• 대한방사성의약품학회지
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• 제3권2호
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• pp.98-102
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• 2017

We demonstrate a detail protocol for the radiosynthesis of a $^{125}I-labeled$ tetrazine prosthetic group and its application to the efficient radiolabeling of trans-cyclooctene-group conjugated human serum albumin (3) using inverse-electron-demand Diels-Alder reaction. Radioiodination of the stannylated precursor (2) was carried out by using [$^{125}I$]NaI and chloramine T as an oxidant at room temperature for 15 min. After HPLC purification of the crude product, the purified $^{125}I-labeled$ azide ([$^{125}I$]1) was obtained with high radiochemical yield ($65{\pm}8%$, n = 5) and excellent radiochemical purity (>99%). Inverse-electron-demand Diels-Alder reaction between ([$^{125}I$]1) and 3 gave the $^{125}I-labeled$ human serum albumin ([$^{125}I$]4) with more than 99% of radiochemical yield as determined by radio-thin-layer chromatography (radio-TLC). These results clearly indicate that the present radiolabeling method will be useful for the efficient and convenient radiolabeling of trans-cyclooctene-group containing biomolecules.

• 대한방사성의약품학회지
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• 제5권2호
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• pp.83-88
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• 2019

In order to understand the in vivo biodistribution of repebody protein (RB), an efficient and simple radiolabeling method for the protein is needed. We demonstrate a detailed protocol for the radiosynthesis of an ¹¹¹In radiolabeled tetrazine prosthetic group and its application to the efficient radiolabeling of trans-cyclooctene-group conjugated repebody protein using inverse-electron-demand Diels-Alder reaction. First, 1,2,4,5-tetrazine (Tz) conjugated with a DOTA chelator, was used for preparing the radiolabeled DOTA complex with ¹¹¹In. Second, the trans-cyclooctene (TCO) functionalized repebody protein was synthesized which allows for the preparation of radiolabeled proteins by copper-free click chemistry. Following incubation with the ¹¹¹In-radiolabeled DOTA complex (¹¹¹In-Tz), the TCO-functionalized RB (TCO-RB) was radiolabeled successfully with ¹¹¹In, with a high radiochemical yield (69.5%) and radiochemical purity (>99%). The radiolabeling of repebody protein by copper-free click chemistry was accomplished within 20 min, with great efficiency in aqueous conditions. These results clearly indicate that the present radiolabeling method will be useful for the efficient and convenient radiolabeling of trans-cyclooctene-group containing biomolecules.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2008년도 추계 학술발표회
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• pp.700-707
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• 2008

As plan connecting island to island or island to land is needed, a lot of long-span bridge is being designed lately in Southern part of Korea. With development of pile equipment, overhanging large-scaled concrete pile are adopted to foundation type of main tower or pylon. About the number of 15~30 group piles per tower foundation is designed to resist long-spaning super-structure load, but by restricted condition of site investigation cost, a few boring-hole tests are performed to identify sub-ground layers. Up to now, direct-curved method connecting two or three known boring logs and representative interval method are usually used to evaluate unknown depth and rock properties at locations where piles are constructed. Because this approach is not logical and so rough, much difference occurs between designed length of piles and real length of it. In this paper, using a lot of various prediction method(reciprocal distance method, inverse square distance method and kriging method etc.), we suggest optimum length of group piles.

• Geomechanics and Engineering
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• 제18권5호
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• pp.527-534
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• 2019

Although ground investigation had carried out prior to the construction, many problems have arisen during the civil-engineering works because of the presence of the unexpected underground utility lines or anomalies. In this study, a new geophysical exploration method was developed to solve those problems by improving and supplementing the existing methods. This new method was based on the difference of electrical resistance values between anomalies and surrounding ground medium. A theoretical expression was suggested to define the characteristics of the anomalies such as location, size and direction, by applying the electric field analysis. An inverse analysis algorithm was also developed to solve the theoretical expression using the measured electrical resistance values which were generated by the voltage flowing the subsurface medium. To verify the developed method, field applications were conducted at the sites under construction or planned. From the results of the field tests, it was found that not only the new method was more predictive than the existing methods, but its results were good agreed with the measured ones. Therefore, it is expected that application of the new exploration method reduces the unexpected accidents caused by the underground uncertainties during the underground construction works.

• 대한수학회지
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• 제59권3호
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• pp.621-634
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• 2022

The scaled inverse of a nonzero element a(x) ∈ ℤ[x]/f(x), where f(x) is an irreducible polynomial over ℤ, is the element b(x) ∈ ℤ[x]/f(x) such that a(x)b(x) = c (mod f(x)) for the smallest possible positive integer scale c. In this paper, we investigate the scaled inverse of (xⁱ - x^j) modulo cyclotomic polynomial of the form Φ_p^s (x) or Φ_p^sq^t (x), where p, q are primes with p < q and s, t are positive integers. Our main results are that the coefficient size of the scaled inverse of (xⁱ - x^j) is bounded by p - 1 with the scale p modulo Φ_p^s (x), and is bounded by q - 1 with the scale not greater than q modulo Φ_p^sq^t (x). Previously, the analogous result on cyclotomic polynomials of the form Φ_2ⁿ (x) gave rise to many lattice-based cryptosystems, especially, zero-knowledge proofs. Our result provides more flexible choice of cyclotomic polynomials in such cryptosystems. Along the way of proving the theorems, we also prove several properties of {x^k}_k∈ℤ in ℤ[x]/Φ_pq(x) which might be of independent interest.

• 전기의세계
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• 제29권4호
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• pp.256-259
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• 1980

A singular pertubation theory is applied to obtain an approximate solution for suboptimal control of nuclear reactors with spatially distributed parameters. The inverse of the neutron velocity is regarded as a small perturbing parameter, and the model, adopted for simplicity, is a cylindrically symmetrical reactor whose dynamics are described by the one group diffusion equation with one delayed neutron group. The Helmholtz mode expansion is used for the application of the optimal theory for lumped parameter systems to the spatially distributed parameter systems. An asymptotic expansion of the feedback gain matrix is obtained with construction of the boundary layer correction up to the first order.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2006년도 추계학술대회 논문집
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• pp.311-312
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• 2006

• 한국음향학회:학술대회논문집
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• 한국음향학회 2002년도 하계학술발표대회 논문집 제21권 1호
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• pp.457-460
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• 2002

• 한국정밀공학회지
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• 제29권4호
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• pp.441-448
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• 2012

This paper describes the optimal home positioning algorithm of Eclipse-II, a new conceptual parallel mechanism for motion simulator. Eclipse-II is capable of translation and 360 degrees continuous rotation in all directions. In unexpected situations such as emergency stop, riders have to be resituated as soon as possible through a shortest translational and rotational path because the return paths are not unique in view of inverse kinematic solution. Eclipse-II is man riding. Therefore, the home positioning is directly related to the safety of riders. To ensure a least elapsed time, ZYX Euler angle inverse kinematics is applied to find an optimal home orientation. In addition, the subsequent decrease of maximum acceleration and jerk values is achieved by combining the optimal return path function with cubic spline, which consequently reduces delivery force and vibration to riders.

• 소음진동
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• 제8권3호
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• pp.542-552
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• 1998

The noise sources, structure-borne and/or air-borne, in machinery can be defined by their locations and strengths. However the locations of that noise sources are well known in many cases. In those cases, the problem can be defined as an inverse problem to known the strengths of the noise sources in the frequency domain, the modeling scheme is classified by thecoherent or incoherent source. This paper expands the basic concept to the case of the complex noise sources, in which the set of coherent and incoherent noise sources are matched with the noise of a real vehicle. The error factors in the experiment and the optimal number of the monopole sources to match the real suond filed are also investigated. The results of the noise source modeling of heavy machinery show that the incoherent and coherent/incoherent source models are applicable to the high frequency and the low frequency region, respectively. The noise source model also enables the noise source analysis to rank the contribution of real source group such as engine, T/M, exhuast, etc.