. DEVS formalism is modeling methodology. To specify model, this formalism separates behavior and structure, therefore it is able to design complex model easily. HLA is standard framework of distribute simulation environment, It is defined to facilitate the interoperability and the reusability. RTI (Run Time Infrastructure) is software that provides common service to simulation systems and implementation of the HLA Interface Specification. Method of implementation is that modules cooperating with RTI are added to simulator on DEVS simulation environment. On the DEVS simulation environment (DEVS-Obj -C) that already developed, Highest class of abstract simulator uses service that RTI provide, then This environment is able to change DEVS model into Federate and run distribute simulation that inter-operates with the RTI. Because this distributed simulation environment includes convenience of modeling that obtains through the DEVS formalism and accompanies HLA standard, this environment make it possible to simulate with_ complex systems and heterogeneous simulations

• Annual Conference of KIPS
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• 2005.11a
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• pp.783-786
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• 2005

HLA는 상호 운용성과 재사용성을 목적으로 미국 국방성 산하 기관인 DMSO에서 개발되어진 분산 시스템 프레임워크이다. 이러한 HLA가 민간 부분 적용을 위해 표준이 발표되었고, HLA는 여러 분야의 범용성을 가지기 위해 복잡한 구현 시스템을 가지게 된다. 특히, 객체의 속성변화를 반영하기 위해서는 많은 통신 부하가 발생한다. 이런 단점을 해결하기 위해 제안하였던 객체 관리 모듈을 이용한 항공 교통관제 시뮬레이션을 구현하여 객체 관리 모듈의 성능 및 적용 분야를 평가한다.

• Proceedings of the Korea Society for Simulation Conference
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• 2003.06a
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• pp.179-184
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• 2003

HLA-RTI is middleware for the distribute simulation that developed in the US Department of Defense. This provides fast accomplishment speed and reliability than distribute simulation Middleware by transfer. However, DDM(Data Distribution Management) service is used as data filtering technology in the existing HLA-RTI. As for this, the problem that network traffic increases in data exchange between the mobility simulation objects is generated. it proposes applying agent technology to the mobility simulation object in order to solve these problems in this paper in this. And this paper applies that to practical simulation and analyzes performance between each data filtering technology with comparison.

• Journal of the Korea Society for Simulation
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• v.14 no.3
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• pp.79-90
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• 2005

There are plenty of optimization models for the signal-system of a single intersection and area traffic. Some of those models are adopted for the real traffic signal control system. The simulators for a single crossroad have been developed, so that we could evaluate optimization models and traffic control systems. However, the simulators for the area traffic are still being developed. Therefore, there are many limitations in the analysis and evaluation for area traffic control system. The area traffic is consisted of several intersections which are very complicated and many traffic strategies are adopted for the control system. This paper features an effective area traffic control system based on the High Lever Architecture(HLA). In this paper, we discuss the design of HLA-based area traffic control simulation. We describe technical motivations for the HLA, the key elements of the architecture and how they are minimum and essential to the goal of reuse and interoperability. A distributed simulation with HLA/RTI provides stable and satisfactory experimental results. Moreover, the prototype traffic control system provides reliable accomplishment compared to the NETSIM and TRANSYT-7F models.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.6
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• pp.1081-1090
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• 2011

High Level Architecture(HLA) is a specification for interoperation among heterogeneous simulators which are executed in a distributed environment. HLA originally allows a number of federates to join in a federation using a single RTI(Run-Time Infrastructure). To interoperate federations without modifying RTI, agent federate, which represents behavior of a federation, can be used. Agent federate can use MOM(Management Object Model) service or agent-user protocol to acquire information of a federation. This paper performs various experiments to measure performance of two architectures. MOM service shows a loss of performance but can be applied without modifying user federates. Experiment results can be used to determine appropriate architecture for interoperation of federations.

• Tribology and Lubricants
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• v.11 no.4
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• pp.1-12
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• 1995

여러 가지 필수적인 윤활유 성상과 함께 요즘 개발된 엔진에서 요구되는 중요한 특성 중 하나가 윤활유 내의 공기 혼입(aeration) 문제이다. 만일 윤활유 내에 공기가 일정 한도 이상 혼입되면 윤활유가 수행하는 일반 기능 중 하중을 분산시키는 압력 분산 작용과 윤활 작용 및 마찰열을 식혀 주는 냉각 작용이 제대로 되지 않아 엔진 수명과 내구성에 심각한 문제를 초래한다. 특히 현재 밸브 소음 저감 및 정비성 향상을 위해 대부분의 엔진에서 채용하고 있는 hydraulic valve lash adjuster(HLA)에 미치는 영향이 가장 심각하다. HLA는 그 작동 특성이 엔진 오일의 비 압축성을 이용하고 있기 때문에 만일 HLA 내부의 고압실에 공기가 오일에 섞여 들어간다변 밸브 시스템 강성이 떨어지게 되어 오히려 HLA 사용 목적에 반해 밸크 이상 거동에 의한 소음이 유발될 뿐만 아니라 심하면 밸브가 파단되는 심각한 현상이 초래되기도 한다. 상기한 바와 같이 aeration 현상은 경우에 따라 매우 심각한 문제를 유발하기도 하며 엔진이 고속 고출력화 하면서 그 특성은 더욱 관심사가 되어 왔다. 따라서 엔진 각 부분의 올바른 기능과 신뢰성 확보를 위해 aeration의 특징 발생 원인 및 대책을 살펴보고 특히 oil aeration이 HLA와 엔진 베어링에 미치는 영향에 대해 분석 고찰해 봄으로써 그 특성을 이해하고자 한다.