• Radiation Oncology Journal
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• v.13 no.2
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• pp.121-128
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• 1995

Purpose: The enhanced cytotoxic effect of combined treatment of hyper-thermia and chemotherapy by increasing intracellular acidity with HMA was investigated. Materials and Methods: FSall tumor cells were injected on the hindlegs of female $C_3H$ mice. When the tumor volume reached about 200mm3, experiments were performed on the groups classified as follows: Group I :Control, Group II : Melphalan alone (2.5mg/kg, 5mg/kg, 10mg/kg, 15mg/kg), Group III : Heat alone $(42.5^{\cdot}C$ for 1 hour) Group IV : Melphalan + Heat $(42.5^{\cdot}C$ for 1 hour), Group V : HMA(10mg/kg) + Melphalan(5.0mg/kg) + Heat$(42.5^{\cdot}C$ for 1hour). Each group included 8-12 mice on each experiment HMA (3-amino-6-chloro-5-(1-homopiperidyl )-N-(diaminomethylene) -c-pyrazinecarboxamide), an analog of amiloride which increases intracellular pH(pHi) was dissolved in dimethyl sulfoxide (DMS) and injected into the tumor-bearing mice through the tail vein. 10mg/kg of HMA and each dose of melphalan were injected into peritoneum of the tumor-bearing mice 30 minutes before heating. Tumor growth delay was calculated when the tumor volme reached at $1500mm^3$ Excision assay was performed on each group and repeated 2-4 times. Results : Tumor growth delay of each experimental groups at $1500mm^3$ were 9, 10, 13 and 19 days respectively. In vivo-in vitro excision assay using FSall tumor cells, the cytotoxicity of each experimental groups was $1.2{\times}10^7,\;1{\times}10^7,\;6{\times}10^6,\;1.7{\times}10^6\;and\;1{\times}10^5$ clonogenic cells/gm respectively When HMA was added to the combined treatment of heat and .chemotherapy, the tumor growth was delayed more than combined treatment without HMA i.e., 6 days tumor growth delay at $1500mm^3$ of tumor volume. Conclusion: The combined effect of cytotoxicity by heat and chemotherapy can be much more enhanced by HMA.

• The Journal of Korean Physical Therapy
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• v.21 no.3
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• pp.81-86
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• 2009

Purpose: This study compared the characteristics of the brake response time during the driving task between elderly and younger drivers. Methods: The participants consisted of an elderly group (n=12) and a younger group (n=12). The brake response time (BRT), which consisted of the reaction time (RT) and movement time (MT), was assessed in an actual driving car. The BRT was measured at the initiation and termination of the brake response for the driving task Results: The elderly group showed a significantly longer delay in the initiation and termination of the brake response than the younger group. The BRT correlated significantly with both the RT and MT. However, the RT showed a more significant correlation. Conclusion: A delay in the initiation and termination of the brake response may have clinical implications. A further study will be needed to determine the different factors contributing to the driving performance of elderly drivers.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.11 no.7
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• pp.3678-3698
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• 2017

With the rapid development of vehicular ad hoc Network (VANET), it has gained significant popularity and received increasing attentions from both academics and industry communities in aspects of security and efficiency. To address the security and efficiency issues, a self-authentication and deniable efficient group key agreement protocol is proposed in this paper. The scheme establishes a group between road side units (RSUs) and vehicles by using self-authentication without certification authority, and improves certification efficiency by using group key (GK) transmission method. At the same time, to avoid the attacker attacking the legal vehicle by RSUs, we adopt deniable group key agreement method to negotiation session key (sk) and use it to transmit GK between RSUs. In addition, vehicles not only broadcast messages to other vehicles, but also communicate with other members in the same group. Therefore, group communication is necessary in VANET. Finally, the performance analysis shows superiority of our scheme in security problems, meanwhile the verification delay, transmission overheard and message delay get significant improvement than other related schemes.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.11A
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• pp.1037-1043
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• 2006

This work presents an effective overlay multicast tree construction algorithm for synchronized real-time media multicast service over the Internet. The proposed algorithm is designed to minimize delay variance among group members to provide the synchronized service as well as average delay of group members in order to support the service in real-time. Basically, of orthogonal genetic algorithm is employed to obtain the near optimal tree with a low computational complexity since the given problem is NP-complete. Finally, experimental results are provided to show the superior performance of the proposed algorithm.

• Korean Journal of Construction Engineering and Management
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• v.7 no.5
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• pp.177-190
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• 2006

Construction projects are facing delay problems. Delays in construction have been immense effect on performance or satisfactory delivery of the project. Delays have been causing project cost overrun as well as it is a source of dispute hence damaging the relationship between the project participants. The purpose of this study was to explore the causes of delay risk through a field survey study. Data were collected from construction professionals working in owner, consultant and contractor organizations. All together 208 questionnaire instruments were used and analyzed by employing statistical tools (SPSS computer program). 19 delay factors were identified by this study, out of which following factors were critical: Frequent interruptions from public (local people, pressure group etc.), changed site condition, failure to provide required construction site, unrealistic project time estimation and design errors.

• The KIPS Transactions:PartC
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• v.12C no.1 s.97
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• pp.105-110
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• 2005

With the proliferation of multimedia group applications, the construction of multicast trees satisfying QoS requirements is becoming a problem of prime importance. In this paper, we study the delay- and delay variation-bounded multicast tree (DVBMT) problem which is NP-complete. The problem is to construct a spanning tree for destination node, which has the minimized multicast delay variation, and the delay on the path from the source to each destination is bounded. A solution to this problem is required to provide decent real-time communication services such as on-line games, shopping, and teleconferencing. Performance comparison shows that the proposed scheme outperforms DDVCA which is known to be effective so far in any network topology. The enhancement is up to about $3.6{\%}{\~}11.1{\%}$ in terms of normalized surcharge for DUVCA. The time complexity of our algorithm is $O(mn^2)$.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.19 no.2
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• pp.102-106
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• 2008

A new compact UWB bandpass filter with sharp-rejection, low insertion-loss and flat group-delay is developed In this paper, using the transversal filtering combined with SIR(stepped impedance resonator) concept. To form the required passband, multiple out-of-band transmission zeros are created around band-edges, securing very low insertion loss in the very wide frequency range. Also it is found to be beneficial to realize a sharp rejection of higher order with a relatively small overall size and simultaneously have very smoothly varying group-delay which is proper for the UWB applications. The validity of the proposed technique is proven theoretically and experimentally.

• Korean Journal of Optics and Photonics
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• v.15 no.3
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• pp.214-221
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• 2004

We theoretically and experimentally investigate the effect of apodization on the transmission characteristics of linearly chirped fiber Bragg gratings(CFBGs). Based on the UV beam scanning method along a phase mask, we fabricated several apodized CFBGs with different apodization profiles such as Gaussian, Raised-cosine, Blackman, and Hyperbolic tangent. During the UV beam scanning, the phase mask is dithered by a PZT(Piezoelectric transducer) which is precisely controlled by a computer program so that the apodization profiles can be flexibly applied to the grating. We measured the reflection spectra and group delay characteristics of CFBGs with the different apodization profiles, and compared them according to their properties such as reflectivity, sidelobes, and group delay ripple (GDR). The peak-to-peak of GDR could be suppressed to less than 20 ps.

• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2004.09a
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• pp.113-114
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• 2004

In order to classify the groundwater recharge characteristics in an urban area, a time series analysis of groundwater level data was performed. For this study, the daily groundwater level data from 35 monitoring wells were collected for 3 years (Fig. 1). The use of the cross-correlation function (CCF), one of the time series analysis, showed both the close relationship between rainfall and groundwater level change and the lag time (delay time) of groundwater level fluctuation after a rainfall event. Based on the result of CCF, monitored wells were classified into two major groups. Group I wells (n=10) showed a fast response of groundwater level change to rainfall event, with a delay time of maximum correlation between rainfall and groundwater level near 1 to 7 days. On the other hand, the delay time of 17-68 days was observed from Group II wells (n=25) (Fig. 1). The fast response in Group I wells is possibly caused by the change of hydraulic pressure of bedrock aquifer due to the rainfall recharge, rather than the direct response to rainfall recharge.

• International Journal of Advanced Culture Technology
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• v.10 no.4
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• pp.294-303
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• 2022

The purpose of this study is to examine the effects of sensory integration training on children with developmental delays. To achieve this goal, an educational experiment is conducted in five main areas: gross motor ability, fine motor ability, adaptive ability, language and social ability in children with developmental delay. The study subjects were children with developmental delays aged 3-6 years diagnosed at Beijing Institute of Pediatrics and Beijing Medical University and received sensory integration intervention and homebased training at the Golden Rain Forest Beijing Tongzhou Center from 2018 to 2021. According to the purpose of the analysis, the data collected are subjected to descriptive statistics using SPSS 21.0 statistical program, Two-way MANOVA analysis, and data analysis method of multivariate analysis is used to process the collected data. In addition, a total of 39 subjects were selected, including 19 children who received sensory integration training and 20 children who only received family training. The results show that the sensory integration training group outperformed the home training group in all aspects and developmental quotient, but the home training group also showed higher levels of significance for improvements in gross motor, fine motor and developmental quotient.