• The Journal of Internal Korean Medicine
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• v.34 no.3
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• pp.289-297
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• 2013

Objectives : The purpose of this study was to review the clinical studies on antihypertensive effects of Oryeong-san. Methods : We searched papers using KTKP, Oasis, CNKI, PubMed, Embase, Science Direct, CINAHL, J STAGE and CiNii, and the key words "Oryeong-san (韓)", "Wuling-san (中)", "Gorei-san (日)", and "Hypertension" were used. Search range included randomized controlled trials (RCTs), clinical reports, reviews and animal experiments. Papers not matched with inclusion criteria were excluded. Results : A total 479 studies were found, with 457 excluded during title and screening. After scanning 22 papers, a final 3 RCTs and 6 case reports were selected and analyzed. In the 3 RCTs, the number of patients varied between 65 and 156. Patients with hypertension were randomized into groups for treatment group and control group. They were all treated with antihypertensive drugs (Vamlodipine Besylate, Benazepril, Perindopril); the treatment group was also given modified Oryeong-san. After treatment, results were that blood pressure was significantly decreased in the treatment group, compared to the control. The other 6 case reports reported that modified Oryeong-san alone or the combination of Oryeong-san plus antihypertensive drugs had beneficial effects on blood pressure. Conclusions : Oryeong-san appears to be effective in improving blood pressure and hypertension-related symptoms. The results of this study could be applied to clinical treatment of hypertension. Further large-scale clinical researches should be conducted.

• The Journal of Internal Korean Medicine
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• v.38 no.4
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• pp.443-454
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• 2017

Objectives: This study assessed the application of Oryung-san (Wuling-san or Gorei-san), a common diuretic in traditional medicine, as an antihypertensive agent. Methods: Experimental studies of the pharmacological properties of Oryung-san, including diuretic action and lowering effects on blood pressure, and toxicology and clinical trials were reviewed. Results: In pharmacology, various, relatively safe diuretics are used to lower blood pressure and are the oldest and most studied antihypertensive agents. Despite many new drug approvals, antihypertensive diuretics are frequently used in Korea and Japan where high levels of sodium uptake are common. Oryung-san has been demonstrated to have diuretic, antihypertensive, and nephroprotective effects. Conclusions: Oryung-san might be effective for lowering blood pressure based on the results of this literature review. Further evaluations and large-scale clinical trials of Oryung-san to treat primary hypertension are warranted.