• Archives of Pharmacal Research
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• 제26권1호
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• pp.34-39
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• 2003

The traditional Asian medicinal herb, roots of Astragalus (A.) membranaceus (Leguminosae), is used for many purposes, some of which are purported to stimulate the release of growth hormone in vivo. Extracts of A. membranaceus were tested to determine whether they stimulate the release of growth hormone in rat pituitary cell culture. A. membranaceus was extracted sequentially with 80% ethanol (fraction A), n-hexane (fraction B); the test compound from the herbal extraction was isolated using silica gel column chromatography and was identified with spectral data. Test compound was also extracted by traditional boiling water methods. Induction of growth hormone in pituitary cell culture was conducted with isolated compounds and extracted fractions of A. Radix (dried roots of A. membranaceus). The fraction A was not active in the rat pituitary cell culture, but the fraction B derived from the ethanol fraction stimulated the release of growth hormone in culture. Six compounds from fraction B (1-6) were isolated and identified previously. The compounds 1,2-benzendicarboxylic acid diisononylester (1), $\beta$-sitosterol (2), and 3-Ο-$\beta$-D-galactopyranosyl-$\beta$-sitosterol (5) did not induce growth hormone release in the culture. Formononetin (3), 9Z, 12Z-octadecadienoic acid (4), stigmast-4-en-6$\beta$-o1-3-one (6) and 98-E, a mixture of 1'-9, 12-octadecadienoic acid (Z,Z)-2',3'-dihydroxy-propylester (7) and 1'-hexadecanoic acid-2',3'-dihydroxy-propylester (8) stimulated the release of growth hormone in the rat pituitary cell culture significantly compared to the control. In conclusions, four compounds isolated from extracts of A. Radix induced growth hormone release in the rat pituitary cell culture. The 98-E isolate was the most active inducer of growth hormone release.

• International Journal of Computer Science & Network Security
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• 제21권5호
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• pp.133-138
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• 2021

The concept of inclusive development provides equal opportunities for all participants in access to the labor market and resource allocation. This concept emphasizes the equality of human capital, the ecological state of the environment, social protection and food security. This concept is fundamentally different from the standard perception of economic growth, because it has broader goals than simply increasing incomes and GDP. It rejects the position that positive results are an automatic consequence of growth; here the basic condition is human development and increase of its well-being, reduction of poverty. Therefore, it is not the result of distribution that becomes primary, but the involvement in the process of social reproduction. An alternative system of characterization of the country's position according to the resulting indicator of the Inclusive Development Index was presented at the World Economic Forum in Davos. In this research the methodical development of the system of estimation of the index of inclusive development for regions of the NUTS 4 level of the European classification is resulted.

• Biotechnology and Bioprocess Engineering:BBE
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• 제5권4호
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• pp.275-287
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• 2000

Fermentation strategies for recombinant protein production in Pichia pastoris have been investigated and are reviewed here. Characteristics of the expression system, such as phenotypes and carbon utilization, are summarized. Recently reported results such as growth model establishment, app58lication of a methanol sensor, optimization of substrate feeding strategy, DOstat controller design, mixed feed technology, and perfusion and continuous culture are discussed in detail.

• International Journal of Advanced Culture Technology
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• 제12권1호
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• pp.85-93
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• 2024

In this paper, focusing on Oscar Wilde's novel "The Picture of Dorian Gray," we explore the protagonist's lack of conscience and unethical attitude, emphasizing its relevance to our self-development and growth. The primary goal is to interpret the impact of Dorian Gray's actions and choices on personal development and growth, highlighting the importance of a specific mindset and attitude to the reader. It dissects how Wilde navigates the intricate layers of Dorian's character, exposing the ethical dilemmas and transformative moments that contribute to the profound changes within him. The examination sheds light on the depth and complexity of Dorian Gray's character, offering readers a nuanced understanding of the forces at play in his moral and psychological journey. Interpretation of Wilde's intent to impart lessons on the reader's personal growth and development through Dorian's story is undertaken. The discussion also explores the impact of Dorian's unethical attitude on contemporary readers and its influence on our daily lives and values.

• Advances in nano research
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• 제3권3호
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• pp.143-168
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• 2015

Initiation of crack and its growth simulation requires accurate model of traction - separation law. Accurate modeling of traction-separation law remains always a great challenge. Atomistic simulations based prediction has great potential in arriving at accurate traction-separation law. The present paper is aimed at establishing a method to address the above problem. A method for traction-separation law prediction via utilizing atomistic simulations data has been proposed. In this direction, firstly, a simpler approach of common neighbor analysis (CNA) for the prediction of crack growth has been proposed and results have been compared with previously used approach of threshold potential energy. Next, a scheme for prediction of crack speed has been demonstrated based on the stable crack growth criteria. Also, an algorithm has been proposed that utilizes a variable relaxation time period for the computation of crack growth, accurate stress behavior, and traction-separation atomistic law. An understanding has been established for the generation of smoother traction-separation law (including the effect of free surface) from a huge amount of raw atomistic data. A new curve fit has also been proposed for predicting traction-separation data generated from the molecular dynamics simulations. The proposed traction-separation law has also been compared with the polynomial and exponential model used earlier for the prediction of traction-separation law for the bulk materials.

• The Journal of Asian Finance, Economics and Business
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• 제8권5호
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• pp.29-35
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• 2021

This study discusses the effect of human capital and technology on economic growth in Indonesia using annual time series data over the 35-year research period (1984-2019). This study uses an autoregressive distribution gap to the cointegration approach to understanding the relationship between human capital, technology, and economic growth. Human capital is inherent in humans and becomes capital in providing the best performance that has an impact on their own income. We use the human capital framework in this study where education is one mechanism to increase human capital. Based on the results of our estimation, we find that the increase in human capital using the education mechanism affects economic growth. This shows the role of human capital investment is very important in economic growth. Technology shows a significant positive effect on economic growth. Increasing human resources and technology are important factors in efforts to increase economic growth in Indonesia. Educational development is the key to the success of increasing human capital and technological development because education plays a role in improving the quality of human resources. Increasing human resources here is in the form of increased knowledge, mastery of technology, innovation, and the ability to develop technology to encourage technology development.

• The Journal of Asian Finance, Economics and Business
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• 제8권4호
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• pp.93-104
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• 2021

In recent years, there has been a substantial theoretical and empirical study on the role that financial market development has significantly played in promoting economic growth and development in the world. The development of an economy requires the financial industry to be developed. In the context of rapid economic development, global warming has become a serious problem with issues such as rising average temperatures, climate change, rising sea level, and increasing carbon dioxide emissions. This study aims to examine the influence of economic growth, financial development, transportation capacity, and environmental degradation. Using time-series data from 1986 to 2019 and environmental degradation being measured by CO2 emissions, the study employs a quantity of ample unit root tests, the structural break unit root tests, Autoregressive Distributed Lag (ARDL), and cointegration bounds test. The results show that there is a significant long-term cointegration among study variables. Empirical findings also indicate that an increase in per capita GDP and financial development worsens environmental quality whereas transportation capacity and foreign investment can improve environmental quality.

• 기술혁신학회지
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• 제15권3호
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• pp.557-585
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• 2012

본 논문은 영국 중동부지역의 고성장기업 육성을 위한 지원체계 구축과 성장기업 오너들의 리더쉽 함양과 기업경영을 보다 효과적으로 운영할 수 있도록 지속적으로 지원할 수 있는 조직운영체계를 분석하는데 목적을 두었다. 이러한 지원체계는 고성장기업들간의 상호협력 인적 네트워크를 통하여 활발하게 운영될 수 있다. 따라서 본 연구에서는 고성장기업육성 프로그램의 기존문헌조사 연구들과 정책지원 수요조사를 바탕으로 하여 맞춤형 기업서비스 프로그램을 개발하고 지원하며 이를 실행하는데 있어서 나아갈 정책프레임을 제시하고자 한다.

• Mycobiology
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• 제46권2호
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• pp.147-153
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• 2018

Certain beneficial microorganisms isolated from rhizosphere soil promote plant growth and induce resistance to a wide variety of plant pathogens. We obtained 49 fungal isolates from the rhizosphere soil of paprika plants, and selected 18 of these isolates that did not inhibit tomato seed germination for further investigation. Based on a seed germination assay, we selected four isolates for further plant tests. Treatment of seeds with isolate JF27 promoted plant growth in pot tests, and suppressed bacterial speck disease caused by Pseudomonas syringae pathovar (pv.) tomato DC3000. Furthermore, expression of the pathogenesis-related 1 (PR1) gene was higher in the leaves of tomato plants grown from seeds treated with JF27; expression remained at a consistently higher level than in the control plants for 12 h after pathogen infection. The phylogenetic analysis of a partial internal transcribed spacer sequence and the b-tubulin gene identified isolate JF27 as Aspergillus terreus. Taken together, these results suggest that A. terreus JF27 has potential as a growth promoter and could be used to control bacterial speck disease by inducing resistance in tomato plants.

• Clinical and Experimental Reproductive Medicine
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• 제27권4호
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• pp.381-385
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• 2000

Objective: To verify the effect of two forms (growth factor and growthfactor-reduced) of solubilized Matrigel on the development in mouse preimplantation embryos. Methods: Late 2-cell stage eggs were cultured through the blastocyst stage in the presence of GF- or GFR-Matrigel (0.5%, v/v). Morphological development, cell number and % apoptotic nuclei of blastocyst were measured by Roecst staining and TUNEL of nuclei. Results: Morphological development, number of cells per embryo was significantly increased in the presence of GF- or GFR-Matrigel. Culture of the embryos in the GF-Matrigel gave the best result. Conclusion: Low concentration of solubilized Matrigel improved development of mouse embryos regardless of growth factor content of the Matrigel. Growth factors and extracellular matrix protein included in the Matrigel synergistically potentiated the development of mouse embryos.