• Journal of the Korean Society of Physical Medicine
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• v.13 no.4
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• pp.51-58
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• 2018

PURPOSE: This study was conducted to determine if the Harrison hip score (HHS), a tool for assessing hip joint function, and the Burg balance scale (BBS), a general balance assessment tool, actually reflect the balance ability of total hip arthroplasty (THA) patients 3 months after surgery. In addition, this study investigated the initial weight distribution strategy for bilateral lower extremity after THA surgery to understand the balance of THA patients. METHODS: Fourteen 3-month THA patients performed static dual standing and sit-to-stand (STS) tasks. Ground reaction forces on each leg were collected to calculate the weight distribution symmetricity (SWD), and the HHS, functional HHS (f-HHS), and BBS were evaluated. Correlation analyses between SWD and the HHS (also f-HHS) and BBS were then applied to the THA patients. RESULTS: The correlations between functional evaluation tools (HHS, f-HHS, BBS) and SWD were weak strength for the static balance task, but moderate for the dynamic STS task. Among the evaluation tools used in the present study, f-HHS was most useful for evaluation of dynamic balance ability. CONCLUSION: The results suggest that use of HHS, f-HHS, and BBS as functional evaluation tools does not provide meaningful information regarding balance ability, but that they are useful for evaluating dynamic balance ability of THA patients. The dynamic balance ability at 3 months after THA seems to be under development.

• Journal of Family Resource Management and Policy Review
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• v.21 no.1
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• pp.19-44
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• 2017

The intergenerational transfer between parents and children is a major concern due to low birth rates and aging society of Korea. This study investigated the influences of children's support for parent regarding parents' decision to bequest, including the influences of parental characteristics, household-related factors, and characteristics of children. The data are the 5th wave of KReIS, a sample of 1,834 married household heads(HHs), which were classified into 142 baby boomers (1955-1963), 534 post-liberation HHs (1945-1954), and 1,158 Japanese-era HHs (-1945). The results were as follows: First, 49.3% of baby boomer HHs, 59.2% of post-liberation HHs, and 59.1% of Japanese-era HHs, were willing to make bequest decision. Second, in the baby boomer HHs, although the children's contact with their parents represented an emotional resource transfer, a child's economic resource transfer to his/her parents did not affect the parents' bequest decisions. However, in the post- liberation HHs, children's contact with parents, and economic resource transfers were significant variables. In addition, in the Japanese-era HHs, only children's contact with their parents was a significant variable. Third, in the baby boomer HHs, the variables that influenced parents' bequest decisions were household financial assets and having a daughter rather than having son and daughter. However, the variables that heavily influenced bequest decisions of the post-liberation HHs were the presence of a spouse, home ownership, household expenditures, and satisfaction of relationships with children. In the Japanese-era HHs, the variables that significantly affected parents' bequest decisions were home ownership, household expenditures, and household financial assets.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.930-938
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• 2003

The purpose of the present study was to investigate the effects of Hyunhosaiksan (HHS) on antithrombotic actions which include blood activation, thrombus removal, warming of circulating blood, and the control of pain on abdomen and lower and upper burning spaces. HHS significantly inhibited platelet aggregation induced by ADP and epinephrine in a HHS dose-dependent manner when analyzed by the Sigmoid Emax model in WinNonlin. EC50 values of HHS were 1.71 ㎍/ml and 0.004 ㎍/ml for ADP and epinephrine respectively. In the vivo study, HHS inhibited pulmonary embolism induced by collagen and epinephrine, which was however statistically insignificant. HHS increased number of platelets, APTT and volume of fibrinogen significantly as compared with the control group in dextran-induced thrombus model. Furthermore, HHS stimulated levels of blood flow in vivo though its effect was not observed in vitro. These results suggest that Hyunhosaiksan (HHS) can be used for treating numerous diseases related with blood aggregation and circulation problems. Further systematic investigations on the synergic effects among drugs used in the oriental medicine as well as in the western medicine in relation to thrombosis therapy would provide an important insight into the potential therapeutic applications.

• Journal of Life Science
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• v.25 no.11
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• pp.1235-1243
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• 2015

Hwangheuk-san (HHS) is a Korean multi-herb formula comprising four medicinal herbs. HHS, which was recorded in “Dongeuibogam,” has been used to treat patients with inflammation syndromes and digestive tract cancer for hundreds of years. However, little is known about its anti-tumor efficacy. The present study investigated the pro-apoptotic effect and mode of action of HHS against AGS human gastric carcinoma cells. HHS inhibited the cell growth of AGS cells in a dose-dependent manner, which was associated with the induction of apoptotic cell death, as evidenced by the formation of apoptotic bodies, chromatin condensation, and an accumulation of cells in the sub-G1 phase. HHS-induced apoptotic cell death was associated with the up-regulation of pro-apoptotic Bax protein expression, down-regulation of antiapoptotic Bcl-2 protein, and the release of cytochrome c from mitochondria to the cytosol. The treatment of AGS cells with HHS significantly elevated the generation of reactive oxygen species (ROS). Additionally, apoptosis-inducing concentrations of HHS induced the activation of both caspase-9 and -8, initiator caspases of the mitochondrial-mediated intrinsic and death receptor-mediated extrinsic pathways, respectively, and caspase-3, accompanied by proteolytic degradation of poly (ADP-ribose)-polymerase. However, ROS scavenger and pan-caspases inhibitor significantly blocked HHS-induced growth inhibition and apoptosis. Taken together, these findings suggest that HHS induces apoptosis through ROS- and caspase-dependent mechanisms and that HHS may be a potential chemotherapeutic agent for the control of human gastric cancer.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.7
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• pp.950-956
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• 2012

Salicornia herbacea L. is an annual herb that grows in salt marshes and salt fields along the seashores. It is also commonly used as a folk remedy in Korea. The objective of this study was to investigate the beneficial effects of Salicorrnia herbacea L. (SH) hot water extract on obesity. Five-week old male Sprague-Dawley rats (n=36) were divided into two groups and provided either a normal fat diet (11.5% fat from kcal) or a high fat diet (40.5% fat from kcal) for 6 weeks to induce obesity. Then, rats were blocked into six groups of six mice each and provided either a diet containing SH (0.5% of diet; g/kg) or a normal diet for another 6 weeks. Final body weights were significantly reduced when rats were fed SH among the high fat diet groups (HNS and HHS). Serum triglyceride concentrations significantly decreased in every group provided SH. HDL-cholesterol concentrations significantly increased in SH-fed groups among the high fat diet groups. Further, atherogenic index significantly decreased when rats were fed SH diet (HHS). There were no differences in LDL-cholesterol between the high fat diet groups, and glucose concentrations decreased when rats were fed SH diet (HNS). These results indicate that dietary intake of Salicornia herbacea L. hot water extract might have beneficial effects on obesity by reducing body weight, fat weights, and improving blood lipid profile.

• The Korea Journal of Herbology
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• v.31 no.5
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• pp.93-98
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• 2016

Objectives : Hwangheuk-san is a complex prescription composed of oriental traditional medicine and has been reported for antioxidant, antimicrobial and anticancer effects in the recent study. Methicillin-resistant Staphylococcus aureus (MRSA) is one of important causes of fatal infectious diseases such as septicemia, endocarditis, toxic shock syndrome, pneumonia, skin and soft tissue infections (SSTIs). S. aureus is reported as being for a variety of human diseases and its epidemiological relevance is mainly due to their ability of becoming highly resistant to common antimicrobials such as tetracycline, penicillin, cphalosporin and aminoglycoside. The objective of this study is to determine the antimicrobial effect of Hwangheuk-san ethanol extracts (HHS) and synergistic effects with antibiotics oxacillin against MRSA.Methods : The antimicrobial activity of HHS was measured by the disc diffusion method, broth microdilution method and the checkerboard dilution test, time-kill curve assay was performed to investigate synergistic effects with antibiotics oxacillin against MRSA.Results : HHS showed antimicrobial activity against MRSA with a MIC value of 125 ㎍/㎖. In the checkerboard test, the interaction of HHS with antibiotics oxacillin produced almost synergy or partial synergy against MRSA. This study showed that HHS reduced the MICs of oxacillin tested, and a remarkable antibacterial effect of HHS, with membrane permeability enhancers.Conclusions : These results suggest that HHS has the antimicrobial effect and synergistic effects with antibiotics oxacillin against MRSA. This study thus can be a valuable source for the development of a new drug with low MRSA resistance.

• Journal of The Geomorphological Association of Korea
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• v.27 no.4
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• pp.13-28
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• 2020

In this study, the distribution and topographic development of marine terraces, UHS (Upper Higher Surface) and HHS (High Higher Surface) at Yeondae-san area, Gampo-eup were discussed. We critically examined on the substance of the Yeongdong-myeon (a low-lying erosion surface) in the east coast of Korea. In study area, UHS including UHS-246m, UHS-241m, UHS-235m, UHS-220m, UHS-210m and UHS-220 is found on the highest altitude among the marine terraces in Korea. The existence of UHS requires new interpretation on topographical surface like Yeongdong-myeon, which has been commonly accepted as a theory in the society of Korean Geography. Since UHS is distributed continuously ascending on the altitude of HHS, the period of formation should be understood in the same context. And UHS of paleo-shoreline 246m has been estimated to be formed about 1.5 million years ago.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.625-629
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• 2000

The objective of ECMS(Environmentally Conscious Manufacturing Systems) is to consider environmental effects through the entire product life cycle from product development stage to design, manufacturing, supplying, using and disposing stage. Recently, environment-oriented recycling, reusing and manufacturing technologies have been researched actively in every engineering fields. In the field of chemical engineering, HHS (Health Hazard Scores) which classifies and analyzes hazardous materials in production processes has been presented. Metal cutting processes also have a lot of harmful factors, and especially hazardous components in cutting fluids have been known to have a bad effect on workers and working area. However, research works such as HHS have been little accomplished in metal cutting processes. In this research, a environmentally conscious machining process is presented by classifying hazardous components in cutting fluids, by using LCA(Life Cycle Assessments) and HHS method, and by evaluating environmental effects from cutting fluids.

• Proceedings of the Safety Management and Science Conference
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• 2000.05a
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• pp.225-239
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• 2000

The objective of ECMS(Environmentally Conscious Manufacturing Systems) is to consider environmental effects through the entire product life cycle from product development stage to design, manufacturing, supplying, using and disposing stage. Recently, environment-oriented recycling, reusing and manufacturing technologies have been researched actively in every engineering fields. In the field of chemical engineering, HHS(Health Hazard Scores) which classifies and analyzes hazardous materials in production processes has been presented. Metal cutting processes also have a lot of harmful factors, and especially hazardous components in cutting fluids have been known to have a bad effect on workers and working area. However, research works such as HHS have been little accomplished in metal cutting processes. In this research, a environmentally conscious machining process is presented by classifying hazardous components in cutting fluids, by using LCA(Life Cycle Assessments) and HHS method, and by evaluating environmental effects from cutting fluids.

• Journal of the Korea Safety Management & Science
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• v.2 no.1
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• pp.141-159
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• 2000

The objective of ECMS(Environmentally Conscious Manufacturing Systems) is to consider environmental effects through the entire product life cycle from product development stage to design, manufacturing, supplying, using and disposing stage. Recently, environment-oriented recycling, reusing and manufacturing technologies have been researched actively in every engineering fields. In the field of chemical engineering, HHS(Health Hazard Scores) which classifies and analyzes hazardous materials in production processes has been presented. Metal cutting processes also have a lot of harmful factors, and especially hazardous components in cutting fluids have been known to have a bad effect on workers and working area. However, research works such as HHS have been little accomplished in metal cutting processes. In this research, a environmentally conscious machining process is presented by classifying hazardous components in cutting fluids, by using LCA(Life Cycle Assessments) and HHS method, and by evaluating environmental effects from cutting fluids.