• 대한수의학회지
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• 제24권1호
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• pp.50-57
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• 1984

Tuberculin(HCSM) 반응유우 60두에 대하여 가열살균처리한 우결핵균에서 얻은 PPD-BS tuberculin을 이용한 추벽피내재검사법과 석탄산살균처리한 우결핵균에서 얻은 SFA tuberculin을 이용한 경측피내재검사법간의 민감성과 특이성을 비교하였다. 또한 SFA tuberculin과 현행 조형 PPD(PPD-A) tuberculin을 이용한 비교검사법의 가치를 판독기준에 따라 분석하였다. 병소우군에서 PPD-BS와 SFA tuberculin간에 민감성은 차이가 없었으나 무병소우와 감염우동거군에서 SFA tuberculin은 PPD-BS tuberculin에 비하여 비특이반응이 현저히 낮았다(P<0.01). SFA와 PPD-A를 이용한 비교검사법은 판독기준에 따라 가양성반응과 가음성반응에 크게 영향을 주었으며, 피내반응차이 4mm를 판독기준으로 할 때 병소우와 무병소우를 감별할 수 없었다. 이 연구에서 SFA tuberculin은 PPD-BS에 비하여 병소우에서 민감성간에는 차이가 없었으나 무병소우에서 특이성이 현저히 높았다는 점으로 보아 앞으로 HCSM tuberculin 반응우에 대한 재검사는 현행 PPD에서 SFA tuberculin으로 대체함으로써 비특이반응우를 더욱 감소시킬 수 있다는 것을 의미한다.

• 대한수의학회지
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• 제48권1호
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• pp.49-52
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• 2008

The trend in the prevalence of bovine tuberculosis (BTB) in Korean dairy cattle was investigated in relation to test programs used between 1961 and 2004, during which a total of 8,961,061 dairy cows were tested and 10,248 confirmed to have BTB. The annual prevalence increased in the late 1960s, then decreased during the 1970s and 1980s, and started to increase again from the late 1990s. It seemed that the prevalence varies according to the different test program used. The prevalence of BTB was higher when the tests were performed with heat-concentrated synthetic medium (HCSM) or purified protein derivative (PPD) tuberculin alone compared to that when using combined HCSM and PPD tuberculin testing.

• 대한수의학회지
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• 제10권2호
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• pp.13-19
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• 1970

For the establishment of more reliable and applicable methods for the diagnosis of tuberculosis in dairy cattle, avian- and mammalian PPD tuberculins were prepared according to the methods of Weybridge purified protein derivative tuberculins with minor modifications. PPD tuberculin was not only a very pure product from a chemical standpoint, but also one which, judged on the basis of laboratory results, was likely to be more potent and reliable than HCSM tuberculin.

• 대한미생물학회지
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• 제5권1호
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• pp.41-48
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• 1970

In order to assay one lot of the potency of tuberculin for intradermic use, four guinea pigs sensitized with heat killed M. tuberculosis were used by the method originally of the Agriculture Research Service Center(A. R. S.) and Bureau of Animal. Industry(B. A. I.) in the United. States of America in which guinea pigs were used on 21st day after sensitization. There is doubt whether the guinea pigs are sensitized or not. Therefore, this study has taken the method of Middle Brook-Dubos hemagglutination test, and observed the humoral hemagglutinating antibody in the blood. The results obtained are as follows. 1. The maximum titer of hemagglutinating antibody was demonstrated 30days after sensitizing the guinea pigs with killed tubercle bacilli. The maximum titer was continued for a period of 45 days and thereafter declined gradually. 2. The swelling and redness of the region of the sensitized guinea pigs was shown to be reached to the maximum size within 24 hours after intradermal inoculation with HCSM tuberculin and gradually reduced 96 hours after inoculation. The swelling and redness could not be detected by macro-observation after 14 days.

• 대한미생물학회지
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• 제6권1호
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• pp.41-60
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• 1971

The author prepared a tuberculin sample using synthetic medium for the test material in this experiment. For the test animals, guinea pigs, healthy calf sensitized with heat killed tubercle bacilli, naturally infected dairy cattle, goat, and calf were used. A reduced reactivity to tuberculin was observed when the second tuberculin test was done within 28 days after the first. The results obtained are summarized as follows. 1. The experimental HCSM tuberculin was shown the similar activities as the control products of standard tuberculin. 2. The potency of the experimental tuberculin preserved at $5^{\circ}C$ in refrigerator maintained the activity for three years. 3. By the intradermal test, the experimental tuberculin was proved to be specific to detect tuberculous dairy cattles and goats. 4. The appearance of skin reaction to tuberculin in naturally infected dairy cattles, goat and beef cattles was soft and diffuse swellings or circumscribed swellings accompanied by induration. 5. In the case of observing tuberculous dairy cattles, goats and beef cattles, as the criterion of the reaction to the caudal fold test, results were taken as positive when findings are either hard and circumscribed or soft and diffuse swellings of 3 mm at least in size. 6. The acid fast organisms isolated from tuberculin positive animals were identified mostly as M. tuberculosis var. bovis. 7. When the tuberculin test was repeated in the tuberculin positive animals, the reactivity decreased rapidly, lasting 4 weeks at least.

• 대한수의학회지
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• 제39권6호
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• pp.1119-1125
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• 1999

Since Robert Koch found tubercle bacilli in 1882, the studies on tubercle bacilli of human and animal had been carried out. Being old tuberculin(OT) introduced in 1890, the specificity of the diagnosis of tuberculosis has been improved by continual uses of heat concentrated synthetic medium(HCSM) and purified protein derivatives(PPD) tuberculin. Now, two types of tuberculin test are used worldwidly ; the single intradermal test(SIT) using bovine tuberculin and the single intradermal comparative tuberculin test(SICTT) using avian and bovine tuberculins. In the SICTT, each countries have used with different combination of both avian and bovine tuberculins' titers. However, this kinds of studies have not reported in Korea. Therefore, the studies on the combination of their tuberculins' titers were performed through intradermal test of guinea pigs sensitized with either Mycobacterium bovis or M avium and were examined in 10 cattles of SIT positive reactors. Also, IFN-${\gamma}$ assay, the latest diagnostic method of bovine tuberculosis, was experimentally applied to SIT positive reactors. For determining the optimal titers, sensitized guinea pigs with M bovis and M avium were intradermally injected avian and bovine tuberculin. In guinea pigs sensitized with M bovis, bovine tuberculin 50 T.U. showed significant difference from all tested concentrations of avian tuberculin(p < 0.05). In guinea pigs sensitized with M avium, there is significantly different between bovine tuberculin and avian tuberculin by 25 T.U.(p < 0.01). Therefore, optimal titers of bovine and avian PPD tuberculins' titers for the SICTT in Korea were 5,000 and 2,500 tuberculin units, respectively, and the swelling diffences between bovine and avian site in SIT positive reactors were above 3mm. Also, in IFN-${\gamma}$ assay, the 9 SIT positive reactors were showed all the positive reactions.

• 경영과정보연구
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• 제39권3호
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• pp.17-35
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• 2020

본 연구는 의료 SCM 경쟁역량 강화를 위해 빅데이터 분석을 통한 물류공동화 시스템 도입의 필요성을 역설하면서 고객 니즈를 반영한 현 상황 시나리오 비즈니즈 모델을 개발하는 것이다. 물류공동화 사용의도에 필요한 의료 SCM 경쟁역량으로써는 협업시스템, 가격리더십, 인도속도, 프로세스유연성으로 구분하여 살펴보았다. 의료기관 간의 업무 효율화를 실현하기 위해 가장 중요한 고려 사항을 분석한 워드클라우드(wordcloud) 결과는 돌발상황, 정보공유, 배송, 실시간, 배송, 편리성 등의 단어가 많이 언급되었다. 주말에 긴급 돌발상황에 즉각적 대응을 할 수 있는 시스템 구축의 필요성을 피력한 것으로 해석할 수 있다. 또한 소통과 편리성의 추구와 더불어 재고관리의 효율성을 기할 수 있는 실시간 정보공유의 중요성을 엿볼 수 있다. 따라서 빅데이터 분석을 통한 실시간으로 물류파이프라인의 가시성을 높일 수 있는 비즈니스모델의 지향을 현장에서 필요로 한다는 판단이다. 의료 SCM 경쟁역량에 대한 공급사슬네트워크의 적응성의 효과를 분석함으로써 경쟁역량의 획득이 물류공동화 실행을 통해서 이루어질 수 있음을 밝히게 되었다. 물류공동화와 같은 파트너십이 강화될수록 결국 SCM 경쟁역량으로 이어지게 될 것이다. 의료기관의 공동물류화 시스템이 기업 상호간의 파트너십의 활성화를 유도할 수 있는 방향으로 기업 간 전략적인 접근을 모색하여 SCM 경쟁역량을 높일 수 있도록 하여야 할 것이다. 특히 물류공동화 시스템 구축에 따른 빅데이터 분석을 통하여 HSCM의 활용도 모색을 강구해 나가야 할 것이다.