• Proceedings of the Korean Society of Soil and Groundwater Environment Conference
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• 2003.09a
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• pp.47-51
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• 2003

본 연구는 용도별 토양에 대찬 중금속 및 불소 농도 특성을 알아보기 위하여 비교적 오염 개연성이 구분될 것으로 판단되는 도로, 공장, 학교운동장, 적환장, 공원, 약수터 주변 등, 그동안 비교적 조사 자료가 부족하였던 토양을 대상으로 한강 남쪽에 위치한 11개 구청(양천구, 강서구, 구로구, 영등포구, 관악구, 동작구, 강남구, 강동구, 서초구)에서 6개의 용도별로 시료를 채취하여 pH, Cd, Cu, Pb, Hg, F 항목을 분석하였다. 조사 결과 용도별 토양의 pH는 4.7~9.5의 범위로 나타났으며, 중금속 및 불소 평균 농도는 Cd 0,391mg/kg, Cu 12.354mg/kg, Pb 13.04mg/kg, Hg 0.0866mg/kg, F 206.8mg/kg이었다. 용도별 토양에 대한 최대, 최저 농도는 Cd이 잡종지 0.632mg/kg, 학교용지 0.079mg/kg, Cu는 도로용지 21.354mg/kg, 학교용지 2.159mg/kg, Pb은 도로용지 24.70mg/kg, 학교용지 1.03mg/kg, Hg은 잡종지 0.1780mg/kg, 학교용지 0.0087mg/kg, F의 경우 임야 282.0mg/kg, 학교용지164.9mg/kg로 나타나서 전체적으로 Cd, Cu, Hg은 대부분 적환장으로 이용되고 있는 잡종지가, Pb은 도로용지에서 각각 높은 농도를 나타내었고, F는 임야 지역을 대상으로 한 토양에서 높은 농도를 보였다. 그러나 학교용지는 Cd, Cu Pb, Hg, F등에서 상대적으로 다른 용도별 토양보다 낮은 농도를 나타내었다.

• Natural Product Sciences
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• v.12 no.3
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• pp.166-173
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• 2006

Silymarin is an antihepatotoxic substance isolated from the fruits of silybum mariamum. Possibly due to their antioxidant and membrane stabilizing properties, the compounds was shown to protect various organs and cells against a number of insults (Kvasnicka et al., 2003). Among the main silymarin components, [silybin($SB_A,\;SB_B$, isosilybin ($ISB_A,\;ISB_B$) silydianin (SD) and silychristin (SC)], silybin is the major pharmacologically active compound. Korean Pharmaceutical Codex (2nd ed.) describes silybin as the main substance of Cardus Marianus extract as supportive treatment of chronic inflammatory liver disorders. The aim of this work was to analyze silybin from various preparations containing cardus marianus extract, nicotinamide, and riboflavin (CNR). Nine commercial products were tested using reversed-phase HPLC-PDA assay. The limits of detection and quantification were $0.2\;{mu}g/ml$ and $1\;{mu}g/ml$, respectively. Calibration curve showed a good linearity ($r^2$=1.00000) in the range of $1{\sim}500\;{\mu}g/ml$ of silybin standard solutions.

• Tuberculosis and Respiratory Diseases
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• v.84 no.3
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• pp.217-225
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• 2021

Background: Despite the proven benefits of dexamethasone in hospitalized coronavirus disease 2019 (COVID-19) patients, the optimum time for the administration of dexamethasone is unknown. We investigated the progression of COVID-19 pneumonia based on the timing of dexamethasone administration. Methods: A single-center, retrospective cohort study based on medical record reviews was conducted between June 10 and September 21, 2020. We compared the risk of severe COVID-19, defined as the use of a high-flow nasal cannula or a mechanical ventilator, between groups that received dexamethasone either within 24 hours of hypoxemia (early dexamethasone group) or 24 hours after hypoxemia (late dexamethasone group). Hypoxemia was defined as room-air SpO₂ <90%. Results: Among 59 patients treated with dexamethasone for COVID-19 pneumonia, 30 were in the early dexamethasone group and 29 were in the late dexamethasone group. There was no significant difference in baseline characteristics, the time interval from symptom onset to diagnosis or hospitalization, or the use of antiviral or antibacterial agents between the two groups. The early dexamethasone group showed a significantly lower rate of severe COVID-19 compared to the control group (75.9% vs. 40.0%, p=0.012). Further, the early dexamethasone group showed a significantly shorter total duration of oxygen supplementation (10.45 days vs. 21.61 days, p=0.003) and length of stay in the hospital (19.76 days vs. 27.21 days, p=0.013). However, extracorporeal membrane oxygenation and in-hospital mortality rates were not significantly different between the two groups. Conclusion: Early administration of dexamethasone may prevent the progression of COVID-19 to a severe disease, without increased mortality.

• Journal of agricultural medicine and community health
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• v.23 no.2
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• pp.269-274
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• 1998

The purpose of this study is to establish the basic consultation data for diabetes in adults and to demonstate the necessity of preventive regular medical examinations. The study was carried out at Chungyang County, Chungchungnam-Do from the first of January, 1996 to the end of December. Below is the statistical data of this study which concerns the distinction of sex, ages, and occupations from the 600 examinees. 1. According to the distinction of sex, there are 12 males and 11 females among the 300 examinees in each group. That means, the diabetic percentage is 4.0% versus 3.6% and male/female diabetic ratio is 1.1:1 2. According to the distinction of ages, there is one people 0.25% aged 20years old and 5 peoples 1.3% aged 30 years old among the 400 examinees. There are 6 peoples 1.0% aged 40 years old and 6 peoples 1.0% aged 50 years old among the 600 examinees. There are 4 peoples 2.0% aged 60 years old among the 200 examinees. 3. According to the distinction of occupations, there are 13 white collar workers 6.5% among the 200 examinees, and there are 8 blue collar workers(4%) among the 200 examinees. There are 2 government employees 1% among the 200 examinees. This show that there is less diabets in government employees than other occupational groups of the same number. 4. Among the white and blue collar workers, 7 diabetis's blood glucose levels are 140mg%--200 mg% and 6 are 200mg%. 5. Among the community medical insurance holders, 7 diabetic's blood glucose levels are 140 mg%--200mg% and 1 is 200mg%. 6. Among the government employees, 2 diabetic's bleed glucose levels are 140mg--200mg% and there is no 200mg%.

• Journal of Technology Innovation
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• v.24 no.2
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• pp.57-89
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• 2016

This paper used individual establishment level data to estimate the effects of government support for the research and development of 'small and medium enterprises'(SMEs). We analyzed, on the establishment level, the degree of technical advancement, strength of private R&D incentives, and the effect on employment levels of firms which participated in the 2010 government R&D support project. The results of this study are as follows. First, the size and frequency of government investment in the R&D of SMEs were both positively correlated with the amount of patent registrations. Furthermore, we found that the amount of patent registrations were positively correlated with the size of the establishments, but the average level of technological advancement for the firms running the research was lower than the average level of technological advancement for the firms merely participating in the project. Second, the government's R&D policy was found to be complementary to private R&D incentives, and a 1% increase in government R&D investment resulted in an inelastic increase (0.193~0.245%) of the firms' post-program R&D spending. Third, we found that R&D support from the government contributed to an increase of employment by the participating firms. Additionally, we found that the impact of R&D support on job creation varied for the firm size and technological characteristics. Therefore, it is important for governments to take into consideration each type of small business, when setting R&D policies.

• Analytical Science and Technology
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• v.27 no.2
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• pp.114-120
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• 2014

The aim of this study was to investigate of total ash, acid-insoluble ash and heavy metals content contained in commercial herbal medicines classified by parts used. A total of 1504 samples (84 species) purchased from markets in Seoul, are classified by five kinds of plant parts. The mean of total ash and acidinsoluble ash content (%) were as follows; Herba 9.0, 1.1, Caulis and cortex 6.1, 1.0, Flos fructus and semen 5.1, 0.8, Radix 4.6, 0.7 and Rhizoma 4.3, 0.4. The total amount of individual heavy metals content (mg/kg) (Pb, As, Cd and Hg) was high in Herba 1.13 and decreased in the order of Caulis and cortex 1.07, Rhizoma 0.91 and Radix 0.91, and was low in Flos fructus and semen 0.73. In addition, acid-insoluble ash contents was correlated with the total amount of individual heavy metals (r=0.314) (p<0.01).

• Journal of Korean Library and Information Science Society
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• v.26
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• pp.93-130
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• 1997

The objective of this study is to catch hold of the problem occurring in the process in which librarians have obtained government publications and to show the method that can construct the rational distribution system of government publications. For this study, total 56 librarians who work for 44 institutes sponsored by central government and 12 institutes sponsored by local government were chosen as the objects of research and questionnaire survey to know how to obtain government publications. How to construct the rational distribution system of government publications is as follows. (1) The exclusive organization to manage overall service for government publications should be established newly or previous similar organization should be reorganized. (2) As reinforcing the law concerning deposit copy, government publications should be distributed obligatorily to all of the depository agency, and the depository library system of government publications should be introduced and managed newly. Especially the management of deposit copy and the depository library system of government publications should be undertaken by the exclusive agency of government publications. (3) Free-government publications should be converted to pay-government publications as much as possible so that everyone can purchase government publications easily. And free-government publications which are difficult to convert to pay-government publications should be distributed according to rational standard by the exclusive agency of government publications. (4) Pay-government publications should be sold by private distribution organization under exclusive agency of government publications. Also printing, editing and pricing of pay-government publications should be done by private distribution organization to compete with general books. (5) In order to promote the sales of pay-government publications, the sales centers of government publications must be established even in city and county. Also special government publications which have much demand should be sold even in general book stores. Especially the management of the sales centers should be undertaken by private distribution organization. (6) It is necessary to abolish or improve unreasonable regulations or system related to government publications and to make legislative, institutional devices for government publications. (7) The public relations for government publications should be enforced much through TV or radio etc. , and the various bibliographic tools of government publications should be developed and disseminated for the sake of much utilization of government publications. (8) By using new technology like CD-ROMs or communication networks, electronic production and distribution of government publications should be push ahead positively. And electronic information distribution center to su n.0, pport it should be established by government agency.

• Journal of Korean Library and Information Science Society
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• v.23
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• pp.79-108
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• 1995

Government Publications are published to keep records of governmental activities and performances. In a rapidly changing information-oriented society, it is badly required for the operation system of government publications and a library to be effectively managed with government publications for satisfying 'right to know' of people and improving the obligation of government to 'let people know.' Accordingly, the purpose of this paper is to analyze such five research items as the situation of the publication and distribution of, government publications, the operation system of the publications in library, the number of publications regarding secondary information sources for the publications, and the legal deposit of the publications in the National Library, in order to proceed with a subject as to how much the government publication is satisfying 'right to know' of people. The research findings were suggested as follow : 1) Despite the fact that the publication of government publications has been gradually increased every year in numbers and kinds, it is unfortunately pointed out that the publications, distributions and sellings of them were not well organized and systematic. That is, the government publications had not been published more than 1.47% of all publications in number. Moreover, more than the half of the publications were non-periodically or annually published. To make the matter worse, it was not easy to get an access to the publications because of the publications not to be sold. 2) It a n.0, ppears that people could not use the publications efficiently because the library and administrative document office did not pay sufficient attention to public relations for all sorts of government publications. Not only that, there were not enough numbers of publications regarding such secondary information sources as bibliography, index and catalog. A speedy searching capacity for the information gave rise to another serious problem which the government publications could not be effectively used. 3) It is legally stated that all sorts of government publication should be deposited to the National Libraries. However, the law was not properly put into force because of lack of understanding of government agencies about the law.

• Journal of Environmental Health Sciences
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• v.49 no.2
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• pp.66-77
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• 2023

Background: Along with the increase in consumer interest in and consumption of tattoo products, the controversy over harmful heavy metals associated with the use of tattoo cosmetics is also increasing. Therefore, investigation of hazardous metals in these tattoo products is needed. Objectives: This study was performed to provide useful data for establishing reasonable standards to securely manage tattoo cosmetics, tattoo stickers, and tattoo inks distributed in the market. Methods: Thirteen kinds of hazardous metal contents (Pb, As, Cd, Sb, Ni, Co, Cu, Cr, Se, Ba, Zn, Sn, and Hg) were analyzed for 23 tattoo cosmetics, ten tattoo stickers, and 16 tattoo inks. Hg was measured through the combustion-gold amalgamation method, and other hazardous metals were measured by inductively coupled plasma-mass spectrometry (ICP-MS) after acidic decomposition using a microwave apparatus. Results: The detected ranges of Pb, As, Cd, Sb, Ni, and Hg in tattoo cosmetics were 0.07~1.18, 0.06~0.41, ND~0.07, 0.01~3.44, 0.12~2.75, and ND~0.01 ㎍/g, respectively. All of the hazardous metals detected were below the recommended maximum standards of the Ministry of Food and Drug Safety. The mean amount of Pb detected in tattoo stickers for children was 0.24 ㎍/kg and Cd was not detected, meaning both metals met the recommended criteria. There was no statistically significant difference in all measured metals between children's tattoo stickers and adults' tattoo stickers. In the results of the study on the hazardous metal content of tattoo inks, four products (25%) for Pb, one product (6%) for As, 13 products (81%) for Ni, four products (25%) for Cu, and five products (31%) for Zn exceeded the recommended standards approved by the government. The highest predicted exposure amount for hazardous metals exceeding the recommended level of tattoo inks in a single tattooing was 5.69 ㎍/kg for Ni, 8.51 ㎍/kg for Zn, 0.44 ㎍/kg for Pb, 8.07 ㎍/kg for Cu, 0.44 ㎍/kg for As, and 71.36 ㎍/kg for Ba. Conclusions: It is necessary to prepare criteria for content limitation for the management of Co, Cr, Ba and Se tattoo cosmetics, and tattoo inks require thorough quality control.

• Analytical Science and Technology
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• v.36 no.6
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• pp.267-280
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• 2023

This study investigated the contents of Pb, Cd, As, and Hg for 4333 samples with 2 09 types of herbal medicines distributed in Seoul area from 2019 to 2021, and evaluated risk assessment according to medicinal part used and origin. The contents of heavy metals were analyzed by inductively coupled plasma mass spectrometry (ICP-MS) and mercury analyzer. The average contents (mg/kg) of heavy metals by medicinal parts were 0.123 to 1.290 for Pb, 0.018 to 0.131 for Cd, 0.034 to 0.290 for As, and 0.003 to 0.015 for Hg. The contents of Pb were higher in Leaves and Whole Herbs (above-ground part) than underground part (Radix & Rhizoma) (ANOVA-test, p < 0.05). The contents of Cd were high in Leaves, Radix & Rhizoma, and Stems & Woods (ANOVA-test, p <0 .05), and exceeded regulatory limits in various types. Levels of Pb, Cd concentrations exceeding regulatory limits were observed in 8, 22 samples (8, 14 types). No sample exceeded regulatory limits of As and Hg. In the comparison between countries of origin, the contents of Cd, As, and Hg were high in imported herbal medicines (t-test, p < 0.05). As a result of the risk assessment, except for Thujae Orientalis Folium and Spirodelae Herba, the MOE values of Pb were all 1 or more, and most samples were safe. The Hazard Index (HI) for Cd, As, and Hg were evaluated to be less than 100 % even if the risk (%) of each heavy metal was added, and the risk from taking herbal medicines was evaluated to be safe.