• 한국산학기술학회논문지
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• 제14권9호
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• pp.4197-4203
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• 2013

본 실험연구는 인버터 압축기를 적용한 실내기 3실을 가진 멀티형 열펌프 시스템의 난방운전 시 열펌프의 난방성능을 연구하였다. 멀티형 열펌프의 운전특성은 항온항습 기능을 가진 공기엔탈피방식의 멀티형 칼로리미터를 이용하여 측정되었다. 난방표준 및 난방저온 온도조건에서 실내기 운전조합에 따른 실험을 수행하여 난방성능 변화를 관찰하였다. 실내기 3실을 가진 열펌프의 실내기 운전조합에 따른 난방표준 및 난방저온 운전에서 난방능력, 난방 COP, P-h선도로부터, 3실을 가진 열펌프의 운전특성과 냉매 사이클의 거동을 조사하였다. 열펌프의 운전부하와 성능은 실내기 조합에 의한 부분부하에 의존하므로 열펌프의 난방능력과 사이클의 거동은 다르게 관찰되었다. 표준온도 시험조건 대비 저온 시험조건의 난방능력과 난방 COP는 감소하였다. 또한 실내기 조합에 대한 냉매사이클은 P-h 선도를 사용하여 분석되었다.

• 한국산학기술학회논문지
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• 제9권6호
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• pp.1487-1493
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• 2008

본 연구에서는 인버터 압축기를 적용한 3실형 멀티-열펌프 시스템의 냉방운전 시 시스템의 성능특성을 조사하였다. 시스템의 운전특성은 항온항습 기능을 가진 공기엔탈피방식의 칼로리미터를 이용하여 측정되었으며, 냉방표준 및 냉방저온 온도조건에서 실내기 조합에 따른 실험이 수행되었다. 3실형 열펌프의 실내기 조합운전에 따른 냉방 표준운전 및 냉방저온운전 시의 냉방능력, COP, P-h선도로부터, 3실형 열펌프의 운전특성과 냉방사이클의 거동을 이해하였다. 열펌프의 운전부하와 성능은 실내기 조합에 의존하므로 시스템의 능력과 사이클의 거동은 다르게 관찰되었다. 과냉도 증가와 압축일의 감소로 표준조건보다 저온조건에서 냉방능력과 COP가 더 높았다. 또한 P-h 선도를 이용하여 사이클의 운전특성도 분석하였다.

• Journal of Microbiology and Biotechnology
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• 제10권4호
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• pp.441-448
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• 2000

The production and cation flux-mediated activation of the P-type ATPase in Helicobacter pylori was investigated. Using the polymerase chain reaction (PCR), the proton pump genotype of H. pylori was found to be positive for both F-type and P-type ATPases. Yet, their production in terms of enzyme specific activity varied substantially depending on H. pylori strains, ranging over 3-fold. Its main constituent appeared to be the P-type ATPase pool, in contrast to other common bacterial compositions. Interestingly, the F-type ATPase was observed only when intact H. pyloricells were exposed to pH 4.5 or above (37$^{\circ}C$ for 1 h). In contrast, significant amounts of the P-type ATPase still remained after 1 h of cell treatment even at pH below 4.5. By enriching the acidic medium with RPMI(pH 3.0), the P-type ATPase was stabilized, accompained by inactivation of the F-type ATPase. Using H. pylori membrane vesicles, it was found that ammionia-mediated cation flux increased the rate of ATP hydrolysis by the P-type ATPase. Accordingly, these data strongly suggest that the P-type ATPase is involved or functions as an effective regulator for the cation flux across the H. pylori membrane, thereby reducing the risk of excess proton influx.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2007년도 추계학술대회 논문집
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• pp.473-474
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• 2007

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2012년도 추계학술대회 논문집
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• pp.737-738
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• 2012

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2007년도 춘계학술대회 논문집
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• pp.741-742
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• 2007

• Journal of Neurogastroenterology and Motility
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• 제24권4호
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• pp.577-583
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• 2018

Background/Aims Potassium-competitive acid blockers are expected to be the next generation of drugs for the treatment of diseases caused by gastric acid. In 2015, vonoprazan fumarate, a novel potassium-competitive acid blocker, was approved by the Japanese health insurance system. Since its approval, patients refractory to vonoprazan can be encountered in clinical settings. We designed this study to clarify the pathophysiology of gastroesophageal reflux disease refractory to vonoprazan. Methods In this retrospective study, we involved patients who had refractory symptoms after administration of standard-dose proton pump inhibitors or vonoprazan and underwent diagnostic testing with esophageal high-resolution manometry and 24-hour multichannel intraluminal impedance and pH monitoring while using proton pump inhibitors or vonoprazan. Patients were diagnosed based on the Rome IV criteria for functional gastrointestinal disorders and diagnostic test results. Results Twenty-seven patients were analyzed during this study. Gastric pH ${\geq}4$ was sustained for a longer period of time, and the esophageal acid exposure time and number of acid reflux events were shorter in the vonoprazan group than in the proton pump inhibitor group. The percentage of patients diagnosed with acidic gastroesophageal reflux disease in the vonoprazan group was lower than that in the proton pump inhibitor group. Conclusions Intra-gastric pH and acid reflux were strongly suppressed by 20-mg vonoprazan. When patients with gastroesophageal reflux disease present symptoms after administration of 20-mg vonoprazan, the possibility of pathophysiologies other than acid reflux should be considered.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2009년도 추계학술대회 논문집
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• pp.95-96
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• 2009

• Clinical Endoscopy
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• 제57권4호
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• pp.417-423
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• 2024

Since the introduction of vonoprazan, a potassium-competitive acid blocker (P-CAB), it has been demonstrated to reversibly inhibit gastric acid secretion by engaging in potassium-competitive ionic binding to H⁺/K⁺-ATPase. In contrast, proton pump inhibitors (PPIs) achieve H⁺/K⁺-ATPase inhibition through covalent binding to cysteine residues of the proton pump. Reported cases have indicated an emerging trend of P-CAB-related gastropathies, similar to those associated with PPIs, as well as unique gastropathies specific to P-CAB use, such as the identification of web-like mucus. Pathologically, parietal cell profusions, which show a positively correlated with hypergastrinemia, have a higher incidence in P-CAB users compared to PPI users. Thus, this review aims to summarize the endoscopic and pathological findings reported to date concerning P-CAB-related gastric mucosal lesions. Additionally, it seeks to discuss the differences between the PPIs and P-CABs in terms of the formation and frequency of associated gastropathies. This review highlights the evident differences in the mechanism of action and potency of acid inhibition between P-CABs and PPIs, notably contributing to differences in the formation and frequency of associated gastropathies. It emphasizes the necessity to distinguish between P-CAB-related and PPI-related gastropathies in the clinical setting.

• 한국해양공학회:학술대회논문집
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• 한국해양공학회 2004년도 학술대회지
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• pp.13-16
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• 2004

Deep sea water has mid temperature, abundant nutrients and minerals, and good tooter quality. For the purpose of drawing up deep sea water without pump pit construction, tile authors are considering to use air-lift pump. This report describes fundamental experimental investigation for air-lift pump characteristic and improvement in efficiency.