• Journal of IKEEE
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• v.21 no.3
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• pp.309-319
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• 2017

The research investigates the inhibition of fatty acid biosynthesis of the human Acetyl-CoA Carboxylase enzyme by the aromatic-structure inhibitors (also known as ligands) containing variables of substituents, contributing an important role in the treatment of fatty-acid metabolic syndrome expressed by the group of cardiovascular risk factors increasing the incidence of coronary heart disease and type-2 diabetes. The effective interoperability between ligand and enzyme is characterized by a 50% concentration of enzyme inhibitor ($IC_{50}$) which was determined by experiment, and the factor of geometry structure of the ligands which are modeled by quantum mechanical methods using HyperChem 8.0.10 and Gaussian 09W softwares, combining with the calculation of quantum chemical and chemico-physical structural parameters using HyperChem 8.0.10 and Padel Descriptor 2.21 softwares. The result data are processed with the combination of classical statistical methods and modern bioinformatics methods using the statistical softwares of Department of Pharmaceutical Technology - Jadavpur University - India and R v3.3.1 software in order to accomplish a model of the quantitative structure - activity relationship between aromatic-structure ligands inhibiting fatty acid biosynthesis of the human Acetyl-CoA Carboxylase.

• Proceedings of the KIEE Conference
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• 2003.07d
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• pp.2567-2569
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• 2003

본 논문은 비선형 시스템의 퍼지모델을 위해 정보 Granules 기반 퍼지추론 시스템 모델의 최적화를 제시한다. 퍼지모델은 주로 경험적 방법에 의해 추출되기 때문에 보다 구체적이고 체계적인 방법에 의한 동정 및 최적화 될 필요성이 요구된다. 제안된 규칙베이스 퍼지모델은 HCM 클러스터링 방법, 컴플렉스 알고리즘 및 퍼지추론 방법을 이용하여 시스템 구조와 파라미터 동정을 수행한다. 두 가지 형태의 퍼지모델 추론 방법은 간략추론, 선형추론에 의해 시행된다. 본 논문에서는 퍼지모델의 입력변수와 퍼지 입력 공간 분할 및 입출력 데이타의 중심값을 구해서 후반부 다항식함수에 의한 정보 Granules 기반 구조 동정과 파라미터 동정을 통해 비선형 시스템을 표현한다. 전반부 파라미터의 동정에는 HCM 클러스터링 방법과 컴플렉스 알고리즘을 사용하고, 후반부는 표준 HCM 클러스터링과 표준 최소자승법을 사용하여 동정한다. 그리고 학습 및 테스트 데이타의 성능견과의 상호균형을 얻기 위한 하중값을 가진 성능지수를 제시함으로써 근사화와 예측성능의 향상을 꾀한다. 제안된 비선형 모델의 성능평가를 통해 그 우수성을 보인다.

• The Journal of Asian Finance, Economics and Business
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• v.8 no.8
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• pp.259-270
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• 2021

The purpose of this study is to explore the link between job satisfaction and organizational commitment at higher education institutions (HEIs) in emerging countries such as Vietnam and to determine extrinsic work factors that influence job satisfaction. Higher education is critical for socio-economic growth and the overall development of each country. Hence, an understanding of what motivates employees' actions and attitudes should be obtained before determining the extent of employee satisfaction. The conceptual model was developed by incorporating job satisfaction-related variables, their relationships, and the impact of job satisfaction on organizational commitment. An empirical study was conducted on a study sample of public and private universities, with 316 academics and non-academic employees surveyed. The current study employed the partial least squares structural equation modeling to test the proposed hypotheses. The results reveal a positive and significant relationship between job satisfaction and organizational commitment. The findings confirm that extrinsic work factors (job itself, supervision, working conditions, payment, and reward and recognition) have a positive and significant relationship with job satisfaction. Furthermore, the study indicates that employees at HEIs who have a high level of ability utilization and supervisor support are more likely to be satisfied with their jobs.

• Asian-Australasian Journal of Animal Sciences
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• v.26 no.4
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• pp.529-536
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• 2013

The objective of this study was to investigate the effect of levels of cottonseed meal with various carbohydrate sources in concentrate on feed intake, nutrient digestibility, rumen fermentation and microbial protein synthesis in dairy bulls. Four, 6 months old dairy bulls were randomly assigned to receive four dietary treatments according to a $2{\times}2$ factorial arrangement in a $4{\times}4$ Latin square design. Factor A was carbohydrate source; cassava chip (CC) and cassava chip+rice bran in the ratio of 3:1 (CR3:1), and factor B was cotton seed meal levels in the concentrate; 109 g CP/kg (LCM) and 328 g CP/kg (HCM) at similar overall CP levels (490 g CP/kg). Bulls received urea-lime treated rice straw ad libitum and were supplemented with 10 g of concentrate/kg BW. It was found that carbohydrate source and level of cotton seed meal did not have significant effects on ruminal pH, ammonia nitrogen concentration, microbial protein synthesis or feed intake. Animals which received CC showed significantly higher BUN concentration, ruminal propionic acid and butyric acid proportions, while dry matter, organic matter digestibility, populations of total viable bacteria and proteolytic bacteria were lower than those in the CR3:1 treatment. The concentration of total volatile fatty acids was higher in HCM than LCM treatments, while the concentration of butyric acid was higher in LCM than HCM treatments. The population of proteolytic bacteria with the LCM treatments was higher than the HCM treatments; however other bacteria groups were similar among the different levels of cotton seed meal. Bulls which received LCM had higher protein digestibility than those receiving HCM. Therefore, using high levels of cassava chip and cotton seed meal might positively impact on energy and nitrogen balance for the microbial population in the rumen of the young dairy bull.

• 대한치과보철학회:학술대회논문집
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• 1999.04a
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• pp.48-48
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• 1999

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.340-342
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• 2004

In this paper, we introduce a new category of fuzzy inference systems baled on information granulation to carry out the model identification of complex and nonlinear systems. Informal speaking, information granules are viewed as linked collections of objects(data, in particular) drawn together by the criteria of proximity, similarity, or functionality. Granulation of information with the aid of Hard C-Means(HCM) clustering algorithm help determine the initial parameters of fuzzy model such as the initial apexes of the membership functions and the initial values of polyminial functions being used in the premise and consequence part of the fuzzy rules. And the initial parameters are tuned effectively with the aid of the genetic algorithms(GAs) and the least square method. The proposed model is contrasted with the performance of the conventional fuzzy models in the literature.

• Proceedings of the KIEE Conference
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• 2004.11c
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• pp.343-345
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• 2004

We propose a new category of fuzzy set-based fuzzy inference systems based on data granulation related to fuzzy space division for each variables. Data granules are viewed as linked collections of objects(data, in particular) drawn together by the criteria of proximity, similarity, or functionality. Granulation of data with the aid of Hard C-Means(HCM) clustering algorithm help determine the initial parameters of fuzzy model such as the initial apexes of the membership functions and the initial values of polyminial functions being used in the premise and consequence part of the fuzzy rules. And the initial parameters are tuned effectively with the aid of the genetic algorithms(GAs) and the least square method. Numerical example is included to evaluate the performance of the proposed model.

• The Korean Journal of Health Service Management
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• v.4 no.1
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• pp.87-97
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• 2010

The study analyzed the cash flow and external funding in focusing on the relationship of the two factors in Korean hospitals and some changes in the relationship. The results analyzing this study were summarized as follows: First, the discriminant function of new external funds was generally the ratio of cash flow from operating activities to sales, the ratio of cash flow from investment activities to sales, the ratio of cash flow from financing activities to sales in order. The prediction rate of total discriminant function was more than 92%. Second, in case of Korean hospitals, it was known that the ratio of cash flow from operating activities to sales, particularly the net income to sales was the biggest influencing factor on the decision to external funding.

• Proceedings of the KIEE Conference
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• 2005.07d
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• pp.2885-2887
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• 2005

We introduce a hybrid identification of information granulation(IG)-based fuzzy model to carry out the model identification of complex and nonlinear systems. To optimally design the IG-based fuzzy model we exploit a hybrid identification through genetic alrogithms(GAs) and Hard C-Means (HCM) clustering. An initial structure of fuzzy model is identified by determining the number of input, the seleced input variables, the number of membership function, and the conclusion inference type by means of GAs. Granulation of information data with the aid of HCM clustering help determine the initial paramters of fuzzy model such as the initial apexes of the membership functions and the initial values of polyminial functions being used in the premise and consequence part of the fuzzy rules. And the inital parameters are tuned effectively with the aid of the GAs and the least square method. Numerical example is included to evaluate the performance of the proposed model.

• Proceedings of the KIEE Conference
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• 2006.10c
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• pp.217-219
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• 2006

본 연구는 정보입자와 유전알고리즘의 기호코딩을 통해 퍼지집합 기반 다항식 뉴럴네트워크(IG based gFSPNN)의 최적 설계 제안한다. 기존의 Furry Srt-based Polynomial Neural Networks의 최적설계를 위해 유전자 알고리즘의 이진코딩을 사용하였다. 이지코딩은 스티링 길이 때문에 연산시간이 급격히 증가되는 현상과 해밍절벽(Hamming Cliff)에 따른 급격한 비트변환이 힘들다는 단점이 내제 하였다. 이에 본 논문에서는 스티링 길이와 해밍절벽에 따른 문제를 해결 하기위해 기호코딩을 사용하였다._데이터들의 특성을 모델에 반영하기 위해 Hard C-Means(HCM)을 결합한 Information Granulation(IG)을 사용하여 최적모델 구축 속도를 빠르게 하였다. 실험적 예제를 통하여 제안된 모델의 성능을 평가한다.