• Childhood Kidney Diseases
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• v.12 no.2
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• pp.133-142
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• 2008

For solid organ transplant, ABO blood type of donor and recipient should be compatible in principle. Recent improvement of immunosuppressant made HLA typing not so important while no-mismatch transplant still shows the longest graft survival. PRA(panel reactive antibody) test is to screen and identify recipients with HLA sensitization. When solid organ transplant is scheduled, cross-match test of donor cell and recipient serum should be performed and positive result of cross-match prohibits transplantation. Donor specific antibody(DSA) test can predict the severity of recipient immune reaction against donor organ. Today's mainstay of allograft immunosuppressant regimen is triple therapy of steroid, calcineurin inhibitor(cyclosporine, tacrolimus), azathioprine or mycophenolate mofetil(MMF). Antibody induction using Thymoglobulin or anti-IL-2 receptor antibody(basiliximab or daclizumab) is frequently practiced as well.

• Journal of the Korea Society for Simulation
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• v.22 no.2
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• pp.73-83
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• 2013

This paper presents design and implementation of the monitoring system for the distributed simulation of underwater warfare. As importance of defense modeling and simulation(M&S) has raised, Simulation-Based Acquisition(SBA) was authorized for an obligatory process in the development process of weapon systems. Yet, it requires tremendous resources to develop a large-scale simulation system that describes complex and broad battlefields. Therefore, an approach of the distributed system was devised to develop a new simulation system combining legacy simulators that were developed for confined purpose and sole operations. High-Level Architecture(HLA) of distributed systems is a standardized protocol by IEEE for the distributed simulation system and Run-Time Infrastructure(RTI) is an implementation of HLA to structure efficient distributed systems. The main objective of this paper is to derive appropriate monitoring factors for underwater warfare simulation, design and implementation of the monitoring system to analyze the factors based on HLA/RTI.

• Journal of the Korea Society for Simulation
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• v.24 no.1
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• pp.9-16
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• 2015

In this paper, the multi-resolution simulation of standard linkage architecture is consists of the engineering-level (QUEST), engagement-level (SADM), the mission-level (EADSIM). It was developed the engineering-level model using battle experiment integrated development environment in the battle experimental engineering system. The engagement level model was developed using the SADM and the mission-level model was developed using EADSIM. The standard linkage architecture is designed and implemented in order to interlocking model of multiple layers. Each different simulation programs in a distributed environment was designed by HLA interface specifications for satisfying interworking. Also the integrated interoperation gateway was developed for relaying the each different simulation programs. The effective naval weapon system for measure of effectiveness develops using to improve the fidelity of the model between the various layers through multi-resolution interoperation simulation. According to the operator requirement is quickly battlefield environment can be constructed. The other simulation program that being designed through standards linkage architecture can linkage easily and efficiently.

• Journal of KIISE
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• v.42 no.5
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• pp.621-628
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• 2015

The rapid growth of network technology makes the high-tech weapon. Thus, in the modern war, the ability to immediately use of the high-tech weapon is important. To realize this ability, continuous trainning is necessary but, this trainning spends many money. To improve the budget efficiency, Modeling and Simulation(M&S) are used. However, they seriously decrease the reality. Recently, the system which can support the combination of Live with Virtual simulation is on the rise. The typical example is L-V-C Environment and many kind of middleware which can support the L-V-C Envrionment are already proposed. Previous middleware can support the interoperability between different simulations but, it cannot completely interoperate three(Live, Virtual, Constructive) simulation environments. In this paper, to solve this problem, we propose the scheme which is combination between different middlewares. And we conduct the API mapping between HLA and DDS which are typical middleware and verify the scheme.

• The KIPS Transactions:PartD
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• v.12D no.5 s.101
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• pp.709-718
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• 2005

To correspond with the unpredictable future tactical environment, Ive expanded the application of M&S(Modeling & Simulation) that is more scientific and more economic in a field of weapon system development process. This paper describes experience in development of ADSF(Air Defense Simulation Framework) that supports not only HLA(High Level Architecture) which is an international standard in M&S but also TCP/IP as well as real-time distributed simulation. ADSF has been applied to the M-SAM(Medium Range Surface to Air Missile) System Simulator, and satisfying test results through GPS(Global Positioning System) timer has been acquired. As a result, an ADSF which is able to support HLA and TCP/IP as veil as precise real-time simulation has been successfully made. we were in need or a real-time simulation engine to support Air Defense System Simulators that were consisted of several subsystems.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2004.06a
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• pp.85-85
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• 2004

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1247-1251
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• 2012

Background: Helicobacter pylori is an important gastrointestinal pathogen related to the development of not only atrophic gastritis and peptic ulcer, but also gastric cancer. Human leukocyte antigens (HLA) may play particular roles in host immune responses to bacterial antigens. This study aimed to investigate the association between HLA-DQA1 and DQB1 genotypes and haplotypes vs H. pylori infection in an Indonesian population. Methods: We selected 294 healthy participants in Mataram, Lombok Island, Indonesia. H. pylori infection was determined by urea breath test (UBT). We analyzed HLA-DQA1 and DQB1 genotypes by PCR-RFLP and constructed haplotypes of HLA-DQA1 and DQB1 genes. Multiple comparisons were conducted according to the Bonferroni method. Results: The H. pylori infection rate was 11.2% in this Indonesian population. The DQB1*0401 genotype was noted to be associated with a high risk of H. pylori infection, compared with the DQB1*0301 genotype. None of the HLA-DQA1 or DQB1 haplotypes were related to the risk of H. pylori infection. Conclusions: The study suggests that HLADQB1 genes play important roles in H. pylori infection, but there was no statistically significant association between HLA-DQA1 or DQB1 haplotypes and H.pylori infection in our Lombok Indonesian population.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.3
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• pp.132-142
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• 2023

Human leukocyte antigen (HLA) typing was performed in the diagnostic immunology laboratory of the Seoul National University Hospital. Among 611 HLA-DR tests, specific bead reactions suspected of being false positive and false negative in Lot 20 reagents were found. Therefore, we aimed to identify the factors causing cut-off corrections by examining cases where cut-off corrections were not made for 533 test results and cases where cut-off corrections were made for 78 cases after the cut-off corrections of specific beads. Frequency analysis was conducted to verify the demographic characteristics, and descriptive statistics were used to assess the humidity in the laboratory as a variable. Cross-tabulation was done to examine the association between cut-off corrections and demographic characteristics. Independent samples t-tests were conducted to verify the difference in humidity based on cut-off corrections. Finally, logistic regression analysis was conducted to examine the relationship between humidity levels and the rate of cut-off corrections, and results showed as the humidity level in the laboratory highs, the number of cut-off corrections decreased by a factor of 0.986. This suggests cut-off corrections rate increases when the humidity lowers. Therefore, it indicates that humidity in the laboratory is also a factor that affects HLA typing results.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.749-752
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• 2003

The HLA is defined by three components: (1) Rules, (2) the HLA Interface Specification, and (3) the Object Model Template(OMT). The RTI(Run-Time Infrastructure) software implements the interface specification. It provides services in a manner that is comparable to the way a distributed operating system provides services to applications. A way to test whether is suitable for a standard, and all service was implemented is tested through two phases of processes to verify the RTI which proposed in DMSO. In this paper, we discuss Level One Test Procedures and a method. Confirms whether RTI was implemented in Interface Specification according to Level One Test Procedures appropriately through a test. Develops Test Suite for every each step to test whether a correct command and the expected results are occur.

• Journal of Genetic Medicine
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• v.11 no.1
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• pp.1-10
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• 2014

Type 1 diabetes (T1D) is a chronic autoimmune disease characterized by selective destruction of pancreatic ${\beta}$-cells resulting in insulin deficiency. The genetic determinants of T1D susceptibility have been linked to several loci, in particular to the human leukocyte antigen (HLA) region, which accounts for 50% of the genetic risk of developing T1D. Multiple genes in the HLA region, which are in strong linkage disequilibrium, are thought to be involved. Another important locus, with a smaller effect on genetic predisposition to T1D, is the insulin gene. The advent of numerous single nucleotide polymorphism markers and genome screening has enabled the identification of dozens of new T1D susceptibility loci. Some of them appear to predispose to T1D independently of the HLA and may be important in families with T1D who lack strong HLA susceptibility. Other loci may interact with each other to cause susceptibility. The autoimmune response against ${\beta}$-cells can also be triggered by environmental factors in the presence of a predisposing genetic background. Deciphering the environmental and genetic factors involved should help to understand the origin of T1D and aid in the design of individualized prevention programs.