• Radiation Oncology Journal
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• 제13권2호
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• pp.121-128
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• 1995

Purpose: The enhanced cytotoxic effect of combined treatment of hyper-thermia and chemotherapy by increasing intracellular acidity with HMA was investigated. Materials and Methods: FSall tumor cells were injected on the hindlegs of female $C_3H$ mice. When the tumor volume reached about 200mm3, experiments were performed on the groups classified as follows: Group I :Control, Group II : Melphalan alone (2.5mg/kg, 5mg/kg, 10mg/kg, 15mg/kg), Group III : Heat alone $(42.5^{\cdot}C$ for 1 hour) Group IV : Melphalan + Heat $(42.5^{\cdot}C$ for 1 hour), Group V : HMA(10mg/kg) + Melphalan(5.0mg/kg) + Heat$(42.5^{\cdot}C$ for 1hour). Each group included 8-12 mice on each experiment HMA (3-amino-6-chloro-5-(1-homopiperidyl )-N-(diaminomethylene) -c-pyrazinecarboxamide), an analog of amiloride which increases intracellular pH(pHi) was dissolved in dimethyl sulfoxide (DMS) and injected into the tumor-bearing mice through the tail vein. 10mg/kg of HMA and each dose of melphalan were injected into peritoneum of the tumor-bearing mice 30 minutes before heating. Tumor growth delay was calculated when the tumor volme reached at $1500mm^3$ Excision assay was performed on each group and repeated 2-4 times. Results : Tumor growth delay of each experimental groups at $1500mm^3$ were 9, 10, 13 and 19 days respectively. In vivo-in vitro excision assay using FSall tumor cells, the cytotoxicity of each experimental groups was $1.2{\times}10^7,\;1{\times}10^7,\;6{\times}10^6,\;1.7{\times}10^6\;and\;1{\times}10^5$ clonogenic cells/gm respectively When HMA was added to the combined treatment of heat and .chemotherapy, the tumor growth was delayed more than combined treatment without HMA i.e., 6 days tumor growth delay at $1500mm^3$ of tumor volume. Conclusion: The combined effect of cytotoxicity by heat and chemotherapy can be much more enhanced by HMA.

• The Journal of Korean Physical Therapy
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• 제21권3호
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• pp.81-86
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• 2009

Purpose: This study compared the characteristics of the brake response time during the driving task between elderly and younger drivers. Methods: The participants consisted of an elderly group (n=12) and a younger group (n=12). The brake response time (BRT), which consisted of the reaction time (RT) and movement time (MT), was assessed in an actual driving car. The BRT was measured at the initiation and termination of the brake response for the driving task Results: The elderly group showed a significantly longer delay in the initiation and termination of the brake response than the younger group. The BRT correlated significantly with both the RT and MT. However, the RT showed a more significant correlation. Conclusion: A delay in the initiation and termination of the brake response may have clinical implications. A further study will be needed to determine the different factors contributing to the driving performance of elderly drivers.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권7호
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• pp.3678-3698
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• 2017

With the rapid development of vehicular ad hoc Network (VANET), it has gained significant popularity and received increasing attentions from both academics and industry communities in aspects of security and efficiency. To address the security and efficiency issues, a self-authentication and deniable efficient group key agreement protocol is proposed in this paper. The scheme establishes a group between road side units (RSUs) and vehicles by using self-authentication without certification authority, and improves certification efficiency by using group key (GK) transmission method. At the same time, to avoid the attacker attacking the legal vehicle by RSUs, we adopt deniable group key agreement method to negotiation session key (sk) and use it to transmit GK between RSUs. In addition, vehicles not only broadcast messages to other vehicles, but also communicate with other members in the same group. Therefore, group communication is necessary in VANET. Finally, the performance analysis shows superiority of our scheme in security problems, meanwhile the verification delay, transmission overheard and message delay get significant improvement than other related schemes.

• 한국통신학회논문지
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• 제31권11A호
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• pp.1037-1043
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• 2006

본 논문은 인터넷 상에서 동기화된 실시간 미디어 멀티캐스트 서비스에 적합한 오버레이 멀티캐스트 트리를 구성하는 알고리즘을 제안한다. 제안하는 알고리즘은 멀티캐스트 송신 단에서 각 종단 시스템 사이의 전송 지연에 대한 평균과 변이를 최소화하는 트리 구성을 찾는다. 그러나 위의 문제는 NP-완전하므로, 이러한 문제의 계산 복잡도를 낮추면서, 근사해를 찾기 위한 방법으로 OGA (Orthogonal Genetic Algorithm)을 이용하였다. 실험 결과에서 제안하는 알고리즘이 기존 알고리즘에 비해 통기화된 실시간 미디어 데이터 전송을 위한 효과적인 트리를 구성한다는 것을 보인다.

• 한국건설관리학회논문집
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• 제7권5호
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• pp.177-190
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• 2006

Construction projects are facing delay problems. Delays in construction have been immense effect on performance or satisfactory delivery of the project. Delays have been causing project cost overrun as well as it is a source of dispute hence damaging the relationship between the project participants. The purpose of this study was to explore the causes of delay risk through a field survey study. Data were collected from construction professionals working in owner, consultant and contractor organizations. All together 208 questionnaire instruments were used and analyzed by employing statistical tools (SPSS computer program). 19 delay factors were identified by this study, out of which following factors were critical: Frequent interruptions from public (local people, pressure group etc.), changed site condition, failure to provide required construction site, unrealistic project time estimation and design errors.

• 정보처리학회논문지C
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• 제12C권1호
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• pp.105-110
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• 2005

멀티미디어 그룹 애플리케이션들이 증가함에 따라, QoS 요구사항을 만족하는 멀티캐스트 트리를 생성하는 것은 매우 중요한 문제로 부각되고 있다. 본 논문에서는 NP-complete ans제인 지연시간 제한과 지연변이 제한을 만족하는 멀티캐스트 트리(DVBMT : delay- and delay variation-bounded multicast tree) 문제를 다루겠다. 이 문제는 목적노드들을 포함하는 신장 트리를 생성하는 것으로, 이들 목적노드들은 최소화된 멀티캐스트 지연변이를 가지며, 시작노드에서 각 목적노트로의 경로상의 지연시간은 제한된 지연시간을 만족한다. 이러한 문제의 해법은 온라인 게임이나 쇼핑, 또는 원격 회의와 같은 실시간 통신 서비스를 제공하는데 필요하다. 지금까지 DVBMT 문제를 이상적으로 다루었다고 알려진 DDVCA보다 본 논문에서 제시한 알고리즘이 더욱 효율적이라는 것은 성능 평가를 통해 확인할 수 있다. 이를 통해 확인된 성능 향상은 DDVCA를 normalized surcharge로 계산 했을 때, 약 $3.6{\%}$에서 $11.1{\%}$에 이른다. 본 논문에서 제안한 알고리즘의 시간복잡도는 $O(mn^2)$이다.

• 한국전자파학회논문지
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• 제19권2호
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• pp.102-106
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• 2008

본 논문에서는, 병렬 결합의 두 전송선으로 구성된 transversal 여파 특성 구조와 SIR 개념을 함께 이용하여, 급격한 차단 특성, 낮은 삽입 손실, 평탄한 군지연 특성을 가지는 새로운 소형 UWB 대역 통과 여파기가 개발된다. 요구되는 대역 특성을 얻기 위해, 매우 넓은 대역에서의 낮은 삽입 손실을 확보한 채, 다수의 차단용 극점들이 생성된다. 또한 상대적으로 작은 구조로써 높은 차수의 급격한 차단 특성을 구현하고, 동시에 UWB 응용에 적합하도록 완만한 군지연을 구현한 것이 장점이다. 제안한 기술의 타당성이 이론과 실험에 의해 증명된다.

• 한국광학회지
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• 제15권3호
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• pp.214-221
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• 2004

색분산 보상에 사용되는 선형 첩 광섬유 격자의 제작에 있어서 Group Delay Ripple(GDR)을 줄이기 위한 apodization 기술에 대해 이론적으로 분석하고 실험적으로 규명하고자 한다. 첩격자의 제작에는 위상 마스크를 이용한 UV 빔 스캐닝 기법을 적용하였고, PZT(Piezoelectric transducer)를 이용하여 위상 마스크를 빔 스캐닝 중에 적절하게 흔들어줌으로써 apodization이 일어나도록 하였다. 이러한 모든 과정이 컴퓨터 제어로 이루어지기 때문에 다양한 apodization 프로파일을 적용할 수 있었다. Gaussian, Raised-cosine, Blackman, 그리고 Hyperbolic tangent 등의 프로파일을 적용하여 첩격자를 제작하였으며 실험 결과 0.05 nm 구간평균 peak-to-peak GDR이 20ps 이하로 감소하였다.

• 한국지하수토양환경학회:학술대회논문집
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• 한국지하수토양환경학회 2004년도 임시총회 및 추계학술발표회
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• pp.113-114
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• 2004

In order to classify the groundwater recharge characteristics in an urban area, a time series analysis of groundwater level data was performed. For this study, the daily groundwater level data from 35 monitoring wells were collected for 3 years (Fig. 1). The use of the cross-correlation function (CCF), one of the time series analysis, showed both the close relationship between rainfall and groundwater level change and the lag time (delay time) of groundwater level fluctuation after a rainfall event. Based on the result of CCF, monitored wells were classified into two major groups. Group I wells (n=10) showed a fast response of groundwater level change to rainfall event, with a delay time of maximum correlation between rainfall and groundwater level near 1 to 7 days. On the other hand, the delay time of 17-68 days was observed from Group II wells (n=25) (Fig. 1). The fast response in Group I wells is possibly caused by the change of hydraulic pressure of bedrock aquifer due to the rainfall recharge, rather than the direct response to rainfall recharge.

• International Journal of Advanced Culture Technology
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• 제10권4호
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• pp.294-303
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• 2022

The purpose of this study is to examine the effects of sensory integration training on children with developmental delays. To achieve this goal, an educational experiment is conducted in five main areas: gross motor ability, fine motor ability, adaptive ability, language and social ability in children with developmental delay. The study subjects were children with developmental delays aged 3-6 years diagnosed at Beijing Institute of Pediatrics and Beijing Medical University and received sensory integration intervention and homebased training at the Golden Rain Forest Beijing Tongzhou Center from 2018 to 2021. According to the purpose of the analysis, the data collected are subjected to descriptive statistics using SPSS 21.0 statistical program, Two-way MANOVA analysis, and data analysis method of multivariate analysis is used to process the collected data. In addition, a total of 39 subjects were selected, including 19 children who received sensory integration training and 20 children who only received family training. The results show that the sensory integration training group outperformed the home training group in all aspects and developmental quotient, but the home training group also showed higher levels of significance for improvements in gross motor, fine motor and developmental quotient.