• Korean Journal of Child Studies
• /
• v.13 no.2
• /
• pp.145-160
• /
• 1992

The purpose of this study was to investigate the relationships between children's self-concepts and (1) types of functional family systems. (2) family cohesion and adaptability levels, and (3) the satisfaction of children with their current family systems. The subjects of this study were 347 middle S. E. S. children (168 boys, 179 girls) in grade 6. Analysis of functional family systems was by The Family Adaptability and Cohesion Evaluation Scales III(1985) of the Circuplex Model (Olson et al., 1979). The Self-concept Inventory (Lim Jae Leun, 1987) was used to assess children's self-concepts. The data were analyzed with one-way ANOVA, $Scheff{\acute{e}}$ and Pearson correlation. It was found that there were no differences in children's self-concepts by types of functional systems. There were differences in children's self-concepts by family cohesion and adaptability levels. That is, the higher the level of cohesion and adaptability the more positive the child's self-concept. The more the child was satisfied with his/her current family system, the more positive the child's self-concept. Children whose family systems were at a high level of family cohesion and adaptability were more satisfied with their current family systems.

• Clinical and Experimental Pediatrics
• /
• v.64 no.5
• /
• pp.239-246
• /
• 2021

Background: The consequences of severe acute respiratory syndrome corona virus 2 on mother and fetus remain unknown due to a lack of robust evidence from prospective studies. Purpose: This study evaluated the effect of coronavirus disease 2019 (COVID-19) on neonatal outcomes and the scope of vertical transmission. Methods: This ambispective observational study enrolled pregnant women with COVID-19 in North India from April 1 to August 31, 2020 to evaluate neonatal outcomes and the risk of vertical transmission. Results: A total of 44 neonates born to 41 COVID-19-positive mothers were evaluated. Among them, 28 patients (68.3%) (2 sets of twins) were delivered within 7 days of testing positive for COVID-19, 23 patients (56%) (2 sets of twins) were delivered by cesarean section; 13 newborns (29.5%) had low birth weight; 7 (15.9%) were preterm; and 6 (13.6%) required neonatal intensive care unit admission, reflecting an increased incidence of cesarean delivery and low birth weight but zero neonatal mortality. Samples of cord blood, placental membrane, vaginal fluid, amniotic fluid, peritoneal fluid (in case of cesarean section), and breast milk for COVID-19 reverse transcription-polymerase chain reaction tested negative in 22 prospective delivery cases. Nasopharyngeal swabs of 2 newborns tested positive for COVID-19: one at 24 hours and the other on day 4 of life. In the former case, biological samples were not collected as the mother was asymptomatic and her COVID-19 report was available postdelivery; hence, the source of infection remained inconclusive. In the latter case, all samples tested negative, ruling out the possibility of vertical transmission. All neonates remained asymptomatic on follow-up. Conclusion: COVID-19 does not have direct adverse effects on the fetus per se. The possibility of vertical transmission is almost negligible, although results from larger trials are required to confirm our findings.

• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.5
• /
• pp.2241-2247
• /
• 2012

Objective: This qualitative study retrospectively examined the experience and psychological impact of contralateral prophylactic mastectomy (CPM) among Southern Chinese females with unilateral breast cancer history who underwent BRCA1/2 genetic testing. Limited knowledge is available on this topic especially among Asians; therefore, the aim of this study was to acquire insight from Chinese females' subjective perspectives. Methods: A total of 12 semi-structured in-depth interviews, with 11 female BRCA1/BRCA 2 mutated gene carriers and 1 non-carrier with a history of one-sided breast cancer and genetic testing performed by the Hong Kong Hereditary Breast Cancer Family Registry, who subsequently underwent CPM, were assessed using thematic analysis and a Stage Conceptual Model. Breast cancer history, procedures conducted, cosmetic satisfaction, pain, body image and sexuality issues, and cancer risk perception were discussed. Retrieval of medical records using a prospective database was also performed. Results: All participants opted for prophylaxis due to their reservations concerning the efficacy of surveillance and worries of recurrent breast cancer risk. Most participants were satisfied with the overall results and their decision. One-fourth expressed different extents of regrets. Psychological relief and decreased breast cancer risk were stated as major benefits. Spouses' reactions and support were crucial for post-surgery sexual satisfaction and long-term adjustment. Conclusions: Our findings indicate that thorough education on cancer risk and realistic expectations of surgery outcomes are crucial for positive adjustment after CPM. Appropriate genetic counseling and pre-and post-surgery psychological counseling were necessary. This study adds valuable contextual insights into the experiences of living with breast cancer fear and the importance of involving spouses when counseling these patients.

• Journal of Gastric Cancer
• /
• v.23 no.1
• /
• pp.207-223
• /
• 2023

Gastric cancer (GC) is the fourth leading cause of cancer-related deaths worldwide. Under the standard of care, patients with advanced GC (AGC) have a median survival time of approximately 12-15 months. With the emergence of immunotherapy as a key therapeutic strategy in medical oncology, relevant changes are expected in the systemic treatment of GC. In the phase III ATTRACTION-2 trial, nivolumab, a monoclonal anti-programmed cell death 1 (PD-1) antibody, as a third- or later-line treatment improved overall survival (OS) compared with placebo in patients with AGC. Furthermore, nivolumab in combination with 5-fluorouracil and platinum as a first-line treatment improved OS in patients with human epidermal growth factor receptor-2 (HER2)-negative AGC in the global phase III CheckMate-649 study. Another anti-PD-1 antibody, pembrolizumab, in combination with trastuzumab and cytotoxic chemotherapy as a first-line treatment, significantly improved the overall response rate in patients with HER2-positive AGC. Therefore, immune checkpoint inhibitors (ICIs) are essential components of the current treatment of GC. Subsequent treatments after ICI combination therapy, such as ICI rechallenge or combination therapy with agents having other modes of action, are being actively investigated to date. On the basis of the success of immunotherapy in the treatment of AGC, various clinical trials are underway to apply this therapeutic strategy in the perioperative and postoperative settings for patients with early GC. This review describes recent progress in immunotherapy and potential immunotherapy biomarkers for GC.

• 한국해양학회지
• /
• v.30 no.2
• /
• pp.91-115
• /
• 1995

Air-sea heat fluxes in the East Sea were estimated from the various ship's data observed from 1961 to 1990 and the JMA buoy #6 data from 1976 to 1985. The oceanic heat transport in the sea was also determined from the fluxes above and the heat storage rate of the upper layer of 200m from the sea surface. In winter, The incoming solar radiation is almost balanced with the outgoing longwave radiation. but the sea loses her heat through the sea surface mainly due to the latent and sensible heat fluxes. The spatial variation of the net surface heat flux is about 100 Wm/SUP -2/, and the maximum loss of heat is occurred near the Tsugaru Strait. There are also lots of heat losses in the southern part of the East Sea, Korea Strait and Ulleung Basin. Particularly, the heat strong loss in the south-western part of the sea might be concerned with the formation of her Intermediate Homogeneous Water. In summer, the sea is heated up to about 120∼140 Wm/SUP -2/ sue to strong incoming solar radiation and weak turbulent heat fluxes and her spatial variation is only about 20 Wm/SUP -2/. The oceanic heat flux is positive in the southeasten part f the sea and the magnitude of the flux is larger than that of the net surface heat flux. This shows the importance of the area. In the southwestern part of the sea, however, the oceanic heat flux is negative. This fact implies cold water inflow, the North Korean Cold Water. The sigh of net surface heat flux is changed from negative to positive in March and from positive to negative in September. The heat content in the upper surface 200 m from the sea surface reaches its minimum in March and maximum in October. The annual variation of the net surface heat flux is 580 Wm/SUP -2/ in southwestern part of the sea. The annual mean values of net surface heat fluxes are negative, which mean the net heat transfer from the sea to the atmosphere. The magnitude of the flux is about 130 Wm/SUP -2/ near the Tsugaru Strait. The net surface fluxes in the Korea Strait and the Ulleung Basin are relatively larger than those of the rest areas. The spatial mean values of surface heat fluxes from 35$^{\circ}C$ to 39$^{\circ}$N are 129, -90, -58, and -32 Wm/SUP -2/ for the incoming solar radiation, latent hear flux, outgoing longwave radiation, and sensible heat flux, respectively.

• Korean Journal of Human Ecology
• /
• v.6 no.2
• /
• pp.37-45
• /
• 1997

The purpose of this study is to identify parental stress of working mothers with young children and to fine its rented variables. subjects were consisted of 108 working mothers who had children from 3 to 6 ages. The measurement instruments are the questionnaire which consisting the following parts; Parenting Daily Hassles, Employment Subjective Expected Utility, Beck Depression Inventory, Emotionality, Activity, Sociablity Temperament Scale. The data were analyzed by the statistical method based on frequency, percentile, t-test, F-test, Pearson's correlation, and multiple regression. The main results were as follows: 1. Parental stress of working mother had a significant correlation with working mothers' negative attitudes for their occupations. 2. The higher working mothers' depression resulted in the higher working parental stress. 3. There was a significant positive correlation between children's difficult temperament and parental stress of working mothers. 4. The influential variables on parental stress of working mothers were mothers' attitude to her occupations and children's temperament.

• Journal of Yeungnam Medical Science
• /
• v.37 no.2
• /
• pp.128-132
• /
• 2020

Tanycytic ependymoma is a rare variant of ependymoma that commonly affects the cervical and thoracic spinal cord. It usually arises as intramedullary lesions, and extramedullary cases are extremely rare. We report a case of a 44-year-old woman who was diagnosed with tanycytic ependymoma in her lumbar spine at level 2-3. The tumor mass developed in an intradural extramedullary location. Histopathologically, tanycytic ependymoma can be misdiagnosed as schwannoma or pilocytic astrocytoma. Immunohistochemical findings such as strong positivity for glial fibrillary acidic protein, perinuclear dot-like positive patterns for epithelial membrane antigen, and focal positivity for S100 protein are helpful in diagnosing tanycytic ependymoma. It is important to be aware of this rare tumor to ensure appropriate patient management and accurate prognosis.

• Journal of Veterinary Clinics
• /
• v.7 no.2
• /
• pp.489-495
• /
• 1990

The purpose of this study was to investigate the contamination rates of Keratinophilic fungi in soils In Chonju. From september to November 1986, 98 soil samples were collected at the school and children's play ground, dog barn, pig barn, cow barn, horse barn and fowl barn( total 33 sites ). The samples were collected at the different depths(0～2cm, 30cm, 50cm ) in each of the sites, respectively. Each sample was cultured at 25$^{\circ}C$ according to Modified hair baiting method by using horse mane hair as a bait. The results obtained were summerized as follows ; 1. Eighty one of the 98 soil samples were found to be positive for Keratinophilic fungi. 2. In the examination of keratinophilic fungi in 98 soil samples, the organisms isolated weie as follows; Microsporum gypseum 20, Trichophyton ajelloi 15, Chrysosporium tropicum 40, C. Keratinophilum 24, C. tuberculatum 6 and Chrysosporium spp. like organism 4 strains. 3. The positive rates of keratinophilic fungi in each of the depths were 87.9%(29/33) in surface layer, 90.9%(30/33) in middle layer and 68.8％(22/32) in deep layer. 4. The positive rates of Keratinophilic fungi in each of the sites were 100%(3/3) in horse barn 91.7％ (l1/12) in dog barn, 88.9%(16/18) in pig barn, 86.7%(13/15) in cow barn, 76.2%(16/21) in fowl barn and 75.9%(22/29) in school and children's play ground. 5. The isolation rates of M. gypseum, Pathogenic fungi for human and animals, were as follows ; 58.3％ in dog barn(surface layers 100％, middle layers 50％, deep layers 25％) and 16.7％ in pig barn(surface 33.3％, middle 16.7%, deep 0％). In the cow barn, the isolation rates were 13.3%(surface 40.0％, middle 0%, deep 0％) and 10% in horse barn(surface l00％, middle 100%, depp 100%). In the fowl barn, the isolation rates was 19.1%(surface 28.8%, middle 14.3%, deep 14.3%) and 3.5% in school and children's play ground(surface 0％, middle 0％, deep 11.1%).

• Journal of Gastric Cancer
• /
• v.16 no.3
• /
• pp.141-151
• /
• 2016

Purpose: The aim of the present study was to elucidate the clinicopathological significance and diagnostic accuracy of immunohistochemistry (IHC) for determining the mesenchymal epidermal transition (c-MET) expression in patients with gastric cancer (GC). Materials and Methods: The present meta-analysis investigated the correlation between c-MET expression as determined by IHC and the clinicopathological parameters in 8,395 GC patients from 37 studies that satisfied the eligibility criteria. In addition, a concordance analysis was performed between c-MET expression as determined by IHC and c-MET amplification, and the diagnostic test accuracy was reviewed. Results: The estimated rate of c-MET overexpression was 0.403 (95% confidence interval [CI], 0.327~0.484) and it was significantly correlated with male patients, poor differentiation, lymph node metastasis, higher TNM stage, and human epidermal growth factor receptor 2 (HER2) positivity in IHC analysis. There was a significant correlation between c-MET expression and worse overall survival rate (hazard ratio, 1.588; 95% CI, 1.266~1.992). The concordance rates between c-MET expression and c-MET amplification were 0.967 (95% CI, 0.916~0.987) and 0.270 (95% CI, 0.173~0.395) for cases with non-overexpressed and overexpressed c-MET, respectively. In the diagnostic test accuracy review, the pooled sensitivity and specificity were 0.56 (95% CI, 0.50~0.63) and 0.79 (95% CI, 0.77~0.81), respectively. Conclusions: The c-MET overexpression as determined by IHC was significantly correlated with aggressive tumor behavior and positive IHC status for HER2 in patients with GC. In addition, the c-MET expression status could be useful in the screening of c-MET amplification in patients with GC.

• Research in Community and Public Health Nursing
• /
• v.8 no.2
• /
• pp.211-224
• /
• 1997

The purpose of this study is to find a solution to effectively nurse elderly people in the aging society of next generation by analyzing relationship among the social problem of elderly people in the future society, their preferred life style, and their understanding level of an asylum for the aged. Data for this study were collected by questioning 316 persons(257 visitors at C University hospital and 59 residents in Chun - Ra Nam Do) from December 1996 to March 1997. The results were as follows: The assumption that an individual's preferred life style at old age depends on his /her understanding level of the social problem of elderly people was verified ($X^2=9.75$, p<0.00). The assumption that one's understanding of an asylum for the aged depends on his /her understanding level of the social problem of elderly people was verified ($X^2=4.40$, p<0.05). The assumption that one's understanding of an asylum for the aged depends on his/her pre-ferred life style at old age was verified($X^2=34.51$, p<0.01). Among those who want to live together with children when they get old, the following differences in their conception were noted: Elderly people who has lost his /her wife /husband should marry again(p<0.01). Children should take care of their parents(p<0.01). Children should live with their parents(p<0.01), A desirable living style for an elderly people. An undesirable living style for an elderly people. Among those who want to live alone when they get old, the following differences were observed: It is okay for children to live separately from their parents as long as they provide financial support(p<0.01). Any child, regardless of the distinction of sex or the order of birth among siblings, can take care of his/her parents(p<0.05), It is desirable for an elderly people to live alone (p<0.01). It is undesirable for an elderly people to live in an asylum for the aged(p<0.05). It was verified that those who view an asylum for the aged in a negative way believe that children should take care of their parents. Also, it was verified that those who view an asylum for the aged in a positive way believe that children should provide financial support to their parents even though they do not live together(p<0.01). Regardless of the subjects' opinions on seriousness of the social problem of elderly people, the assumption that any child, regardless of the distinction of sex or the order of birth among siblings, can take care of his/her parents was verified(p<0.01) (p<0.05). Regardless of the subjects' view on asylum for the aged, the assumption that it is undesirable place for an elderly people to live was verified (p<0.01). The assumption that one's understanding of an asylum for the aged depends on the distinction of sex among general characteristics such as sex, age, educational background, occupation, and religion was verified(t=-2.82, p<0.01). The assumption that an individual's preferred life style at old age depends on the distinction of sex among general characteristics such as sex, age, educational background, occupation, and religion was verified(t=l.68, p<0.l).