• 제목/요약/키워드: H-continuous

검색결과 2,171건 처리시간 0.033초

Nafamostat Mesilate Inhibits TNF-${\alpha}$-Induced Vascular Endothelial Cell Dysfunction by Inhibiting Reactive Oxygen Species Production

  • Kang, Min-Woong;Song, Hee-Jung;Kang, Shin Kwang;Kim, Yonghwan;Jung, Saet-Byel;Jee, Sungju;Moon, Jae Young;Suh, Kwang-Sun;Lee, Sang Do;Jeon, Byeong Hwa;Kim, Cuk-Seong
    • The Korean Journal of Physiology and Pharmacology
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    • 제19권3호
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    • pp.229-234
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    • 2015
  • Nafamostat mesilate (NM) is a serine protease inhibitor with anticoagulant and anti-inflammatory effects. NM has been used in Asia for anticoagulation during extracorporeal circulation in patients undergoing continuous renal replacement therapy and extra corporeal membrane oxygenation. Oxidative stress is an independent risk factor for atherosclerotic vascular disease and is associated with vascular endothelial function. We investigated whether NM could inhibit endothelial dysfunction induced by tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$ ). Human umbilical vein endothelial cells (HUVECs) were treated with TNF-${\alpha}$ for 24 h. The effects of NM on monocyte adhesion, vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1) protein expression, p38 mitogenactivated protein kinase (MAPK) activation, and intracellular superoxide production were then examined. NM ($0.01{\sim}100{\mu}g/mL$) did not affect HUVEC viability; however, it inhibited the increases in reactive oxygen species (ROS) production and p66shc expression elicited by TNF-${\alpha}$ (3 ng/mL), and it dose dependently prevented the TNF-${\alpha}$ -induced upregulation of endothelial VCAM-1 and ICAM-1. In addition, it mitigated TNF-${\alpha}$ -induced p38 MAPK phosphorylation and the adhesion of U937 monocytes. These data suggest that NM mitigates TNF-${\alpha}$ -induced monocyte adhesion and the expression of endothelial cell adhesion molecules, and that the anti-adhesive effect of NM is mediated through the inhibition of p66shc, ROS production, and p38 MAPK activation.

지속적 양압술과 수면중 주기적 사지운동 장애의 관계에 대한 예비적 연구 : 앙와위가 주기적 사지운동 장애와 관련되는가? (Preliminary Study of The Periodic Limb Movement Disorder Following Nasal CPAP : Is It Associated With Supine-Sleeping Position?)

  • 양창국;알렉스클럭
    • 수면정신생리
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    • 제4권2호
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    • pp.164-171
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    • 1997
  • Introduction : Periodic limb movement disorder (PLMD) is shown to common in patients with OSA and may become evident or worsened when treated with nasal continuous positive airway pressure (CPAP). Whether this is due to im proved sleep continuity. adverse nocturnal body positioning, uncovered by CPAP, or due to the CPAP stimulus is still debat-ed. We hypothesized that the increase in PLM activity following CPAP is associated with more supine-sleeping tendencies when being treated with CPAP. In the present work, we compared differences in the PLMD index (PLMI) and sleeping position of patients with sleep disordered breathing before and after CPAP treatment. Method : We studied 16 patients (mean age 46 yr, 9M, 7F) with OSA (11 patients) or UARS (5 patients) who either had PLMD on initial polysomnogram (baseline PSG) or on nasal CPAP trial (CPAP PSG). All periodic leg movements were scored on anterior tibialis EMG during sleep according to standard criteria (net duration; 0.5-5.0 seconds, intervals; 4-90 seconds. 4 consecutive movements). Paired t-tests compared PLMD index (PLMI), PLMD-related arousal index (PLMD-ArI), respiratory disturbance index (RDI), and supine sleeping position spent with baseline PSG and CPAP PSG. Results : Ten patients (63%) on baseline PSG and fifteen patients (94%) on CPAP PSG had documented PLMD ($PLMI{\ge}5$) respectively with significant increase on CPAP PSG(p<0.05). Ten patients showed the emergence (6/10 patients) or substantial worsening (4/10 patients) of PLMD during CPAP trial. Mean CPAP pressure was $7.6{\pm}1.8\;cmH_2O$. PLMI tended to increase from baseline PSG to CPAP PSG, and significantly increase when excluding 2 outlier (baseline PSG, $19.0{\pm}25.8/hr$ vs CPAP PSG, $29.9{\pm}12.5/hr$, p<0.1). PLMD-ArI showed no significant change, but a significant decrease was detected when excluding 2 outlier (p<0.1). There was no significant sleeping positional difference (supine vs non-supine) on baseline PSG, but significantly more supine position (supine vs non-supine, p<0.05) on CPAP PSG. There was no significant difference in PLMI during supine-sleeping and nonsupine-sleeping position on both of baseline PSG and CPAP PSG. There was also no significant difference in PLMI during supine-sleeping position between baseline PSG and CPAP PSG. With nasal CPAP, there was a highly significant reduction in the RDI (baseline PSG, $14.1{\pm}21.3/hr$ vs CPAP PSG, $2.7{\pm}3.9/hr$, p<0.05). Conclusion : This preliminary data confirms previous findings that CPAP is a very effective treatment for OSA, and that PLMD is developed or worsened with treatment by CPAP. This data also indicates that supine-sleeping position is more common when being treated with CPAP. However, there was no clear evidence that supine position is the causal factor of increased PLMD with CPAP. It is, however, suggested that the relative movement limitation induced by CPAP treatment could be a contributory factor of PLMD.

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Software development for the visualization of brain fiber tract by using 24-bit color coding in diffusion tensor image

  • Oh, Jung-Su;Song, In-Chan;Ik hwan Cho;Kim, Jong-Hyo;Chang, Kee-Hyun;Park, Kwang-Suk
    • 대한자기공명의과학회:학술대회논문집
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    • 대한자기공명의과학회 2002년도 제7차 학술대회 초록집
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    • pp.133-133
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    • 2002
  • Purpose: The purpose of paper is to implement software to visualize brain fiber tract using a 24-bit color coding scheme and to test its feasibility. Materials and Methods: MR imaging was performed on GE 1.5 T Signa scanner. For diffusion tensor image, we used a single shot spin-echo EPI sequence with 7 non-colinear pulsed-field gradient directions: (x, y, z):(1,1,0),(-1,1,0),(1,0,1),(-1,0,1),(0,1,1),(0,1,-1) and without diffusion gradient. B-factor was 500 sec/$\textrm{mm}^2$. Acquisition parameters are as follows: TUTE=10000ms/99ms, FOV=240mm, matrix=128${\times}$128, slice thickness/gap=6mm/0mm, total slice number=30. Subjects consisted of 10 normal young volunteers (age:21∼26 yrs, 5 men, 5 women). All DTI images were smoothed with Gaussian kernel with the FWHM of 2 pixels. Color coding schemes for visualization of directional information was as follows. HSV(Hue, Saturation, Value) color system is appropriate for assigning RGB(Red, Green, and Blue) value for every different directions because of its volumetric directional expression. Each of HSV are assigned due to (r,$\theta$,${\Phi}$) in spherical coordinate. HSV calculated by this way can be transformed into RGB color system by general HSV to RGB conversion formula. Symmetry schemes: It is natural to code the antipodal direction to be same color(antipodal symmetry). So even with no symmetry scheme, the antipodal symmetry must be included. With no symmetry scheme, we can assign every different colors for every different orientation.(H =${\Phi}$, S=2$\theta$/$\pi$, V=λw, where λw is anisotropy). But that may assign very discontinuous color even between adjacent yokels. On the other hand, Full symmetry or absolute value scheme includes symmetry for 180$^{\circ}$ rotation about xy-plane of color coordinate (rotational symmetry) and for both hemisphere (mirror symmetry). In absolute value scheme, each of RGB value can be expressed as follows. R=λw|Vx|, G=λw|Vy|, B=λw|Vz|, where (Vx, Vy, Vz) is eigenvector corresponding to the largest eigenvalue of diffusion tensor. With applying full symmetry or absolute value scheme, we can get more continuous color coding at the expense of coding same color for symmetric direction. For better visualization of fiber tract directions, Gamma and brightness correction had done. All of these implementations were done on the IDL 5.4 platform.

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온도와 광주기 조건이 코드링나방 수컷의 활동력에 마치는 영향 (Effects of Temperature and Photoperiod on Male Activity in Laspeyresia pomonella (L.) in New York)

  • 송유한;H. 리델
    • 한국응용곤충학회지
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    • 제24권2호
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    • pp.71-77
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    • 1985
  • 광주기 16:8(명기:암기) 온도 $23^{\circ}C$ 이상 $30^{\circ}C$ 이하의 실험실 조건에서 코드링나방(Laspeyresia pomonella) 수컷의 활동리듬을 활동력 측정장치로 조사한 바, 소등시에 한번(제1활동기)과 점등시에 한번(제2활동기)의 두 번의 활동최성기를 나타내었다. 제1활동기는 소등 $5{\sim}6$시간 전에 시작되었으며 소등신호에 의해 활동시작시간이 결정되는 것으로 나타났다. 또한 계속조명조건에서는 활동주기가 24시간보다 약간 길어지는 경향이었으며 이는 곤충의 일주활동성의 특성에 부합되는 것으로 나타났다. 광주기 16:8 하에서 $11.3^{\circ}C$ 부터 $30^{\circ}C$까지 8단계의 온도조건을 두어 숫나방의 활동리듬을 조사한 결과 $11.3^{\circ}C$에서는 전혀 활동하지 못하였다. 또한 $20^{\circ}C$ 이하의 온도에서는 제2활동기가 나타나지 않았으며 $18^{\circ}C$ 이하에서는 제1활동기 중 암기에서의 활동이 완전히 억제되었다. 온도범위 $20^{\circ}C{\sim}30^{\circ}C$ 하에서는 온도가 상승함에 따라 제2활동기와 제1활동기 중 암기에서의 활동성이 증대되었다. 이러한 온도상승에 따른 제1활동기의 암기에서의 활동력 증대로 인하여 활동 평균시간이 암기쪽으로 이동하였다. 코드링나방의 온도에 따른 평균 활동시간의 변동은 상기한 저온에서의 암기에 활동력 감퇴에 의해 나타나는 것으로 추정된다.

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연속 부가차로 엇갈림 구간 진출입 행태분석에 관한 연구: 클로버형 입체교차로를 중심으로 (Analysis on Entry and Exit Behaviors at the Weaving Section of a Continuous Auxiliary Lane: Focused on Clover-shaped Interchanges)

  • 박제진;하태준;오재철;최흥섭
    • 한국ITS학회 논문지
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    • 제16권6호
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    • pp.79-89
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    • 2017
  • 고속도로 위빙구간은 진입과 진출차량에 의한 상충이 발생되는 지점으로 본선과의 영향을 최소화하기 위하여 집산로를 설치토록 하고 있다. 집산부의 설계속도는 50km/h이나 실제 운전자는 설계속도에 맞춰 적정한 감속이 이루어지지 않고 있어 사고위험이 상존해 있다. 현재 집산로가 설치된 위빙구간의 경우 전구간 진출입 가능한 행태로 설계되고 있어 운전행태를 분석하기 위해 본 연구를 실시하였다. 본 연구에서는 운전자의 행태를 분석하기 위해 클로버형 입체교차로를 중심으로 현장조사를 실시하였고, 조사된 자료를 활용하여 진출입 엇갈림 구간에서의 주행속도 및 차로변경위치, 운전자 주행행태를 분석하였다. 이를 통해 향후 엇갈림 진출입구간에 대한 교통안전성 향상 및 기초자료로 활용이 가능할 것으로 사료된다.

Dental Prescale과 편측 교합력 측정기를 이용한 정상성인의 교합력 비교 (COMPARISON OF BITE FORCE WITH DENTAL PRESCALE AND UNILATERAL BITE FORCE RECORDER IN HEALTHY SUBJECTS)

  • 권호근;유자혜;권영숙;김백일
    • 대한치과보철학회지
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    • 제44권1호
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    • pp.103-111
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    • 2006
  • Statement of problem: The previous unilateral bite force recorder has several limitations for taking long time for measuring and causing discomfort to subjects. Because of these reasons, it could not use widely for epidemiological researches. However, 'Dental Prescale System' which is new equipment for measuring bite force, is more convenient for measuring bite force than previous unilateral recorder. Purpose: The purpose of this study was to compare a new technique(Dental Prescale System) using pressure sensitive foils for recording of maximal jaw closing force with conventional measurement using unilateral bite force recorder Material and method: This studies included 22 healthy dental students in college of dentistry Yonsei university in Rep of Korea. Mean age was 23.9 years. All subjects had continuous dental arches and no significant malocclusion or signs from the teeth and craniomandibular system. The Dental Prescale System (Fuji Film, Tokyo, Japan) consists of a horseshoe-shaped pressure sensitive sheet (50H, R type) and a computerized scanning system.(FPD705) We also used unilateral bite force recorder(Denbotics Co. Seoul, Rep.Korea) for comparing with Dental Prescale. Results and conclusion: The total bite force recorded with Dental Prescale System (1423 N) was systematically higher than that recorded by unilateral bite force recorder. (256 N) However, the maximum bite force values measured in the two ways were significantly correlated (r=0.46, p<0.05). The Dental Prescale bite force calculated for first molar (208 N) was lower than that recorded by unilateral bite force recorder. (256 N) The two values were also very significantly correlated. (r=0.66. p<0.001) There were significantly different in bite force between two measurement methods. The reasons were first, unilateral bite force recorder measured only the bite force of a part of teeth, and Dental Prescale measured the total teeth force. Second, in measurement, a difference in muscle contraction appeared by an extent of mouth-opening. Third, unilateral bite force recorder has the reducing effect of the bite force by protective tape. Fourth, Dental Prescale has limitations during the computer scanning procedure. Therefore, Dental Prescale System is considered to be a very promising alternative to be conventional bite force recording methods.

EFFECT OF HEAT CURING METHODS ON THE TEMPERATURE HISTORY AND STRENGTH DEVELOPMENT OF SLAB CONCRETE FOR NUCLEAR POWER PLANT STRUCTURES IN COLD CLIMATES

  • Lee, Gun-Che;Han, Min-Cheol;Baek, Dae-Hyun;Koh, Kyung-Taek
    • Nuclear Engineering and Technology
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    • 제44권5호
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    • pp.523-534
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    • 2012
  • The objective of this study was to experimentally investigate the effect of heat curing methods on the temperature history and strength development of slab concrete exposed to $-10^{\circ}C$. The goal was to determine proper heat curing methods for the protection of nuclear power plant structures against early-age frost damage under adverse (cold) conditions. Two types of methods were studied: heat insulation alone and in combination with a heating cable. For heat curing with heat insulation alone, either sawdust or a double layer bubble sheet (2-BS) was applied. For curing with a combination of heat insulation and a heating cable, an embedded heating cable was used with either a sawdust cover, a 2-BS cover, or a quadruple layer bubble sheet (4-BS) cover. Seven different slab specimens with dimensions of $1200{\times}600{\times}200$ mm and a design strength of 27 MPa were fabricated and cured at $-10^{\circ}C$ for 7 d. The application of sawdust and 2-BS allowed the concrete temperature to fall below $0^{\circ}C$ within 40 h after exposure to $-10^{\circ}C$, and then, the temperature dropped to $-10^{\circ}C$ and remained there for 7 d owing to insufficient thermal resistance. However, the combination of a heating cable plus sawdust or 2-BS maintained the concrete temperature around $5^{\circ}C$ for 7 d. Moreover, the combination of the heating cable and 4-BS maintained the concrete temperature around $10^{\circ}C$ for 7 d. This was due to the continuous heat supply from the heating cable and the prevention of heat loss by the 4-BS. For maturity development, which is an index of early-age frost damage, the application of heat insulation materials alone did not allow the concrete to meet the minimum maturity required to protect against early-age frost damage after 7 d, owing to poor thermal resistance. However, the combination of the heating cable and the heat insulating materials allowed the concrete to attain the minimum maturity level after just 3 d. In the case of strength development, the heat insulation materials alone were insufficient to achieve the minimum 7-d strength required to prevent early-age frost damage. However, the combination of a heating cable and heat insulating materials met both the minimum 7-d strength and the 28-d design strength owing to the heat supply and thermal resistance. Therefore, it is believed that by combining a heating cable and 4-BS, concrete exposed to $-10^{\circ}C$ can be effectively protected from early-age frost damage and can attain the required 28-d compressive strength.

아말감과 복합레진의 수복 과정과 수복 후 발생하는 상아세관액 흐름의 실시간 측정 (REAL-TIME MEASUREMENT OF DENTINAL TUBULAR FLUID FLOW DURING AND AFTER AMALGAM AND COMPOSITE RESTORATIONS)

  • 김선영;조병훈;백승호;임범순;이인복
    • Restorative Dentistry and Endodontics
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    • 제34권6호
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    • pp.467-476
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    • 2009
  • 본 연구의 목적은 아말감과 복합레진의 수복 과정과 수복 후 상아세관액의 흐름(dentinal fluid flow, DFF)을 측정하기 위함이다. 치근을 절제한 제 3 대구치를 자체 제작한 미세 유체 흐름 측정장치에 연결한 후 1급 와동을 형성하여 아말감과 복합레진 수복을 시행하였다. DFF의 측정은 와동 형성부터 수복 후 30분까지 연속적으로 이루어졌고, 수복 후 3, 7일에 재 측정하였다. 주수 하에 와동 형성 시 DFF는 inward로, 끝난 후에는 outward로 바뀌었다. 아말감 충전 시 DFF는 inward로 바뀌었고 충전 완료 후 미약한 outward DFF를 보였다. 복합레진 수복의 경우, 산 처리 후 수세와 건조 시 각각 inward와 outward DFF를 보였고 primer도포 후 공기 분사는 급격한 outward, 소수성 본딩제를 적용하는 단계에서는 outward 였던 DFF가 감소하여 0에 가까워지거나 약간 inward 흐름을 보였다. 접착제와 복합레진의 광중합은 급격한 inward의 DFF를 일으켰다. 수복 후 30분, 3일, 7일째 수복 재료에 따른 DFF의 감소에 통계적으로 유의한 차이는 없었다 (p>0.05).

전자궁 적출술 후 자가통증조절장치를 이용하여 정맥과 경막외로 투여된 Alfentanil의 진통효과 비교 (Patient Controlled Analgesia of Alfentanil after a Total Abdominal Hysterectomy: A Comparison of the Intravenous and Epidural Route)

  • 최수경;윤석화;이준화;황재하;정우석;김윤희;이원형
    • The Korean Journal of Pain
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    • 제20권2호
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    • pp.169-173
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    • 2007
  • Background: Although the use of intravenous patient controlled analgesia (IVPCA) has been compared to the use of patient conrolled epidural analgesia (PCEA), there is no optimal administration route of alfentanil for the treatment of postoperative pain. This randomized double-blind study compared the efficacy of the use of IVPCA and PCEA for postoperative pain and the side effects after a total abdominal hysterectomy (TAH). Methods: Sixty patients undergoing a TAH were randomly assigned to receive either IVPCA (Group I) or PCEA (Group E) for the infusion of alfentanil for postoperative pain control. In both groups, a loading dose of $750{\mu}g$ alfentanil was administered. All patients received the same continuous infusion rate (0.3 mg/h), bolus dose (0.15 mg), and lockout time (15 min). The incidence of side effects, the VAS (visual analog scale) of pain, blood pressure, and heart rate were checked for 20 hours after the loading dose injection. Results: The VAS of pain was not significantly different between the two groups of patients. The onset of the analgesic effect was significantly more rapid in the Group I patients than in the Group E patients. There was no difference in side effects for either group. Conclusions: When considering multiple factors such as the onset of analgesia, technical difficulties or infection after the procedure, IVPCA using alfentanil is more useful than PCEA for postoperative pain control after a TAH.

온실가스감축효과를 고려한 태양광 연계형 에너지저장장치(ESS) 보급전략에 대한 연구 (A Research on PV-connected ESS dissemination strategy considering the effects of GHG reduction)

  • 이원구;김강원;김발호
    • 에너지공학
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    • 제25권2호
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    • pp.94-100
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    • 2016
  • 에너지저장장치(ESS)는 전력수급 불균형 해소, 신재생에너지의 출력안정, 주파수 조정용 등 전력공급 안정성 향상 및 효율적 전기에너지사용 등에 기여하는 중요자원으로, 전세계적으로 '23년까지 '14년 설치용량의 약 30배가 증가한 55.9GWh의 보급이 전망되고 있다. 이와 같이 급증하는 세계시장에서 국내 ESS 업계의 경쟁력 확보를 위해서는 자국내 설치실적(Track Record) 확보가 필요한데, 우리나라는 주파수 조정용(FR용(用))과 그간 지속되어 왔던 전력수급 불균형 상황에 대비하기 위한 부하이동용 중심으로 ESS를 보급하여 왔다. 하지만, 주파수 조정용의 경우 통상적으로 화력발전소 정격용량의 약 5% 범위에서 설치효용이 발생하는 것으로 평가되고 있어, 화력발전이 비약적으로 증가하지 않는 한 국내 시장의 확장성이 부족하다고 할 수 있으며, 여유로운 예비력 확보정책에 따라 부하이동용에 대해서도 보급필요성이 저하되고 있는 바, 새로운 방식의 보급확대 대상이 필요하다고 할 수 있다. 유망한 신규보급대상은 간헐적 출력의 약점은 있으나, 신기후체제 대응과 산업육성을 위해 지속적으로 추진예정인 신재생에너지와의 연계설치를 통해 신재생에너지의 출력을 안정화 하고, 신재생에너지 발전량의 계통투입시기 조절을 통한 이산화탄소 저감효과를 기대할 수 있는 분야라고 할 수 있다. 본 연구에서는 향후 에너지정책의 최대 화두인 신기후체제 대응을 위한 온실가스 감축수단을 활용할 수 있도록, 태양광 연계형 ESS 충방전모드를 온실가스 저감효과를 고려토록 설계한 후, 투자유도를 위한 REC 가중치 산정방법에 대한 정책대안을 제시하였다.