• Korean Journal of Psychosomatic Medicine
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• v.22 no.1
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• pp.31-39
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• 2014

Objectives : This study aimed to investigate the psychiatric status of HIV-infected/AIDS inpatients in a general hospital over the past 2.5 years. Methods : A retrospective chart review was conducted of psychiatric consultations performed between January 1, 2011, and July 30, 2013. The records of 97 HIV-infected/AIDS patients were analyzed. These included a total of 282 psychiatric consultations. Results : Of the 97 patients, 91(93.8%) were male, the mean age was 48 years, and mean number of consultations was 2.8. Depressed mood was reported in 102 consultations(23.8%), insomnia in 60(14.0%), and anxiety in 31(7.2%). Psychiatric disorders diagnosed on initial consultation included depressive disorder(37 patients ; 37.0%), cognitive disorder(11 ; 11.0%), and delirium(9 ; 9.0%). Recommended psychotropic medication included Lorazepam(99 ; 17.2%), Escitalopram(90 ; 15.7%), and Quetiapine(84 ; 14.6%). Conclusions : The main complaints of HIV-infected/AIDS patients were depressed mood, insomnia, and suicidal ideation(including suicide attempts). In total, 85(93.3%) patients of those consulted were diagnosed as meeting the criteria for a psychiatric condition. However, considering that only 16.9% of patients consulted received follow-up treatment, longitudinal research is needed to examine the influence of psychiatric disorders on the transmission of HIV-infection/AIDS, as well as on prognosis and treatment adherence.

• Tuberculosis and Respiratory Diseases
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• v.61 no.6
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• pp.554-561
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• 2006

Background: In AIDS patients, the respiratory tract is one of the most frequently involved site of by an opportunistic infection, and an even common, casual pulmonary infection manifests in a peculiar ways in AIDS patients. In Korea, because of the low prevalence of AIDS, there is insufficient data compared with other Southeast Asian counties. However, considering the sexual behavior of the younger generation, it is expected that it will not be long before AIDS becomes a major public health issue in Korea. This study examined the clinical manifestation of HIV positive people and AIDS patients. The pulmonary manifestion of HIV-positive was evaluated. This study focused on the differences in the clinical manifestation between AIDS patients with pulmonary disease and simple HIV positive people. The characteristics of common pulmonary infections in AIDS patients were also analyzed. Method: The medical records of 28 HIV positive patients who visited the hospital of ChungAng University Hospital from January, 2001 to February, 2006 were analyzed retrospectively. Result: Twenty-seven patients out of 28 HIV positive patients were male and the average age was 40.6(23-65). Patients in their thirties were most commonly affected. Elven patients had pulmonary diseases. Pulmonary tuberculosis (4 cases) and pneumocystis pneumonia (4 cases) were the most common respiratory infection. One patient showed a peculiar type of systemic cryptococcus. which was accompanied by lung and pleural dissemination. The CD4+lymphocyte count of patients with a pulmonary infection was significantly lower in patients with a pulmonary manifestation than those with only a HIV infection ($79.5/mm^3$ vs $400/mm^3$, respectively)(p<.05). Patients with pulmonary disease were in a more severe immunosuppressive state. There were 4 patients with pulmonary tuberculosis, 4 with pneumocystis pneumonia, 4 with secondary syphilis, 2 with primary syphilis, and 2 with HZV infection. The average CD4 lymphocyte counts was $56/mm^3$ in those with pulmonary tuberculosis, $42/mm^3$ in those with pneumocystis pneumonia, and $455/mm^3$ in those with secondary syphilis. Conclusion: This study examined the clinical manifestation of HIV positive patients, particularly AIDS patients with pulmonary disease, A more severe immunosuppressive status was observed in HIV-related pulmonary compared with those with HIV-related extrapulmonary disease, and the frequency of pulmonary tuberculosis in pulmonary disease was higher than expected. Respiratory infection in AIDS manifest in uncommon ways e.g. disseminated cryptococcosis involving the lung and pleura. Evidently, AIDS patients with a respiratory infection have a more severe form of immunosuppression than those with a simple HIV infection. As expected, patients with a pulmonary infection were in a more severe immunosuppressed state than those with a simple HIV infection. Opportunistic infections can show peculiar clinical presentations in AIDS patients.

• Journal of Korean Academy of Nursing
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• v.27 no.1
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• pp.201-211
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• 1997

This study was an evaluation study of AIDS education program. The purpose of this study was to clarify the education effects on AIDS for health care workers to develop a better next education program. This study was done by self reporting with a 67 items of structured questionnaire by 431 health care workers included doctors, nurses, laboratory technicians, and health educators. Data were collected at the time of completion of each AIDS education with the help of education program manager. Both the AIDS related knowledge score and the acceptance attitudes score were significantly higher in the male group, in the medical institution employer group, in the group who have met the HIV infected person, who has known the HIV positive person, and the group of laboratory technician, but the AIDS prevention intention score was statistically higher in the group of female and laboratory technician group. The post education scores of AIDS related knowledge. acceptance attitudes, and preventive intention were statistically higher than those of the preeducation. The most increased item among AIDS prevention intention list was 'I will provide the meeting between the HIV infected persons and the public (+21.9%)'. But even the decreased item among AIDS prevention intention list was 'I will advice to female not to have extra marital sexual contact to avoid AIDS(-3.1%)'. It could be concluded that the health care workers were ignorant of vertical transmission of AIDS, they were afraid of disclosing the infection status, and have less AIDS prevention intention. Therefore it is needed to take an assessment process before each new education trategy to increase AIDS related the effect of the education on AIDS.

• Korean Journal of Adult Nursing
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• v.26 no.2
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• pp.234-243
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• 2014

Purpose: The purpose of this study was to investigate the factors influencing the health-promoting behaviors of the people living with HIV. Methods: Descriptive cross-sectional study design was used. The study participants included 99 people living with HIV recruited via the Korea HIV/AIDS Network of Solidarity from May 15 to August 15, 2012. Self-report questionnaires were used fo data collection measuring perceived stress, depression, self-efficacy, health-promoting behaviors (HPLP-II), and the perceived health status. The analysis was done using SPSS/Win 18.0 program. Descriptive statistics, pearson correlation, t-test, ANOVA and stepwise multiple regressions were used for data analysis. Results: Perceived stress (r=-.21, p=.040), depression (r=-.37, p<.001), self-efficacy (r=.42, p<.001), perceived health status (r=.29, p=.003), and health-promoting behaviors were significantly correlated with each other. The self-efficacy, religion and perceived health status were significant factors, which explained about 26% of the variance of the health-promoting behaviors. Multiple regression analysis showed that a powerful predictor of health-promoting behaviors among people living with HIV was self-efficacy. Conclusion: This study suggested that a focus of nursing intervention program on self-efficacy is necessary in order to increase health-promoting behaviors among people living with HIV.

• The Korean Journal of Food & Health Convergence
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• v.6 no.4
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• pp.17-19
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• 2020

HIV/AIDS disease still remain a global pandemic and it's management has undergone series of treatment changes and improvement although there is still no permanent cure.Dolutegravir belongs to a group of HIV drugs called integrase inhibitors. Integrase inhibitors block an HIV enzyme called integrase. By blocking integrase, integrase inhibitors prevent HIV from multiplying and can reduce the amount of HIV in the body.Dolutegravir combination based regimen has turned out to be very effective (antiviral) with negligible rare side effects on clients. This drug (Dolutegravir based regimen) combination has successfully increased the appetite for food of all the clients, unlike others and has shown to reduce viral load in the most shortest period ever. It can be deduced that development of resistant mutant virus will be reduced if not eliminated with dolutogravir based regimen.The role of Continuous adherence counseling has shown to improve clients treatment management. It is important to note that the availability of food has direct effect on the economic status or financial weight on the client. Hence the progress that is increase in body mass index (BMI) is a direct impact of the availability of food for the clients.

• Korean Journal of Occupational Health Nursing
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• v.17 no.1
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• pp.14-22
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• 2008

Purpose: The purpose of this descriptive study was to examine the knowledge, attitudes and prevention behavior to AIDS of nurses. Method: The subject of this study were 217 nurses in Busan. Data was analyzed by using descriptive statistics, t-test, ANOVA, Pearson's correlation, and Scheffe's test. Results: Total knowledge of AIDS(mean score was 6.71 out of 12) was average. Total attitudes of AIDS(mean score was 13.16 out of 25)was average. Prevention behaviors were above average(mean score was 57.63 out of 75). According to the results of analyzing the difference between general characteristics of the subject and AIDS related knowledge, attitudes and prevention behaviors, a significant difference was present with religion(p<.05) in attitudes score; with age(p<.001), marital status(p<.001), education level(p<.05), position(p<.05) and clinical experience(p<.05) in prevention behaviors. According to the results of analyzing the difference between AIDS related characteristics of the subject and AIDS related knowledge, attitudes and perceived behaviors, a significant difference was present with experience in taking care of HIV/AIDS patients(t=2.19, p<.05) in attitudes score; and experience in HIV positive after care(t=-2.64, p<.01) and general nursing training about AIDS(t=2.23, p<.01). There was a positive correlation among knowledge score and attitudes score(r=.170, p<.05). Conclusion: These findings suggested that AIDS education and training programs should be developed and run for nurses. Expecially, health education related with AIDS is needed in young and less experienced nurses. In following such a program, there will be greater compliance with prevention behaviors. Furthermore, it is necessary to provide work-related guidelines regarding AIDS for nurses.

• Korean Journal of Health Education and Promotion
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• v.14 no.2
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• pp.125-147
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• 1997

This study was conducted in order to identify the extent to which Health Belief Model (HBM) constructs explain the likelihood of taking preventive behaviors for AIDS among the young adolescents in Korea. HBM was applied as the theoretical framework for developing questionnaire items in this study. The survey instrument included all of the constructs of Health Belief Model, namely, perceived susceptibility, perceived severity, perceived benefit, perceived barriers, cue to actions for preventive behaviors concerning AIDS. Additionally, demographic characteristics of the respondents, their sexual experiences, and AIDS Knowledge Test were included in the study. Each of HBM constructs were developed with a 5-point Likert type scale from l(never agree) to 5 (absolutely agree). The survey was conducted with a total of 247 military men in a city on September 18, 1996, using self-reported questionnaire. The results of the study were summarized as follows: 1. Because the subjects for this study were military soldiers, their demographic characteristics were limited to all men, young age, and ummarried. Educational status was evenly distributed between high school graduates and university students. 2. On the average, the respondents started their first sexual relationship at 18 years old and 82.6% of them did not use condom when having their first sexual experience. Thirty-one percent of the subjects had sexual contact with prostitutes and the average number of sexual contact with prostitutes was 5 times during the past 2 years. 3. The results of AIDS Knowledge Test scores demonstrated that the respondents had a high level of knowledge about AIDS. However, some misconceptions about transmission of AIDS through casual contact were still prevailed. Sixty-six percent of the respondents expressed that people infected with HIV should be isolated from the society in order to protect the general public. 4. All the respondents expressed that they had heard about AIDS before. TV was found to be the source which provided information on AIDS most frequently. 5. Among fundamental constructs of Health Belief Model, scores of perceived benefit of taking preventive action against AIDS marked the highest score, while scores of perceived susceptibility were the lowest. As a result of Multiple Stepwise Regression analysis, 13 variable groups were found to predict the preventive action by 25%. Among them, only perceived benefit variables was the most significant factor to explain preventive behaviors by 17%.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.1
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• pp.91-96
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• 2012

Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China. Methods: Cervical cytology, HPV detection by Hybrid Capture-$2^{TM}$ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters. Results: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with $cells/{\mu}L$ had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5). Conclusions: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.

• Journal of Preventive Medicine and Public Health
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• v.49 no.4
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• pp.240-248
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• 2016

Objectives: Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) adversely impacts food security in households of people living with HIV/AIDS (PLWHA). Little research has focused on food insecurity among PLWHA in India. The purpose of this study was to identify the prevalence of and factors relating to food security in households of PLWHA in the Siliguri subdivision of Darjeeling, West Bengal, India. Methods: A cross-sectional community-based study was carried out among 173 PLWHA residing in Siliguri and registered at the Anti-retroviral Therapy Centre of North Bengal Medical College & Hospital. Data was collected at the household level with interviews of PLWHA using a food security survey instrument. We analyzed the associations using logistic regression. Results: The prevalence of household food security among the participants was 50.9% (88/173). Five years or more of schooling, higher socioeconomic class and males were found to be significantly associated with a higher likelihood of food security. A later stage of the disease and the presence of other family members with HIV/AIDS were significantly associated with a lower likelihood of food security. The major coping strategies to deal with food insecurity in the acute phase HIV infection included borrowing money (56.1%), followed by spousal support, loans from microfinance institutions, banks, or money lenders, borrowing food, or selling agricultural products. Conclusions: The present study revealed that only about half of households with PLWHA were food secure. Prior interventions relating to periods of food and economic crisis as well as strategies for sustaining food security and economic status are needed in this area.

• Korean Journal of Microbiology
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• v.44 no.4
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• pp.277-281
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• 2008

HIV affects many organ systems. Patients with HIV infection have substantially increased risk of developing various cancers, primarily by opportunistic infection with oncogenic viruses due to their immunocompromised status. However, extensive evidence also indicates that the viral protein, Tat itself, may playas a major factor in the development of AIDS-related neoplasms. The molecular mechanism underlying Tat's oncogenic activity may include deregulation of cellular genes. Therefore, in this study, we examined the effect of HIV-l Tat on CD99 as one of the target cellular genes, which is a well-known tumor marker in several cancers. By using established HeLa clones that are stably expressing Tat, we found that CD99 is upregulated by endogenous Tat, whereas STAT3 is down regulated. Upon the screening of genes differentially expressed between Tat-stable cells and the control cells by using the gene fishing technique, DEG, we detected 3 genes which expression is affected by the presence of Tat. Furthermore, the methylation specific PCR analysis of the stably Tat expressing cell lines revealed that the CD99 promoter is de methylated in the presence of Tat. Taken together, these results open a potential role of CD99 in AIDS-related oncogenesis via epigenetic regulation by HIV-1 Tat.