• Nutrition Research and Practice
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• 제11권6호
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• pp.487-491
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• 2017

BACKGROUND/OBJECTIVES: Although globally the numbers of children diagnosed with failure to thrive (FTT) have decreased, FTT is still a serious pediatric problem. We aimed to investigate the effects of zinc supplementation for 6 months on growth parameters of infants and children with FTT. SUBJECTS/METHODS: In this retrospective study, of the 114 participants aged between 4 months and 6 years, 89 were included in the zinc supplementation group and were provided with nutrition counseling plus an oral zinc supplement for 6 months. The caregivers of the 25 participants in the control group received nutrition counseling alone. Medical data of these children, including sex, age, height, weight, serum zinc level, and serum insulin-like growth factor 1 (IGF1) level were analyzed. RESULTS: Zinc supplementation for 6 months increased weight-for-age Z-score and serum zinc levels (5.5%) in the zinc supplementation group of underweight category children. As for stunting category, height-for-age Z-score of the participants in the zinc supplementation group increased when compared with the baseline, and serum zinc levels increased in the normal or mild stunting group. Serum IGF1 levels did not change significantly in any group. Thus, zinc supplementation was more effective in children in the underweight category than those in the stunted category; this effect differed according to the degree of the FTT. CONCLUSION: These findings suggest that zinc supplementation may have beneficial effects for growth of infants and children with FTT, and zinc supplementation would be required according to degree of FTT.

• Childhood Kidney Diseases
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• 제10권2호
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• pp.219-227
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• 2006

Purpose : We aim to identify the clinical and demographic characteristics in children who underwent renal transplantation(RTx) and to evaluate the influence on growth of RTx in children. Methods : We reviewed 17 medical records of chronic renal failure patients who underwent RTx from April 1992 and June 2004 at Busan Paik Hospital. Age and sex distribution, cause of disease, donor analysis, patient and graft survival rate, and the status of growth after RTx were analysed by retrospective study. Results : Eighteen RTx were performed in 17 patients(8 boys, 9 girls). The mean age at the time of RTx was $15.8{\pm}3.5$ years and the mean duration of dialysis therapy before RTx was $22.4{\pm}18.0$ months. The 1 year and 5 year patient survival rate were each 100%, and the 1 year and 5 year graft survival rate were 88%, 36% respectively. The most common cause of graft failure was chronic rejection. The mean final height of male patients was $162.8{\pm}10.0$ cm(143.0-172.5 cm) and of female patients was $154.5{\pm}12.1$ cm(135.8-160.0 cm). The mean height standard deviation score(Ht SDS) increased after RTx from -1.95 to -1.53 but the increment rate was not statistically significant. Similar changes were noted in individual patient analysis. Also there was no significant difference between the living-related donors and cadaveric donors. Conclusion : Our data shows that even successful RTx rarely results in full growth rehabilitation. To overcome retarded growth in children with chronic renal failure, appropriate combined management of metabolic and nutritional problems, correction of anemia, proper use of recombinant growth hormone therapy, early renal transplantation and shortening of the duration of dialysis would be necessary.

• 한국철도학회논문집
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• 제18권3호
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• pp.186-193
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• 2015

본 연구에서는 차세대 고속열차의 신뢰성 성장률 분석에 대한 연구를 수행하였다. 차세대 고속열차의 신뢰성 평가를 효과적으로 수행하기 위해서 6개의 서브시스템으로 분류를 하였으며, 이에 대한 기능블록선도와 신뢰성블록선도를 도출하였다. 또한 안정화 시험 중에 수행된 시험결과를 바탕으로 고장정보분석을 수행하였다. 그리고 Duane 모델에 기반한 신뢰성 성장률 분석을 차세대 고속열차의 실험 결과에 적용하였다. 본 연구를 통해서 지속적인 차량의 유지 보수 활동이 신뢰성 성장에 영향을 미치고 있음을 확인하였다.

• 한국철도학회논문집
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• 제11권3호
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• pp.280-285
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• 2008

Gurson model과 shear failure model 두 가지 파괴모델을 이용하여 노치인장시험과 초기 균열을 가지는 파쇄튜브의 압축거동을 유한요소법으로 해석하였다. Shear failure model의 파라미터 값은 노치인장시편의 시험 및 해석을 통하여 결정하였다. 항복강도와 파괴전단변형률 등의 파라미터 값을 정한 후, Gurson model과 shear failure model을 파쇄튜브의 해석에 적용하였다. Gurson model과 shear failure model이 인장시편에 대하여는 비슷한 파괴 거동을 보여주지만 파쇄튜브의 압축력과 균열 성장 속도에서는 다른 결과를 보임을 확인하였다. 즉, shear failure model에서는 Gurson model에 비하여 균열이 전파되기 위해 더 큰 압축력이 요구되었다. 이러한 현상은 shear failure model 이 재질의 손상 과정에 대한 고려를 포함하고 있지 않기 때문인 것으로 생각된다. 어느 모델이 튜브의 해석에 적당한 지를 실험을 통하여 검증할 필요가 있다.

• Pediatric Infection and Vaccine
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• 제13권2호
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• pp.201-205
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• 2006

원발성 면역 결핍증에는 항체형성에 영향을 주는 질환이 가장 흔하고 그중 선택적으로 분비성 IgA 결핍이 많으나 IgG 농도가 정상 혹은 증가되어 있는 어떤 환자에서는 4가지의 IgG 아형 중에서 한 두 개 이상의 결핍이 발견된다. 대부분의 환자, 특히 IgG4 결핍증 환자에서 폐구균, 포도구균, 헤모필루스균 등에 의한 부비동염, 중이염, 폐렴 등이 반복된다. 상기 10세 여아는 평소에 잦은 상기도 감염을 앓아 왔고, 결핵성 림프절염으로 약물요법을 시행한 병력이 있으며, 매년 2~3차례 폐렴으로 입원치료를 받아왔다. 키와 몸무게가 모두 3백분위수 미만으로 성장부전(growth failure)가 지속되었다. 2003년 9월 심한 폐렴으로 입원 치료 중에 면역결핍 검사를 시행하였다. IgG, IgM level은 정상이었으나 IgG subclass 2, 3, 4에서 모두 감소된 수치를 보여 IgG 아형 결핍을 보였다. 저자들은 반복적인 호흡기 질환을 앓는 환아에서 성장부전이 동반된 IgG 아형 결핍 1례를 보고하는 바이다.

• Journal of Genetic Medicine
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• 제11권2호
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• pp.74-78
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• 2014

Sotos syndrome (SS, OMIM 117550) is characterized by prenatal and postnatal overgrowth with multiple congenital anomalies. However, there have been few cases of growth retardation caused by renal failure from infancy. We report a case of dysplasia of the bilateral kidneys with renal failure and poor postnatal growth. A 2-month-old boy visited the emergency room owing to poor oral intake and abdominal distension. He was born at the gestational age of 38 weeks with a birth weight of 4,180 g. After birth, he had feeding difficulty and abdominal distension. Upon physical examination, his height and weight were in less than the 3rd percentile, while his head circumference was in the 50th percentile on the growth curve. He also showed a broad and protruding forehead and high hairline. Blood laboratory tests showed severe azotemia; emergent hemodialysis was needed. Abdominal ultrasonography revealed bilateral renal dysplasia with multiple cysts and diffuse bladder wall thickening. A posterior urethral valve was suggested based on vesicoureterography and abdominal magnetic resonance findings. Results of a colon study to rule out congenital megacolon did not reveal any specific findings. The conventional karyotype of the patient was 46, XY. Array comparative genomic hybridization study revealed a chromosome 5q35 microdeletion including the NSD1 gene, based on which SS was diagnosed. We describe a case of SS presenting with end stage renal disease due to posterior urethral valve. The typical somatic overgrowth of SS in the postnatal period was not observed due to chronic renal failure that started in the neonatal period.

• 한국프랜차이즈경영연구
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• 제5권2호
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• pp.51-67
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• 2014

인류 문명사에서 패권을 차지한 국가의 경우 지속적인 확장을 통해 문명을 발달시켜왔듯, 기업들 또한 끊임없이 소비자 마음을 차지하기 위한 '전쟁(Campaign)'을 치루고 있다는 점에서 동일하다. 국가나 기업이나 성공과 실패의 사례를 살펴보면 특정한 반복적인 '유형(Pattern)'을 찾아볼 수 있다. 본 논문은 세계적 프랜차이즈 기업인 버거킹의 성공과 실패요인을 '시장 동태성(dynamism)' 관점에서 파악하고 그 시사점에 대해 논의해 보았다. 기업의 성패는 한 국가의 패턴처럼 성장과 침식 및 정체 그리고 쇠퇴를 하거나 끊임 없는 자구책으로 재활성화를 통해 지속적인 성장을 추구한다. 버거킹 또한 성장기에는 공격적이고 창의적인 마케팅 활동으로 차별화된 버거킹만의 브랜딩을 성공적으로 전개해왔다. 그러나 창업주의 경영권 매각과 이후 연이은 경영권의 교체로 인해, 일관된 기업 철학과 브랜드 관리를 소홀히 할 수밖에 없었으며, 결국 웰빙 트렌드라는 외부 위협으로 인해 증시에서 상장 폐지되는 커다란 '위기(공명)'를 맞이하게 된다. 최근 들어 버거킹은 과거의 영광을 되찾기 위해 국내외 시장에서 공격적인 마케팅 활동을 전개하고 있으며, 세계 최고의 레스토랑을 지향함으로써 브랜드 자산 가치를 더욱 강화하고 있다. 버거킹의 브랜드 사례는 성공을 꿈꾸는 많은 프랜차이즈 기업들에게 '창의적이고 혁신적인 아이디어'가 세계적인 기업이 되는 데 왜 필요한지에 대해 새로운 시사점을 제공할 것이다.

• 품질경영학회지
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• 제25권3호
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• pp.96-107
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• 1997

The recent stream to reliability prediction is that it is totally inclusive in depth to consider even the operating and environmental condition at the level of finished goods as well as component itselves. In this study, firstly we present the reliability prediction methods by entire failure rate model which failure rate at the system level is added to the failure rate model at the component level. Secondly we build up the improved bases of reliability demonstration through a, pp.ication of Kaplan-Meier, Cumulative hazard, Johnson's methods as non-parametric and Maximum Likelihood Estimator under exponential & Weibull distribution as parametric. And also present the methods of curve fitting to piecewise failure rate under Weibull distribution, PRST (Probability Ratio Sequential Test), curve fitting to S-shaped reliability growth curve, computer programs of each methods. Lastly we show the practical for determination of optimal burn-in time as a method of reliability enhancement, and also verify the practical usefulness of the above study through the a, pp.ication of failure and test data during 1 year.

• 콘크리트학회논문집
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• 제11권3호
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• pp.181-192
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• 1999

The progressive failure following strain localization in concrete can be analyzed effectively using finite element modeling of fracture process zone of concrete with a finite element embedded discontinuity. In this study, a finite element with embedded discontinuous line is utilized for the analysis of progressive failure in concrete. The finite element with embedded discontinuity is a kind of discrete crack element, but the difficulties in discrete crack approach such as remeshing or adding new nodes along with crack growth can be avoided. Using a discontinuous shape function for this element, the displacement discontinuity is embedded within an element and its constitutive equation is modeled from the modeling of fracture process zone. The element stiffness matrix is derived and its dual mapping technique for numerical integration is employed. Then, a finite element analysis program with employed algorithms is developed and failure analysis results using developed finite element program are verified through the comparison with experimental data and other analysis results.

• 한국신뢰성학회:학술대회논문집
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• 한국신뢰성학회 2005년도 학술발표대회 논문집
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• pp.199-208
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• 2005

In the calendar and the advertising catalog, the surface Is usually coated by coating polypropylene film. The delamination failure of coating film depends on surface roughness and quality of the substrate paper. In this paper, the mechanisms of delamination failure between the coating film and the paper is investigated by using the root cause analysis as one of techniques of reliability evaluation. The papers used in failure analysis are three kind products made by two domestic and one foreign companies. It found that the main causes of delamination failure between the coating film and the paper were the creation of microvoids caused by shape of filler and their growth caused by contraction of paper.