• Journal of Yeungnam Medical Science
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• v.17 no.2
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• pp.123-128
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• 2000

Purpose: This study was aimed to develop a new vaginal applicator(Shin's Applicator) for 2-channel high-dose rate vaginal brachytherapy to evaluate uniformity of surface dose, and to present 3-dimensional dose distribution of the applicator. Methods: Shin's Applicator was inexpensively constructed using human soft tissue equivalent acrylic bar. We evaluated dose uniformity along the applicator surface using film densitometer and performed vaginal intracavitary brachytherapy after insertion of the applicator using HDR brachytherapy planning software and brachytherapy unit(Ralstron-20B). Results: Shin's Applicator allows improved dose distribution than the existing 1-channel cylinder and achieves diminished urinary bladder and rectal dose by 20%. Conclusions: From the above results, it can be concluded that Shin's Applicator may be an improved form of a vaginal applicator. Furthermore, it can be suggested that this applicator has an advantage, for it prevents vaginal stenosis after radiation therapy and can be used as a disposable vaginal dilator. Further follow up examination with radiological study may be helpful to evaluate the therapeutic efficacy of this applicator.

• The Journal of The Korea Institute of Intelligent Transport Systems
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• v.8 no.1
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• pp.53-64
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• 2009

For a realization of the ubiquitous society, applying IT to vehicle industry has recently been an attractive issue to make wireless communication in body area network possible to everywhere. In this paper, we propose the physical layer symbol structure based on PPM scheme of the IEEE 802.15.4a for the off-body high data rate WBAN system. We propose four symbol structures which is classified according to the number of the chip and whether the channel coding is used or not. We calculate the required SNR through the link budget calculation and the recently proposed off-body WBAN channel environment was applied in the simulation. The results of four systems show that small number of burst's chip enhances the performance and the system is capable to achieve the data rate of 10 Mbps.

• Korean Journal of Applied Biomechanics
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• v.26 no.3
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• pp.249-255
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• 2016

Objective: This purpose of this study was to analyze the relationship between dimensionless leg stiffness and kinetic variables during gait performance, and its modulation with body weight. Method: The study sample consisted of 10 young women divided into 2 groups (Control, n=5 and Obese, n=5). Four camcorders (HDR-HC7/HDV 1080i, Sony Corp, Japan) and one force plate (AMTI., USA) were used to analyze the vertical ground reaction force (GRF) variables, center of pressure (COP), low limb joint angle, position of pelvis center and leg lengths during the stance phase of the gait cycle. Results: Our results revealed that the center of mass (COM) displacement velocity along the y-axis was significantly higher in the obese group than that in control subjects. Displacement in the position of the center of the pelvis center (Z-axis) was also significantly higher in the obese group than that in control subjects. In addition, the peak vertical force (PVF) and dimensionless leg stiffness were also significantly higher in the obese group. However, when normalized to the body weight, the PVF did not show a significant between-group difference. When normalized to the leg length, the PVF and stiffness were both lower in the obese group than in control subjects. Conclusion: In the context of performance, we concluded that increased dimensionless leg stiffness during the gait cycle is associated with increased velocity of COM, PVF, and the change in leg lengths (%).

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• v.9 no.1
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• pp.1113-1116
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• 2005

Using COMSAT which provides multi-beam switching function, the optimal transmission channel environment which provides the high data rate communication are proposed in this paper. Also the link budget for communication transponder of COMSAT is designed. Based on the channel modeling for group delay, non-linear and gain flatness characteristics, the system performances which provide various data rate services were analyzed in Ka-band satellite channel. As the transmission data rate is increased, the degradation due to these channel characteristics is severely increased. The linear component of group delay and the AM-AM component of non-linear characteristics severely affect the system performance. To efficiently provide the various service via the same transmission system it is necessary to equalize the primary impairment factors. The optimum operating points of HDR satellite transmission system are implemented and operated by considering the analyzed results on channel characteristics.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.31-31
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• 2016

국내 해안선을 따라 발생되는 침식 및 퇴적현상으로 인하여 해안구조물의 안정성과 같은 안전 문제가 발생되고 있다. 이러한 자연현상을 대비하여 연안지역 특성에 맞는 침식 저감 대책 마련에 대한 연구가 되고 있다. 침식현상은 다양한 외력조건과 지리적 특성을 함께 고려해야 한다. 고립파로 인한 침식 발생 현상에 대한 국외 연구들이 다수 수행되어 왔으며, 국내에는 이와 관련된 연구가 상대적으로 부족하다. 고립파는 파고의 특성에 따라 파형이 결정되는 특징을 가지고 있어, 침식현상과 지진해일의 실험적 연구에 있어 입사파로 주로 활용되고 있다. 기존의 방법과 동일하게 sluice gate를 순간적으로 개방하여 고립파를 재현하는 방식으로 파랑을 재현하였다. 본 연구에서는 폭 0.80 m, 높이 0.75 m, 수로연장 12.00 m의 강화유리로 설계된 직사각형 단면 수로에서 실험을 수행하였다. 측면에 두 대의 카메라(Model No. : Sony, HDR-XR550)를 고정설치하여 경사면 하상변화를 촬영하였고, 영상분석을 통하여 하상변동을 측정하였다. 유사특성에 따른 하상변동을 연구하기 위하여 경사면에 포설된 유사로는 주문진 표준사($d_{50}=0.6268mm$, $c_u=1.68$)와 안트라사이트($d_{50}=1.547mm$, $c_u=1.387$)를 동일한 실험조건에서 함께 사용하였다. 경사면에서 고립파의 처오름, 처내림을 추적하여 그 경향을 분석하였다. 하상의 침식 및 퇴적구간 길이, 침식, 퇴적의 높이 및 깊이와 같은 형상분석을 통한 영향인자를 함께 무차원화 하여 실험결과를 제시하였다. 본 연구의 결과를 바탕으로 Sluice gate를 이용한 고립파 수리실험으로 경사면 하상의 침식 및 퇴적 현상에 관한 기초적인 실험자료로 활용될 것이다.

• BMB Reports
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• v.54 no.2
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• pp.98-105
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• 2021

The clustered regularly interspaced short palindromic repeats (CRISPR) system is a family of DNA sequences originally discovered as a type of acquired immunity in prokaryotes such as bacteria and archaea. In many CRISPR systems, the functional ribonucleoproteins (RNPs) are composed of CRISPR protein and guide RNAs. They selectively bind and cleave specific target DNAs or RNAs, based on sequences complementary to the guide RNA. The specific targeted cleavage of the nucleic acids by CRISPR has been broadly utilized in genome editing methods. In the process of genome editing of eukaryotic cells, CRISPR-mediated DNA double-strand breaks (DSB) at specific genomic loci activate the endogenous DNA repair systems and induce mutations at the target sites with high efficiencies. Two of the major endogenous DNA repair machineries are non-homologous end joining (NHEJ) and homology-directed repair (HDR). In case of DSB, the two repair pathways operate in competition, resulting in several possible outcomes including deletions, insertions, and substitutions. Due to the inherent stochasticity of DSB-based genome editing methods, it was difficult to achieve defined single-base changes without unanticipated random mutation patterns. In order to overcome the heterogeneity in DSB-mediated genome editing, novel methods have been developed to incorporate precise single-base level changes without inducing DSB. The approaches utilized catalytically compromised CRISPR in conjunction with base-modifying enzymes and DNA polymerases, to accomplish highly efficient and precise genome editing of single and multiple bases. In this review, we introduce some of the advances in single-base level CRISPR genome editing methods and their applications.

• Nuclear Engineering and Technology
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• v.54 no.4
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• pp.1414-1420
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• 2022

High dose rate (HDR) brachytherapy treatment planning usually involves optimization methods to deliver uniform dose to the target volume and minimize dose to the healthy tissues. Four optimizations were used to evaluate the high-risk clinical target volume (HRCTV) coverage and organ at risk (OAR). Dose-volume histogram (DVH) and dosimetric parameters were analyzed and evaluated. Better coverage was achieved with PGO (mean CI = 0.95), but there were no significant mean CI differences than GrO (p = 0.03322). Mean EQD₂ doses to HRCTV (D₉₀) were also superior for PGO with no significant mean EQD₂ doses than GrO (p = 0.9410). The mean EQD₂ doses to bladder, rectum, and sigmoid were significantly higher for NO plan than PO, GrO, and PGO. PO significantly reduced the mean EQD₂ doses to bladder, rectum, and sigmoid but compromising the conformity index to HRCTV. PGO was superior in conformity index (CI) and mean EQD₂ doses to HRCTV compared with the GrO plan but not statistically significant. The mean EQD₂ doses to the rectum by PGO plan slightly exceeded the limit from ABS recommendation (mean EQD₂ dose = 78.08 Gy EQD₂). However, PGO can shorten the treatment planning process without compromising the CI and keeping the OARs dose below the tolerance limit.

• The Journal of Korean Society for Radiation Therapy
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• v.24 no.2
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• pp.61-66
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• 2012

Purpose: The purpose of this study is to compare plans prescribed to point A with these prescribed to point H recommended by ABS (American Brachytherapy Society) in high dose rate intracavitary brachytherapy for cervical carcinoma. Materials and Methods: This study selected 103 patients who received HDR (High Dose Rate) brachytherapy using tandem and ovoids from March 2010 to January 2012. Point A, bladder point, and rectal point conform with Manchester System. Point H conforms with ABS recommendation. Also Sigmoid colon point, and vagina point were established arbitrarily. We examined distance between point A and point H. The percent dose at point A was calculated when 100% dose was prescribed to point H. Additionally, the percent dose at each reference points when dose is prescribed to point H and point A were calculated. Results: The relative dose at point A was lower when point H was located inferior to point A. The relative doses at bladder, rectal, sigmoid colon, and vagina points were higher when point H was located superior to point A, and lower when point H was located inferior to point A. Conclusion: This study found out that as point H got located much superior to point A, the absorbed dose of surrounding normal organs became higher, and as point H got located much inferior to point A, the absorbed dose of surrounding normal organs became lower. This differences dose not seem to affect the treatment. However, we suggest this new point is worth being considered for the treatment of HDR if dose distribution and absorbed dose at normal organs have large differences between prescribed to point A and H.

• The Journal of Korean Society for Radiation Therapy
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• v.27 no.2
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• pp.123-129
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• 2015

Purpose : The goal of this study was to verify and analyze the source position according to the curvature of the universal applicator and 4 different angle applicators when using RALS(Remote After Loading System). Materials and Methods : An interval of 1 cm and 15 second dwell times in each source position were applied for plan. To verify the accuracy of source position, we narrowed the distance between MultiSource container and GAFCHROMIC$^{(R)}$ EBT3 film by 5 cm, 10 cm, 20 cm so that the universal applicator transfer tube had some curvature. Also 4 applicators(Intrauterine tube: $0^{\circ}$, $15^{\circ}$, $30^{\circ}$, Ovoid tube: $65^{\circ}$) were used in the same condition. The differences between desired and actual source position were measured by using Image J. Results : In case of using 4 different angles of applicator with the straight universal applicator transfer tube, the average error was the lowest for $0^{\circ}$ applicator, greatest for $65^{\circ}$ applicator. However, All average errors were within ${\pm}2mm$ recommended in TG-56. When MultiSource container was moved 5 cm, 10 cm, 20 cm towards the EBT3 film, the average errors were beyond ${\pm}2mm$. The first dwell position was relatively located in accuracy, while the second and third dwells were displaced by an increasing magnitude with increasing curvature of the transfer tube. Furthermore, with increasing the angle of applicators, the error of all other dwell positioning was increased. Conclusion : The results of this study showed that both the curvature of universal applicator transfer tube and the angle of applicators affect the source dwell position. It is recommended that using straight universal applicator transfer tubes is followed in all cases, in order to avoid deviations in the delivered source dwell position. Also, It is advisable to verify the actual dwell position, using video camera quality control tool prior to all treatments.

• Journal of the Korean Society of Radiology
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• v.6 no.2
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• pp.143-149
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• 2012

Today each hospital is trend that change rapidly by up to date, digitization and introducing newest medical treatment equipment. So, we introduce new CR system and supplement film system's shortcoming and PACS, EMR, RTP system's network that is using in hospital harmoniously and accomplish quality improvement of medical treatment and service elevation about business efficiency enlargement and patient Accordingly, we wish to introduce our case that integrate reflex that happen with radiation oncology here upon to PACS using CR system and estimate the availability. We measured that is Gantry, Collimator Star Shot, Light vs. Radiation, HDR QA(Dwell position accuracy) with Medical LINAC(MEVATRON-MX) Then, PACS was implemented on the digital images on the monitor that can be confirmed through the QA. Also, for cooperation with OCS system that is using from present source and impose code that need in treatment in each treatment, did so that Order that connect to network, input to CR may appear, did so that can solve support data mistake (active Pinacle's case supports DICOM3 file from present source but PACS does not support DICOM3 files.) of Pinacle and PACS that is Planning System and look at Planning premier in PACS. All image and data constructed integration to PACS as can refer and conduct premier in Hospital anywhere using CR system. Use Dosimetry IP in Filmless environment and QA's trial such as Light/Radition field size correspondence, gantry rotation axis' accuracy, collimator rotation axis' accuracy, brachy therapy's Dwell position check is available. Business efficiency by decrease and so on of unnecessary human strength consumption was augmented accordingly with session shortening as that integrate premier that is neted with radiation oncology using CR system to PACS. and for the future patient information security is essential.