• 한국사회복지학
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• 제64권2호
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• pp.85-109
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• 2012

본 연구는 50대 레즈비언의 생애사연구로서, 연구참여자가 '지식의 주체'라는 페미니스트 인식론적 입장으로부터 '레즈비언 정체성'과 '레즈비언의 삶'에 관한 지식을 생산하고자 하였다. 구술자는 동성애 섹슈얼리티가 본질적이고 태생적인 것이 아니라 "만들어진 것"이라는 생애사적 관점을 견지했으며, 구술자가 들려준 생애이야기는 동성애에 할당된 사회적 의미를 체현하고 '순응하는 몸'인 동시에 억압과 차별을 인식하고 타개하고자 실천하는 '저항하는 몸'에 관한 것이었다. 이 생애이야기에는 섹스-젠더-섹슈얼리티의 자연화된 고리를 끊어낼 만큼 고통스러웠던 화상과 '불완전한 몸'이라는 자의식으로부터 상처받은 삶의 굴곡뿐만 아니라, 이를 넘어 타자에게 진정으로 공감하고 위로하는 "복받은 몸"으로 의미를 재구성하는 놀라운 탄력성까지 오롯이 담겨져 있었다. 이렇게 연구참여자를 비정상과 병리 등의 의미가 부착된 이분법적 구분의 '성적 소수자'가 아니라, 사회적 불평등과 억압에서도 자신의 삶을 탄력적으로 살아가며 일상의 실천으로 변화를 만들어내는 주체적인 행위자로서 이해하는 것은 사회복지 이론과 실천에서 전혀 다른 전망을 요구한다. "젠더와 섹슈얼리티를 어떻게 배치해할 것인가?"에 대한 전환적인 모색은 새로운 시대에 당면한 사회복지학이 제시해야 하는 중대한 전망이며, 이는 '성적 소수자'에게만 할당된 이슈가 아니라, 사회의 권력관계와 위계구조를 조직하고 억압과 불평등을 영속화하는 섹슈얼리티와 이에 연동하는 젠더에 관한 '우리 모두'의 아젠다인 것이다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권11호
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• pp.6813-6820
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• 2013

The present study was conducted to investigate the prognostic significance of co-expression patterna of HER-2, IL-6, TNF-a and TGF-${\beta}1$ in breast cancer, by correlating the number of markers with positive expression with clinicopathological characteristics indicative of tumor progression and overall survival. One hundred thirty consecutive patients with primary breast cancer were prospectively included and evaluated. Serum concentrations of the above markers were measured by ELISA. Median split was used to subdivide patients with marker positive or negative expression. The presence of ${\geq}3$ positive markers was independently associated with extended lymph node (>3) involvement (aOR, 11.94, p=0.001) and lymphovascular invasion (aOR, 12.04, p=0.018), increasing the prognostic significance of each marker considered separately. Additional prognostic information regarding survival was also provided; as the number of positive markers increased, a gradually reduction of survival time was observed. In addition, patients with 4 positive markers had significantly shorter survival (25 vs 39 months, p=0.006) and a more than 4 fold increased risk of death (aHR, 4.35, p=0.003) compared to patients with 3 positive markers. Our findings suggest that the coexpression pattern of these four markers could be used clinically as a useful marker for tumor extension and outcome of breast cancer.

• Journal of Information Technology Applications and Management
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• 제20권2호
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• pp.127-146
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• 2013

The online social networking services (SNS) have been growing as the means of communication. In this study, we investigated word-of-mouth (WOM) effect under the SNS environment and evaluated the impact of message sender's influence on the WOM effect. Especially, this study focused on the betweenness centrality calculated through the social network analysis (SNA) of SNS network information, and proposed it as the measure of WOM message sender's influence, SNA may provide more accurate and objective measures than subjective self-reporting survey method. Fifty-one Facebook users responded to each of their four Facebook friends, who had been selected based on their betweenness centrality, Statistical analyses were performed using the responses and the betweenness centralities of the Facebook friends. The results showed that the direction (positive vs, negative) of a WOM message in SNS had an impact on the attitude of the message receiver toward the product. Moreover, the betweenness centrality of the message sender as well as his/her opinion leadership had a moderating effect on the WOM effect. Opinion leadership is a measure that has been frequently used for indicating the influence of WOM message sender in the previous studies. Considering the result that the betweenness centrality of the message sender was Significantly correlated to his/her opinion leadership, the betweenness centrality can be used for indicating the influence of WOM message sender.

• Asian Pacific Journal of Cancer Prevention
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• 제17권6호
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• pp.2989-2993
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• 2016

The commonest cancer in Egyptian females occurs in the breast cfDNA is a non-invasive marker for tumor detetion and prognostic assessment in many types of cancer including breast cancer. This study aimed to assess the role of cfDNA and its fragmentation pattern in breast cancer prognosis and treatment response. Forty female patients with malignant breast tumors and a comparable group of healthy blood donors were enrolled prospectively. cfDNA levels and fragmentation patterns were investigated after cfDNA extraction, gel electrophoresis and gel analysis. The percentage of breast cancer patients positive for cfDNA (92.5%) was significantly higher than that of controls (55%). Also, mean concentration of cfDNA was significantly higher than in the control group (P<0.05). Most Her-2 positive patients had long cfDNA fragments, this being significant as compared to Her-2 negative patients (P<0.05). Metastasis was also positively linked to significantly higher cfDNA (P<0.05) and the mean cfDNA integrity index was significantly higher in non-responders compared to treatment responders (P<0.05). In conclusion, both qualitative and quantitative aspects of cfDNA and its different fragments in breast cancer patients could be related to prognosis, metastasis and treatment response. Long cfDNA fragments could be particularly useful for prediction purposes.

• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3321-3324
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• 2016

Background: Androgen receptors (ARs) are expressed in more than 70% of breast cancers (BCs) and have been implicated in BC pathogenesis. Some triple negative (TN)BC tumors express AR and may benefit from AR-targeted therapies. The aim of this study was to evaluate survival and the prevalence of AR expression and its correlation with other risk factors in triple negative BCs in women from Western Iran. Materials and Methods: In a retrospective study between 2009-2015, 41 patients with TNBC were referred to the Private Clinic of Oncology, Kermanshah city, Iran. ER, PR and AR-positive expression was defined as ${\geq}10%$ nuclear staining and also HER2 (2+), FISH was performed. Nuclear staining was considered representative for Ki67 and P53. The mean follow-up for the patients was 25 months. In this time, 5 patients died and 4 lost to follow-up were censored from survival analysis. Results: The mean age at diagnosis was 46.9 years (range, 24-71 years) and all patients were female. The OS rates for AR-positive and AR-negative patients were 90% and 85.1%, respectively, and the mean OS was 26.3 and 23.2 months. Therefore, there was no significant difference between the two groups (Hazard ratio: 0.580, 95% CI: 0.086-3.893, P=0.575). Conclusions: In TNBC patients, evaluation of AR status may provide additional information on prognosis and treatment. The results of studies showed that the prevalence AR expression may differ in the world and probably ethnicity can be an influencing factor.

• 복식문화연구
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• 제19권6호
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• pp.1221-1234
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• 2011

The purpose of this study was to investigate the differences and interaction effects in impression formation according to eyeglasses, earrings, hair length, and clothing color worn by woman in Her 20s. A quasi-experimental method was used for this study. The experimental design was a $3{\times}2{\times}2{\times}4$(eyeglasses${\times}$earrings${\times}$hair length${\times}$clothing color) factorial design. The model of stimulus photographs was a woman with an oval shape face in her late twenties. She wore a tailored collared jacket with a white dress shirt. The subjects were 362 female college students. First, the women wearing glasses were found to be more potent but gave more negative impressions in terms of loveliness, politeness, and attractiveness than the women without glasses. Second, the women wearing earrings were perceived to have higher individuality, attractiveness, potency, loveliness, and elegance than the women without earrings. Third, the women with short hair were evaluated to have higher individuality, potency, and elegance, and to have lower loveliness, politeness, and attractiveness than the women with long hair. Fourth, the red clothes were perceived to have the higher individuality, loveliness, and attractiveness than the dark red or grey clothes. The light grey clothes were considered as the most elegant and the dark grey clothes were shown to have low attractiveness. Fifth, the women wearing the horn-rimmed glasses with short hair were evaluated to have high individuality. The women wearing glasses with short hair were evaluated lower in loveliness than those with long hair. The women with short hair, wearing glasses without earrings were evaluated very low in attractiveness.

• 한국해양학회지
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• 제30권2호
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• pp.91-115
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• 1995

동해에서의 해양-대기 열교환량을 1961년부터 1990년까지의 선상관측자료와 1976 년부터 1985년까지의 일본기상처 부표자료를 이용하여 구하였다. 그리고 이 결과와 해 양상층부 200m 내의 열용량의 계절변화로부터 해양내부의 열유동량을 계산하였다. 겨 울에는 유입되는 단과복사량과 방출되는 장파오복사량의 크기가 비슷해 복사에 의한 열방출량은 적지만 열속과 자멸속이 강하여 전 해역에서 대기로 많은 열량을 방출한 다. 유효열방출량의 공간적인 변화폭은 100 Wm/SUP -2/이상이며, 최대의 열방출량은 쓰가루해협 부근에서 일어나고 대한해협과 울릉분지역등 남부역이 높은 방출량이 나타 난다. 특히 남서 해역의 강한 열방출이 겨울에 동해 중층균실수의 형성에 영향을 주는 것으로 보인다. 여름에는 강한 태양복사와 낮은 난류속의 영향으로 전해역에서 120~ 140 Wm/SUP -2/의 비슷한 크기로 해양이 가열된다. 해양내부의 열유동은 일본연안에서 양의 값을 나타내 여름의 강한 대마난류에 의한 열량의 유입을 보이며, 그 크기는 해 면을 통해 흡수한 열량보다 커서 여름에는 대마난류에 의한 열유입이 중요함을 보여준 다. 한국연안에서는 음의 값으로 수온이 낮은 북한 한류계수의 남하를 나타낸다. 봄과 가을은 3월과 100월에 각각 최소, 최대를 나타낸다. 유효열교환량의 연변화폭은 남서 해역의 경우 약 580 Wm/SUP -2/이다. 해표면을 통한 연평균 유효열교환량은 모든 해역 에서 음의 값으로 대기중으로 열량을 방출하며, 그 크기는 쓰가루해협부근에서 -130 Wm/SUP -2/로 강하고 대한해협과 울릉분지역에서도 이웃하는 해역보다 많은 열량을 방 출한다. 위도 35$^{\circ}$~39$^{\circ}$N 사이에서의 공간적인 연평균값의 크기는 단파복사량, 자멸 속, 장파복사, 열속의 크기로 각각 129, -90, -58, -32Wm/SUP -2/으로 유효열교환량은 -51W/SUP -2이다.

• 대한한방내과학회지
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• 제27권2호
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• pp.546-553
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• 2006

Schizophrenia is a disturbance condition that lasts for at least 6 months and includes at least 1 month of active-phase symptoms(i.e., two [or more] of the following : delusions, hallucinations. disorganized speech, grossly disorganized or catatonic behavior, negative symptoms) In this study, we report one case of schizophrenia with acute cerebral infarction. The patient has been diagnosed with schizophrenia more than 20 years ago, and after this recent cerebral infarction, all of her schizophrenic symptoms such as auditory hallucination, delirium, depression, insomnia were aggravated. Her schizophrenic symptoms, PANSS and NIHSS total scores were considerably reduced after oriental treatment(Guibi-tang(歸脾湯)), so we report this as a potential treatment.

• 아동학회지
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• 제33권2호
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• pp.243-261
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• 2012

This study examined the effects of the mother-child relationship and marital satisfaction on the subjective well-being of mothers with young children. The subjects consisted of 237 mothers with young children. Data were analyzed by means of multiple regression analysis, T-test and one way ANOVA. The results included that 1) There were clear differences in terms of the mother's level of education, her monthly income in household, and job satisfaction when it came to the subjective well-being of mothers. 2) The mother-child relationship and marital satisfaction were both positively correlated with the cognitive and affective factor (positive affects) of subjective well-being, whereas there were negative correlations with regard to affective factors (negative affects) of subjective well-being. 3) The mother-child relationship and marital satisfaction accounted for 32.5% of subjective well-being. More specifically, marital satisfaction was the most influential variable when it came to determining the level of life satisfaction (which is also a cognitive factor of subjective well-being), whereas the mother-child relationship was the most influential variable when it came to the affective factor of subjective well-being.

• Asian Pacific Journal of Cancer Prevention
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• 제16권2호
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• pp.823-829
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• 2015

The aim of the present study was to investigate the expression of the transcription factor Ki-67, ER, PR, Her2/neu, p21, EGFR, and TOP II-${\alpha}$ in the tumor tissue of patients with invasive ductal carcinoma(IDC); in addition, we examined correlations between these markers. Two hundred and sixteen IDC patients, who were not previously been treated with chemo- or radiotherapy, were included in the study. All tumors were grade I-III. Expression of molecular markers was determined by immunohistochemical analysis on paraffin-embedded tissue sections. Follow-up data were collected for 3 months to 10 years and analyzed for tumor recurrence, survival time, and prognostic risk factors. We determined Ki-67 expression correlates with the expression of ER, PR, HER-2, EGFR, and TOP-${\alpha}$, as well as lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in IDC. Positive Ki-67 expression was a risk factor for rapid tumor recurrence and may help tumor progression, leading to poor prognosis in IDC. Ki-67 was directly correlated with EGFR, TOP II-${\alpha}$, lymph node involvement, high tumor grade, lymphovascular invasion, high tumor stage, and high TNM stage in the hormone receptor subtypes of breast cancer. In triple negative breast cancer, Ki-67 correlated with TOP II-${\alpha}$. Expression of Ki-67 correlated with that of ER, PR, HER-2, EGFR, TOP II-${\alpha}$, and p21. In addition, the biomarker Ki-67 has a role as a prognostic factor and indicates a poor prognosis in IDC.