• Korean System Dynamics Review
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• v.8 no.2
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• pp.5-23
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• 2007

According to the system dynamics model of this study, if there is a significant network effect on vehicle operating costs, it is difficult to achieve the shift to AFV even in the long term without a policy intervention because the car market is locked in to the current structure. Network effect can be caused by an increasing return to scale in fuel supply sector as well as in maintenance service sector. It is also related to the fact that the reliability and awareness of consumers on new products increases with the growth of the market share of the new products. There are several possible policy options to break the 'locked in' structure of car market, such as subsidy on vehicle price (capital cost), subsidy on fuel (operating cost) and niche management policy. Combined policy options would be more effective than relying on a single policy option to increase the market share of AFV.

• Journal of Korean Institute of Industrial Engineers
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• v.40 no.2
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• pp.195-204
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• 2014

The transition from fossil to renewable energy is inevitable due to fossil depletion. So, Renewable energy is very important for energy security and economic growth although it's R&D is long-term and high risky project. We propose new valuation method which combined system dynamics and compound real option method for long-term and high risk projects such as renewable energy. This method can show dynamic valuation results for the complex causal interaction and be easy for Monte-Carlo simulation to estimate volatility. And it can reflect the value of flexible decision for uncertainty. We applied the empirical analysis for Korea's photovoltaic industry by using this method. As results by empirical analysis, photovoltaic's R&D has high valuation using this method compared by traditional valuation methods such as DCF.

• Journal of Clinical Otolaryngology Head and Neck Surgery
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• v.29 no.2
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• pp.259-263
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• 2018

There are many treatment options for the malignant melanoma. Wide excisional surgery is one of the most acceptable treatments for locoregional treatment. Depending on the pathologic classification, however, some other treatment option can be included such as chemotherapy, radiotherapy and immunotherapy as adjuvant treatment. Small cell type malignant melanoma is a rare variant of malignant melanoma. It is known that melanomas manifesting this morphology are invariably in vertical growth phase and have an aggressive course. The authors encountered small cell type malignant melanoma and would like to share the experience of successful treatment with surgery plus immunotherapy as one of adjuvant treatment options.

• Toxicological Research
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• v.26 no.4
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• pp.301-313
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• 2010

Growth promoters including hormonal substances and antibiotics are used legally and illegally in food producing animals for the growth promotion of livestock animals. Hormonal substances still under debate in terms of their human health impacts are estradiol-$17\beta$, progesterone, testosterone, zeranol, trenbolone, and melengestrol acetate (MGA). Many of the risk assessment results of natural steroid hormones have presented negligible impacts when they are used under good veterinary practices. For synthetic hormonelike substances, ADIs and MRLs have been established for food safety along with the approval of animal treatment. Small amounts of antibiotics added to feedstuff present growth promotion effects via the prevention of infectious diseases at doses lower than therapeutic dose. The induction of antimicrobial resistant bacteria and the disruption of normal human intestinal flora are major concerns in terms of human health impact. Regulatory guidance such as ADIs and MRLs fully reflect the impact on human gastrointestinal microflora. However, before deciding on any risk management options, risk assessments of antimicrobial resistance require large-scale evidence regarding the relationship between antimicrobial use in food-producing animals and the occurrence of antimicrobial resistance in human pathogens. In this article, the risk profiles of hormonal and antibacterial growth promoters are provided based on recent toxicity and human exposure information, and recommendations for risk management to prevent human health impacts by the use of growth promoters are also presented.

• Clinical and Experimental Pediatrics
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• v.54 no.6
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• pp.241-245
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• 2011

Tuberous sclerosis complex (TSC) is a genetic multisystem disorder that results from mutations in the TSC1 or TSC2 genes, and is associated with hamartomas in several organs, including subependymal giant cell tumors. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. The TSC1- and TSC2-encoded proteins modulate cell function via the mammalian target of rapamycin (mTOR) signaling cascade, and are key factors in the regulation of cell growth and proliferation. The mTOR pathway provides an intersection for an intricate network of protein cascades that respond to cellular nutrition, energy levels, and growth factor stimulation. In the brain, TSC1 and TSC2 have been implicated in cell body size, dendritic arborization, axonal outgrowth and targeting, neuronal migration, cortical lamination, and spine formation. The mTOR pathway represents a logical candidate for drug targeting, because mTOR regulates multiple cellular functions that may contribute to epileptogenesis, including protein synthesis, cell growth and proliferation, and synaptic plasticity. Antagonism of the mTOR pathway with rapamycin and related compounds may provide new therapeutic options for TSC patients.

• Journal of the korean academy of Pediatric Dentistry
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• v.42 no.3
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• pp.270-274
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• 2015

Although there are a number of studies on the treatment planning and the prognosis of dental implants, limited studies provide the information on the implant placement on growing adolescents. The aim of this review is to discuss the use of dental implants in growing patients and the impact of skeletal and dentoalveolar growth on the long-term stability of implants. The general information regarding skeletal growth of maxilla and mandible would be briefly reviewed and the general treatment options would be discussed.

• STI Policy Review
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• v.2 no.2
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• pp.1-9
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• 2011

Innovation Policy has evolved to solve social problems through technological innovation. Industrial innovation policy promotes technological innovation so that it consolidates industrial competitiveness and aims at economic growth; however, societal innovation policy promotes technological innovation in the social service domain to improve the quality of life and strengthen sustainability. A different policy regime is required because the objectives and directions of societal innovation policy are different from those of industrial innovation policy. This report consolidates the concepts and characteristics of societal innovation policy that suggest policy options.

• Journal of Korean Neurosurgical Society
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• v.64 no.4
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• pp.486-494
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• 2021

The growth of pulsed electromagnetic field (PEMF) therapy and its progress over the years for use in post-operative bone growth has been revolutionary in its effect on bone tissue proliferation and vascular flow. However, further progress in PEMF therapy has been difficult due to lack of more evidence-based understanding of its mechanism of action. Our objective was to review the current understanding of bone growth physiology, the mechanism of PEMF therapy action along with its application in spinal surgery and associated outcomes. The authors of this review examined multiple controlled, comparative, and cohort studies to compare fusion rates of patients undergoing PEMF stimulation. Examining spinal fusion rates, a rounded comparison of post-fusion outcomes with and without bone stimulator was performed. Results showed that postoperative spinal surgery PEMF stimulation had higher rates of fusion than control groups. Though PEMF therapy was proven more effective, multiple factors contributed to difficulty in patient compliance for use. Extended timeframe of treatment and cost of treatment were the main obstacles to full compliance. This review showed that PEMF therapy presented an increased rate of recovery in patients, supporting the use of these devices as an effective post-surgical aid. Given the recent advances in the development of PEMF devices, affordability and access will be much easier suited to the patient population, allowing for more readily available treatment options.

• Environmental and Resource Economics Review
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• v.21 no.3
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• pp.465-491
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• 2012

Climate change, a result of increasing global warming, has been receiving more public attention due to its serious impact upon many industries. In this study we consider sustainable- (Green-) Growth and Green-Finance, and in particular temperature derivatives, as appropriately active responses to the world's significant climate change trends. We characterize the daily average temperatures in Seoul, South Korea with their seasonal properties and cycles of error terms. We form forecasting models and perform Monte Carlo simulations, and find that the risk-neutral values for CDD call-options and HDD put-options have risen since 1960s, which implies that the trend of temperature increase can be quantified in the financial markets. Contrary to the existing models, the Vasicek model with the explicit consideration of cycles in the error terms suggests that the significant option-values for the CDD call -options above certain exercise prices, implying that there is the possibility of explicit hedging against the considerable and stable increase in temperature.

• KIEAE Journal
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• v.10 no.2
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• pp.63-69
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• 2010

Diverse problems in wind environment has occurred through rapid urbanization and growth of high-rise building numbers, This study aims to propose the CFD (Computational Fluid Dynamics) simulation method and evaluation standard of wind environment in site planning of high rise apartment housing. The CFD simulation method proposed in this study is not existing detail simulation, but it is the method that a designer can correct and develop the design through immediate evaluation of design options in concept design phase. Therefore, the proposed CFD simulation method of wind environment in this study uses the BIM based CFD tool in which the 3D model in concept design phase can be used as for the CFD simulation. In this paper, the study examines existing evaluation standards of comfortableness level in wind environment for pedestrian near buildings, and selects new evaluation method which is possible to apply to the proposed CFD simulation method. In addition, it is to examine calculation time-spending and appropriate mesh division method for finding CFD result which is useful to find the best design options in aspect of wind environment in concept design phase. Furthermore, it proposes the wind environment evaluation method through BIM based CFD simulation.