• Ocean and Polar Research
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• 제38권4호
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• pp.287-294
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• 2016

Marine sponges have been a remarkably rich source of pharmacologically active and structurally diverse natural products. As a part of our continuing search for novel secondary metabolites of biomedical importance from marine invertebrate, we encountered the sponge Lipastrotethya sp. from Chuuk, Micronesia. The crude organic extract of this animal exhibited considerable cytotoxicity against the K562 cell line. Guided by the $^1H$ NMR analysis, flash chromatography of the crude extract followed by HPLC yielded a new triterpene glycoside, along with ten known saponins of the sarasinoside class. The structure of this new compound was determined by combined spectroscopic methods such as COSY, HSQC and HMBC experiment. Among these metabolites, six compounds exhibited moderate cytotoxicity against ACHN, MDA-MB-231, NCI-H23 and NUGC-3 cell lines.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.199.2-199.2
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• 2003

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root bark of Paeonia suffruticosa led to the isolation of ten known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2) methyl 3-hydroxy-4- methoxybenzoate (3), acetovanillone (4), benzoic acid (5), benzoylpaeoniflorin (6), paeonoside (7), paeoniflorin (8), oxypaeoniflorin (9) and apiopaeonoside (10). Among them, 4 exhibited the highest survival rate in a dose-dependent manner (100% with a dose of 30 mg/kg versus 16.7% for the control experiment) and showed reduction of plasma alanine aminotransferase (ALT) value on the in vivo assay model of sepsis induced by LPS/GalN.

• 로봇학회논문지
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• 제18권2호
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• pp.155-163
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• 2023

Auto Guided Vehicle (AGV) equipped with mecanum wheels can move in all directions, unlike ordinary wheeled AGVs. In this paper, we propose a robust trejectory tracking control method for the mecanum wheeled AGVs in the presence of disturbances. It is constructed by combining impedance control with Integral Sliding Mode Control (ISMC), which shows robust performance against disturbances, and adding a disturbance observer (DOB) that estimates and removes disturbances. Simulation result using MATLAB/SIMULINK shows that the proposed control method has robust performance in tracking the reference trajectory under the circumstance with disturbance. The control performance is further improved when the disturbance observer is additionally used. In addition, the performance of the proposed control method was verified through experiment. It shows the result of tracking the set trajectory well.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송∙미디어공학회 2020년도 추계학술대회
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• pp.33-36
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• 2020

Virtual try on is getting interested from researchers these days because its application in online shopping. But single pose virtual try on is not enough, customer may want to see themselves in different pose. Multiple pose virtual try on is getting input as customer image, an in-shop cloth and a target pose, it will try to generate realistic customer wearing the in-shop cloth with the target pose. We first generate the target segmentation layout using conditional generative network (cGAN), and then the in-shop cloth are warped to fit the customer body in target pose. Finally, all the result will be combine using a Resnet-like network. We experiment and show that our method outperforms stage of the art.

• The Korean Journal of Pain
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• 제29권3호
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• pp.158-163
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• 2016

Background: Phenol and alcohol have been used to ablate nerves to treat pain but are not specific for nerves and can damage surrounding soft tissue. Lidocaine at concentrations > 8% injected intrathecal in the animal model has been shown to be neurotoxic. Tests the hypothesis that 10% lidocaine is neurolytic after a peri-neural blockade in an ex vivo experiment on the canine sciatic nerve. Methods: Under ultrasound, one canine sciatic nerve was injected peri-neurally with 10 cc saline and another with 10 cc of 10% lidocaine. After 20 minutes, the sciatic nerve was dissected with gross inspection. A 3 cm segment was excised and preserved in 10% buffered formalin fixative solution. Both samples underwent progressive dehydration and infusion of paraffin after which they were placed on paraffin blocks. The sections were cut at $4{\mu}m$ and stained with hemoxylin and eosin. Microscopic review was performed by a pathologist from Henry Ford Hospital who was blinded to which experimental group each sample was in. Results: The lidocaine injected nerve demonstrated loss of gross architecture on visual inspection while the saline injected nerve did not. No gross changes were seen in the surrounding soft tissue seen in either group. The lidocaine injected sample showed basophilic degeneration with marked cytoplasmic vacuolation in the nerve fibers with separation of individual fibers and endoneurial edema. The saline injected sample showed normal neural tissue. Conclusions: Ten percent lidocaine causes rapid neurolytic changes with ultrasound guided peri-neural injection. The study was limited by only a single nerve being tested with acute exposure.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제16권3호
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• pp.499-507
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• 1994

The aim of this experiment is to compare the healing process of extraction sockets after immediate implant placement with those using autogenous bone grafts and guided tissue regeneration with Gore-Tex. The first lower premolars and the second premolars of six experimental dogs were extracted and Stryker fin type implants were placed into the extraction sockets immediately after extraction. In the control group, any graft materials were'not used and the dead space around implants was left in itself and covered with only periosteum. In the experimental group A, implants were covered with Gore tex without any bone grafts, and in the experimental group B, the dead space around implants was filled with the bone chips gained from drilling procedure. Each experimental dogs were sacrificed at the 1st, 2nd, 3rd, 6th, and 8th week and the specimens were observed by gross examination, radiological examination, and light microscopic examination. The following results were obtained. 1. Well healed soft tissue and no mobility of the implants were observed in control and two experimental groups. 2. In the radiogical examination, radiopacity around implants had been increased gradually. 3. In the microscopic examination, there were good healing process and active new bone formation in both in the experimental groups, Especially the more amount of new bone formation occurred in the experimental group B using bone chips. 4. Bone chip grafts and guided tissue regeneration (GTR) using Gore-Tex may be one of the successful methods in the immediate implantation.

• 한국정보기술응용학회:학술대회논문집
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• 한국정보기술응용학회 2002년도 추계공동학술대회 정보환경 변화에 따른 신정보기술 패러다임
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• pp.296-303
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• 2002

중심(HUb) 항만이 되기 위한 주요과제는 자동화이다. 선진항만은 이미 자동화 컨테이너 터미널을 실용화하고 있는 단계이고, 국내의 경우는 자동화 컨테이너터미널을 구축하기 위한 기본계획 및 실시설계가 되고있는 실정이다. 자동화 컨테이너터미널의 핵심은 자동화 장비인 ATC(Automated Transfer Crane)와 AGV(Automated Guided Vehicle)의 효율적인 운영이다. 자동화 장비의 효율적인 운영은 자동화 컨테이너터미널의 생산성을 결정짓는 가장 중요한 요소이다. 본 논문에서는 자동화 컨테이너터미널에 효율적인 3가지의 ATC 운영규칙과 AGV 배정규칙을 사용하여 자동화 컨테이너터미널에서 컨테이너 선적시간을 최소로 할 수 있는 가장 적합한 장비운영 규칙을 제안하고자 한다. 자동화 컨테이너터미널에서 자동화 장비 운영에는 예기치 않은 교착이나 간섭이 발생하므로, 장비운영에 관한 계획은 이벤트 중심으로 실시간으로 이루어져야 한다. 그래서 본 논문에서는 실시간 계획에 가장 적합한 ATC 운영규칙과 AGV 배정규칙을 제안하고, 이들 규칙들의 수행도를 평가하기 위해 실제 자동화 컨테이너터미널에서 생길 수 있는 다양한 환경들에서 시뮬레이션 한다. 이 시뮬레이션을 통해 다양한 파라미터 -야드의 리마샬링(re-marshaling 정도, 컨테이너 처리 개수, 운영 AGV 대수- 에서 가장 로버스터(robust)한 자동화 장비의 통합운영규칙을 제시한다.

• 제어로봇시스템학회논문지
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• 제6권3호
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• pp.298-308
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• 2000

In this paper a new two-arm cooperative assembly(or insertion) algorithm is proposed. As a force-guided control method for the cooperative assembly the adaptive accommodation controller is adopted since it does not require any complicated contact state analysis nor depends of the geometrical complexity of the assembly parts. Also the RMRC(resolved motion rate control) method using a relative jacobian is used to solve inverse kinematics for two manipulators. By using the relative jacobian the two cooperative redundant manipulators can be formed as a new single redundant manipulator. Two arms can perform a variety of insertion tasks by using a relative motion between their end effectors. A force/torque sensing model using an approximated penetration depth calculation a, is developed and used to compute a contact force/torque in the graphic assembly simulation . By using the adaptive accommodation controller and the force/torque sensing model both planar and a spatial cooperative assembly tasks have been successfully executed in the graphic simulation. Finally through a cooperative assembly task experiment using a humanoid robot CENTAUR which inserts a spatially bent pin into a hole its feasibility and applicability of the proposed algorithm verified.

• 한국산업정보학회:학술대회논문집
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• 한국산업정보학회 2002년도 추계공동학술대회
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• pp.296-303
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• 2002

중심(Hub) 항만이 되기 위한 주요과제는 자동화이다. 선진항만은 이미 자동화 컨테이너 터미널을 실용화하고 있는 단계이고, 국내의 경우는 자동화 컨테이너터미널을 구축하기 위한 기본계획 및 실시설계가 되고 있는 실정이다. 자동화 컨테이너터미널의 핵심은 자동화 장비인 ATC(Automated Transfer Crane)와 AGV(Automated Guided Vehicle)의 효율적인 운영이다. 자동화 장비의 효율적인 운영은 자동화 컨테이너터미널의 생산성을 결정짓는 가장 중요한 요소이다. 본 논문에서는 자동화 컨테이너터미널에 효율적인 3가지의 ATC 운영규칙과 AGV 배정규칙을 사용하여 자동화 컨테이너터미널에서 컨테이너 선적시간을 최소로 할 수 있는 가장 적합한 장비운영 규칙을 제안하고자 한다. 자동화 컨테이너터미널에서 자동화 장비 운영에는 예기치 않은 교착이나 간섭이 발생하므로, 장비운영에 관한 계획은 이벤트 중심으로 실시간으로 이루어져야 한다. 그래서 본 논문에서는 실시간 계획에 가장 적합한 ATC 운영규칙과 AGV 배정규칙을 제안하고, 이들 규칙들의 수행도를 평가하기 위해 실제 자동화 컨테이너터미널에서 생길 수 있는 다양한 환경들에서 시뮬레이션 한다. 이 시뮬레이션을 통해 다양한 파라미터 -야드의 리마샬링(re-marshaling) 정도, 컨테이너 처리 개수, 운영 AGV 대수- 에서 가장 로버스터(robust)한 자동화 장비의 통합운영규칙을 제시한다.

• 정보보호학회논문지
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• 제30권3호
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• pp.443-454
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• 2020

자바스크립트 엔진은 주로 웹 브라우저에 적재되어 웹 페이지를 표시하는 여러 기능 중 자바스크립트 코드를 입력으로 받아 처리하는 모듈이다. 자바스크립트 엔진 내 취약점은 종단 사용자의 시스템 보안을 위협할 수 있어 많은 퍼징 테스트 연구가 수행되었다. 그중 일부 연구는 자바스크립트 엔진 내 테스트 커버리지를 유도하는 방식으로 퍼징 효율을 높였으나, 최적화되어 동적으로 생성된 기계어 코드에 대한 커버리지 유도 퍼징은 시도되지 않았다. 최적화된 자바스크립트 코드는 예외적인 흐름 발생 시 코드를 해제하는 런타임 가드의 기능으로 인해 퍼징을 통한 충분한 반복 테스트가 어렵다. 본 논문은 이러한 문제점을 해결하기 위해 최적화 해제를 회피하여 최적화된 기계어 코드에 대해 퍼징 테스트를 수행하는 방법을 제안한다. 또한, 동적 바이너리 계측 방식으로 수행된 런타임 가드의 커버리지를 계측하고 커버리지 증가를 유도하는 방식을 제안한다. 실험을 통해, 본 연구가 제안하는 방식이 런타임 가드 커버리지, 시간당 테스트 횟수의 두가지 척도에서 기존의 방식보다 뛰어남을 보인다.