• 대한물리의학회지
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• 제13권4호
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• pp.51-58
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• 2018

PURPOSE: This study was conducted to determine if the Harrison hip score (HHS), a tool for assessing hip joint function, and the Burg balance scale (BBS), a general balance assessment tool, actually reflect the balance ability of total hip arthroplasty (THA) patients 3 months after surgery. In addition, this study investigated the initial weight distribution strategy for bilateral lower extremity after THA surgery to understand the balance of THA patients. METHODS: Fourteen 3-month THA patients performed static dual standing and sit-to-stand (STS) tasks. Ground reaction forces on each leg were collected to calculate the weight distribution symmetricity (SWD), and the HHS, functional HHS (f-HHS), and BBS were evaluated. Correlation analyses between SWD and the HHS (also f-HHS) and BBS were then applied to the THA patients. RESULTS: The correlations between functional evaluation tools (HHS, f-HHS, BBS) and SWD were weak strength for the static balance task, but moderate for the dynamic STS task. Among the evaluation tools used in the present study, f-HHS was most useful for evaluation of dynamic balance ability. CONCLUSION: The results suggest that use of HHS, f-HHS, and BBS as functional evaluation tools does not provide meaningful information regarding balance ability, but that they are useful for evaluating dynamic balance ability of THA patients. The dynamic balance ability at 3 months after THA seems to be under development.

• 가족자원경영과 정책
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• 제21권1호
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• pp.19-44
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• 2017

The intergenerational transfer between parents and children is a major concern due to low birth rates and aging society of Korea. This study investigated the influences of children's support for parent regarding parents' decision to bequest, including the influences of parental characteristics, household-related factors, and characteristics of children. The data are the 5th wave of KReIS, a sample of 1,834 married household heads(HHs), which were classified into 142 baby boomers (1955-1963), 534 post-liberation HHs (1945-1954), and 1,158 Japanese-era HHs (-1945). The results were as follows: First, 49.3% of baby boomer HHs, 59.2% of post-liberation HHs, and 59.1% of Japanese-era HHs, were willing to make bequest decision. Second, in the baby boomer HHs, although the children's contact with their parents represented an emotional resource transfer, a child's economic resource transfer to his/her parents did not affect the parents' bequest decisions. However, in the post- liberation HHs, children's contact with parents, and economic resource transfers were significant variables. In addition, in the Japanese-era HHs, only children's contact with their parents was a significant variable. Third, in the baby boomer HHs, the variables that influenced parents' bequest decisions were household financial assets and having a daughter rather than having son and daughter. However, the variables that heavily influenced bequest decisions of the post-liberation HHs were the presence of a spouse, home ownership, household expenditures, and satisfaction of relationships with children. In the Japanese-era HHs, the variables that significantly affected parents' bequest decisions were home ownership, household expenditures, and household financial assets.

• 동의생리병리학회지
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• 제17권4호
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• pp.930-938
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• 2003

The purpose of the present study was to investigate the effects of Hyunhosaiksan (HHS) on antithrombotic actions which include blood activation, thrombus removal, warming of circulating blood, and the control of pain on abdomen and lower and upper burning spaces. HHS significantly inhibited platelet aggregation induced by ADP and epinephrine in a HHS dose-dependent manner when analyzed by the Sigmoid Emax model in WinNonlin. EC50 values of HHS were 1.71 ㎍/ml and 0.004 ㎍/ml for ADP and epinephrine respectively. In the vivo study, HHS inhibited pulmonary embolism induced by collagen and epinephrine, which was however statistically insignificant. HHS increased number of platelets, APTT and volume of fibrinogen significantly as compared with the control group in dextran-induced thrombus model. Furthermore, HHS stimulated levels of blood flow in vivo though its effect was not observed in vitro. These results suggest that Hyunhosaiksan (HHS) can be used for treating numerous diseases related with blood aggregation and circulation problems. Further systematic investigations on the synergic effects among drugs used in the oriental medicine as well as in the western medicine in relation to thrombosis therapy would provide an important insight into the potential therapeutic applications.

• 생명과학회지
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• 제25권11호
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• pp.1235-1243
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• 2015

황흑산은 동의보감의 복강과 장옹의 처방을 위해 기록된 처방전으로 오랫동안 사용되어 왔으나, 항암 효능에 대한 구체적인 연구는 전혀 이루어진 바 없다. 본 연구에서는 AGS 인체 위암세포를 대상으로 황흑산 처리에 의한 증식억제와 연관된 apoptosis 유발 및 관련 기전 연구를 수행하였다. AGS 위암세포에 황흑산 추출물을 처리함에 처리 농도 의존적으로 증식이 억제되었으며, 이는 apoptosis 유발과 연관성이 있음을 핵의 형태적 변형과 sub-G1기 세포의 축적 등으로 확인하였다. 황흑산 추출물에 의한 apoptosis 유도에는 pro-apoptotic Bax 단백질의 발현 증가와 anti-apoptotic Bcl-2의 발현 감소 및 미토콘드리아에서 세포질로의 cytochrome c 유리와 연관성이 있었으며, 세포 내 활성산소종(reactive oxygen species, ROS)의 축적을 증가시켰다. 또한 황흑산 추출물에 의한 apoptosis 유발은 caspases (caspase-3, -8 및 -9)의 활성을 증가시켰으며, poly (ADP-ribose)-polymerase 단백질의 단편화를 초래하였다. 그러나 ROS scavenger 및 pan-caspases inhibitor는 황흑산 추출물에 의한 apoptosis의 유발을 거의 완벽하게 억제하였으며, 암세포의 증식억제도 차단하였다. 이상의 결과는 황흑산 추출물에 의한 apoptosis가 ROS 생성 및 caspase 활성 의존적으로 일어남을 의미하는 것으로 황흑산의 항암기전 해석을 이해하고 향후 지속적인 연구를 위한 유용한 자료로 사용될 것이다.

• 한국식품영양과학회지
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• 제41권7호
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• pp.950-956
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• 2012

본 연구는 함초 열수 추출물의 항비만 효과 및 지질대사 개선 효과를 살펴보기 위하여 5주령된 수컷 흰쥐 36마리를 1주일간 적응시킨 후 정상식이군(NF), 고지방식이(HF)를 6주간 급여하여 비만을 유도하였다. 다시 정상식이군(N), 정상식이+함초 0.5%군(NS), 비만유도 후 정상식이군(H), 비만유도 후 정상식이+함초 0.5%군(HS), 비만유도 후 고지방식이군(HH), 비만유도 후 고지방식이+함초 0.5%군(HHS) 6군으로 나누어 6주간 실험 식이를 급여하였다. 고지방식이로 인하여 대조군과 비교하여 체중이 유의적으로 증가하였으나 함초를 급여한 HHS군의 체중과 체중증가량이 대조군인 HH군과 비교하여 유의적으로 감소하였다. 식이섭취량의 유의차는 없었으나 HHS군의 식이효율이 HH군과 비교하여 유의적으로 감소하여 함초 급여 시 동량의 식이량을 섭취하였으나 체중의 증가량이 적은 것으로 확인되었다. 함초의 급여에 따른 간장의 무게는 대조군과 비교하여 NS, HNS군에서 유의적으로 감소하였으며 HHS군은 감소하는 경향을 보였다. 부고환지방의 무게는 비만 유도군에서 정상군과 비교하여 무게가 유의적으로 증가하였으며 함초를 급여한 NS, HHS군에서 무게가 감소하는 경향을 보였고 HHS군에서는 유의적으로 감소하였다. 신장주변지방의 무게 또한 동일한 경향으로 비만 유도된 군의 지방의 무게가 유의적으로 증가하였고 HNS, HHS군의 지방무게가 유의적으로 감소하였다. 혈청중 지질의 농도는 함초를 급여한 군 모두에서 대조군과 비교하여 중성지방의 농도가 유의적으로 감소하였다. 총 콜레스테롤의 농도는 NS군에서 유의적으로 감소하였으나 비만군에서는 유의차를 보이지 않았다. HDL-콜레스테롤의 농도는 HNS, HHS군에서 유의적으로 감소하였고, LDL-콜레스테롤은 NS군에서 유의적으로 감소하였으나 비만군에서는 유의차를 보이지 않았다. 정상식이와 비교하여 비만유도군의 혈당이 증가된 것이 확인되었고 함초의 급여로 HNS군의 혈당이 유의적으로 감소되었다. 동맥경화지수는 HHS군이 대조군 HH군과 비교하여 유의적으로 감소하였으며 심장위험 지수도 동일하게 HHS군에서 유의적으로 감소하였다. 혈청 중 렙틴의 농도는 N

• 대한본초학회지
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• 제31권5호
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• pp.93-98
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• 2016

Objectives : Hwangheuk-san is a complex prescription composed of oriental traditional medicine and has been reported for antioxidant, antimicrobial and anticancer effects in the recent study. Methicillin-resistant Staphylococcus aureus (MRSA) is one of important causes of fatal infectious diseases such as septicemia, endocarditis, toxic shock syndrome, pneumonia, skin and soft tissue infections (SSTIs). S. aureus is reported as being for a variety of human diseases and its epidemiological relevance is mainly due to their ability of becoming highly resistant to common antimicrobials such as tetracycline, penicillin, cphalosporin and aminoglycoside. The objective of this study is to determine the antimicrobial effect of Hwangheuk-san ethanol extracts (HHS) and synergistic effects with antibiotics oxacillin against MRSA.Methods : The antimicrobial activity of HHS was measured by the disc diffusion method, broth microdilution method and the checkerboard dilution test, time-kill curve assay was performed to investigate synergistic effects with antibiotics oxacillin against MRSA.Results : HHS showed antimicrobial activity against MRSA with a MIC value of 125 ㎍/㎖. In the checkerboard test, the interaction of HHS with antibiotics oxacillin produced almost synergy or partial synergy against MRSA. This study showed that HHS reduced the MICs of oxacillin tested, and a remarkable antibacterial effect of HHS, with membrane permeability enhancers.Conclusions : These results suggest that HHS has the antimicrobial effect and synergistic effects with antibiotics oxacillin against MRSA. This study thus can be a valuable source for the development of a new drug with low MRSA resistance.

• 한국지형학회지
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• 제27권4호
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• pp.13-28
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• 2020

In this study, the distribution and topographic development of marine terraces, UHS (Upper Higher Surface) and HHS (High Higher Surface) at Yeondae-san area, Gampo-eup were discussed. We critically examined on the substance of the Yeongdong-myeon (a low-lying erosion surface) in the east coast of Korea. In study area, UHS including UHS-246m, UHS-241m, UHS-235m, UHS-220m, UHS-210m and UHS-220 is found on the highest altitude among the marine terraces in Korea. The existence of UHS requires new interpretation on topographical surface like Yeongdong-myeon, which has been commonly accepted as a theory in the society of Korean Geography. Since UHS is distributed continuously ascending on the altitude of HHS, the period of formation should be understood in the same context. And UHS of paleo-shoreline 246m has been estimated to be formed about 1.5 million years ago.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2000년도 춘계공동학술대회 논문집
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• pp.625-629
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• 2000

The objective of ECMS(Environmentally Conscious Manufacturing Systems) is to consider environmental effects through the entire product life cycle from product development stage to design, manufacturing, supplying, using and disposing stage. Recently, environment-oriented recycling, reusing and manufacturing technologies have been researched actively in every engineering fields. In the field of chemical engineering, HHS (Health Hazard Scores) which classifies and analyzes hazardous materials in production processes has been presented. Metal cutting processes also have a lot of harmful factors, and especially hazardous components in cutting fluids have been known to have a bad effect on workers and working area. However, research works such as HHS have been little accomplished in metal cutting processes. In this research, a environmentally conscious machining process is presented by classifying hazardous components in cutting fluids, by using LCA(Life Cycle Assessments) and HHS method, and by evaluating environmental effects from cutting fluids.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2000년도 춘계학술대회
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• pp.225-239
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• 2000

The objective of ECMS(Environmentally Conscious Manufacturing Systems) is to consider environmental effects through the entire product life cycle from product development stage to design, manufacturing, supplying, using and disposing stage. Recently, environment-oriented recycling, reusing and manufacturing technologies have been researched actively in every engineering fields. In the field of chemical engineering, HHS(Health Hazard Scores) which classifies and analyzes hazardous materials in production processes has been presented. Metal cutting processes also have a lot of harmful factors, and especially hazardous components in cutting fluids have been known to have a bad effect on workers and working area. However, research works such as HHS have been little accomplished in metal cutting processes. In this research, a environmentally conscious machining process is presented by classifying hazardous components in cutting fluids, by using LCA(Life Cycle Assessments) and HHS method, and by evaluating environmental effects from cutting fluids.

• 대한안전경영과학회지
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• 제2권1호
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• pp.141-159
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• 2000

The objective of ECMS(Environmentally Conscious Manufacturing Systems) is to consider environmental effects through the entire product life cycle from product development stage to design, manufacturing, supplying, using and disposing stage. Recently, environment-oriented recycling, reusing and manufacturing technologies have been researched actively in every engineering fields. In the field of chemical engineering, HHS(Health Hazard Scores) which classifies and analyzes hazardous materials in production processes has been presented. Metal cutting processes also have a lot of harmful factors, and especially hazardous components in cutting fluids have been known to have a bad effect on workers and working area. However, research works such as HHS have been little accomplished in metal cutting processes. In this research, a environmentally conscious machining process is presented by classifying hazardous components in cutting fluids, by using LCA(Life Cycle Assessments) and HHS method, and by evaluating environmental effects from cutting fluids.