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Inflammation and Insufficient or Disordered Sleep (염증 반응과 수면 장애)

  • Lee, Suk Jun;Kim, Jinkwan
    • Korean Journal of Clinical Laboratory Science
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    • v.47 no.3
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    • pp.97-104
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    • 2015
  • Sleep is not only an essential physiological function, but also serves important roles in promoting growth, maturation, and overall health of humans. There is increasing interest regarding the impact of sleep and its disorders on the regulation of inflammatory processes and end-organ morbidities, particularly in the context of metabolic and cardiovascular diseases (CVD) and their complications. Obstructive sleep apnea syndrome (OSAS) is an increasingly common health problem in children. In the last decade, the emergence of increasing obesity rates has further led to remarkable increases in the prevalence of OSAS, along with more prominent neurocognitive, behavioral, cardiovascular and metabolic morbidities. Although the underlying mechanisms leading to OSAS-induced morbidities are likely multifactorial and remain to be fully elucidated, activation of inflammatory pathways by OSAS has emerged as an important pathophysiological component of the end-organ injury associated with this disorder. To this effect, it would appear that OSAS could be viewed as a chronic, low-grade inflammatory disorder. Furthermore, the concurrent presence of obesity and OSAS poses a theoretically increased risk of OSAS-related complications. In this study, we will critically review the current state of research regarding the impact of insufficient and disrupted sleep and OSAS on the immune processes and inflammatory pathways that underlie childhood OSAS as a distinctive systemic inflammatory condition in children, and will explore potential interactions between OSAS and obesity.

Improvement of Hygienic Quality of Panax Ginseng Leaf Tea (고려인삼 엽록차의 위생적 품질개선 연구)

  • 이영주;김종군;권중호;변명우;김석원;조한옥
    • Journal of Food Hygiene and Safety
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    • v.5 no.1
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    • pp.13-19
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    • 1990
  • The microbial populations of exportable ginseng leaf tea were $3.6{\times}10^{5}/g$ in mesophilic aerobic bacteria, $2.1{\times}10^{3}/g$ in mesophilic aerobic spores, $1.6{\times}10^{4}/g$ in yeast, $1.9{\times}10^{4}/g$ in molds and $1.2{\times}10^{4}/g$ in coliforms, respectively, which are higher levels than the legaJIy permissible loads of microorganisms for ginseng powders in Korea. In a comparative study of the decontaminating effects on microorganisms, ethylene oxide fumigation and 5 kGy irradiation could decrease microorganisms below the detectable level. And there is no growth of microorgllnisms after three months of storage at $30{\pm}1^{circ}C$. The decimal reduction doses (Dw value) for microorganisms contaminated were 0.70 kGy in coliforms, 0.75 kGy in total bacteria, 0.85 kGy in molds. and 0.95 kGy in yeast, respectively. In the organoleptic test for ginseng leaf tea, the irradiated samples showed no significant difference from the control group in overall flavor, taste, color and acceptability. However the extracts of ethylene oxide fumigated sample were significantly different in color and taste from other groups even after three months storage.

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Effects of Additives on the Quality Improvement of Minced Ginger (Zingiber officinale Roscoe) During Storage (생강(Zingiber officinale Roscoe) 다대기의 저장 중 품질개선을 위한 첨가물 효과)

  • Lee, Myung-Hee;Lee, Kyoung-Hae;Cho, Chang-Won;Kim, Kyung-Tack
    • Journal of Food Hygiene and Safety
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    • v.25 no.1
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    • pp.59-64
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    • 2010
  • The effects of vinegar, alcohol and ascorbic acid on the color, microorganism, sensory properties and flavor pattern of minced ginger (MG) were investigated during storage for 28 days at $30^{\circ}C$. The values of L (lightness), a (redness) and b (yellowness) of the control (T-0) and all the treatments changed slightly at the initial stage of storage, however the elapse of time accelerated the changes. The total bacterial counts of T-0 showed $5.37{\times}10^7\;CFU/g$ at the initial stage, but the MG-treatments decreased the bacteria above 4 log compared to T-0. It was showed that the additives were effective for inhibition of the growth of microorganism. Sensory properties of flavor intensity test showed no significant difference between T-0 and MG-treatments (p < 0.05). The result of volatile flavor contents of electronic nose analyzer (ENZ) showed that MG-treatments (T-I, T-II, T-III) was recognized stronger than non-treatment at the initial stage, but the change of flavor compound were stabilized soon regardless of type or quantity of additives during total storage period at $30^{\circ}C$.

Antimicrobial Activity of Flos Syzygii Aromatici Extracts against Mice Infected with Escherichia coli O157:H7 (Escherichia coli O157:H7에 감염된 마우스에 대한 정향 추출물의 항균효과)

  • Lee, Soo-Mi;Son, Song Ee;Lee, Hu Jang
    • Journal of Food Hygiene and Safety
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    • v.32 no.4
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    • pp.336-340
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    • 2017
  • The present study evaluated the antibacterial effect of Flos syzygii Aromatici methanolic extracts (FSAE). In addition, the effectiveness of FSAE against Escherichia coli O157:H7 infection was studied using ICR female mice. At 24 h after incubation of E. coli O157:H7, FSAE at the concentration of 0.269 (p < 0.05), 0.538 (p < 0.001) and 1.075 mg/mL (p < 0.001) significantly inhibited the growth of E. coli O157:H7 compared to the control group. After single challenge with E. coli O157:H7, forty female ICR mice were divided into four experimental groups which were orally administered with saline (control), 0.538 (group 1), 1.075 (group 2) and 2.15 mg/mL (group 3) of FSAE, respectively. On the 3rd day, the number of fecal E. coli O157:H7 in group 2 (p < 0.05) and group 3 (p < 0.01) was significantly decreased compared to that in the control group. On the 7th day post-treatment, the number of fecal E. coli O157:H7 in all FSAE-treated groups was significantly decreased compared to that in the control group (group 1, p < 0.05; group 2 and 3, p < 0.001). According to the results of the present study, administration of FSAE to mice can reduce the severity of E. coli O157:H7 infection. Therefore, the current study suggests that FSAE could be a good candidate for the treatment of enteric infections in domestic animals.

Suppression of Solid Matters Precipitation of Takju and Its Quality Improvement by Carrageenan (Carrageenan에 의한 탁주 고형물 침전 억제 및 품질 개선에 관한 연구)

  • Park, Hyun-Jeong;Shin, Wan-Chul;Song, Jae-Chul
    • The Korean Journal of Food And Nutrition
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    • v.19 no.3
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    • pp.288-295
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    • 2006
  • This study was conducted to examine the possibility of improvement effect in suppression of precipitation and nasty smell creation in Takju mash. First of all, gum shown to be lowest precipitation velocity was selected and this was applied to the fermentation of Takju mash for comparing with the control in terms of fermentation aspects and various qualities of Takju mash. Precipitation amount and precipitation velocity of suspension in Takju mash added with carrageenan was shown to be the lowest than that of others. Compared with the control, alcohol was highly generated in Takju mash added with carrageenan, especially between two and four days. Total acidity was shown to be highly increased until 2 days in Takju mash and thereafter to be slightly increased. Takju mash added with carrageenan was shown to be lower on the second stage than the control. Fusel oil produced from mash added with carrageenan was 0.046${\sim}$0.113${\mu}$l/ml and mash added with carrageenan generated less fusel oil than the control by 1.6${\sim}$3.2 fold. Yeast growth on the mash added with carrageenan was revealed to be helpful during fermentation periods. In general, sensory characteristics of Takju mash were shown to be more superior in mash added with carrageenan than in other samples. While nasty smell produced from a sample without gums was perceived after 2 days of Takju mash storage, nasty smell of Takju mash added with carrageenan was recognized after 6 days during storage. In conclusion, precipitation of suspension and nasty smell production in Takju mash were found to be suppressed by addition of carrageenan during Takju fermentation.

The Regulatory Role of Serratia marcescens Threonine Dehydratase in a Isoleucine Biosynthesis (이소루신 생합성 과정에서 Serratia marcescens Threonine Dehydratase의 조절 역할)

  • 최병범;방선권;김승수
    • The Korean Journal of Food And Nutrition
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    • v.9 no.4
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    • pp.372-378
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    • 1996
  • The effects of branched chain amino acids and metabolites in growth media on the biosynthesis of Serratia marcescens threonine dehydratase activity were examined. The enzyme activity was decreased above 60% by leucine among the range from 1 to 20 mM, and the enzyme activity was decreased approximately 20% by a low concentration of valine (1 to 4 mM), but not affected at high concentration (20 mM). However, the enzyme activity was increased approximately 100 to 140% by a low concentration of isoleucine (1 to 4 mM), but decreased approximately 25 to 80% at high concentration (15 to 30 mM). The enzyme activity was decreased by 25 and 58% by the simultaneous addition of all three branched chain amino acids at 2 and 10 mM concentration, respectively, but increased by 75 and 50% by the combination addition of isoleucine plus valine and isoleucine plus leucine at 2 mM, respectively. cAMP was decreased the enzyme activity approximately 10 to 40% by a low concentration (1 to 2 mM), but increased by 80% at high concentration (10 mM). These data suggest that S. marcescens threonine dehydratase should be multivalently repressed by branched chain amino acids, but positively regulated by a low isoleucine concentration and may play a regulatory role in an isoleucine biosynthetic pathway unlike the E. coli K-12 enzyme.

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Cymbidium Hybrid 'Purple Princess' with Dark Purple Flower (진한 자주색계 중형 심비디움 'Purple Princess')

  • Kim, Mi-Seon;Jeong, Myeong-Il;Lee, Young-Ran
    • Horticultural Science & Technology
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    • v.28 no.4
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    • pp.715-718
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    • 2010
  • $Cymbidium$ 'Purple Princess' ('Show Girl' x 'Eiko') is a new cultivar having dark purple sepal and petal (RHS, RP59A) with purple lip (RHS, RP59A). A cross was made between pink colored $C.$'Show Girl' as maternal line and dark purple colored $C.$ 'Eiko' as paternal line in 1994. It was preliminarily selected as Line No. 94019267 in 1999 considering the characters of flower shape and color, leaf growing shape and growth habit in normal culture condition. Multiplication, cultivation, and characteristic trials were conducted from 2000 to 2003. The line was named as Wongyo F1-7 and phenotype was characterized in 2004 as a new 'Purple Princess'. 'Purple Princess' has about 13.2 flowers per flower stalk and flower size of 5.2 cm. General appearance of petals and sepals is slightly incurved shape. The plant size is intermediate having erect peduncle. Blooming starts from early December under optimal culture condition. Leaf attitude and twisting is erect and very weak respectively. Erect leaf will be suitable for growing and handling in the nursery as pot orchid flowers.

Pollen Tube Elongation and Fruit Set of Asian Pear (Pyrus pyrifolia) upon Mechanical Damage on the Style (동양배 암술의 기계적 손상에 따른 화분관 신장과 착과)

  • Kang, Sam-Seok;Kim, Yoon-Kyeong;Choi, Jang-Jeon;Cho, Kwang-Sik;Hwang, Hae-Sung;Jeong, Sang-Bouk;Lee, Hee-Jae
    • Horticultural Science & Technology
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    • v.28 no.6
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    • pp.942-947
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    • 2010
  • In the present study, pollen tube growth and fruit set in Asian pear ($Pyrus$ $pyrifolia$) were examined upon the mechanical damage on the stigma and style following the artificial pollination. When the upper middle part of style was cut off at 48 h after the artificial pollination, pollen tube grew to the middle of the style and the subsequent pollen tube elongation and fruit set normally occurred. When the style was cut off before the pollen tube reached the middle of the style, however, no pollen tube elongation and fruit set occurred. With the pollen tube elongation through the style, callose plugs at the basal part of the pollen tube were formed to the direction of the elongation at regular intervals. When the upper part of pollen tube attached pollen grain was cut off, however, callose plugs were formed defectively in the pollen tube, and the pollen tube opened and lost their turgor pressure. These facts might be the reason for the ceased or delayed pollen tube elongation and ultimately the failure of the fertilization.

Deriving Strategic Priorities of Green ICT Policy using AHP and ANP (AHP와 ANP 방법론을 이용한 그린 ICT 정책의 전략적 우선순위 도출 방안)

  • Shim, Yong-Ho;Byun, Gi-Seob;Lee, Bong-Gyou
    • Journal of Internet Computing and Services
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    • v.12 no.1
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    • pp.85-98
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    • 2011
  • Recently, the world faces a global environmental crisis by the increase of energy consumption and global warming. Since the crisis directly affects political, economic, social, and environmental areas, many countries prepare Green ICT policy to overcome it. However, although Green IT policy provides many benefits by solving environmental pollution and increasing energy efficiency, Korean government did not prepare measures by the policy. The purpose of this study is to suggest priorities of political goals for maximizing the efficiency after introducing Green ICT policy in Korea. Major variables are drawn for the analysis, and they are eco-friendliness, technology evolution, economic efficiency, energy efficiency, and stable supply of energy. The variables are suggested based on 'Low Carbon, Green Growth Act', then the survey was conducted to policy expert using AHP(Analytic Hierarchy Process) and ANP(Analytic Network Process) for prioritizing variables. As a result of the AHP, it is derived in the order of eco-friendliness, technology evolution, economic efficiency, energy efficiency, and stable supply of energy. The ANP result shows in the order of technology evolution, energy efficiency, economic efficiency, eco-friendliness, and stable supply of energy. The research is conducted to analyze the priorities of goals for Green IT policy, and the analysis results are possible to use as a practical guideline for establishing associated policies in the future.

An Analysis of the Economic Effects for the IoT Industry (사물인터넷 산업의 경제적 파급효과 분석)

  • Jeong, Woo-Soo;Kim, Sa-Hyuk;Min, Kyoung-Sik
    • Journal of Internet Computing and Services
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    • v.14 no.5
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    • pp.119-128
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    • 2013
  • As ICT technology becomes advanced, the importance of future internet is emphasized and in part of that, M2M (Machine-to Machine communications) is magnified in terms of importance and usage in public and private sector. M2M is emerging as a next generation strategic industry but there is no existing analyzed data or market classification, so it disrupts establishing policies on the M2M industry. As the technology is progressing, the evolution from M2M to IoT (Internet of Things) has started and many countries actively try to find technological trend through market analysis in order to develop new growth engine. Therefore, in order to strengthen competitiveness, we should secure differentiated capabilities in industry and service. This article examines Korea's domestic market and international market trends in IoT and analyses the economic impact of the IoT industry using quantitative methodology and evaluates relations between the IoT industry and other relevant industries. As a result, the effect of IoT industry on production inducement is KRW474.6 billion; the effect on value-added inducement is KRW314.7 billion; and it is measured that 3,628 jobs will be created by the IoT industry.