• Title/Summary/Keyword: HANA

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Bioequivalence of Hana Ondansetron Tablet to Zofran Tablet (Ondansetron 8 mg) (조프란 정(온단세트론 8 mg)에 대한 하나 온단세트론 정의 생물학적 동등성)

  • Cho, Hea-Young;Kim, Soo-Jin;Shim, Young-Sun;Lim, Dong-Koo;Oh, In-Joon;Moon, Jai-Dong;Lee, Yong-Bok
    • Journal of Pharmaceutical Investigation
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    • v.30 no.3
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    • pp.213-218
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    • 2000

  • Ondansetron is a potent, highly selective 5-hydroxytryptamine3(5-HT3) receptor- antagonist, for the management of nausea and vomiting induced by cytotoxic chemotherapy and radiography, and the treatment of post-operative nausea and vomiting. The purpose of the present study was to evaluate the bioequivalence of two ondansetron tablets, $Zofran^{TM}$, (Glaxo Wellcome Korea Ltd.) and Hana ondansetron (Hana Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, $23.56{\pm}1.79$ year in age and $67.35{\pm}8.35\;kg$ in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one tablet containing 8 mg of ondansetron was orally administered, blood was taken at predetermined time intervals and the concentrations of ondansetron in serum were determined using HPLC with UV detector. Pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two tablets were 7.53%, -0.23% and -3.92%, respectively when calculated against the $Zofran^{TM}$, tablet. The powers $(1-{\beta})$ for $AUC_t,\;C_{max}\;and\;T_{max}$ were above 99.00%, above 99.00% and 84.99%, respectively. Minimum detectable differences $(\Delta)\;at\;{\alpha}=0.1\;and\;1-{\beta}=0.8$ were all less than 20% (e.g., 12.25%, 10.88% and 18.37% for $AUC_t,\;C_{max}\;and\;T_{max}$, respectively). The 90% confidence intervals were all within ${\pm}20%$ (e.g., $-0.70{\sim}15.76,\;-7.53{\sim}7.08\;and\;-16.27{\sim}8.42\;for\;AUC_t,\;C_{max}\;and\;T_{max}$, respectively). All of the above parameters met the criteria of KFDA for bioequivalence, indicating that Hana ondansetron tablet is bioequivalent to $Zofran^{TM}$, tablet.

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Study on Construction Example of Free Formed Curved Facade using External UHPC Panels -Focused on the Remodeling Construction of Samsung-dong KEB Hana Bank - (UHPC 외장패널을 활용한 비정형 곡면 파사드의 시공사례에 대한 연구 - 삼성동 KEB 하나은행 리모델링 공사 -)

  • Park, Young-Mi;Kim, Hye Won;Park, Ki-Hong;Kim, Sung-Jin
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2017.05a
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    • pp.62-63
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    • 2017

  • According to the rapid development of digital technology, the free formed buildings with complex and various curved surfaces are being constructed. Most of the external cladding of free formed buildings have been applied materials such as metal, glass, FRP, GFRC, etc. However, these materials have many disadvantages such as a complicated manufacturing process for realizing 3D irregular shape and an increase in production period and cost. Therefore, the studies for UHPC which is an optimized material for overcoming this problem for a long time in overseas. This study reviewed the remodeling construction of Samsung-dong KEB Hana Bank appling the exterior curved UHPC panel for the first time in Korea. As a result, we confirmed the possibility of UHPC panels with various free formed shapes.

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Research on Laser Soldering of Micro Solder-balls (마이크로 솔더볼의 레이저 솔더링에 관한 연구)

  • Kang H.S.;Suh J.;Lee J.H.;Kim J.O.;Shin H.W.;Kim D.Y.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2006.05a
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    • pp.661-662
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    • 2006

  • This research is on a laser soldering using the micro solder-balls used in flip chip packaging process. A laser source used in laser soldering is Nd:YAG laser(250W and 60W). Solder-balls of 100, 300, $500{\mu}m$ size are used in experiments. The laser head to deliver a laser beam and the nozzle to transfer solder-balls are manufactured to bump solder-balls. After soldering solder-balls the shear test is carried out to determine the wetting at the interface between the surface and a solder-balls With the results of solder bumping tests a laminated molding is accomplished for manufacturing the three dimensional molding.

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In-pile Test Results of HANA Claddings in Halden Research Reactor

  • Baek, Jong-Hyuk;Choi, Byoung-Kwon;Jeong, Yong-Hwan;Jung, Yun-Ho;Kim, Kyu-Tae
    • Proceedings of the Korean Nuclear Society Conference
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    • 2005.05a
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    • pp.425-426
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    • 2005

  • 1. The oxide thickness on the fuelled test rods was within the following range from 7 ${\mu}m$ to 17 ${\mu}m$. In general, the HANA claddings showed better corrosion behavior than the two reference alloys (A-Cladding and Zr-4). 2. The weight gains of corrosion coupons were ranged from 21 to 56 mg/$dm^2$.

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