• Title/Summary/Keyword: Guided mode

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Docking and Quantum Mechanics-Guided CoMFA Analysis of b-RAF Inhibitors

  • Muddassar, M.;Pasha, F. A.;Yoo, Kyung-Ho;Lee, So-Ha;Cho, Seung-Joo
    • Bulletin of the Korean Chemical Society
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    • v.29 no.8
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    • pp.1499-1504
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    • 2008
  • Pyrazine derivatives bind to b-RAF receptor which is important in cancer therapy. The ligand-receptor interactions have been studied by comparative molecular field analysis (CoMFA) and molecular docking methods. Applying conventional ligand-based alignment schemes for the whole set was not successful. However, QM and DFT results suggested that some ligands have electrostatic interaction while others have steric interactions. On the basis of these results, we divided the dataset into two subsets. Electrostatic effect was found to be important in one set while steric effect for the other. Best docking modes were obtained for each subset based on the available crystal structure. These receptor-guided CoMFA models propose an interesting possibility which is difficult to obtain otherwise. i.e., in one binding mode the electrostatic interaction plays a key role for one subset ($q^2$ = 0.46, $r^2$ = 0.98), while in another binding mode steric effect is important with another subset ($q^2$ = 0.43, $r^2$ = 0.74).

Nonlinear guided-wave properties in planar waveguides with two nonlinear bounding thin films (비선형 박막으로 둘러싸인 평면 광도파로에서의 비선형 도파광 특성)

  • 정종술;송석호;이일항
    • Korean Journal of Optics and Photonics
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    • v.7 no.2
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    • pp.136-141
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    • 1996
  • We present a novel description of TE nonlinear guided waves in planar waveguides with two nonlinear bounding thin films. The nonlinear dispersion relations of the nonlinear waveguides are obtained by adopting the nonlinear transfer matrix. The optical properties obtained from these equations include: the power dependence of mode indices, the transition of the field maximum location, and the power distribution. The planar waveguide with self-focusing nonlinear layers shows the optical bistability of power-dependent mode indices, and the critical powers for the optical bistability increase with decreasing thickness of the nonlinear layers. The power distributions display the optical bistabilities, similar to those of nonlinear Fabry-Perot etalon.

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Inspection of Heat Exchanger Tubing Defects with Ultrasonic Guided Waves (유도초음파를 이용한 열 교환기 튜브 결함 탐상)

  • Shin, Hyeon-Jae;Rose, Joseph L.;Song, Sung-Jin
    • Journal of the Korean Society for Nondestructive Testing
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    • v.20 no.1
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    • pp.1-9
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    • 2000
  • This study shows the defect detection and sizing capability of ultrasonic guided waves in the nondestructive inspection of heat exchanger and steam generator tubing. Phase and group velocity dispersion curves for the longitudinal and flexural modes of a sample Inconel tube were presented for the theoretical analysis. EDM(Electric Discharge Machining) wears in tubing under a tube support plate and circumferential laser notches in tubing were detected by an axisymmetric and a non-axisymmetric transducer set up, respectively. EDM wears were detected with L(0, 2), L(0, 3) and L(0, 4) modes and among them L(0, 4) mode was found to be the most sensitive. It was also found that the flexural modes around L(0, 1) mode could be used for the detection and sizing of laser notches in the tubing.

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The Pigrailing and The Loss Analysis of low loss LiNbO$_3$ Optical Waveguide with Fiber-to-fiber Insetion Loss<6dB (Total Fiber-to-fiber Insertion Loss가 <6dB 인 Ti:$LiNbO_3$ 과도파로 Pigtailing 및 손실분석)

  • 김성구;박계춘;조재철
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.11 no.7
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    • pp.557-564
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    • 1998
  • A low loss x-cut $LiNbO_3$optical waveguide was fabricated by Yi in-diffusion, and the properties of guided-mode and the total insertion loss of the pigtailed waveguide with polarization maintaining fiber(PMF) were measured at optical wavelength 1550nm. for forming the waveguides, the parameters of diffusion, Ti thickness, waveguide line-width, length, diffusion temperature, time and atmosphere were set $1400{\AA}$, $8{\mu}m$, 3.3cm, $1050^{\circ}C$, 8 hours and wet bubbled oxygen, respectively. And then after the polishing and piatailing, it showed that the total insertion loss was -4.1dB for TM mode, -5.5dB for TE mode, and mode size, that is, the horizontal/ vertical size were $13.8{\mu}m/18{\mu}m$ for TM mode, $9.6{\mu}m/6.5{\mu}m$ for TE mode.

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Determination of dielectric property of subsurface by dispersive guided GPR wave (레이다파의 분산성 가이드 현상을 이용한 지하 물성 계산)

  • Yi, Myeong-Jong;Endres, Anthony L.;Kim, Jung-Ho
    • 한국지구물리탐사학회:학술대회논문집
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    • 2006.06a
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    • pp.25-30
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    • 2006
  • When wet soil overlies dry soil, which can be found in the infiltration test, the radar wave is not attenuated and guided within wet soil layer. This phenomenon is known to be the dispersive guided wave and happens when the thickness of upper wet layer is less than or comparable to the wavelength of radar wave. In this study, we have conducted the FDTD modeling and obtained the velocity dispersion curve to identify the dispersive guided wave through F-K analysis. This guided wave can be explained by modal propagation theory and a simple inversion code was developed to obtain the two layer's dielectric constants as well as layer thickness. By inverting the dispersion curve from synthetic modeling data, we could obtain the accurate dielectric constants and layer thickness. Moreover, we could enhance the accuracy by including the higher mode data. We expect this method will be very useful to get the quantitative property of subsurface when the condition is similar.

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Position Controller of Rail Guided Unmanned Monitoring System with the Driving Slip Compensator (주행 슬립 오차 보상기를 가지는 레일 가이드 무인 설비 감시 장치의 위치 제어기)

  • Bae, Jongnam;Kwak, Yunchang;Lee, Dong-Hee
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.66 no.5
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    • pp.792-799
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    • 2017
  • The real time unmanned monitoring system of an equipment's internal parts and condition requires the monitoring device to be able to stop at a set location on the rail. However, due to the slip between the driving surface and the roller, an error occurs between the actual position and the command position. In this paper, a method to compensate the position error due to the roller slip is proposed. A proximity sensor located at both ends of the rail detects the starting point and the maximum position pulse, linearly compensating the error between the angular position of the motor and the mechanically fixed starting and maximum position pulse of the rail in forward and reverse direction. Moreover, unlike the existing servo position controller, the motor adopts the position detection method of Hall sensor in BLDC (Brushless DC) and applies an algorithm for low-speed driving so that a stable position control is possible. The proposed rail guided unmanned monitoring system with driving slip compensator was tested to verify the effectiveness.

Magnetic Property Effects of the Strip on Transducer Sensitivity in a Magnetostrictive Strip Type Guided Wave Transducer (자왜 스트립 도파변환기에서 스트립의 자기적 특성이 변환기 감도에 미치는 영향)

  • Kim, Sung-Joon;Choi, Myoung-Seon
    • Journal of the Korean Society for Nondestructive Testing
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    • v.28 no.2
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    • pp.205-210
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    • 2008
  • Magnetic hysteresis loops of a nickel strip and a Fe-Co alloy strip, which have been used in magnetostrictive strip type guided wave transducers for long range ultrasonic testing of pipelines, were measured and then magnetic property effects of a strip on transducer sensitivity were analyzed. The sensitivity of an optimized Fe-Co strip transducer was superior to that of the nickel strip transducer by a factor of about 30. It was shown that this was mainly attributed to the differences in remanence magnetization and coercivity of the two magnetostrictive materials.

Damage Detection of Railroad Tracks Using Piezoelectric Sensors (압전센서를 이용하는 철로에서의 손상 검색 기술)

  • Yun Chung-Bang;Park Seung-Hee;Inman Daniel J.
    • Proceedings of the Computational Structural Engineering Institute Conference
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    • 2006.04a
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    • pp.240-247
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    • 2006
  • Piezoelectric sensor-based health monitoring technique using a two-step support vector machine (SYM) classifier is discussed for damage identification of a railroad track. An active sensing system composed of two PZT patches was investigated in conjunction with both impedance and guided wave propagation methods to detect two kinds of damage of the railroad track (one is a hole damage of 0.5cm in diameter at web section and the other is a transverse cut damage of 7.5cm in length and 0.5cm in depth at head section). Two damage-sensitive features were extracted one by one from each method; a) feature I: root mean square deviations (RMSD) of impedance signatures and b) feature II: wavelet coefficients for $A_0$ mode of guided waves. By defining damage indices from those damage-sensitive features, a two-dimensional damage feature (2-D DF) space was made. In order to minimize a false-positive indication of the current active sensing system, a two-step SYM classifier was applied to the 2-D DF space. As a result, optimal separable hyper-planes were successfully established by the two-step SYM classifier: Damage detection was accomplished by the first step-SYM, and damage classification was also carried out by the second step-SYM. Finally, the applicability of the proposed two-step SYM classifier has been verified by thirty test patterns.

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Performance Evaluation of DC-Suppression GS Coding for the Holographic Data Storage Using Integer Programming Models (정수계획법 모형을 이용한 홀로그래픽 저장장치의 DC-억압 GS코딩의 성능평가)

  • Park, Taehyung;Lee, Jaejin
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.38A no.8
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    • pp.650-655
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    • 2013
  • For the DC-free encoding of source data, the Guided Scrambling (GS) technique is widely used as multi-mode coding in the optical data storage system. For DC-suppression GS coding in the holographic data storage system, the conservative array and balanced coding criteria are proposed. In this paper, equivalent integer programming models are developed to determine the optimal control bits for the minimum digital sum value (MDSV), conservative array, and balanced coding criteria. Using the proposed integer programming models, we compare the performance of GS encoding for the various combination of control bit/array sizes and scrambling polynomials.

Nondestructive inspection of spent nuclear fuel storage canisters using shear horizontal guided waves

  • Choi, Sungho;Cho, Hwanjeong;Lissenden, Cliff J.
    • Nuclear Engineering and Technology
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    • v.50 no.6
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    • pp.890-898
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    • 2018
  • Nondestructive inspection (NDI) is an integral part of structural integrity analyses of dry storage casks that house spent nuclear fuel. One significant concern for the structural integrity is stress corrosion cracking in the heat-affected zone of welds in the stainless steel canister that confines the spent fuel. In situ NDI methodology for detection of stress corrosion cracking is investigated, where the inspection uses a delivery robot because of the presence of the harsh environment and geometric constrains inside the cask protecting the canister. Shear horizontal (SH) guided waves that are sensitive to cracks oriented either perpendicular or parallel to the wave vector are used to locate welds and to detect cracks. SH waves are excited and received by electromagnetic acoustic transducers (EMATs) using noncontact ultrasonic transduction and pulse-echo mode. A laboratory-scale canister mock-up is fabricated and inspected using the proposed methodology to evaluate the ability of EMATs to excite and receive SH waves and to locate welds. The EMAT's capability to detect notches from various distances is evaluated on a plate containing 25%-through-thickness surface-breaking notches. Based on the results of the distances at which notch reflections are detectable, NDI coverage for spent nuclear fuel storage canisters is determined.