• Ocean and Polar Research
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• v.38 no.4
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• pp.287-294
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• 2016

Marine sponges have been a remarkably rich source of pharmacologically active and structurally diverse natural products. As a part of our continuing search for novel secondary metabolites of biomedical importance from marine invertebrate, we encountered the sponge Lipastrotethya sp. from Chuuk, Micronesia. The crude organic extract of this animal exhibited considerable cytotoxicity against the K562 cell line. Guided by the $^1H$ NMR analysis, flash chromatography of the crude extract followed by HPLC yielded a new triterpene glycoside, along with ten known saponins of the sarasinoside class. The structure of this new compound was determined by combined spectroscopic methods such as COSY, HSQC and HMBC experiment. Among these metabolites, six compounds exhibited moderate cytotoxicity against ACHN, MDA-MB-231, NCI-H23 and NUGC-3 cell lines.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.199.2-199.2
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• 2003

The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root bark of Paeonia suffruticosa led to the isolation of ten known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2) methyl 3-hydroxy-4- methoxybenzoate (3), acetovanillone (4), benzoic acid (5), benzoylpaeoniflorin (6), paeonoside (7), paeoniflorin (8), oxypaeoniflorin (9) and apiopaeonoside (10). Among them, 4 exhibited the highest survival rate in a dose-dependent manner (100% with a dose of 30 mg/kg versus 16.7% for the control experiment) and showed reduction of plasma alanine aminotransferase (ALT) value on the in vivo assay model of sepsis induced by LPS/GalN.

• The Journal of Korea Robotics Society
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• v.18 no.2
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• pp.155-163
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• 2023

Auto Guided Vehicle (AGV) equipped with mecanum wheels can move in all directions, unlike ordinary wheeled AGVs. In this paper, we propose a robust trejectory tracking control method for the mecanum wheeled AGVs in the presence of disturbances. It is constructed by combining impedance control with Integral Sliding Mode Control (ISMC), which shows robust performance against disturbances, and adding a disturbance observer (DOB) that estimates and removes disturbances. Simulation result using MATLAB/SIMULINK shows that the proposed control method has robust performance in tracking the reference trajectory under the circumstance with disturbance. The control performance is further improved when the disturbance observer is additionally used. In addition, the performance of the proposed control method was verified through experiment. It shows the result of tracking the set trajectory well.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2020.11a
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• pp.33-36
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• 2020

Virtual try on is getting interested from researchers these days because its application in online shopping. But single pose virtual try on is not enough, customer may want to see themselves in different pose. Multiple pose virtual try on is getting input as customer image, an in-shop cloth and a target pose, it will try to generate realistic customer wearing the in-shop cloth with the target pose. We first generate the target segmentation layout using conditional generative network (cGAN), and then the in-shop cloth are warped to fit the customer body in target pose. Finally, all the result will be combine using a Resnet-like network. We experiment and show that our method outperforms stage of the art.

• The Korean Journal of Pain
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• v.29 no.3
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• pp.158-163
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• 2016

Background: Phenol and alcohol have been used to ablate nerves to treat pain but are not specific for nerves and can damage surrounding soft tissue. Lidocaine at concentrations > 8% injected intrathecal in the animal model has been shown to be neurotoxic. Tests the hypothesis that 10% lidocaine is neurolytic after a peri-neural blockade in an ex vivo experiment on the canine sciatic nerve. Methods: Under ultrasound, one canine sciatic nerve was injected peri-neurally with 10 cc saline and another with 10 cc of 10% lidocaine. After 20 minutes, the sciatic nerve was dissected with gross inspection. A 3 cm segment was excised and preserved in 10% buffered formalin fixative solution. Both samples underwent progressive dehydration and infusion of paraffin after which they were placed on paraffin blocks. The sections were cut at $4{\mu}m$ and stained with hemoxylin and eosin. Microscopic review was performed by a pathologist from Henry Ford Hospital who was blinded to which experimental group each sample was in. Results: The lidocaine injected nerve demonstrated loss of gross architecture on visual inspection while the saline injected nerve did not. No gross changes were seen in the surrounding soft tissue seen in either group. The lidocaine injected sample showed basophilic degeneration with marked cytoplasmic vacuolation in the nerve fibers with separation of individual fibers and endoneurial edema. The saline injected sample showed normal neural tissue. Conclusions: Ten percent lidocaine causes rapid neurolytic changes with ultrasound guided peri-neural injection. The study was limited by only a single nerve being tested with acute exposure.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.16 no.4
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• pp.499-507
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• 1994

The aim of this experiment is to compare the healing process of extraction sockets after immediate implant placement with those using autogenous bone grafts and guided tissue regeneration with Gore-Tex. The first lower premolars and the second premolars of six experimental dogs were extracted and Stryker fin type implants were placed into the extraction sockets immediately after extraction. In the control group, any graft materials were'not used and the dead space around implants was left in itself and covered with only periosteum. In the experimental group A, implants were covered with Gore tex without any bone grafts, and in the experimental group B, the dead space around implants was filled with the bone chips gained from drilling procedure. Each experimental dogs were sacrificed at the 1st, 2nd, 3rd, 6th, and 8th week and the specimens were observed by gross examination, radiological examination, and light microscopic examination. The following results were obtained. 1. Well healed soft tissue and no mobility of the implants were observed in control and two experimental groups. 2. In the radiogical examination, radiopacity around implants had been increased gradually. 3. In the microscopic examination, there were good healing process and active new bone formation in both in the experimental groups, Especially the more amount of new bone formation occurred in the experimental group B using bone chips. 4. Bone chip grafts and guided tissue regeneration (GTR) using Gore-Tex may be one of the successful methods in the immediate implantation.

• Proceedings of the Korea Society of Information Technology Applications Conference
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• 2002.11a
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• pp.296-303
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• 2002

The main subject to become a hub port is automation. The automated container terminal has already operated in advanced ports and it has been planned for the basic planning and operation design in domestic case. The key of automated container terminal is effective operation of both ATC(automated transfer crane) and AGV(automated guided vehicle) which is automated handling equipments. This is essential to poductivity of automated container terminal. This study suggests the most optimal method of equipment operation in order to minimize loading time using each three types of effective ATC operation methods and AGV dispatching rules in automated container terminals. As the automated equipment operation causes unexpected deadlocks or interferences, it should be proceeded on event-based real time. Therefore we propose the most effective ATC operation methods and AGV dispatching rules in this paper. The various states occurred in real automated container terminals are simulated to evaluate these methods. This experiment will show the most robust automated equipment operation method on various parameters(the degree of yard re-marshaling, the number of containers and the number of AGVs)

• Journal of Institute of Control, Robotics and Systems
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• v.6 no.3
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• pp.298-308
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• 2000

In this paper a new two-arm cooperative assembly(or insertion) algorithm is proposed. As a force-guided control method for the cooperative assembly the adaptive accommodation controller is adopted since it does not require any complicated contact state analysis nor depends of the geometrical complexity of the assembly parts. Also the RMRC(resolved motion rate control) method using a relative jacobian is used to solve inverse kinematics for two manipulators. By using the relative jacobian the two cooperative redundant manipulators can be formed as a new single redundant manipulator. Two arms can perform a variety of insertion tasks by using a relative motion between their end effectors. A force/torque sensing model using an approximated penetration depth calculation a, is developed and used to compute a contact force/torque in the graphic assembly simulation . By using the adaptive accommodation controller and the force/torque sensing model both planar and a spatial cooperative assembly tasks have been successfully executed in the graphic simulation. Finally through a cooperative assembly task experiment using a humanoid robot CENTAUR which inserts a spatially bent pin into a hole its feasibility and applicability of the proposed algorithm verified.

• Proceedings of the Korea Society for Industrial Systems Conference
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• 2002.11a
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• pp.296-303
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• 2002

The main subject to become a hub port is automation. The automated container terminal has already operated in advanced ports and it has been planned for the basic planning and operation design in domestic case. The key of automated container terminal is effective operation of both ATC(automated transfer crane) and AGV(automated guided vehicle) which is automated handling equipments. This is essential to productivity of automated container terminal. This study suggests the most optimal method of equipment operation in order to minimize loading time using each three types or effective ATC operation methods and AGV dispatching rules in automated container terminals. As the automated equipment operation causes unexpected deadlocks or interferences, it should be proceeded on event-based real time. Therefore we propose the most effective ATC operation methods and AGV dispatching rules in this paper. The various states occurred in real automated container terminals are simulated to evaluate these methods. This experiment will show the most robust automated equipment operation method on various parameters(the degree of yard re-marshaling, the number of containers and the number of AGVs)

• Journal of the Korea Institute of Information Security & Cryptology
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• v.30 no.3
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• pp.443-454
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• 2020

The JavaScript engine is a module that receives JavaScript code as input and processes it, among many functions that are loaded into web browsers and display web pages. Many fuzzing test studies have been conducted as vulnerabilities in JavaScript engines could threaten the system security of end-users running JavaScript through browsers. Some of them have increased fuzzing efficiency by guiding test coverage in JavaScript engines, but no coverage guided fuzzing of optimized, dynamically generated machine code was attempted. Optimized JavaScript codes are difficult to perform sufficient iterative testing through fuzzing due to the function of runtime guards to free the code in the event of exceptional control flow. To solve these problems, this paper proposes a method of performing fuzzing tests on optimized machine code by avoiding deoptimization. In addition, we propose a method to measure the coverage of runtime-guards by the dynamic binary instrumentation and to guide increment of runtime-guard coverage. In our experiment, our method has outperformed the existing method at two measures: runtime coverage and iteration by time.