• Title/Summary/Keyword: HAQ

Search Result 88, Processing Time 0.03 seconds

The Role of Meat Protein in Generation of Oxidative Stress and Pathophysiology of Metabolic Syndromes

  • Ahmad, Muhammad Ijaz;Ijaz, Muhammad Umair;Haq, Ijaz ul;Li, Chunbao
    • Food Science of Animal Resources
    • /
    • v.40 no.1
    • /
    • pp.1-10
    • /
    • 2020
  • Various processing methods have a great impact on the physiochemical and nutritional properties of meat that are of health concern. Hence, the postmortem processing of meat by different methods is likely to intensify the potential effects on protein oxidation. The influence of meat protein oxidation on the modulation of the systemic redox status and underlying mechanism is well known. However, the effects of processed meat proteins isolated from different sources on gut microbiota, oxidative stress biomarkers, and metabolomic markers associated with metabolic syndromes are of growing interest. The application of advanced methodological approaches based on OMICS, and mass spectrometric technologies has enabled to better understand the molecular basis of the effect of processed meat oxidation on human health and the aging process. Animal studies indicate the involvement of dietary proteins isolated from different sources on health disorders, which emphasizes the impact of processed meat protein on the richness of bacterial taxa such as (Mucispirillum, Oscillibacter), accompanied by increased expression of lipogenic genes. This review explores the most recent evidences on meat processing techniques, meat protein oxidation, underlying mechanisms, and their potential effects on nutritional value, gut microbiota composition and possible implications on human health.

Diet-Right: A Smart Food Recommendation System

  • Rehman, Faisal;Khalid, Osman;Haq, Nuhman ul;Khan, Atta ur Rehman;Bilal, Kashif;Madani, Sajjad A.
    • KSII Transactions on Internet and Information Systems (TIIS)
    • /
    • v.11 no.6
    • /
    • pp.2910-2925
    • /
    • 2017
  • Inadequate and inappropriate intake of food is known to cause various health issues and diseases. Due to lack of concise information about healthy diet, people have to rely on medicines instead of taking preventive measures in food intake. Due to diversity in food components and large number of dietary sources, it is challenging to perform real-time selection of diet patterns that must fulfill one's nutrition needs. Particularly, selection of proper diet is critical for patients suffering from various diseases. In this article, we highlight the issue of selection of proper diet that must fulfill patients' nutrition requirements. To address this issue, we present a cloud based food recommendation system, called Diet-Right, for dietary recommendations based on users' pathological reports. The model uses ant colony algorithm to generate optimal food list and recommends suitable foods according to the values of pathological reports. Diet-Right can play a vital role in controlling various diseases. The experimental results show that compared to single node execution, the convergence time of parallel execution on cloud is approximately 12 times lower. Moreover, adequate accuracy is attainable by increasing the number of ants.

Synthesis and characterization of sugarcane bagasse/zinc aluminium and apple peel/zinc aluminium biocomposites: Application for removal of reactive and acid dyes

  • Safa, Yusra;Tariq, Saadia Rashid;Bhatti, Haq Nawaz;Sultan, Misbah;Bibi, Ismat;Nouren, Shazia
    • Membrane and Water Treatment
    • /
    • v.9 no.5
    • /
    • pp.301-307
    • /
    • 2018
  • In this research work, synthesis of sugarcane bagasse/zinc aluminium biocomposite and apple peel/zinc aluminium biocomposite and their application for removal of Reactive Red-241 and Acid Orange-7, respectively, was studied using various parameters. At pH 2 the sorption was the highest for both dyes. The trend showed that the dye sorption declined by decreasing the biocomposite dose and enhanced by increasing the dye concentration and temperature. Equilibrium was achieved at 60 minutes for Reactive Red-241 onto sugarcane bagasse/zinc aluminium biocomposite and 90 minutes for Acid Orange-7 onto apple peel/zinc aluminium biocomposite.The research data was good fitted to pseudo-2nd-order kinetic model and Langmuir isotherm. FT-IR analysis was used to confirm the biosorption of the selected dyes at the surface of biosorbent through various binding sites. Surface morphology modification of both biocomposites before and after biosorption was inspected through SEM. Crystallinity of biocomposite was examined through XRD analysis. It was implied that sugarcane bagasse/ zinc aluminium biocomposite and apple peel/ zinc aluminium biocomposite are good adsorbents for dyes elimination from aqueous solutions.

Recently Emerging Signaling Landscape of Ataxia-Telangiectasia Mutated (ATM) Kinase

  • Farooqi, Ammad Ahmad;Attar, Rukset;Arslan, Belkis Atasever;Romero, Mirna Azalea;ul Haq, Muhammad Fahim;Qadir, Muhammad Imran
    • Asian Pacific Journal of Cancer Prevention
    • /
    • v.15 no.16
    • /
    • pp.6485-6488
    • /
    • 2014
  • Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.

Direct Fabrication of a-Si:H Thin Film Transistor Arrays on Flexible Substrates: Critical Challenges and Enabling Solutions

  • O'Rourke, Shawn M.;Loy, Douglas E.;Moyer, Curt;Bawolek, Edward J.;Ageno, Scott K.;O'Brien, Barry P.;Marrs, Michael;Bottesch, Dirk;Dailey, Jeff;Naujokaitis, Rob;Kaminski, Jann P.;Allee, David R.;Venugopal, Sameer M.;Haq, Jesmin;Colaneri, Nicholas;Raupp, Gregory B.
    • 한국정보디스플레이학회:학술대회논문집
    • /
    • 2008.10a
    • /
    • pp.1459-1462
    • /
    • 2008
  • In this paper we describe solutions to address critical challenges in direct fabrication of amorphous silicon thin film transistor (TFTs) arrays for active matrix flexible displays. For all flexible substrates a manufacturable handling protocol in automated display-scale equipment is required. For metal foil substrates the principal challenges are planarization and electrical isolation, and management of stress (CTE mismatch) during TFT fabrication. For plastic substrates the principal challenge is dimensional instability management.

  • PDF

Camptodactyly: An unsolved area of plastic surgery

  • Singh, Veena;Haq, Ansarul;Priyadarshini, Puja;Kumar, Purshottam
    • Archives of Plastic Surgery
    • /
    • v.45 no.4
    • /
    • pp.363-366
    • /
    • 2018
  • Background Camptodactyly refers to permanent flexion contracture at the proximal interphalangeal joint. Most cases are limited to fifth-finger involvement. Although common, the treatment of camptodactyly is controversial. Many published studies have emphasized conservative treatment, while others have described surgical procedures. The problem with this deformity is that it presents in several forms, which means that there is no single model for effective treatment. The aim of this paper is to present the difficulties encountered with this condition and the management thereof on an individual basis. Methods This is a case series of 14 patients (nine males, five females) who underwent surgical treatment. The results were classified using the method from Mayo Clinic as excellent, good, fair, and poor. Results Fourteen patients with 15 fingers underwent surgery, and the results achieved were as follows: excellent, 0; good, 1; fair, 6; poor, 8. The treatment of camptodactyly still remains controversial, and hence proper planning individualized to each patient is needed to achieve the maximal improvement with realistic goals. Conclusions Although we performed individualised surgery, our careful follow-up was not able to identify any method as superior over another with respect to gain in extension and loss of flexion. We therefore propose that the extensor mechanism should not be disturbed during surgery to treat camptodactyly cases.

IMPACT OF FOURWING SALTBUSH ON FEED AND WATER INTAKE AND ON BLOOD SERUM PROFILE IN SHEEP

  • Rasool, E.;Rafique, S.;Haq, I.U.;Khan, A.G.;Thomson, E.F.
    • Asian-Australasian Journal of Animal Sciences
    • /
    • v.9 no.2
    • /
    • pp.123-126
    • /
    • 1996
  • Sixteen Harnai males were used to evaluate the influence of varying levels of fourwing saltbush hay on feed and water intakes as well as the blood serum mineral status in a completely randomized design. The animals were grouped randomly into four, with four animals in each. The four groups were randomly allotted low, medium, high and very high levels of saltbush hay supplementation in addition to wheat straw. The animals were given fresh water at free of choice. Weekly body weight was recorded for each individual animal. Blood serum was collected for mineral contents. The experiment lasted for eight weeks. The inclusion of saltbush leaves in the diet showed a non-significant effect on the total dry matter intake. There has been a significant increase in the water intake when very high levels of saltbush were included in the ration. Lower levels showed no effect on the water intake. The animals maintained their body weight from week 1 to week 8. No treatment by weeks interactions on the potassium and sodium levels were detected. However higher levels of saltbush increased significantly the potassium and sodium contents in the serum. Calcium contents were significantly(p<0.01) lowered with the inclusion of saltbush leaves in the diet. Whereas Phosphorous contents showed an increasing(p<0.05) trend with the higher levels of saltbush. No clinical or sub-clinical toxicological symptoms were observed in the sheep with the higher mineral contents.

Determination of Substrate Specificities Against β-Glucosidase A (BglA) from Thermotoga maritime: A Molecular Docking Approach

  • Rajoka, Muhammad Ibrahim;Idrees, Sobia;Ashfaq, Usman Ali;Ehsan, Beenish;Haq, Asma
    • Journal of Microbiology and Biotechnology
    • /
    • v.25 no.1
    • /
    • pp.44-49
    • /
    • 2015
  • Thermostable enzymes derived from Thermotoga maritima have attracted worldwide interest for their potential industrial applications. Structural analysis and docking studies were preformed on T. maritima β-glucosidase enzyme with cellobiose and pNP-linked substrates. The 3D structure of the thermostable β-glucosidase was downloaded from the Protein Data Bank database. Substrates were downloaded from the PubCehm database and were minimized using MOE software. Docking of BglA and substrates was carried out using MOE software. After analyzing docked enzyme/substrate complexes, it was found that Glu residues were mainly involved in the reaction, and other important residues such as Asn, Ser, Tyr, Trp, and His were involved in hydrogen bonding with pNP-linked substrates. By determining the substrate recognition pattern, a more suitable β-glucosidase enzyme could be developed, enhancing its industrial potential.

Combining Ability in Mungbean (Vigna radiata (L.) Wilczek) II. Traits Related to Indetemination

  • Srinives, P.;Khattak, G.S.S.;Haq, M.A.;Ashraf, M.
    • KOREAN JOURNAL OF CROP SCIENCE
    • /
    • v.46 no.5
    • /
    • pp.424-427
    • /
    • 2001
  • Combining ability study was carried out on the components of synchronization in maturity and determinate growth habit in mungbean, using 6$\times$6 diallel cross. Both additive and non-additive gene effects were found conditioning the inheritance of days to first flower, days between first pod and 90% pod maturity (DDd1), plant height from first pod stage to 90% pod maturity (DDhl, DDh2, and DDh3). Only non-additive gene action was important in degree of determination from first pod stage to 90% pod maturity (DDd2). While only additive action was important in plant height at first flower. The predominant additive gene action was observed in all traits but non-additive was significant in only DDd$_2$. For synchronization in maturity, determinate growth habit, and their components, the best combiners were NM92, VCl560D, and NM89, whereas the best indeterminate combinations were NM92 $\times$ NM89, NM92 $\times$ VCl560D, and NM92 $\times$ ML-5.

  • PDF

Nasolabial and extended nasolabial flaps for reconstruction in oral submucous fibrosis

  • Qayyum, Muhammad Umar;Janjua, Omer Sefvan;Haq, Ehtesham Ul;Zahra, Rubbab
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
    • /
    • v.44 no.4
    • /
    • pp.191-197
    • /
    • 2018
  • Objectives: The objective of the study was to evaluate the results of nasolabial/extended nasolabial flaps as a modality for treatment of oral submucous fibrosis. Materials and Methods: Eleven patients of Stage III or IVa maximum interincisal opening were selected to be operated. Nasolabial/extended nasolabial flaps were done for both the sides. All of the flaps were done in a single stage and were inferiorly based. A similar flap harvest/surgical technique was utilized for all the cases. Results: The preoperative mouth opening ranged from 5 to 16 mm, with a mean of 10.09 mm. At 6 months the mouth opening ranged from 29 to 39 mm. Some of the complications encountered were poor scar, wisdom tooth traumatising the flap, decreased mouth opening due to non compliance and too much bulk. All of theses were managed satisfactorily. Conclusion: The nasolabial flap is a very reliable flap to restore the function of oral cavity. Important adjuvant measures are habit cessation, lifestyle changes, and aggressive physiotherapy.