• Journal of Chest Surgery
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• 제23권3호
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• pp.507-513
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• 1990

We experienced an intraatrial baffle repair for unroofed coronary sinus syndrome in TOF. The patient was a 32-month old female, with complaints of cyanosis, exertional dyspnea and growth retardation. Physical examination showed cyanosis of lip, clubbing of finger, growth retardation and systolic murmur[0 /Gr VI] on left sternal border. With an aid of noninvasive and invasive diagnostic procedure, the patient was diagnosed as TOF combined with unroofed coronary sinus syndrome and LSVC connecting to left atrium. After patch closure of VSD, infundibulectomy and pulmonary valvotomy, the intraatrial baffle redirection of anomalous LSVC to right atrium was undertaken. The Dacron baffle was constructed along the roof of the left atrium to the plane of the atrial septum. The intraatrial septum was then reconstructed with Dacron which was sutured to residual septal tissue. After surgery, the systemic oxygen saturation was elevated to 95.5%, as compared with preoperative value 61%. The postoperative course was uneventful.

• 대한한방소아과학회지
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• 제18권2호
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• pp.119-126
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• 2004

Objective : We used herbal medicine to treat various disease and also to keep good general condition of children. We aimed to evaluate the effect of herbal medicine on the growth of children treated with herbal medicine. Method: We studied 187 children who visited the department of Pediatrics, KyungHee Oriental Medical Hospital from March 2004 to August 2004. They meet condition as follows; they were treated for more than 6 months and they visited our clinic more than 3 times. Whenever patients visited our hospital, we measured their height, body weight and obesity degree using DS-102(dszenix, Seoul). We measured height percentile of first time visit, and that of last time visit. And we compared them using the Growth Statistics Curve made by the Korean Association of Pediatrics, 1998. Results : The mean growth of total children showed 4.04 percentile upwardly; the growth- up percentile of boys was 4.52 and that of girls was 3.26. Analysis according to disease resulted as follows; children with respiratory disease showed 10.29 percentile growth-up, digestive disease 4.21percentile, urinary disease 4 percentile, allergic disease 2.65 percentile, weak children 2.52 percentile and other disease 3.19 percentile. Conclusion : Herbal medical treatment helped growth not only in children who took medicine for growth retardation problem but children with various disease. Moreover herbal medical treatment applied to keep good general condition of children also gave positive effect on the growth of children.

• 대한유전성대사질환학회지
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• 제4권1호
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• pp.23-29
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• 2004

시스틴증은 상염색체 열성으로 발생하는 매우 드문 용해소체 축적병으로서, 용해소체 막을 통한 시스틴 운반의 장애로 발생한다. 용해소체 내 시스틴의 축척과 결정화에 의해 전신의 여러 조직에 파괴가 진행되어 성장 장애, Fanconi 증후군, 신부전, 눈의 이상, 내분비 질환 등이 나타난다. 치료제인 cysteamine의 투여가 예후를 향상시킬 수 있으므로 조기 진단과 치료가 중요하다. 저자들은 성장 장애를 주소로 내원한 12세 남아에서 slit-lamp 검사와 혈액 백혈구 시스틴 농도 측정을 통하여 시스틴증을 확진하고 cysteamine 치료를 시행하면서 추적 관찰 중이다.

• Asian-Australasian Journal of Animal Sciences
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• 제25권8호
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• pp.1096-1101
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• 2012

Intrauterine growth retardation (IUGR) leads to the dysfunction in digestive system, as well as the alteration in the expression of some functional proteins. Heat shock protein 70 (Hsp70) could be induced by various stress factors, but whether Hsp70 expression is changed in neonatal IUGR infants has not been demonstrated. This study was conducted to explore the expression of Hsp70 in the liver by using the IUGR piglet model. Liver and plasma samples were obtained from IUGR and normal birth weight (NBW) piglets at birth. The neonatal IUGR piglets had significantly lower liver weight than their counterparts. The activities of aspartate aminotransferase and alanine aminotransferase in serum were enhanced significantly in IUGR indicating liver dysfunction. The activities of superoxide dismutase (p<0.01), glutathione peroxidase (p<0.01) and catalase (p>0.05) were lower and the level of malondialdehybe was higher (p<0.05) in IUGR liver compared with in NBW. According to the results of histological tests, fatty hepatic infiltrates and cytoplasmic vacuolization were present in the liver of IUGR piglets, but not in NBW liver. The expression of Hsp70 protein was significantly higher (p<0.05) in IUGR piglet liver than in NBW. Similar to where the hepatic injuries were observed, location of Hsp70 was mostly in the midzonal hepatic lobule indicating that oxidative stress might be responsible for the increased expression of Hsp70.

• Journal of Nutrition and Health
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• 제24권4호
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• pp.366-377
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• 1991

저소득층 영유아의 식이형태가 linear growth에 미치는 영향에 대하여 연구하기 위하여 1987년 3월부터 1988년 1월까지 대전시, 춘천시, 그리고 춘성군 보건소에서 만 2세 미만의 영유아 679명과 그 어머니들을 대상으로 영양조사를 실시하였다. 조사방법은 어머니들을 대상으로 식이섭취를 중심으로한 설문조사를 실시하였고 대상아들의 체중과 키를 측정 하였으며 보건소 기록을 이용하여 대상아들의 출생시 체중의 키값을 구하였다. 대상아들은 한국 소아 발육표준치를 이용한 표준 편차점수(Z-score)로 볼 때 체중, 신장 모두 월령 7, 8개월부터 성장지체를 보였다. 출생체중/신장과 질병효과를 통계적으로 조정하였을 때, 이유식을 먹는 대상아들이 모유나 우유만 먹는 경우보다 더 크지않았으며 각종 보충식을 자주 먹는 대상아들이 가끔 먹거나 거의 안 먹는 경우보다 더 크지 않았다. 일일 열량섭취량 분석도 같은 결과를 보였다. 즉 식이 형태나 식품섭취 빈도가 열량섭취량으로 연결되지 않았다. 이같은 현상은 월령 8개월 이후의 대상아에게서 더 두드러지게 나타났다. 따라서 이유에 관한 영양교육 내용은 기존의 빠른 보충식 도입의 강조 차원 보다는 이시기의 빠른 성장을 뒷받침할 만한 다양한 식품 및 충분한 열량섭취에 관한 보다 자세한 정보가 growth monitoring 함께 어머니들에게 전달되도록 변화되어야할 것으로 생각된다.

• 생물환경조절학회지
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• 제12권4호
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• pp.252-258
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• 2003

UV-B(4 kJ${\cdot}m^{-2}{\cdot}d^{-1}$) 조사와 생장억제제(50 mg${\cdot}L^{-1}$ diniconazole, 500 mg${\cdot}L^{-1}$) 처리가 오이, 토마토 및 고추 플러그 묘의 도장 억제와 정식 이후의 생육과 수량에 미치는 효과를 비교하였다. 플러그 묘의 경장은 UV-B와 diniconazole 처리에서 무처리에 비해 각각 오이 38, 35%, 토마토 37, 41%, 고추 23. 23% 억제되었으며 hexaconaxole,은 억제효과가 낮았다. 그리고 엽면적과 건물중도 UV-B와 생장억제체 처리에 의해 감소되엇다. 뱐면 잎 두께는 UV-B와 생장억제제 처리에 으해 두꺼워지는 경향이었다. 건묘지수는 3작물 모두 UV-B와 생장억제제 처리에 의해 증가외었고 특히 diniconazole와 UV-B 처리가 Hexxonazoile처리에 비해 더 높았다. UV-V를 처리한 플러그 묘는 3작물 모두 정식 시에는 무처리에 비해 초장, 엽면적 등이 짧고 작았으나 정식 후 20-30 일경에는 무처리와 비슷한 수준으로 회복되었다. 이에 반해 생장억제제를 처리한 묘는 회복이 늦어 UV-B 처리한 것에 비해 생장이 저조하였다. 과실 수랴은 오이의 경우 처리간에 차이가 없었으나 토마토와 고추 UV-B를 처리한 것이 생장억제제를 처리한 것에 비해 다소 맣았다. 따라서 UV-B 조사는 과채류 플러그 묘의 도장 억제를 위한 환경 친화적인 방법으로서 이용될 수 있음을 시사해주었다.

• 대한의생명과학회지
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• 제23권2호
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• pp.49-56
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• 2017

Fibroblast growth factor (FGF)-2 is one of the most effective growth factors to increase the growth rate of mesenchymal stem cells (MSCs). Previously, we reported that low dose of FGF-2 (1 ng/ml) induced proliferation of bone marrow-derived mesenchymal stem cells (BMSCs) through AKT and ERK activation resulting in reduction of autophagy and senescence, but not at a high dose. In this study, we investigated the effects of high dose FGF-2 (10 ng/ml) on proliferation, autophagy and senescence of BMSCs for long term cultures (i.e., 2 months). FGF-2 increased the growth rate of BMSCs in a dose dependent manner for a short term (3 days), while during long term cultures (2 months), population doubling time was increased and accumulated cell number was lower than control in BMSCs when cultured with 10 ng/ml of FGF-2. 10 ng/ml of FGF-2 induced immediate de-phosphorylation of ERK1/2, expression of LC3-II, and increase of senescence associated ${\beta}$-galactosidase (SA-${\beta}$-Gal, senescence marker) expression. In conclusion, we showed that 10 ng/ml of FGF-2 was inadequate for ex vivo expansion of BMSCs because 10 ng/ml of FGF-2 induced growth retardation via ERK1/2 de-phosphorylation and induction of autophagy and senescence in BMSCs.

• 한국작물학회지
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• 제7권1호
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• pp.117-121
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• 1969

춘파과맥 ${\ulcorner}$완주봄보리${\lrcorner}$의 종자를 5~100ppm의 지벨레린의 용액에서 백체출현기까지 최아하여 발아 및 포장시험을 실시한바 그 성적을 요약하면 다음과 같다. 1. 지벨레린최아에 으하여 발아율의 감퇴없이 2 (상온구)~3일(저온구)의 발아촉진을 보였다. 2. 지벨레린최아를 하면 초기생육촉진이 일면으로는 주장적현상이 현저하였는데 그경향은 고농도 일수록 심하다. 3. 지벨레린최아로 근생장의 억제작용은 전연 인정되지 않았다. 4. 포장조건에는 발아촉진의 효과가 별로없었고 고농도처리에서는 발아율의 감퇴를 초래하여 수수감소 및 수량감소를 초래하였다. 5. 고농도일수록 초기의 주장화경향이 심하고 회복도 늦으나 생육중기에 가서는 거의 모두 정상으로 회복되며, 따라서 출수 성숙 및 간장이 처리에 의한 변이를 보이지 않았다. 6. 5~10ppm의 농도에서는 발아저해가 적고 초기의 주장화경향이 적으며 수수감퇴도 적은 반면에 수장이나 천립중은 증대경향이어서 결과적으로 중수경향을 보였으나 재 검토가 필요하다. 7. 지벨레린 최아만으로는 발아촉진은 기대되나 조숙화는 기대되지 않는다.

• 대한지역사회영양학회지
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• 제17권3호
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• pp.271-279
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• 2012

The prevalence of atopic dermatitis (AD) has increased recently all over the world. Several studies worldwide reported growth retardation associated with AD, but few studies were reported in Korea. Therefore, the objective of this study was to identity the differences in growth and nutrient intakes between Korean children with and without AD. The participants were 71 AD children and age, gender-matched 81 control children aged 10 to 36 months. Demographic information was gathered by questionnaires. Height and weight were measured at clinic and health centers. Height and weight for age, and weight for height were converted as deviation in Z scores using World Health Organization Standard. A 24 hour dietary recall method was performed to estimate nutrient intakes. A higher percentage of AD children had insufficient energy and intakes of calcium, phosphorus, iron, zinc and vitamin B2, defined as intakes lower than 75% of the Dietary Reference Intakes for Korean, compared to the control group (P < 0.001, P < 0.001, P = 0.003, P = 0.001, P = 0.014, P = 0.001, respectively). The percentages of children with height and weight for age Z score below than-1 (stunted) were significantly higher in the AD group (P < 0.001 and P < 0.001, respectively). Multiple food restriction, defined as ${\geq}$ 3 food elimination, was associated with insufficient energy and intakes of calcium, phosphorus, iron, zinc, vitamins A and B2. In conclusion, children with AD need regular nutrient assessment and education about alternative food choices to avoid r food elimination in order to prevent growth retardation or inadequate nutrient intakes. Further longitudinal studies for growth and nutrient intakes should be performed to understand the patterns of growth in children with AD.

• Reproductive and Developmental Biology
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• 제34권2호
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• pp.81-88
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• 2010

Our objective of current study was to investigate the development of bone and heart in association with diabetes mellitus (DM). DM was induced by administering an intraperitoneal injection of streptozotocin (STZ; 60 mg/kg) to 4-week-old Sprague-Dawley rats. Body weight and blood glucose were monitored, and rats were sacrificed after 2 or 5 weeks. The left ventricle (LV), including the interventricular septum, was weighed, and body weight and tibial bone length were assessed. Young diabetic rats showed reduced growth in terms of tibial length and body weight compared to controls. Moreover, diabetic males showed more significant growth suppression and reduced LV size than diabetic females. Morphometric analysis of tibiae from diabetic rats revealed suppressed bone growth at 2 and 5 weeks, with no difference between genders. STZ-induced diabetes decreased bone growth and retarded pre-pubertal heart development. As a result, diabetes may increase cardiovascular risk factors and lead to eventual heart failure. Therefore, new therapeutic approaches are required for diabetic children exhibiting growth retardation. Heart growth factor, exercise, and cardiopulmonary physical therapy may be required to promote heart development and physiological function.