• Clinical and Experimental Pediatrics
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• v.61 no.2
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• pp.53-58
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• 2018

Purpose: Although the prognosis is generally good in patients with intermediate-risk neuroblastoma, no consensus has been reached on the ideal treatment regimen. This study analyzed treatment outcomes and toxicities in patients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma. Methods: We retrospectively analyzed 20 patients younger than 18 months newly diagnosed with stage 4 MYCN nonamplified neuroblastoma between January 2009 and December 2015. Patients received 9 cycles of chemotherapy and surgery, with or without local radiotherapy, followed by 12 cycles of differentiation therapy with 13-cis-retinoic acid. Chemotherapy consisted of alternating cycles of cisplatin, etoposide, doxorubicin, and cyclophosphamide (CEDC) and ifosfamide, carboplatin, and etoposide (ICE) regimens. Results: The most common primary tumor site was the abdomen (85%), and the most common metastatic sites were the lymph nodes (65%), followed by the bones (60%), liver (55%), skin (45%), and bone marrow (25%). At the end of induction therapy, 14 patients (70%) achieved complete response, with 1 achieving very good partial response, 4 achieving partial response, and 1 showing mixed response. Nine patients (45%) received local radiotherapy. At a median follow-up of 47 months (range, 17-91 months), none of these patients experienced relapse, progression, or secondary malignancy, or died. Three years after chemotherapy completion, none of the patients had experienced grade ${\geq}3$ late adverse effects. Conclusion: Patients younger than 18 months with stage 4 MYCN nonamplified neuroblastoma showed excellent outcomes, without significant late adverse effects, when treated with alternating cycles of CEDC and ICE, followed by surgery and differentiation therapy.

• Journal of Animal Science and Technology
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• v.56 no.3
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• pp.9.1-9.8
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• 2014

This study was performed to investigate the effects of different forms of concentrate fed to Hanwoo steers on performance, carcass characteristics, and economic performance. Forty-two Hanwoo steers (average age of $5.1{\pm}0.8mo$. with body weight of $147.05{\pm}10.85kg$) were randomly allotted into FC (animals fed flakes for entire experimental period) and GC (animals fed grounded concentrate during growing and fattening phases followed by flaked concentrate during finishing phase) groups for 758 d after reaching an age of $30.0{\pm}0.82mo$. There was no difference in body weight (BW) or ADG between the treatments until fattening (15 ~ 22 mo.) phase. However, by finishing phase (23 ~ 30 mo.), the GC group (739.24 kg BW and 0.67 kg ADG) showed greater (P < 0.05) BW and ADG than the FC group (702.93 kg BW and 0.59 kg ADG). Steers in the GC group also showed greater (P < 0.05) BW and ADG than the FC group throughout the entire experimental period (5 ~ 30 mo.). There was no significant difference in carcass weight or backfat thickness between the treatments. M. Longissimus dorsi area of the GC group ($91.00cm^2$) was greater (P < 0.05) than that of the FC group ($83.59cm^2$). Marbling score and percentage of $1^{{+}{+}}$ meat quality grade were 14.0 and 48.0% higher in the GC group compared to the FC group. There was no significant difference in physicochemical characteristics, including moisture and crude protein levels, between the treatments. Gross income per head excluding operating expenses was 59.3% greater in the GC group (1,647,512 won) compared to the FC group (1,034,343 won).

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.1
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• pp.91-99
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• 2011

Adult-learners of online education have been distant from studying for a long time and are rather familiar with the old massive education. As a result, despite the excellent ability in self-control learning that results in great academic performances and academic continuity, the learners give up on learning, feeling depressed for not being able to perform their advantage, the self-control learning ability. The study developed a self-control learning model and UDL design learning model in order to establish e-mentoring system. For the analysis on results of the experiment, the researcher extracted academic grade, the rate of re-register, and the amount of total studying time after dividing new students and transfer students of H cyber university into the control group and the experimental group. In conclusion, the results showed that more satisfied the control group is, the higher academic achievements and the higher academic continuity are accomplished.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1375-1379
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• 2014

Background: Differences in clinicopathological characteristics of gastric cancer (GC) between young and older patients are controversial and a matter of debate. Determining the statistical significance of clinicopathological information with respect to age might provide clues for better management and treatment ofGC. Materials and Methods: A total ofl03 Indiao GC patients were enrolled for study and specimens were classified according to the AjCC-TNM system. Patients were grouped into two age-wise categories, young patients (<40 years; n=13) and older patients (${\geq}40$ years, n=90). The clinicopathological features of both groups were retrospectively examined and compared. p53 alterations were analyzed by polymerase chain reaction-single strand conformational polymorphism and immunohistochemistry methods at gene and protein levels respectively. The cases were considered p53 over-expressed if it was present in more than 25% of the tumor cells and p53 alterations was correlated with the clinicopathological characteristics of the patients as well as etiological factors for GC in both groups. Results: We found significant association of young patients with cancer stage (p=0.01), and very strong association with histology grade (p=0.064) and poorly differentiated (p=0.051) state of GC. However, neither young nor elderly patients showed associations with location, gender, etiological factors and p53 expression and alteration. Overall the male-to-female ratio of GC patients was 3.12 and the value was higher in the young (5.5) than in the older group (2.91). Conclusions: Clinicopathological features of GC like caocer stage, cell differentiation and histological grades were significantly different among young and old age cohorts. We observed a male predominance among the young group that decreased significantly with advancing age. More awareness of GC onset is required to detect cancer at an early stage for successful treatment.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2851-2856
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• 2014

The aim of this study is to evaluate clinicopathologic characteristics and the multi-disciplinary treatment results of metaplastic breast cancer (MBC) patients treated in a single institute. Seventeen female patients with MBC treated in our department between June 2000 and January 2012 were identified and retrospectively evaluated. The median age at diagnosis was 46 years (range, 26-66 years). The median tumor size at diagnosis was 3.5 cm (range 1.5-12 cm). Six (35%) patients underwent breast conservation surgery and 11 (65%) mastectomy. Axillary lymph node metastasis was found in 6 (35%) patients. Twelve (71%) had triple negative tumors. Postoperative RT and systemic adjuvant treatment was given to all patients accordingly to stage and biological characteristics. Median follow-up time was 27 months (range, 12-151 months). At the time of this analysis, 14 (82%) patients were alive with no evidence of disease, and 1 (6%) was alive with disease. The 3-year OS was 91% and 5-year 80%, and DFS rates were 76% and 76%, respectively. Despite the young age of our patients with mostly high grade tumors, larger tumor size and higher rates of lymph node metastasis, the survival outcomes in our study are favorable in comparison with previously reported series.

• Journal of Sasang Constitutional Medicine
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• v.16 no.1
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• pp.100-111
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• 2004

Objectives To study on the relation between Sasang constitution and obesity and that of obese patient's clinical symptom. Methods The subjects were 129 female patients to visit to diet. The subjects were 129 female patients to diet who answered questionnaire QSCC II and were diagnosed by the Sasang constitution from May to December in 2001 at Nara oriental medical clinic. Results 1. Of obese patients 79.1% were Taeumin, 11.6% Soeumin, and 9.3% Soyangin. 2. A relation of a grade of obesity and Sasang constitution. 2-1) 45.8% of the obese patients were high level obesity who had over 35% of body fat. Out of these people, 91.5% were Taeumin. 2-2) 40.3% of the obese patients weight hip ratio was between 0.84 to 0.89 and 84.6% of these people were proved to be Taeumin. 2-3) 39.2% of the people who had a minimum weight hip ratio of 0.90 were significantly Taeumin, 6.7% Soeumin and 16.6% Soyangin. 2-4) 65.7% of Taeumin were obese patients. 3. Obesity treatment with constitution. 3-1) 59.8% of Taeumin were Pyo-zng patients. 3-2) As treatment periods tended to increase, Taeumin and Soeumin patients showed a large decling of body fat, whereas Soeumin patients showed the opposite reaction. 3-3) The weight hip ratio was led by Taeumin with 0.03 and then came Soeumin and Soyangin with a 0.02 ratio. As treatment was taken into process longer Taeumin patients showed a great progress in decreasing their weight hip ratios. 4. Costitutional related symptom with Obesity. 4-1) Taeumin was followed by Soyangin and then Soeumin in family history. 4-2) Soeumin was followed by Taeumin, then Soyangin when complain of physical fatigue was taken into consideration. 4-3) The ordinary exercise was led by Soyangin, Taeumin then Soeumin. 4-4) People who receive stress turned out to be 72.9% much higher than the people who don't. 4-5) Overeating due to stress was found in 83.3% of Soyangin.

• Journal of the Korean Society of School Health
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• v.16 no.1
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• pp.91-104
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• 2003

The purpose of this study is primarily intended to examine the stress and physical, emotional and behavioral stress symptoms of elementary school students supply the basic data of intervention for children's health promotion. The subjects of this study were 616 students who were currently enrolled in 5th and 6th grade elementary school in Jeollabukdo ; 3 schools in J city and other 6 in 3 rural area. The data were collected by self-reported questionnaire from 3rd to 13th April 2002 and collected data were analyzed by SPSS WIN 8.0. The results of this study were as followings. 1. The mean score of stress that children experience was 2.73 and the most stressful factor was a friendship stress. The most frequently experienced stress were feel that a friends would leave them alone. 2. The mean score of stress symptom that children experience was 1.92 and the most stressful symptom was the emotion symptom. The most frequently experienced stressful symptom were feel fatigue of everyday. 3. General characteristics related to stress were showed significantly different according to sex(t=-3.243, p=.001) 4. General characteristics related to stress symptoms were showed significantly different according to sex(t=-2.268, p=.024), family circumstances(F=8.697, p=.000), academic scores(F=11.216, p=.000) and parental concerns on a child(t=-2.561, p=.011). 5. The relation between stress and stress symptoms showed a positive correlation, which was significant statistically(r=.453, p=.000). In conclusion, elementary school students experience various stresses and the stress symptoms have positive close connection with health problems. Therefore, to study the students stress and consequent symptoms further, it is recommended that we should subdivide and analyze the stressor and stress symptoms by proper areas. In the meantime, in order to promote children's health using the data in this study, we should develop the correlated program among individual, family, school and community while we are deeply concerned about and support children continuously.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.1
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• pp.315-320
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• 2013

Background: TGF-${\beta}$-activated kinase-1 (TAK1) has been found to be over-expressed in a variety of solid malignancies and related to tumor growth. The aim of this study was to evaluate the expression level of TAK1 in clear cell renal cell carcinoma (ccRCC) and assess its value as a novel prognostic marker. Methods: TAK1 mRNA was assessed in 51 paired ccRCC tissues and adjacent normal tissues (ADTs) by real-time PCR. Tissue TAK1 protein was also assessed in 91 ADTs and 177 samples of ccRCC immunohistochemically for evaluation of relationships with clinical characteristics. Results: RT-PCR showed that TAK1 RNA level was significantly higher in ccRCC tissues than in the paired ADTs and immunohistochemistry confirmed higher expression of TAK1 protein in ccRCC samples compared with ADTs. TAK1 protein expression in 177 ccRCC samples was significantly correlated with T stage, N classification, metastasis, recurrence and Fuhrman grade, but not age and gender. Patients with low TAK1 levels had a better survival outcome. TAK1 expression and N stage were independent prognosis factors for the overall survival of ccRCC patients. Conclusions: Overexpression of TAK1 predicts a poor prognosis in patients with ccRCC, so that TAK1 may serve as a novel prognostic marker.

• Journal of Environmental Health Sciences
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• v.40 no.2
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• pp.127-136
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• 2014

Objectives: This study was conducted to investigate the removal of high odor concentration from swine wastewater treatment facility by full scale biofilter using liquid with deodorant mixed with earthworm cast and distillery sludge. Methods: The supply of the culture liquid to the microorganism on the media in the biofilter increases the activity and growth of biomass. The experimental equipment was biofilter tower with treatment capacity of 90 m 3/min. The experimental conditions included gas flow of $60m^3/min$, retention time of 20 sec, and gas/liquid ratio of 67. Results: With changing season from winter to summer, the inlet odor concentration of ammonia increased from 2.5 ppm to 29 ppm, and of hydrogen sulfide from 21 ppm to 91 ppm, respectively. The odor treatment system with biofilter using the culture liquid was stable when the high loading rate increased and showed excellent removal grade with an average of 96.7% for ammonia, and an average of 93.7% for hydrogen sulfide. The pH and SCOD in the recirculating culture liquid near the bottom of the biofilter tower decreased with operation time, but its influence on the odor removal rate was negligible, because the organic matter (SCOD) was replaced by some culture liquid supplied 2-4 times per day. Conclusions: The biofilter using culture liquid could successfully remove high odor concentration which was generated from swine wastewater treatment facility.

• Journal of the Korea Society of Computer and Information
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• v.16 no.4
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• pp.83-91
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• 2011

The purpose of this thesis was to implement effective blended PBL(Problem-Based Learning) systems for information communication ethics education. Online learning and face-to-face classes were systematically combined for achieving the teaching-learning goals. And the main module for online learning run on Moodle, an open source learning management system. To examine educational effectiveness of the proposed systems, an experimental study was conducted through the method to the subject of two class in the second-grade of university located in ${\bigcirc}{\bigcirc}$ city. For experiment 60 students(treatment group=30, control group=30) are participated. And they were assigned to one of ten subgroups, comprising of six students, respectively. The results of this study are follows, First, the education using proposed blended PBL method is more effective in cultivating consciousness of information communication ethics than the education using face-to-face PBL learning method. Second, learners who participated in the proposed blended PBL more experienced various effects of PBL, such as (1) Improvement of problem solving ability, (2) Understanding of cooperative learning than the other learners who participated in the face-to-face PBL.